November 26, 2020

Download Ebook Free Benign & Pathological Chromosomal Imbalances

Benign and Pathological Chromosomal Imbalances

Benign and Pathological Chromosomal Imbalances
Author : Thomas Liehr
Publisher : Academic Press
Release Date : 2013-08-31
Category : Science
Total pages :220
GET BOOK

Benign & Pathological Chromosomal Imbalances systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy. Shows how to define the inheritance and formation of cytogenetically visible copy number variations using cytogenetic and molecular approaches for genetic diagnostics, patient counseling, and treatment plan development Uniquely classifies all known variants by chromosomal origin, saving time and money for researchers in reviewing benign and pathologic variants before costly molecular methods are used to investigate Side-by-side comparison of copy number variants with their recently identified submicroscopic form, aiding technology assessment using aCGH and other techniques

Clinical Pathology Board Review E-Book

Clinical Pathology Board Review E-Book
Author : Steven L. Spitalnik,Suzanne Arinsburg,Jeffrey Jhang
Publisher : Elsevier Health Sciences
Release Date : 2014-09-22
Category : Medical
Total pages :712
GET BOOK

Clinical Pathology Board Review covers all of the major subject areas of clinical pathology, presenting you with an essential study guide for certification or recertification. Designed as a companion to Anatomic Pathology Board Review, 2nd Edition, this brand-new medical reference book will be a welcome resource for pathology residents and practicing pathologists alike. Understand all of the major subject areas of clinical pathology tested on the Clinical Pathology board exam, including chemistry, hematology, coagulation, microbiology, immunology (including HLA testing), transfusion medicine (including therapeutic apheresis), cytogenetics, and molecular diagnostics. Prepare for the boards with help from multiple-choice questions offered in a format that mimics that of the actual test. Effectively grasp key concepts with questions that integrate various areas of clinical pathology, as well as questions that bridge concepts in clinical pathology with those in anatomic pathology. Understand why an answer is correct or incorrect with help from brief explanations accompanying each. Review key concepts in laboratory medicine, correlate them to the associated clinical or laboratory information, and apply them to the diagnosis and management of human disease. Designed as a companion to Anatomic Pathology Board Review, 2nd Edition (ISBN: 9781455711406).

Pathology and Genetics of Tumours of Endocrine Organs

Pathology and Genetics of Tumours of Endocrine Organs
Author : International Agency for Research on Cancer,World Health Organization,International Academy of Pathology
Publisher : IARC
Release Date : 2004
Category : Medical
Total pages :320
GET BOOK

This vol. was produced in collaboration with the International Academy of Pathology (IAP). - This publication reflects the views of a working group that convened for an editorial and consensus conference in Lyon, France, April 23-26, 2003

Diagnostic Pathology: Molecular Oncology E-Book

Diagnostic Pathology: Molecular Oncology E-Book
Author : Mohammad A. Vasef,Aaron Auerbach
Publisher : Elsevier Health Sciences
Release Date : 2016-03-23
Category : Medical
Total pages :1100
GET BOOK

This volume in the highly regarded Diagnostic Pathology series provides a clearer understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer. Diagnostic Pathology: Molecular Oncology is the first reference to apply a practical and clinical approach to examining how molecular mutations affect common medical diseases. Additionally, it identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. Easy to use and packed with outstanding illustrations, this is an essential resource for all pathologists or clinicians who need to keep up with the ever-evolving field of molecular medicine. Up-to-date information on a variety of topics Next-generation sequencing for determining gene mutations Diagnostic use of soft tissue mutations Use of solid tissue mutations such as EGFR, BRAF, and KRAS for diagnosis and treatment of different carcinomas and melanoma Interpreting newly found mutations in hematopathology such as MYD88 mutations Understanding bioinformatics Guidance on selecting the right test(s) at the right time for the right patient Comparisons of molecular testing methods (i.e., FISH testing vs. cytogenetics) More than 2,000 images including H&E stains, immunostains, and FISH images

Atlas of Head and Neck Pathology

Atlas of Head and Neck Pathology
Author : Bruce M. Wenig
Publisher : Elsevier Health Sciences
Release Date : 2015-08-11
Category : Medical
Total pages :1591
GET BOOK

Atlas of Head and Neck Pathology delivers authoritative, highly visual guidancefor effectively and accurately diagnosing a wide range of head and neck problems. This comprehensive resource features extensive,high-quality images depicting the histologic, immunohistochemical, cytologic, and diagnostic imaging appearance of every type of head and neck pathology. With a consistent,practical organization and succinct, bulleted format, the Atlas continues to be the resource general pathologists and specialists count on for reliable,easy-to-find answers. Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. Glean all essential, current, need-to-know information with sweeping revisions that include additional images shown in the frozen section, more content on odontogenic lesions and neoplasms, and inclusion of newly described entities such as igG-associated salivary gland diseases, mammary analog secretory carcinoma, and more. Review expanded coverage of critical areas with additional chapters on oral cavity and oropharynx, nasopharynx, and neck. Apply the most current staging of cancers from College of American Pathologists (TNM) and American Joint Committee on Cancer (AJCC). Interpret the findings you're likely to see in practice with the aid of high-quality images now available online for review or download. Take it with you anywhere! With Expert Consult, you'll have access to the full text,online, and as an eBook - at no additional cost!

Breast Pathology E-Book

Breast Pathology E-Book
Author : Frances P. O'Malley,Sarah E Pinder,Anne Marie Mulligan
Publisher : Elsevier Health Sciences
Release Date : 2011-08-01
Category : Medical
Total pages :400
GET BOOK

Breast Pathology, a title in the Foundations in Diagnostic Pathology series, provides all of the most essential information on the pathological entities encountered in practice in an easy-to-use format. Drs. Frances P. O'Malley, Sarah E. Pinder, and Anna Marie Mulligan provide unparalleled expert guidance for the study and diagnosis of a broad spectrum of breast lesions as well as the broad range of appearances of normal breast tissue. The consistent, practical format with a wealth of illustrations, at-a-glance boxes, and tables, make this title ideal for quick reference for both novices and experienced breast pathologists. Reference key information quickly and easily with a consistent, user-friendly format and at-a-glance boxes and tables throughout the text. Examine all aspects of a pathologic entity, including clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnosis, and prognostic and therapeutic considerations. Catch all the nuances of how pathological lesions present through over 400 full-color illustrations. Practice with confidence and overcome your toughest challenges with advice from the top minds in breast pathology. Apply the latest molecular diagnostic techniques to recognize newly identified classifications in breast disease. Get more of the information you need from new and expanded chapters covering a broad range of diseases and topics including fine needle aspiration cytology and the physical handling of core biopsy specimens; handling and evaluation of sentinel lymph nodes; diseases of the male breast; and state-of-the-art coverage of molecular advances in malignant breast disease. Prepare for the future of breast pathology with a new chapter dedicated to gene profiling and stem cell diagnostic techniques.

Pathology of the Urinary Bladder

Pathology of the Urinary Bladder
Author : Christopher Foster,Jeffrey Ross
Publisher : W B Saunders Company
Release Date : 2004
Category : Medical
Total pages :328
GET BOOK

A comprehensive monograph on the pathology of the urinary bladder together with its associated tissue in both genders. It explores the contemporary understanding of the complex embryological reorganization occurring early in the intrauterine life of the developing human and continuing expansion of molecular diagnostics extending through the full range of clinical and pathologic findings encountered in practice. It defines their diagnostic features and criteria, and presents effective strategies for solving diagnostic challenges.

Small Supernumerary Marker Chromosomes (sSMC)

Small Supernumerary Marker Chromosomes (sSMC)
Author : Thomas Liehr
Publisher : Springer Science & Business Media
Release Date : 2011-11-03
Category : Medical
Total pages :220
GET BOOK

Human beings normally have a total of 46 chromosomes, with each chromosome present twice, apart from the X and Y chromosomes in males. Some three million people worldwide, however, have 47 chromosomes: they have a small supernumerary marker chromosome (sSMC) in addition to the 46 normal ones. This sSMC can originate from any one of the 24 human chromosomes and can have different shapes. Approximately one third of sSMC carriers show clinical symptoms, while the remaining two thirds manifest no phenotypic effects. This guide represents the first book ever published on this topic. It presents the latest research results on sSMC and current knowledge about the genotype-phenotype correlation. The focus is on genetic diagnostics as well as on prenatal and fertility-related genetic counseling. A unique feature is that research meets practice: numerous patient reports complement the clinical aspects and depict the experiences of families living with a family member with an sSMC.

Chromosome Abnormalities and Genetic Counseling

Chromosome Abnormalities and Genetic Counseling
Author : R.J. MKinlay Gardner,Grant R Sutherland,Lisa G. Shaffer
Publisher : OUP USA
Release Date : 2011-11-11
Category : Medical
Total pages :634
GET BOOK

Advances in cytogenetics continue to crop up in wonderful ways, and we know exponentially more about chromosomes now than mere decades ago. Likewise, the necessary skills in offering genetic counseling continue to evolve. This new edition of Chromosome Abnormalities in Genetic Counseling offers a practical, up-to-date guide for the genetic counselor to marshal cytogenetic data and analysis clearly and effectively to families.

Congenital Anomalies

Congenital Anomalies
Author : Stefania Tudorache
Publisher : BoD – Books on Demand
Release Date : 2018-05-02
Category : Medical
Total pages :544
GET BOOK

Nowadays, nobody can imagine practicing obstetrics without using obstetrical ultrasound. Working in the prenatal diagnosis field requires dedication, patience, skills, experience, caution, and empathy. The concept of this book was guided by the desire to provide some help to the ultrasound operators. On a daily basis, they are confronted with the challenging task of ruling out or suspecting/confirming the diagnosis of fetal anomalies, either structural or chromosomal. The chapters of this book contain objective and exhaustive updated reviews of the pertinent literature, so that the reader would have a wide reference basis on each subject. Yet, many authors scan the fetus themselves or are directly involved with managing pregnancies with structural malformations or chromosomal anomalies. They kindly shared their personal experience and lessons learned over the years. This book is beneficial for all the professionals working in the prenatal diagnosis.

Urologic Surgical Pathology E-Book

Urologic Surgical Pathology E-Book
Author : Liang Cheng,David G. Bostwick
Publisher : Elsevier Health Sciences
Release Date : 2014-01-24
Category : Medical
Total pages :1040
GET BOOK

With sweeping revisions throughout, the new edition of Urologic Surgical Pathology equips you to accurately diagnose specimens of the entire urinary tract and male reproductive system plus the adrenal glands. Comprehensive in scope, this title begins with a look at normal anatomy and histology for each organ system...followed by discussions of the pathology of congenital anomalies, inflammations, non-neoplastic diseases and neoplasia. Practical guidance in daily urological pathology sign-out and the latest recommended diagnostic approaches — with an emphasis on clinicopathologic and radiographic-pathologic correlations — makes this a true diagnostic decision-making medical reference. A consistent format enables you to locate critical information quickly, and more than 1600 high-quality illustrations — most in full color — make diagnosis even easier. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Rely on the practice-proven experience of today’s authorities to identify and diagnose with confidence. Confirm your diagnostic suspicions by comparing your findings to more than 1600 color images and color graphics. Quickly locate the specific information you need through an abundance of tables, diagrams and flowcharts; boxed lists of types and causes of diseases; differential diagnosis; characteristic features of diseases; complications; classifications; and staging. Stay current with the latest information on: differential diagnosis for all tumor types encountered in urological surgical pathology practice; urologic tumor specimen handling and reporting guidelines; new entities and updated classification schemes; and newer immunohistochemical and genetic diagnostic methods. Develop targeted therapy specific to a particular patient’s problem based on key molecular aspects of disease, especially in relevance to targeted therapy/personalized medicine. Provide the clinician with the most accurate diagnostic and prognostic indicators, by incorporating the latest classification and staging systems in your reports. Deepen your understanding of new diagnostic biomarkers and their utility in differential diagnosis.

Rosai and Ackerman's Surgical Pathology E-Book

Rosai and Ackerman's Surgical Pathology E-Book
Author : Juan Rosai
Publisher : Elsevier Health Sciences
Release Date : 2011-06-20
Category : Medical
Total pages :2892
GET BOOK

Rosai and Ackerman’s Surgical Pathology delivers the authoritative guidance you need to overcome virtually any challenge in surgical pathology. Recognized globally for his unmatched expertise, preeminent specialist Juan Rosai, MD brings you state-of-the-art coverage of the latest advancements in immunohistochemistry, genetics, molecular biology, prognostic/predictive markers, and much more - equipping you to effectively and efficiently diagnose the complete range of neoplastic and non-neoplastic entities. Efficiently review the clinical presentation, gross and microscopic features, ultrastructural and immunohistochemical findings, differential diagnosis, therapy, and prognosis for virtually every pathologic entity. Compare your findings to more than 3,300 outstanding illustrations that capture the characteristic presentation of every type of lesion. Avoid diagnostic pitfalls using Dr. Rosai's expert observations on what to look for, what to be careful about, and which presentations can be misleading. Find quick answers on tumor staging, quality control procedures, and the handling of gross specimens through valuable appendices. Make optimal use of all the very latest advances including our increased understanding of the genetic basis of inherited and acquired disease, the newest molecular genetic and immunohistochemical techniques, and the most recent WHO disease classification schemes.

Pathology of the Skin E-Book

Pathology of the Skin E-Book
Author : J. Eduardo Calonje,Thomas Brenn,Alexander J Lazar,Phillip H. McKee
Publisher : Elsevier Health Sciences
Release Date : 2011-09-09
Category : Medical
Total pages :1906
GET BOOK

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. Eduardo Calonje, Thomas Brenn, Alexander Lazar, and Phillip McKee present new illustrations, updated chapters, and coverage of new entities such as lymphomas, cutaneous tissue tumors, diseases of the nail, and more in this extensively revised fourth edition. This new edition is an absolute must for practicing dermatopathologists and general pathologists who sign out skin biopsies. It has over 5,000 images and new chapters on the pathology of HIV/AIDS, conjunctival tumors, sentinel lymph node biopsies, laboratory techniques in dermatopathology and a section on the pathology of salivary gland tumors. Also, the chapters on disorders of keratinization and diseases of the nails have been completely updated. With access to the full text, image and video bank online at www.expertconsult.com, you'll have convenient access to the guidance you need to formulate the most accurate reports. Recognize all the histological variations of any skin condition through coverage that integrates dermatopathology, clinical correlations, and clinical photographs. Easily reference key points thanks to bulleted lists of clinical features and differential diagnosis tables. Diagnose accurately using over 5,000 histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. Stay current with updated and expanded coverage of diseases of the nail, cutaneous connective tissue tumors, tumors of the lymphoreticular system, and conjunctiva specimens. Minimize errors and formulate accurate reports by applying up-to-date molecular research tools, classification guidelines, immunohistochemical practices, and more. Effectively correlate your findings with clinical features through all-new, high-quality illustrations—none repeated from the previous editions—for each diagnostic entity. Access the fully searchable text online at www.expertconsult.com, along with a downloadable image bank and a link to PathConsult.

Underwood's Pathology

Underwood's Pathology
Author : Simon Cross
Publisher : Elsevier Health Sciences
Release Date : 2013-02-15
Category : Medical
Total pages :800
GET BOOK

Underwood’s Pathology (formerly General and Systematic Pathology) is an internationally popular and highly acclaimed textbook, written and designed principally for students of medicine and the related health sciences. Pathology is presented in the context of modern cellular and molecular biology and contemporary clinical practice. After a clear introduction to basic principles, it provides comprehensive coverage of disease mechanisms and the pathology of specific disorders ordered by body system. An unrivalled collection of clinical photographs, histopathology images and graphics complement the clear, concise text. For this sixth edition, the entire book has been revised and updated. Well liked features to assist problem-based learning – including body diagrams annotated with signs, symptoms and diseases and a separate index of common clinical problems – have been retained and refereshed. Additional value is provided by the complementary online version – hosted on studentconsult.com - which includes the complete, fully searchable text, downloadable images, clinical case studies and a revised, interactive self-assessment section to check your understanding and aid exam preparation. This all combines to make Underwood’s an unsurpassed learning package in this fascinating and most central medical specialty. Contents perfectly matches needs of medical students. Very clinical approach is ideally suited to integrated courses. Each organ system chapter begins with a brief review of normal structure and function, emphasizing aspects that are important to an understanding of the subsequently discussed disease processes. Offers an unrivalled superb collection of clinical photographs, histopathology images, and graphics, approximately 700 in all, that richly depict the appearance of both healthy and diseased tissues. Extensive International Advisory Board validates contents. New co-editor, Dr Simon Cross. Structure of chapters revised to make the book much easier to use during courses that are problem- or case-based. Several new contributors and re-written chapters. Expanded International Advisory Board.

Surgical Pathology of the Head and Neck

Surgical Pathology of the Head and Neck
Author : Leon Barnes
Publisher : Informa Medical
Release Date : 2009
Category : Head
Total pages :1734
GET BOOK

A stand-alone reference dealing with head and neck pathology, this updated edition provides an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases. Includes more than 1,200 photos, drawings, and illustrations.