November 26, 2020

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A Pharmacology Primer

A Pharmacology Primer
Author : Terry Kenakin
Publisher : Elsevier
Release Date : 2010-07-26
Category : Medical
Total pages :318
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The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments. Over 30 new figures and tables More human interest information to provide readers with historical facts on pharmacology research New section on therapeutics to help identify diseaes and drug treatments New section on new biological concepts relevant to pharmacological research (i.e., systems biology) New study sections organized with ASPET and other international pharmacology organizations New coverage of pharmacokinetics and drug disposition

A Pharmacology Primer

A Pharmacology Primer
Author : Terry Kenakin
Publisher : Academic Press
Release Date : 2018-10-26
Category : Medical
Total pages :488
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A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

Medication Workbook for Pharmacy Technicians: A Pharmacology Primer

Medication Workbook for Pharmacy Technicians: A Pharmacology Primer
Author : David R. Bright,Mary F. Powers
Publisher : Morton Publishing Company
Release Date : 2012-01-01
Category : Medical
Total pages :360
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Officially endorsed by the American Pharmacists Association (APhA), this practical workbook provides a basic introduction to pharmacology and reinforces the use of medications for prospective technicians to work in a pharmacy and to help prepare them for the pharmacy technician national certification exams.

Elements of Pharmacology

Elements of Pharmacology
Author : P. J. Bentley
Publisher : Cambridge University Press
Release Date : 1981-08-31
Category : Medical
Total pages :154
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Written primarily for students of medicine, pharmacy, and pharmacology, this introductory book provides a concise summary of the principles that underlie the science of pharmacology. It presents the basic concepts required for understanding the use, mechanisms of action, toxicity and side effects, and therapeutic application of drugs in man. Thus the book may also be of interest to medical practitioners and to biological and medical scientists. Among topics covered are the sources of drugs, the way they are administered and dealt with in the body, as well as concepts about the nature of their actions. The last include their chemical interactions with components of cells and the manner in which these lead to therapeutically desirable as well as undesirable and even toxic effects. In addition, clinically related subjects, such as drug interactions, teratogenic and carcinogenic effects are discussed. The development and testing of new drugs are also described. For easy reference, at the back of the book there is a glossary of drugs named in the text.

A Primer of Drug Action

A Primer of Drug Action
Author : Robert M. Julien, Ph.D.
Publisher : Holt Paperbacks
Release Date : 2013-08-06
Category : Health & Fitness
Total pages :512
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Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular guide continues to lead the way through a rapidly changing field, providing readers with a clear, contemporary, and objective look at every drug and medication that either positively or adversely affects brain function. This edition includes important new information on -Herbal medications -Drug therapy for behavioral and anxiety disorders -Clinical practice guidelines for treating psychological disorders -Depression and the action of antidepressant drugs -The use of newer anticonvulsants in the treatment of bipolar disorder, pain syndromes, and behavioral disorders -Drug therapy for children, adolescents and the elderly -"New generation" antipsychotic agents Authoritative, comprehensive, and suitable for those with little background in biology, A Primer of Drug Action is an indispensable source of information for anyone interested in drug use, abuse, and education.

Julien's Primer of Drug Action

Julien's Primer of Drug Action
Author : Claire D. Advokat,Joseph E. Comaty,Robert M. Julien, Ph.D.
Publisher : Macmillan Higher Education
Release Date : 2014-04-15
Category : Psychology
Total pages :614
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In its 40th anniversary edition, A Primer of Drug Action continues to evolve side by side with the field it covers, drawing on the expertise of its authors in medicine, basic science, and clinical science to offer the most current and comprehensive guide to psychopharmacology available.

Essential Pharmacokinetics

Essential Pharmacokinetics
Author : Thorsteinn Loftsson
Publisher : Academic Press
Release Date : 2015-03-25
Category : Medical
Total pages :178
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Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files

A Primer of Drug Action

A Primer of Drug Action
Author : Robert M. Julien
Publisher : Unknown
Release Date : 2001
Category : Psychopharmacology
Total pages :498
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Pharmacology in Drug Discovery and Development

Pharmacology in Drug Discovery and Development
Author : Terry Kenakin
Publisher : Academic Press
Release Date : 2016-10-21
Category : Medical
Total pages :350
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Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery. Includes example-based cases that illustrate how the pharmacological concepts discussed in this book lead to practical outcomes for further research Provides vignettes on those researchers and scientists who have contributed significantly to the fields of pharmacology and drug discovery throughout history Offers sample questions throughout the book and an appendix containing answers for self-testing and retention

Concise Clinical Pharmacology

Concise Clinical Pharmacology
Author : Ben Greenstein,Adam Greenstein
Publisher : Pharmaceutical Press
Release Date : 2007
Category : Medical
Total pages :302
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This is a concise study guide and thorough introduction to clinical pharmacology from which students can gain a rapid understanding of individual topics within the discipline, and from which they can review and revise certain topics before exams. This is achieved through self-contained two-page "spreads" for each topic, with concise text on the left and a diagram on the right to elaborate and reinforce the text. To further underpin the text, additional two page spreads have been included where appropriate, with case histories on the left and Q&As on the right. The text has a strong clinical focus and, in the main, sections relate to particular body systems or the therapy of a disease-class (eg, cancer). Pharmacological principles and mechanisms are covered, but the main focus is on the therapeutic use of the drugs. Sections cover basic principles of pharmacology, specialised pharmacology (inc. in pregnancy, paediatrics, geriatrics), and the vitamins. The text has been written primarily for pharmacy students, but will also be of interest to clinical medical students. The strong clinical focus should also appeal to practitioners.

Principles of CNS Drug Development

Principles of CNS Drug Development
Author : John Kelly
Publisher : John Wiley & Sons
Release Date : 2009-10-27
Category : Medical
Total pages :324
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This title acts as a primer, giving students and newcomers to the field an opportunity to learn about the breadth of the CNS drug discovery. The book outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets. Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery. Key Features: Discusses in detail the key stages of CNS drug discovery, outlining the particular requirements and obstacles for CNS drugs Addresses safety concerns and future drug targets Provides succinct background information about the major CNS diseases Examples of specific drugs are used throughout to describe the development of a new drug from conception to clinical use and post-market surveillance Primary reasons for drug failure are given for each stage

Primer on Transplantation

Primer on Transplantation
Author : American Society of Transplantation
Publisher : John Wiley & Sons
Release Date : 2010-12-15
Category : Medical
Total pages :368
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Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: immunobiology pharmacology donor management infectious complications pediatric transplantation general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: Interactive Multiple-Choice Questions for each chapter Figures from the book as Powerpoints for downloading All chapters online

Rowan's Primer of EEG E-Book

Rowan's Primer of EEG E-Book
Author : Lara V. Marcuse,Madeline C. Fields,Jiyeoun Jenna Yoo
Publisher : Elsevier Health Sciences
Release Date : 2015-09-22
Category : Medical
Total pages :208
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The new edition of Rowan’s Primer of EEG continues to provide clear, concise guidance on the difficult technical aspects of how to perform and interpret EEGs. Practical yet brief, it is perfectly suited for students, residents, and neurologists alike, while included reference material will be continually useful, even to the experienced doctor. Features brief, to-the-point text with easily understandable language for quick reference. Portable design makes it simple to carry anywhere. Concise, reader-friendly format features improved 4-color design and online quiz-format assessment questions within each chapter. Includes the new nomenclature for EEGs put forth by the American Clinical Neurophysiology Society. Features a greater focus on pediatrics content and includes online videos detailing clinical descriptions of seizures and EEG interpretation. Delivers a concise chart of the EEG changes through the neonatal period. Offers enhanced coverage of epilepsy syndromes with a quick-access chart highlighting age of onset, prognosis, clinical characteristics, and EEG characteristics.

Drug Discovery and Development - E-Book

Drug Discovery and Development - E-Book
Author : Raymond G Hill
Publisher : Elsevier Health Sciences
Release Date : 2012-07-20
Category : Medical
Total pages :368
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The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

What Makes Life Worth Living

What Makes Life Worth Living
Author : Bernard Stiegler
Publisher : John Wiley & Sons
Release Date : 2013-11-18
Category : Political Science
Total pages :200
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In the aftermath of the First World War, the poet Paul Valéry wrote of a ‘crisis of spirit’, brought about by the instrumentalization of knowledge and the destructive subordination of culture to profit. Recent events demonstrate all too clearly that that the stock of mind, or spirit, continues to fall. The economy is toxically organized around the pursuit of short-term gain, supported by an infantilizing, dumbed-down media. Advertising technologies make relentless demands on our attention, reducing us to idiotic beasts, no longer capable of living. Spiralling rates of mental illness show that the fragile life of the mind is at breaking point. Underlying these multiple symptoms is consumer capitalism, which systematically immiserates those whom it purports to liberate. Returning to Marx’s theory, Stiegler argues that consumerism marks a new stage in the history of proletarianization. It is no longer just labour that is exploited, pushed below the limits of subsistence, but the desire that is characteristic of human spirit. The cure to this malaise is to be found in what Stiegler calls a ‘pharmacology of the spirit’. Here, pharmacology has nothing to do with the chemical supplements developed by the pharmaceutical industry. The pharmakon, defined as both cure and poison, refers to the technical objects through which we open ourselves to new futures, and thereby create the spirit that makes us human. By reference to a range of figures, from Socrates, Simondon and Derrida to the child psychoanalyst Donald Winnicott, Stiegler shows that technics are both the cause of our suffering and also what makes life worth living.