June 17, 2021

Download Ebook Free Autophagy And Cardiometabolic Diseases

Autophagy and Cardiometabolic Diseases

Autophagy and Cardiometabolic Diseases
Author : Jun Ren,James R. Sowers,Yingmei Zhang
Publisher : Academic Press
Release Date : 2018-04-12
Category : Medical
Total pages :340
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Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Autophagy and Protein Quality Control in Cardiometabolic Diseases

Autophagy and Protein Quality Control in Cardiometabolic Diseases
Author : Jun Ren
Publisher : Unknown
Release Date : 2015
Category :
Total pages :199
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The Autophagy-lysosome System in Cardiometabolic Disease

The Autophagy-lysosome System in Cardiometabolic Disease
Author : Trent D. Evans
Publisher : Unknown
Release Date : 2019
Category : Electronic dissertations
Total pages :112
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The accumulation of dysfunctional proteins and organelles is a defining feature of metabolic disease in nearly every tissue. A key pathway addressing this challenge is the autophagy-lysosome system which serves to identify, sequester, and degrade cellular components. Here, I first report on harnessing TFEB, a transcription factor master regulator of genes involved in autophagy-lysosome biogenesis, lipid metabolism, and mitochondrial metabolism to drive this pathway in adipocytes. We found that TFEB overexpression protects mice from diet induced obesity and adverse metabolic sequelae including insulin resistance and hepatic steatosis. TFEB modestly induces expression of autophagy and lysosomal genes, but this targeting seemed insufficient to explain the observed metabolic phenotypes. Instead, we found that TFEB robustly induced expression of mitochondrial and lipid metabolic genes, resulting in enhanced thermogenesis. We identified the transcriptional coactivator PGC-1[alpha] as a key target of TFEB in adipocytes and demonstrated that TFEB-induced effects were largely PGC-1[alpha] dependent. These studies position TFEB as a potent regulator of adipocyte physiology with implications for targeting this pathway therapeutically.Second, I functionally characterized genetic variants in the Lysosomal Acid Lipase (LIPA) genetic risk locus for coronary artery disease. LIPA is the sole lysosomal cholesterol esterase crucial for lipid metabolism in the atherosclerotic plaque, and rare loss-of-function variants lead to severe cholesterol accumulation and early death. As a whole, we found the risk variants were associated with a gain-of-function in human monocyte enzyme activity and expression attributable to intronic variants in the locus. We also identified a single exonic variant in the risk locus resulting in the amino acid substitution T16P which could plausibly disrupt enzyme trafficking amounting to a net loss of function. Studied in isolation, however, the exonic variant did not functionally impair enzyme expression, secretion, stability, or trafficking to the lysosome. These results establish the LIPA risk locus for coronary artery disease as resulting from a gain-of-function and set the stage for future studies mechanistically exploring mechanisms of pathogenesis.

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Release Date : 2019-08-08
Category :
Total pages :89
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Characterization of Cardiac Autophagy in the Setting of Metabolic Syndrome Using Animal Models

Characterization of Cardiac Autophagy in the Setting of Metabolic Syndrome Using Animal Models
Author : Anonim
Publisher : Unknown
Release Date : 2014
Category : Dissertations, Academic
Total pages :54
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Cardiovascular diseases (CVD) are the leading cause of mortality worldwide. Approximately 17 million people die of CVD. Obesity is considered to be a major risk factor which predisposes an individual to an increased risk of cardiovascular disease mortality. A clustering of risk factors such as obesity, insulin resistance and dyslipidemia results in the metabolic syndrome (MetS) which has a high prevalence rate of 23.7 percent of the US population. Several studies have shown that cellular autophagy is altered in the setting of metabolic syndrome and may contribute to cardiac dysfunction. However, the status of cardiac autophagic flux and autophagy-regulating pathways in the setting of MetS is unknown. The current literature implicates AMPK and mTOR, the key cellular energy sensors in the homeostatic regulation of autophagy. To test the hypothesis that cardiac autophagy is impaired in the setting of MetS mediated by changes in the upstream regulators- AMPK and mTOR, I used the diet-induced obese (DIO) mice and Zucker obese (ZO) rats (genetic model of obesity) as models of MetS. Under baseline conditions, the DIO mice showed impaired cardiac autophagic flux, a hyper-activated state of mTOR and a repressed state of AMPK. Under a physiological stress such as a fast, DIO mice showed impaired activation of cardiac autophagy despite intact responsiveness of the upstream regulators and intact gene expression. To examine the responsiveness of autophagy and that of its upstream regulators in cardiomyocytes sequestered from the extracellular milieu, I used adult rat ventricular cardiomyocytes (ARVM) isolated from ZO rats subjected to autophagy-inducing interventions. The ARVM from ZO rat hearts showed an impaired activation of autophagy despite intact responsiveness of the upstream regulators, similar to the profile observed in vivo. Overall, my results show that cardiac autophagy is indeed impaired in the setting of MetS despite the responsiveness of its regulatory pathways, AMPK and mTOR.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Author : M. A. Hayat
Publisher : Academic Press
Release Date : 2014-02-14
Category : Medical
Total pages :432
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Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast

Autophagy in Health and Disease

Autophagy in Health and Disease
Author : Roberta A. Gottlieb
Publisher : Academic Press
Release Date : 2012-10-16
Category : Medical
Total pages :227
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Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Author : M. A. Hayat
Publisher : Academic Press
Release Date : 2015-02-17
Category : Science
Total pages :316
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Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 7 provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; and the role of autophagy in apoptosis. Attention is given to autophagy in the cardiovascular system, with particular insights into the role of autophagy in atherosclerosis and the distinctive behavior of autophagy in the sinoatrial node. Cutting-edge findings in the relationships between autophagy and lifestyle are explored with the regulation of macroautophagy in response to exercise, as well as the promotion of carcinogenesis via autophagy in response to cigarette smoking. Volume 7 highlights the importance of understanding the role of autophagy in context, as the complexity of autophagic function becomes increasingly clear. Autophagy may be differentially regulated, and may perform distinctive cell-specific functions even within a single tissue. The overall significance of autophagy thus cannot be oversimplified, and must be explored with granular detail of the specific role, function, and area of impact. This book is an asset to newcomers as a concise overview of the complex significance of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss recent developments in this rapidly-advancing field . Discusses the formation of phagophores / autophagosomes, focusing on imaging tools, three-dimensional morphology, and the role of the endoplasmic reticulum . Covers role of autophagy in monocyte-macrophage differentiation; cell death in cancer; and apoptosis in odontogenesis . Organized for readers into easy-to-access sections: autophagosome biogenesis and regulation; autophagy in protein quality control; autophagy and apoptosis; autophagy in the cardiovascular system; and lifestyle and autophagy

Autophagy

Autophagy
Author : Xihui Xu,Jun Ren
Publisher : Elsevier Inc. Chapters
Release Date : 2013-09-03
Category : Medical
Total pages :440
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Obesity, defined as accumulation of excessive body fat, has grown dramatically and imposes a devastating, pandemic health threat. If uncorrected, obesity may confer an increased susceptibility to the onset and development of insulin resistance, hypertension, type 2 diabetes, and the cadre of metabolic syndrome. More importantly, evidence from our group and other laboratories has demonstrated that obesity contributes to the development of cardiac anomalies. Although multiple signaling pathways have been identified as responsible for cardiac dysfunction in obese individuals, the precise mechanism still remains elusive. The autophagy–lysosome pathway, which regulates the degradation of large intracellular organelles and protein aggregates, is essential for the maintenance of cardiomyocytes under physiological and pathological conditions. Recent studies have suggested that the autophagy pathway plays a pivotal role in the development of cardiac anomalies induced by obesity. In the present chapter, we focus on how autophagy is involved in the regulation of cardiac function in obesity and metabolic syndrome.

Mitochondrial Dysfunction and Cardiovascular Diseases

Mitochondrial Dysfunction and Cardiovascular Diseases
Author : Sebastiano Sciarretta,Richard N. Kitsis,Junichi Sadoshima
Publisher : Frontiers Media SA
Release Date : 2021-03-04
Category : Medical
Total pages :129
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Role of Environmental and Genetic Effect in Cardiomyopathy

Role of Environmental and Genetic Effect in Cardiomyopathy
Author : Qiurong Wang
Publisher : Unknown
Release Date : 2016
Category : Autophagic vacuoles
Total pages :193
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Cardiovascular disease is the leading cause of death in the US and other parts of the world. Various concurrent risk factors are associated with the ever-rising prevalence of heart diseases. Cardiovascular diseases are resulted from a complex interaction between environmental and genetic factors. Although environmental factors play an important role in heart disease, genetic factors are key determinants as well. In this dissertation research, I examined compromised cardiac geometric and contractile function in particular in the form of cardiomyopathies caused by environmental toxic stress, genetic mutation-induced insulin resistance and maternal obesity. Environmental risk factors are known to contribute to heart diseases. Among the environmental toxins, paraquat, a widely used non-selective herbicide, induces cardiotoxicity leading to myocardial injury and contractile dysfunction. Ablation of the essential post-receptor insulin signaling molecule Akt2 ablation conferred insulin resistance which is associated with high incidence of heart disease. Finally, maternal overnutrition and maternal obesity have been shown to contribute to the obesity pandemics in the 21st century and represent a good example for the interaction between environment and genetics, which negatively impact fetal heart development and cardiac health later on in life. Autophagy is a highly regulated intracellular lysosomal-mediated catabolic process which degrades aged, damaged or dysfunctional proteins, intracellular organelles and cytoplasmic components for maintaining cellular homeostasis. Autophagy is a double-edged sword, in some cases it acts as an adaptive response to stress for organismal survival, whereas in other cases it may promote cell death. Autophagy plays an essential role in cardiac homeostasis. Under normal conditions, basal level of autophagy is crucial for organelle turnover. Autophagy levels may be either up- or down-regulated in response to stresses such as ischemia/reperfusion, environmental toxins, insulin resistance and high caloric intake, contributing to cardiac remodeling and heart failure. Thus, the overall aim for my PhD research was to use autophagy as a cellular survival/death regulatory mechanism to examine the role of environmental and genetic factors in myocardial dysfunction and ultimately heart disease under various pathological conditions including paraquat toxicity and Akt2 deletion-induced insulin resistance. In order to examine the influence of maternal obesity on fetal sheep cardiomyocyte contractile and intracellular Ca2+ transient function, I established a novel method of assessment on fetal sheep cardiomyocyte function. First, my data indicated that paraquat-induced cardiac dysfunction was associated with excessive autophagy, which was ameliorated by AMPK deficiency. Furthermore, my data revealed that downregulation of autophagy from AMPK deficiency was mediated through AMPK-TSC2-mTORC1-ULK1 pathway. Secondly, I evaluated the effect of Akt2 ablation induced insulin resistance on diabetic cardiomyopathy, with a focus on the role of apoptosis and autophagy. I found that Akt2 knockout-induced insulin resistance caused cardiac anomalies was mediated via suppressed autophagy and activated apoptosis by decreased FOXO1 and increased p38 MAPK activity, which was effectively attenuated by the mTOR-independent inducer of autophagy trehalose. More intriguingly, activation of FOXO1 which facilitates the expression of autophagy related genes; and inhibition of p38 MAPK which suppresses the activity of Atg9, seem to be involved in trehalose-induced autophagy, in an mTOR-independent fashion. Finally, I successfully established a novel method for measuring mechanical and intracellular Ca2+ properties in fetal sheep cardiomyocytes. My data indicated that maternal obesity caused fetal sheep cardiomyocyte contractile dysfunction and disrupted intracellular Ca2+ homeostasis. Taken together, these findings provide some evidence to suggest that environmental and genetic factors play an important role in heart disease.

Medicinal Plants for Cardiovascular and Neurodegenerative Aging-related Diseases: From Bench to Bedside

Medicinal Plants for Cardiovascular and Neurodegenerative Aging-related Diseases: From Bench to Bedside
Author : Yue Liu,Valentina Echeverria Moran,Youhua Xu
Publisher : Frontiers Media SA
Release Date : 2020-12-08
Category : Science
Total pages :129
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Aging-Related Diseases and Autophagy

Aging-Related Diseases and Autophagy
Author : Elif Damla Arisan
Publisher : Unknown
Release Date : 2016
Category : Science
Total pages :129
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Autophagy is fundamental, evolutionary conserved physiological process at molecular level which targets long-lived cytosolic proteins and organelles to be recycled through lysosomal degradation. Diminished autophagic activity caused cellular stress in many organisms following aging, and inhibition of autophagy in model organisms causes degenerative changes and pathologic diseases observed with high incidence ratio generally in older ages. Consequently the delayed senescence or increased longevity in model organisms often stimulate autophagy, and autophagy inhibition compromises anti-aging effects. The cytoprotective function of autophagy is presented in various human diseases such as lung, liver, cardiovascular diseases, neurodegeneration, myopathies, cancer, stroke, infections and metabolic diseases which are found associated with autophagic targets. These pathologies are defined with their age-dependent characteristics, is not fully understood that how autophagy network regulates metabolism and may cause diseases in age-related manner. In this book chapter, we are going to discuss the autophagy and aging relationship in three different parts. In the first section autophagy and aging relationship is going to be presented through explaining responsible signalling network. The autophagy and age-related neurological disorders, genetic basis of age-dependent diseases and the functional role of autophagy is going to be discussed in the second and third part of the chapter.

Autophagy

Autophagy
Author : M. A. Hayat
Publisher : Academic Press
Release Date : 2013
Category : Medical
Total pages :360
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Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss recent developments in this rapidly-advancing field . Discusses the role of autophagy in cancer cell proliferation and death, and the potential of manipulation of autophagy in cancer cells as an avenue for treatment . Covers the importance of autophagy of mitochondria to cellular homeostasis; insulin secretion by pancreatic beta cells; cardiac function; atheroschlerosis; and organ tolerance to ischemic stress . Organized for readers into easy-to-access sections: general applications; role in cancer; and role in cardiovascular, metabolic, and neurodegenerative diseases

Aldehyde Dehydrogenases

Aldehyde Dehydrogenases
Author : Jun Ren,Yingmei Zhang,Junbo Ge
Publisher : Springer
Release Date : 2019-07-31
Category : Science
Total pages :253
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This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.