April 17, 2021

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Bioactive Natural Products

Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Release Date : 2015-03-23
Category : Science
Total pages :544
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Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Bioactive Natural Products Detection, Isolation, and Structural Determination

Bioactive Natural Products Detection, Isolation, and Structural Determination
Author : Steven M. Colegate,Russell J. Molyneux
Publisher : CRC Press
Release Date : 1993-09-29
Category : Science
Total pages :544
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Bioactive Natural Products covers all the aspects of bioactive natural product research from ethnobotanical investigations to modern, technologically assisted isolation and structural determination of active compounds. An internationally selected group of experts share their knowledge of a wide range of bioactivities and chemical compound classes. Topics in the chapters describing the modern application of detection, isolation, and structural determination techniques are strongly supported by chapters detailing and reviewing research involving various classes of bioactivity. Research areas include the immunomodulatory, antiviral, cytotoxic, anti-inflammatory, and insect behavior classes of bioactivity. Extensive referencing throughout the text is helpful to those readers not familiar with this subject and serves as a critical review for more experienced researchers. The book is also excellent for upper division or post-graduate courses.

Bioactive Natural Products

Bioactive Natural Products
Author : Steven M. Colegate,Russell J. Molyneux
Publisher : CRC Press
Release Date : 2007-12-14
Category : Medical
Total pages :624
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Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the

Bioactive Natural Products (Part B)

Bioactive Natural Products (Part B)
Author : Atta-ur-Rahman
Publisher : Elsevier
Release Date : 2000-03-09
Category : Science
Total pages :826
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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.

Bioactive Natural Products

Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : World Scientific
Release Date : 2011-10-17
Category : Science
Total pages :696
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Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations. Contents:Natural Products in Drug Discovery: Impacts and Opportunities — An Assessment (Goutam Brahmachari)Vascular Regulation by Small Peptides (Toshiro Matsui, Zhengquan Wang and Mitsuru Tanaka)Key Natural Products in Malaria Chemotherapy: From Quinine to Artemisinin and Beyond (Jean Fotie)Natural Product Inhibitors and Activators of Histone Deacetylases (Michael D Scott, Manas K Haldar and Sanku Mallik)Artemisinin: A Promise for the Development of Potent Anticancer Agents (Daniel L da Silva, Luzia V Modolo, Ilza M O Sousa, Rodney A F Rodrigues, Mary Ann Foglio and Ângelo de Fátima)Andrographolide: A Plant-Derived Natural Molecule of Pharmaceutical Promise (Goutam Brahmachari)Natural Products in Alzheimer's Disease: Impacts and Prospects (Shri Kant Mishra, Mark C Stahl and Parampreet Singh)Use of Multi-nutrient Functional Peptide Complex ≪GRINIZATION≫ for Treatment and Prevention of Viral Infections (Viktor Lozitsky, Alla Fedchuk, Irina Gomolyako, Ivan Chekman, Anatoliy Bulavka, Galyna Anokhina, Georgiy Donchenko, Sergiy Pozdnyakov, Xeniya Igrunova, Tetyana Grydina, Lidiya Socheslo, Liubov Mudryk, Nataliya Klochkova, Larysa Shytikova, Valentina Pushkina, Olga Golubovska, Vladimir Shestakov and Anatoliy Pechinka)Anti-Infective Flavonoids: An Overview (María José Abad, Luis Miguel Bedoya, Luis Apaza and Paulina Bermejo)Anti-Helicobacter Pylori Activities of Compounds of Natural Origin (Temitope O Lawal, Kapil K Soni, R C Saxena, Bolanle A Adeniyi and Gail B Mahady)Natural Bioactive Principles in the Treatment of Skin Diseases (Emmanuel C Ibezim)Anti-Diabetic Agents of Natural Origin: A Retrospective Account of Some Promising Chemotypes (Goutam Brahmachari)Fermentation Improvement of Processes Yielding Natural Products for Industry (Arnold L Demain and Sergio Sanchez)Plant Cell Culture and Transgenic Plants: The Goldmines for the Production of Compounds of Pharmacological Interest (Ana Paula de Faria, Ângelo de Fátima, Vagner A Benedito and Luzia V Modolo) Readership: Phytochemists; combinatorial chemists; pharmacologists; institutes for drug research (drug discovery and development); industrial research groups developing drugs from medicinal plants; pharmaceutical companies; manufacturers of herbal and ayurvedic medicines and cosmetic products; manufacturers of natural products; advanced and research students. Keywords:Bioactive Natural Products;Pharmacology;Pharmaceutics;Drug Discovery and Development;Medicinal ChemistryKey Features:Written by active researchers and leading experts in natural products chemistry on biologically active natural productsIncludes recent advances in the domain of discovery and development of new drugs in the pharmaceutical industryAn outstanding source of information with regard to the industrial application of natural products for medicinal purposes

Qualitative and Quantitative Analysis of Bioactive Natural Products 2018

Qualitative and Quantitative Analysis of Bioactive Natural Products 2018
Author : Maria Carla Marcotullio
Publisher : MDPI
Release Date : 2019-04-04
Category : Science
Total pages :374
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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives. Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today. This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Total Synthesis of Bioactive Natural Products

Total Synthesis of Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : Elsevier
Release Date : 2019-04-27
Category : Science
Total pages :350
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Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Bioactive Natural Products

Bioactive Natural Products
Author : Atta-ur- Rahman
Publisher : Elsevier Science Limited
Release Date : 1988
Category : Science
Total pages :1035
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Cover -- Contents -- Foreword -- Preface -- Contributors -- Chapter 1. Acid-catalysed epimerization of bioactive indole alkaloids and their derivatives -- Chapter 2. Antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols fiom plants and fungi -- Chapter 3. Bioactive oleanene glucuronides obtained from fabaceous plants -- Chapter 4. Biotransformation of terpenoids by microorganisms -- Chapter 5. Cycloartane and oleanane saponins from Astragalus sp. -- Chapter 6. Labdane-type diterpenes: Chemistry and biological activity -- Chapter 7. Metabolism of the tomato saponin a-tomatine by phytopathogenic fungi -- Chapter 8. Heme aggregation inhibitors: Antimalarial drugs targeting an essential biomineralization process -- Chapter 9. Bioactive peptides as signal molecules in plant defense, growth and development -- Chapter 10. Enzymes involved in the biosynthesis of brassinosteroids -- Chapter 11. Immunopotentiating effects of a glycoprotein from Chlorella vulgaris stra ...

Medicinal Chemistry of Bioactive Natural Products

Medicinal Chemistry of Bioactive Natural Products
Author : Xiao-Tian Liang,Wei-Shuo Fang
Publisher : John Wiley & Sons
Release Date : 2006-03-17
Category : Science
Total pages :336
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Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics

Bioactive Compounds from Natural Sources, Second Edition

Bioactive Compounds from Natural Sources, Second Edition
Author : Corrado Tringali
Publisher : CRC Press
Release Date : 2011-09-27
Category : Science
Total pages :648
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The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author : Atta-ur Rahman
Publisher : Elsevier
Release Date : 2012
Category : Medical
Total pages :421
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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 37 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural products and medicinal chemistry. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable source for researchers and engineers working in natural product and medicinal chemistry

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author : Anonim
Publisher : Elsevier
Release Date : 2016-06-20
Category : Science
Total pages :470
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Studies in Natural Products Chemistry, Volume 48, provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development. The series covers all aspects of the science, along with the synthesis, testing, and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, the book presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry. Provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures Focuses on the chemistry of bioactive natural products and their exciting new applications in the pharmaceutical industry Presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products Contains contributions by leading authorities in the field

Bioactive Natural Products for the Management of Cancer: from Bench to Bedside

Bioactive Natural Products for the Management of Cancer: from Bench to Bedside
Author : Anil K. Sharma
Publisher : Springer
Release Date : 2019-07-17
Category : Medical
Total pages :218
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This book illustrates the importance of the Natural Biometabolites, which offer a rich reservoir of candidate compounds for drug discovery in the battle against cancer. Recent research and development efforts concerning anti-cancer drugs derived from natural products have led to the identification of numerous candidate molecules that inhibit cancer cell proliferation and metastasis using a variety of mechanisms. Given its scope, the book offers a valuable resource for cancer biologists and general oncologists alike, while also benefitting research professionals in Science, Nursing, Medicine, Biochemistry, Genetics and Bioscience who wish to understand the fundamentals of prognosis and prediction in tumorigenesis. Moreover, the book provides an essential platform for understanding drug resistance mechanisms and combatting the growing menace of multidrug resistance.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author : Atta-ur-Rahman
Publisher : Elsevier
Release Date : 2002-03-01
Category : Science
Total pages :1364
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Bioactive Natural Products (Part G)

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author : Atta-ur-Rahman
Publisher : Elsevier
Release Date : 2017-07-18
Category : Science
Total pages :428
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Studies in Natural Products Chemistry, Volume 54, covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores Offers an essential resource for researchers and engineers working in natural products and medicinal chemistry