November 27, 2020

Download Ebook Free Animal Models For The Study Of Human Disease

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author : P. Michael Conn
Publisher : Academic Press
Release Date : 2013-05-29
Category : Science
Total pages :1108
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Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author : Lina Badimon,Laura Casani,Gemma Vilahur
Publisher : Elsevier Inc. Chapters
Release Date : 2013-05-29
Category : Medical
Total pages :1108
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Experimental approaches to understand the pathophysiology of atherosclerosis and thrombosis involve the combination of both cellular and animal approaches. Animals have been instrumental in biomedical research in order to provide a better understanding on the mechanisms that have already been outlined in in vitro studies. Atherosclerosis studies were firstly carried out in rodents using diet-induced atherosclerosis approaches. However, these diets were un-physiological and the developed lesions were often limited in size, composition, and location largely differing from humans. During the last years, with the advent of molecular genetics and genetic manipulation techniques, the development of gene-engineered animals has allowed an explosion in the number of models resulting in a tremendous progress in the understanding of both atherosclerosis and thrombosis. However, direct translation from rodents to humans has to be taken with caution because of the well-reported species-related differences. Although there is no known animal model for human disease, large animal models have demonstrated better suitability for translation to humans. For instance swine, a species that spontaneously develops atherosclerosis and thrombosis, are more closely mimics of the macrovascular-related thrombotic complications found in humans. This book chapter provides an in depth overview of the currently available small and large animal modelsof atherosclerosis and thrombosis and examinestheir applicability for translational research purposes as well as highlights species-related differences with humans.

Experimental Animal Models of Human Diseases

Experimental Animal Models of Human Diseases
Author : Bartholomew Ibeh
Publisher : BoD – Books on Demand
Release Date : 2018-05-23
Category : Science
Total pages :408
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The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author : Belinda A. Henry,Iain J. Clarke
Publisher : Elsevier Inc. Chapters
Release Date : 2013-05-29
Category : Medical
Total pages :1108
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Body weight is determined by the balance between energy intake and energy expenditure. Obesity ensues when energy intake exceeds that of energy expenditure. To date, the majority of pharmaco-therapies to control body weight have been directed towards the appetitive limb of this energy balance equation. Very few anti-obesity agents target the manipulation of energy expenditure. The recent unequivocal demonstration that functional brown adipose tissue is present in adult humans has sparked a great deal of interest in developing means to exploit thermogenesis to control body weight. Thermogenesis is defined as the dissipation of energy through the production of heat and occurs in specialised tissues including brown adipose tissue and skeletal muscle. This chapter will highlight a number of animal models that are currently utilised in effort to understand the mechanisms that underpin thermogenesis. It will describe the control of thermogenesis in skeletal muscle and adipose tissue as well as detailing the role of thermogenesis in determining the susceptibility to obesity in a number of distinct animal models.

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research
Author : P. Michael Conn
Publisher : Springer Science & Business Media
Release Date : 2008
Category : Medical
Total pages :778
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The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Animals for Medical Research

Animals for Medical Research
Author : Brij M. Mitruka,Howard M. Rawnsley,Dharam V. Vadehra
Publisher : Krieger Publishing Company
Release Date : 1982
Category : Medical
Total pages :591
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This text provides valuable information in selecting and using suitable animal species for research so that the experimental data can be meaningful and relevant to human disease. It will be useful to those involved in experimental biology and medical research.

Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
Author : Anonim
Publisher : Academic Press
Release Date : 2019-07-30
Category : Medical
Total pages :226
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Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Animal Models for Human Cancer, Volume 69

Animal Models for Human Cancer, Volume 69
Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Publisher : John Wiley & Sons
Release Date : 2016-08-15
Category : Medical
Total pages :272
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Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Handbook of Models for Human Aging

Handbook of Models for Human Aging
Author : P. Michael Conn
Publisher : Elsevier
Release Date : 2011-04-28
Category : Medical
Total pages :1075
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The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author : Alistair McGregor,K. Yeon Choi,Scott Schachtele,James Lokensgard
Publisher : Elsevier Inc. Chapters
Release Date : 2013-05-29
Category : Medical
Total pages :1108
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This chapter reviews the various human herpesviruses (HHVs) and their associated diseases. Animal models have been developed to study some HHVs, and these, as well as development of intervention strategies using these models, are discussed. Additionally, specific protocols are included to enable investigators to use the current state of the art techniques to explore various aspects of viral infection in animal models. The protocols presented in this chapter are a collection of techniques that are generally applicable to the study of all herpesviruses in animal models and can be utilized by both the experienced and inexperienced virologist.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author : Heather A. Lawson
Publisher : Elsevier Inc. Chapters
Release Date : 2013-05-29
Category : Medical
Total pages :1108
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Metabolic syndrome (MetS) is a clustering of metabolic complications representing a pre-morbid condition that is a substantial public health burden. Animal models provide an opportunity to examine correlations among different metabolic parameters to understand why metabolic complications sometimes cluster and sometimes do not. This chapter provides an overview of animal models of MetS that are used to understand etiology and pathophysiology, with a focus on methods of identifying and testing candidate genes with the aim of translating results to human studies. Genetic, epigenetic, environmental, and gene by environmental methods and results are discussed along with important lessons learned. Rodent models are the most frequently used, however other animal models including dogs, pigs, sheep, and non-human primates have contributed to our understanding of MetS and each are discussed. Additionally, animal models used to test physiological hypotheses are reviewed along with their potential to illuminate DNA sequence–metabolic function relationships to inform therapies.

Fundamentals of Laboratory Animal Science

Fundamentals of Laboratory Animal Science
Author : Enqi Liu,Jianglin Fan
Publisher : CRC Press
Release Date : 2017-07-28
Category : Medical
Total pages :352
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Laboratory animals are becoming increasingly important for biomedical research. It is said that approximately 70% of biomedical research is associated with the use of experimental animals. Laboratory animal research not only expands our knowledge of science, but also greatly improves human and animal health. The field of laboratory animal science is ever-growing and changing as new experimental techniques are developed and new animal models are created. It is essential to know not only the biological features of each laboratory animal but also how to use and care for them responsibly in order to perform high-quality experiments. Courses in beginning Laboratory Animal Science are starting to be offered in many universities throughout the world. However, a practical introductory textbook that contains state-of-the-art techniques is still lacking. Fundamentals of Laboratory Animal Science provides comprehensive information on the principles and practices of using laboratory animals for biomedical research. Each individual chapter focuses on a key sub-discipline of laboratory animal science: animal welfare and best humane care practices in the laboratory; the quality control of laboratory animals; the anatomy, physiology, and husbandry of commonly used species; the principles of creating and using animal models for studying human diseases; practical techniques used for laboratory animal experiments; experimental design; and animal experimentation management. Knowledge of this broad spectrum of concepts and skills will ensure research goes smoothly while greatly reducing animal pain and distress. Well-illustrated and thoroughly referenced, this book will serve not only as a standard textbook but also as a handy guide for veterinarians, researchers, animal care staff, administrators, and other professionals who are involved in laboratory animal science.

Development of Humanized Mouse Models for Infectious Diseases and Cancer

Development of Humanized Mouse Models for Infectious Diseases and Cancer
Author : Moriya Tsuji,Ramesh Akkina
Publisher : Frontiers Media SA
Release Date : 2020-02-19
Category :
Total pages :129
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Spontaneous Animal Models of Human Disease

Spontaneous Animal Models of Human Disease
Author : Edwin J. Andrews,Billy C. Ward,Norman H. Altman
Publisher : Elsevier
Release Date : 2012-12-02
Category : Science
Total pages :324
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This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models. The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.

Rabbit Biotechnology

Rabbit Biotechnology
Author : Louis-Marie Houdebine,Jianglin Fan
Publisher : Springer Science & Business Media
Release Date : 2009-04-24
Category : Medical
Total pages :136
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Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.