June 12, 2021

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Aging

Aging
Author : Victor R. Preedy
Publisher : Academic Press
Release Date : 2014-03-05
Category : Medical
Total pages :301
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Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams Nutritionists and dietitians will gain an understanding of cell signaling and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

Aging

Aging
Author : Victor R. Preedy
Publisher : Academic Press
Release Date : 2017-10-30
Category : Medical
Total pages :316
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Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams Nutritionists and dietitians will gain an understanding of cell signaling and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

Pathology

Pathology
Author : Victor R. Preedy
Publisher : Academic Press
Release Date : 2020-04-25
Category : Health & Fitness
Total pages :432
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Pathology: Oxidative Stress and Dietary Antioxidants bridges the disciplinary knowledge gap to help advance medical sciences and provide preventative and treatment strategies for pathologists, health care workers, food scientists and nutritionists who have divergent skills. This is important as oxidative stress can be ameliorated with pharmacological, nutraceutical or natural agents. While pathologists and clinical workers understand the processes in disease, they are less conversant in the science of nutrition and dietetics. Conversely, nutritionists and dietitians are less conversant with the detailed clinical background and science of pathology. This book helps to fill those gaps. Saves clinicians and researchers time by helping them to quickly access the very latest details on a broad range of pathologies and oxidation issues Combines the science of oxidative stress and the putative therapeutic usage of natural antioxidants in the diet Includes preclinical, clinical and population studies to help pathologists, nutritionists, dieticians, and clinicians map out key areas for research and further clinical recommendations

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases
Author : Colin R. Martin,Victor R. Preedy
Publisher : Academic Press
Release Date : 2020-06-12
Category : Medical
Total pages :444
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Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

Oxidative Stress and Hormesis in Evolutionary Ecology and Physiology

Oxidative Stress and Hormesis in Evolutionary Ecology and Physiology
Author : David Costantini
Publisher : Springer Science & Business Media
Release Date : 2014-03-27
Category : Science
Total pages :348
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This book discusses oxidative stress and hormesis from the perspective of an evolutionary ecologist or physiologist. In the first of ten chapters, general historical information, definitions, and background of research on oxidative stress physiology, hormesis, and life history are provided. Chapters 2-10 highlight the different solutions that organisms have evolved to cope with the oxidative threats posed by their environments and lifestyles. The author illustrates how oxidative stress and hormesis have shaped diversity in organism life-histories, behavioral profiles, morphological phenotypes, and aging mechanisms. The book offers fascinating insights into how organisms work and how they evolve to sustain their physiological functions under a vast array of environmental conditions.

An Assessment of the Effects of Oxidative Stress and Dietary Antioxidants on Toxin-induced Dilated Cardiomyopathy in the Turkey (meleagris Gallopavo)

An Assessment of the Effects of Oxidative Stress and Dietary Antioxidants on Toxin-induced Dilated Cardiomyopathy in the Turkey (meleagris Gallopavo)
Author : Anonim
Publisher : Unknown
Release Date : 2009
Category :
Total pages :129
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Dilated cardiomyopathy (DCM) or round heart disease is a muscle disease of the heart characterized by left ventricular dilatation and abnormal systolic and diastolic ventricular function. In animals, including turkeys and humans, DCM is a major cause of morbidity and mortality that results in heart failure. In the turkey, DCM can be idiopathic or induced. Since idiopathic or spontaneous DCM occurs in about 2-4 % of normal turkeys, it is of significant concern to the poultry industry. This dissertation was designed to increase our understanding of the pathophysiology of DCM in commercial turkeys. Specific objectives included: evaluating the influence of dietary selenium (Se) and vitamin E on poults fed toxic levels of furazolidone (Fz). Evaluating differences among reciprocal crosses of turkey varieties in susceptibility to a toxic level of Fz that induces DCM were used to assess the role of genetics in DCM. Using glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and plasma uric acid (PUA) as biomarkers, oxidative stress (OS) levels were evaluated. Oxidative stress was also evaluated in poults fed diets containing varying concentration and combinations of vitamin E (0, 50 and 100 IU/kg) and Se (0.0, 0.3 and 0.5 mg/kg). Results from echocardiography measurements at four weeks of age, for poults fed toxic levels of Fz, showed the Narragansett x Bourbon Red reciprocal cross had the lowest internal-diastolic (LVIDd) and systolic dimensions (LVISd), while the Bourbon Red x Narragansett reciprocal cross had the largest LVIDd and LVISd. Left ventricular internal-diastolic and systolic dimension were lower for cross bred than parental poults. In treatment poults, heterosis for ventricular dilation was most significant for Bourbon Red x Narragansett cross. The data suggest that reciprocal crosses respond differently to toxin that induces DCM and genetics may influence a turkey's response to toxic levels of Fz that causes DCM. Results from OS measurements in poults fed normal and those fed normal diets with Fz at two weeks of age, showed no significant differences in MDA and GPx levels. PUA and GSH levels were however significantly increased for poults fed Fz-containing diets. At four weeks of age, no differences were observed for MDA and GPx measurements between poults fed normal and Fz-containing diets. PUA levels increased for poults fed normal diets with Fz, while GSH levels increased only for those fed normal diets. Differences between poults fed normal and Fz-containing diets were significant for GPx measurements.

Antioxidants in Health and Disease

Antioxidants in Health and Disease
Author : Antonis Zampelas,Renata Micha
Publisher : CRC Press
Release Date : 2015-06-09
Category : Medical
Total pages :340
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Antioxidant use in health promotion and disease prevention either through dietary intake or supplementation is controversial. This book reviews the latest evidence-based research in the area, principally through prospective cohort studies and randomized controlled trials. It assesses major dietary antioxidants and discusses their use in diseases such as cancer, diabetes, stroke, coronary heart disease, HIV/AIDS, and neurodegenerative and immune diseases. The use of antioxidants in health is also discussed along with common adverse effects associated with antioxidant use.

Aging

Aging
Author : Victor R. Preedy,Vinood B. Patel
Publisher : Academic Press
Release Date : 2020-05-24
Category : Technology & Engineering
Total pages :398
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Aging: Oxidative Stress and Dietary Antioxidants, Second Edition, bridges the trans-disciplinary divide and covers the science of oxidative stress in aging and the therapeutic use of natural antioxidants in the food matrix in a single volume. The second edition covers new trials and investigations used to determine the comprehensive properties of antioxidants, food items and extracts, as well as any adverse properties they may have. It has been updated to include new clinical human trials and a new section dedicated to animal models of aging. Throughtout the book the processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients. Compares information related to mitochondrial oxidative stress in one disease to diet-related strategies in other unrelated diseases Provides an understanding of cell signalling leading to new suggestions of preventative or therapeutic strategies Includes a new section dedicated to animal models of aging

Towards Prolongation of the Healthy Life Span

Towards Prolongation of the Healthy Life Span
Author : International Association of Biomedical Gerontology. International Congress
Publisher : Unknown
Release Date : 1998
Category : Health & Fitness
Total pages :524
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This volume discusses the latest significant research on biological changes with age and the application of this knowledge to the problem of increasing the healthy life span. Data indicates that formation of superoxide radicals by mitochondria determines the rate of aging. This topic is discussed in order to find possible practical measures to decrease superoxide radical formation. Telomeres and the Hayflick limit are also discussed.

Modulation of Oxidative Stress in the Retinal Pigment Epithelium by Endogenous Pigmentation and Accessible Therapeutics

Modulation of Oxidative Stress in the Retinal Pigment Epithelium by Endogenous Pigmentation and Accessible Therapeutics
Author : Sally M. Yacout
Publisher : Unknown
Release Date : 2018
Category : Biochemistry
Total pages :182
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Age-related changes to endogenous pigments in the retinal pigment epithelium (RPE) are thought to significantly contribute to the etiology and progression of retinal diseases, such as Age-related macular degeneration (AMD). The research in this dissertation studies the modulation of oxidative stress by melanin and the efficacy of accessible therapeutics in attenuating damage to the RPE. Structural and functional characteristics of RPE melanin were studied, including age-related changes in donor melanin. Young melanin provides significant protection to photo-stressed RPE cells, while aged human donor melanin is capable of pro-oxidant behavior in cells. Structural characterization of aged human donor melanin suggests oxidative degradation of the pigment over time, which may contribute to decreased antioxidant capacity. Immunomodulation by RPE melanin was also studied in conjunction with the effects of glycated extracellular matrix proteins. Results show that melanin pigmentation modulates expression of the cytokine interleukin-6 (IL-6) and suggest a novel role for melanin in regulating immune and inflammatory mechanisms in the RPE. With increasing age, the antioxidant infrastructure of the RPE declines, resulting in unregulated oxidative stress and development of diseases such as AMD. The efficacy of plant-derived antioxidants in attenuating blue-light mediated oxidative stress in RPE cells was studied. Low doses of these dietary antioxidants significantly attenuate oxidative damage to RPE cells and are an accessible supplement. Liposomal delivery of L-DOPA supplements was also studied as a treatment option for AMD. This delivery system for L-DOPA stabilizes the supplement, preventing the formation of cytotoxic oxidation products. The supplements studied can serve as low-cost, accessible therapeutics for treatment and prevention of retinal damage and disease progression. The molecular mechanisms of aging are complex and multifaceted. In the retina, changes to endogenous pigmentation overtime promote cell damage and disease progression. The functional role of melanin in the RPE is not fully understood, however the pigment appears to play a significant role in modulating oxidative stress and inflammation. A better understanding of how biochemical changes to the RPE contribute to the onset and progression of age-related disease can better the development of therapeutics and target specific treatments.

Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease

Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease
Author : J T Kumpulainen,J T Salonen
Publisher : Elsevier
Release Date : 1999-01-01
Category : Technology & Engineering
Total pages :466
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Natural antioxidants and anticarcinogens in nutrition, health and disease represents the most recent information and state-of-the-art knowledge on the role of antioxidative vitamins, carotenoids and flavonoids in ageing, atherosclerosis, and diabetes, as well as the role of natural anticarcinogenic compounds, particularly lignans and isoflavonoids, and cancer prevention. It is highly interdisciplinary, and will be of importance to all scientists working in the medical, biomedical, nutritional and food sciences as well as the academics.

Oxidative Stress and Chronic Degenerative Diseases

Oxidative Stress and Chronic Degenerative Diseases
Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
Release Date : 2013-05-22
Category : Science
Total pages :514
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This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Role of Dietary Carotenoids in Different Etiologies of Chronic Liver Diseases

Role of Dietary Carotenoids in Different Etiologies of Chronic Liver Diseases
Author : Uzma Latief
Publisher : Unknown
Release Date : 2018
Category : Technology
Total pages :129
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Carotenoids are tetraterpenoid organic pigments synthesized by a variety of plants and microorganisms. Dietary carotenoids, taken by animals through food, play an essential role in cell differentiation, morphogenesis, vision, prevention of cancer, atherosclerosis, and age-related macular degeneration in humans due to their potential to suppress oxidative stress. As reactive oxygen species and oxidative damage to biomolecules have been found to be involved in the causation and progression of chronic liver diseases (CLDs), including hepatocellular carcinoma (HCC), which is one of the major causes of morbidity and mortality worldwide. Therefore, dietary antioxidants, which inactivate reactive oxygen species and obstruct oxidative damage, are considered as vital prophylactic strategic molecules. Data from various epidemiological studies and clinical trials strongly validate the observation that adequate carotenoid supplementation may significantly reduce the risk of several liver disorders. This chapter, thus, provides a comprehensive account of dietary carotenoids and includes the recent information with respect to their role in prevention of liver diseases.

Government Research Directory

Government Research Directory
Author : Anonim
Publisher : Unknown
Release Date : 2010
Category : Executive departments
Total pages :129
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Oxidative Stress and Aging

Oxidative Stress and Aging
Author : R.C. Cutler,L. Packer,J. Bertram,A. Mori
Publisher : Birkhäuser
Release Date : 2012-12-06
Category : Science
Total pages :399
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Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.