December 1, 2020

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Between the Lines of Genetic Code

Between the Lines of Genetic Code
Author : Leonid Padyukov
Publisher : Academic Press
Release Date : 2013-09-28
Category : Science
Total pages :232
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Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases. Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future

Between the Lines of Genetic Code

Between the Lines of Genetic Code
Author : Robert G Cooper,Hector Chinoy,Ingrid E. Lundberg
Publisher : Elsevier Inc. Chapters
Release Date : 2013-09-28
Category : Science
Total pages :232
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The idiopathic inflammatory myopathies (IIMs) represent a complex spectrum of overlapping connective tissue diseases which have skeletal muscle involvement as one of their major components. While recent immunogenetic research has shown that myositis-specific and myositis-associated autoantibodies (MSAs/MAAs) are clearly associated with and thus define many clinical IIM subsets, future research is needed to clarify whether these antibodies (Abs) are just a secondary epiphenomenon, i.e., representing surrogate markers for underlying human leukocyte antigen (HLA) genes and or genotypes, or whether they play some prime role in the immune processes characterizing the IIM. There is increasing evidence suggesting that the IIM disease subtype an individual will get following any environmental triggering event is likely predetermined by their genotype at HLA, and that epistatic genetic interactions in this region critically determine overall disease phenotype, including disease severity and treatment outcomes. It seems clear in inclusion body myositis (IBM), but not yet in other IIM, that HLA gene dosage determines disease severity, again highlighting the importance of epistatic genetic interactions in determining disease characteristics, including outcome. As for rheumatoid arthritis (RA), it appears that HLA genes and the environment interact to modify IIM disease susceptibility. That a specific IIM subtype (necrotizing myopathy characterized by infiltrating macrophages without the usual T and B cells) can be induced in some genetically susceptible individuals by the specific environmental trigger, i.e., the use of certain lipid-lowering statin drugs, suggests that this may represent a potential human model to further study IIM disease-induction mechanisms.

Between the Lines of Genetic Code

Between the Lines of Genetic Code
Author : Igor Sandalov,Leonid Padyukov
Publisher : Elsevier Inc. Chapters
Release Date : 2013-09-28
Category : Science
Total pages :232
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We introduce new quantitative characteristics of the population using an analogy to the system of multi-spin molecules: the disease fields, which may depend on interactions, and the susceptibility to disease as derivative of genetic vector’s (GV’s) frequency of cases with respect to these fields. The genetic vector’s approach (GVA) is applied to statistical analysis of the interaction of two SNP haplotype of HTR2A and shared epitope (SE) alleles in relation to development of rheumatoid arthritis (RA). The analysis is performed for two independent cohorts, EIRA and NARAC, and based on the evaluation of double- and triple genotype–genotype versus SE alleles correlations. The Gibbs-like parametrization of GV frequencies makes analysis transparent and easy interpretable. We find that the main contribution into association to RA comes from GVs containing double SE. GVA may resolve an opposite role in risk/protection from different pairs of genetic variations and reveal an association to RA whereas the univariate analysis does not show significant association.

Between the Lines of Genetic Code

Between the Lines of Genetic Code
Author : Jesper Tegnér,Francesco Marabita,David Gomez-Cabrero
Publisher : Elsevier Inc. Chapters
Release Date : 2013-09-28
Category : Science
Total pages :232
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Following the success of genome-wide association studies, it is now important to unravel interactions between genes as well as between genes and environment. Here we discuss how to interpret higher order statistical interactions in terms of underlying biological processes purportedly generating such dependencies. In this chapter, we specifically review how biological networks, such as those generated from systems biological approaches, could possibly facilitate the interpretation of observed interactions in the development of complex phenotypes, e.g., complex diseases. We conclude that the statistical challenge is essentially a high-dimensional feature selection problem and there is therefore a need to construct intelligent priors using biological networks as a tool for the discovery and interpretation of interactions.

Exam Prep for: Between the Lines of Genetic Code

Exam Prep for: Between the Lines of Genetic Code
Author : Anonim
Publisher : Unknown
Release Date : 2020
Category :
Total pages :129
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Molecular Biology of the Cell

Molecular Biology of the Cell
Author : Bruce Alberts
Publisher : Unknown
Release Date : 2004
Category :
Total pages :129
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Russian Journal of Genetics

Russian Journal of Genetics
Author : Anonim
Publisher : Unknown
Release Date : 1997
Category : Genetics
Total pages :129
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Discovering Molecular Genetics

Discovering Molecular Genetics
Author : Anonim
Publisher : CSHL Press
Release Date : 2020
Category :
Total pages :129
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Brainfilling Curves - A Fractal Bestiary

Brainfilling Curves - A Fractal Bestiary
Author : Jeffrey Ventrella
Publisher : Lulu.com
Release Date : 2012-03-01
Category : Computers
Total pages :206
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* A lovingly-crafted visual expedition, lead by a lifelong fractal wizard with an obsession for categorizing fractal species * Hundreds of beautiful color images * An in-depth taxonomy of Koch-constructed Fractal Curves * An intuitive introduction to Koch construction * A must-read for anyone interested in fractal geometry

The Selfish Gene

The Selfish Gene
Author : Charles Simonyi Professor of the Public Understanding of Science Richard Dawkins,Richard Dawkins,David Dawkins,RICHARD AUTOR DAWKINS
Publisher : Oxford University Press, USA
Release Date : 1989
Category : Literary Criticism
Total pages :352
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An ethologist shows man to be a gene machine whose world is one of savage competition and deceit

The Mammoth Encyclopedia of Extraterrestrial Encounters

The Mammoth Encyclopedia of Extraterrestrial Encounters
Author : Ronald Story
Publisher : Robinson
Release Date : 2012-03-01
Category : Fiction
Total pages :160
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An illustrated A-to-Z guide to all things alien. Over 400 entries from more than 100 contributors cover everything from the incidents and witnesses involved to the concepts at stake and experts' personal position statements. Entries range from alien abductions, the Fantasy Prone hypothesis and JAL Flight no 1628, to the Lakenheath-Bentwaters Episode, mind control by aliens and Roswell. The contributors include: Isaac Asimov, Jerome Clark, Erich von Daniken, Peter Davenport, Hilary Evans, Timothy Good, Marvin Kottmeyer, Jenny Randles, Carl Sagan, Whitley Streiber and Jacques Vallee. There are over 300 images, eyewitness drawings and photographs.

Diagnostic Pathology and Molecular Genetics of the Thyroid

Diagnostic Pathology and Molecular Genetics of the Thyroid
Author : Yuri E. Nikiforov,Paul W. Biddinger,Lester D. R. Thompson
Publisher : Lippincott Williams & Wilkins
Release Date : 2012-04-20
Category : Medical
Total pages :436
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Diagnostic Pathology and Molecular Genetics of the Thyroid, Second Edition, offers a comprehensive overview of the diagnostic surgical pathology, cytopathology, immunohistochemistry and molecular genetics of the thyroid diseases, including neoplastic and non-neoplastic conditions. The book provides a detailed description of the surgical pathology of thyroid diseases side by side with major advances in immunohistochemistry and molecular genetics that can be used in evaluating thyroid tumors and non-neoplastic diseases.

Across the Bridge

Across the Bridge
Author : Elizabeth James
Publisher : Xlibris Corporation
Release Date : 2004-12-07
Category : History
Total pages :631
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This is the continuing story of two men, alike in many ways, who travel far from their native land but are both drawn back to Durham, the spectacular mediaeval city that dominates the northeastern counties of England. But there is a difference. Six hundred years separates the lives of the two men. Oswald, who has seen action in France and England, is loyal to his King, Edward III, who is also called Plantagenet. When Oswald sees that the lives of Edward and his son, John of Lancaster (called John of Gaunt by many modern historians), are in jeopardy, he calls to his descendent, James Simpson, for help. James Simpson is a scientist of world renown who turns his talents to writing historical fiction. After returning to his native Durham, he settles into a quiet village hoping to continue his writing. But when Oswald contacts him, he realizes that they are closer in relationship and behavior that he had believed. Simpson is surprised to find that Oswald is reaching out to him from the past. He is also surprised that Oswald has a mission for him that requires being transported back into the fourteenth century. Simpson cannot resist being personally drawn into the mystery. With the exception of the main fictional characters in the story, the book is a historically accurate account of life in the fourteenth century and the politics that surrounded the throne of England.

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
Author : Yogesh Dwivedi
Publisher : CRC Press
Release Date : 2012-06-25
Category : Medical
Total pages :482
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With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

The Gene

The Gene
Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
Release Date : 2016-05-17
Category : Medical
Total pages :608
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The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).