June 20, 2021

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Microfluidic Devices for Biomedical Applications

Microfluidic Devices for Biomedical Applications
Author : Xiujun James Li,Yu Zhou
Publisher : Elsevier
Release Date : 2013-10-31
Category : Technology & Engineering
Total pages :676
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Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

Biomedical Applications of Microfluidic Devices

Biomedical Applications of Microfluidic Devices
Author : Michael R. Hamblin,Mahdi Karimi
Publisher : Academic Press
Release Date : 2020-11-12
Category : Technology & Engineering
Total pages :350
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Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students

Diamond-based materials for biomedical applications

Diamond-based materials for biomedical applications
Author : A. Karczemska
Publisher : Elsevier Inc. Chapters
Release Date : 2013-03-19
Category : Technology & Engineering
Total pages :296
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This chapter discusses the possibilities and advantages offered by the use of diamond materials in the fabrication of microfluidic devices. The correct choice of material with optimal properties is crucial in the design of modern microfluidic devices. The different applications of diamond materials in this field are reviewed, along with a discussion of recent development and future trends.

Biomedical Applications for Microfluidic Devices

Biomedical Applications for Microfluidic Devices
Author : Wen Qiao
Publisher : Unknown
Release Date : 2013
Category :
Total pages :129
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My thesis research has focused on the biomedical applications of microfluidic devices, including accommodating liquid intraocular lens, wirelessly powered dielectrophoresis microfluidic platform, and evaporative microarray for molecular in-vitro diagnosis. In the first part, I developed an accommodating intraocular lens that can largely improve cataract patients' living quality by enabling patients to focus on far distance as well as near distance. Compared to natural eyes, today's commercially available accommodating IOLs produce a much limited tuning range. The large performance gap is attributed to the fundamental difference between crystalline lens and the optic-shift IOLs in the operation principles. In the thesis we designed and made a fluidic IOL that can change its curvature as the crystalline lens does. Both mechanical performance and optical quality are tested under the physiological conditions of aged eyes, promising complete restoration of vision accommodation. In the second part, I reported the first microfluidic device integrated with a printed RF circuit so that the device can be wirelessly powered by a commerciallyavailable radio-frequency identification (RFID) reader. The device eliminates the need for wire attachments and external instrument, so the operators can use the device in essentially the same manner as they do with microscope slides. The integrated circuit can be fabricated on a flexible plastic substrate at very low cost using a roll-to-roll printing method. Electrical power at 13.56 MHz transmitted by a RFID reader is inductively coupled to the printed RFIC and converted into 10V DC (direct current) output, which provides sufficient power to drive a microfluidic device to manipulate biological particles such as beads and proteins via the DC dielectrophoresis (DC-DEP) effect. In the third part, I developed a mathematical model for microarray probe/target reaction. The analysis was based on any chemical reaction between target molecules suspended in solution react and probes immobilized on a solid substrate, so it can be used to analysis hybridization efficiency in genomic microarray, as well as binding efficiency in protein microarray. The model indicated that besides diffusion, electrical repelling force between negatively charged probe and target molecules is the main cause for low hybridization efficiency. Based on the model, we further proposed a novel evaporative microarray, which can reduce the target solution thickness down to 80 [mu]m and theoretically enrich the concentration of molecules up to 1000 fold before target/probe chemical reaction. Preliminary data demonstrated the feasibility of integration of evaporation with microarray using black silicon template.

Microfluidics for Medical Applications

Microfluidics for Medical Applications
Author : Albert van den Berg,Loes Segerink
Publisher : Royal Society of Chemistry
Release Date : 2014-11-19
Category : Medical
Total pages :328
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Lab-on-a-chip devices for point of care diagnostics have been present in clinics for several years now. Alongside their continual development, research is underway to bring the organs and tissue on-a-chip to the patient, amongst other medical applications of microfluidics. This book provides the reader with a comprehensive review of the latest developments in the application of microfluidics to medicine and is divided into three main sections. The first part of the book discusses the state-of-the-art in organs and tissue on a chip; the second provides a thorough background to microfluidics for medicine, and the third (and largest) section provides numerous examples of point-of-care diagnostics. Written with students and practitioners in mind, and with contributions from the leaders in the field across the globe, this book provides a complete digest of the state-of-the-art in microfluidics medical devices and will provide a handy resource for any laboratory or clinic involved in the development or application of such devices.

Development of Microfluidic Devices to Maintain and Interrogate Tissue Biopsies

Development of Microfluidic Devices to Maintain and Interrogate Tissue Biopsies
Author : Samantha Margaret Hattersley
Publisher : Unknown
Release Date : 2010
Category :
Total pages :129
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Microfluidics and BioMEMS Applications

Microfluidics and BioMEMS Applications
Author : Francis E. H. Tay
Publisher : Springer Science & Business Media
Release Date : 2013-04-17
Category : Technology & Engineering
Total pages :336
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Microfluidics and BioMEMS Applications central idea is on microfluidics, a relatively new research field which finds its niche in biomedical devices, especially on lab-on-a-chip and related products. Being the essential component in providing driving fluidic flows, an example of micropump is chosen to illustrate a complete cycle in development of microfluidic devices which include literature review, designing and modelling, fabrication and testing. A few articles are included to demonstrate the idea of tackling this research problem, and they cover the main development scope discussed earlier as well as other advanced modelling schemes for microfluidics and beyond. Scientists and students working in the areas of MEMS and microfluidics will benefit from this book, which may serve both communities as both a reference monograph and a textbook for courses in numerical simulation, and design and development of microfluidic devices.

Micro/nanoparticle Synthesis by Microfluidic Devices for Biomedical Applications

Micro/nanoparticle Synthesis by Microfluidic Devices for Biomedical Applications
Author : Lung-Hsin Hung
Publisher : Unknown
Release Date : 2007
Category : Fluidic devices
Total pages :202
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Microfluidic systems have advantages such as low sample consumption, fast reaction over conventional bench top processes and were demonstrated the abilities to generate high quality droplets and particles with narrow size distribution. Divided by material category, recent development of using microfluidic devices for semiconductor, metal, colloidal, and biomaterial particle synthesis were reviewed. Microfluidic systems were designed and fabricated accordingly by applications and upon surface modification for droplet generation and particle synthesis purpose. Poly (dimethylsiloxane) and solvent compatible thiolene adhesive were used as device materials, and soft lithography and molding method were utilized for fast device fabrication. Droplet generation and manipulation were demonstrated in microchannels with adjustable generation rate, size, ratio, and controllable droplet fusion and switch. Base on microfluidic systems and droplet technique, three methods, chemical reaction, solvent evaporation, solvent extraction were applied to generate cadmium sulfide and poly (lactide-co-glycolide) micro/nanoparticles. The sizes of synthesized particles range from 5nm (CdS) to 160mum (PLGA) in diameter with narrow size distribution. By utilizing microfluidic platforms more novel particle synthesis can be prepared and applied for drug delivery and biomedical applications.

Micro- and Nanostructured Microfluidic Devices for Localized Protein Immobilization and Other Biomedical Applications

Micro- and Nanostructured Microfluidic Devices for Localized Protein Immobilization and Other Biomedical Applications
Author : Nicole E Steidle
Publisher : Unknown
Release Date : 2020-10-09
Category : Medical
Total pages :156
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A new immobilization method for the localized adsorption of proteins on thermoplastic surfaces is introduced. Artificial three-phase interfaces were realized by surface structuring to control the wetting behavior which lead to a preferred adsorption in these modified areas. Additionally, different fabrication methods were analyzed to determine mass fabrication capabilities. These fabrication methods also allowed the production of fully structured microchannels to tune the fluids behavior within. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Microfluidic Devices with Integrated Biosensors for Biomedical Applications

Microfluidic Devices with Integrated Biosensors for Biomedical Applications
Author : César Alejandro Parra Cabrera,Josep Samitier i Martí,Universitat de Barcelona. Departament d'Electrònica
Publisher : Unknown
Release Date : 2014
Category :
Total pages :177
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Microfluidics and Bio-MEMS

Microfluidics and Bio-MEMS
Author : Tuhin S. Santra
Publisher : CRC Press
Release Date : 2020-11-01
Category : Medical
Total pages :548
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The past two decades have seen rapid development of micro-/nanotechnologies with the integration of chemical engineering, biomedical engineering, chemistry, and life sciences to form bio-MEMS or lab-on-chip devices that help us perform cellular analysis in a complex micro-/nanoflluidic environment with minimum sample consumption and have potential biomedical applications. To date, few books have been published in this field, and researchers are unable to find specialized content. This book compiles cutting-edge research on cell manipulation, separation, and analysis using microfluidics and bio-MEMS devices. It illustrates the use of micro-robots for biomedical applications, vascularized microfluidic organs-on-a-chip and their applications, as well as DNA gene microarray biochips and their applications. In addition, it elaborates on neuronal cell activity in microfluidic compartments, microvasculature and microarray gene patterning, different physical methods for drug delivery and analysis, micro-/nanoparticle preparation and separation in a micro-/nanofluidic environment, and the potential biomedical applications of micro-/nanoparticles. This book can be used by academic researchers, especially those involved in biomicrofluidics and bio-MEMS, and undergraduate- and graduate-level students of bio-MEMS/bio-nanoelectromechanical systems (bio-NEMS), biomicrofluidics, biomicrofabricatios, micro-/nanofluidics, biophysics, single-cell analysis, bionanotechnology, drug delivery systems, and biomedical micro-/nanodevices. Readers can gain knowledge of different aspects of microfluidics and bio-MEMS devices; their design, fabrication, and integration; and biomedical applications. The book will also help biotechnology-based industries, where research and development is ongoing in cell-based analysis, diagnosis, and drug screening.

Micro- and Nanostructured Microfluidic Devices for Localized Protein Immobilization and Other Biomedical Applications

Micro- and Nanostructured Microfluidic Devices for Localized Protein Immobilization and Other Biomedical Applications
Author : Steidle, Nicole E.
Publisher : KIT Scientific Publishing
Release Date : 2014-12-23
Category :
Total pages :168
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Fabrication and Package of Microfluidic Devices Using CMOS MEMS Process for Biomedical Applications

Fabrication and Package of Microfluidic Devices Using CMOS MEMS Process for Biomedical Applications
Author : 吳俊慶
Publisher : Unknown
Release Date : 2008
Category :
Total pages :53
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Diamond-Based Materials for Biomedical Applications

Diamond-Based Materials for Biomedical Applications
Author : Roger Narayan
Publisher : Elsevier
Release Date : 2013-03-19
Category : Technology & Engineering
Total pages :296
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Carbon is light-weight, strong, conductive and able to mimic natural materials within the body, making it ideal for many uses within biomedicine. Consequently a great deal of research and funding is being put into this interesting material with a view to increasing the variety of medical applications for which it is suitable. Diamond-based materials for biomedical applications presents readers with the fundamental principles and novel applications of this versatile material. Part one provides a clear introduction to diamond based materials for medical applications. Functionalization of diamond particles and surfaces is discussed, followed by biotribology and biological behaviour of nanocrystalline diamond coatings, and blood compatibility of diamond-like carbon coatings. Part two then goes on to review biomedical applications of diamond based materials, beginning with nanostructured diamond coatings for orthopaedic applications. Topics explored include ultrananocrystalline diamond for neural and ophthalmological applications, nanodiamonds for drug delivery systems, and diamond nucleation and seeding techniques for tissue regeneration. Finally, the book concludes with a discussion of diamond materials for microfluidic devices. With its distinguished editors and international team of expert contributors, Diamond-based materials for biomedical applications is an authoritative guide for all materials scientists, researchers, medical practitioners and academics investigating the properties and uses of diamond based materials in the biomedical environment. Presents the fundamental principles and novel applications of this versatile material Discusses the functionalization of diamond particles and surfaces, biotribology and biological behaviour of nanocrystalinediamond coatings and blood compatibility of diamond-like carbon coatings Reviews nanostructured diamond coatings for orthopaedic coatings

Introduction to BioMEMS

Introduction to BioMEMS
Author : Albert Folch
Publisher : CRC Press
Release Date : 2012-08-21
Category : Medical
Total pages :528
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The entire scope of the BioMEMS field—at your fingertips Helping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It focuses on high-impact, creative work encompassing all the scales of life—from biomolecules to cells, tissues, and organisms. Brilliant color presentation Avoiding the overwhelming details found in many engineering and physics texts, this groundbreaking book—in color throughout—includes only the most essential formulas as well as many noncalculation-based exercises. Important terms are highlighted in bold and defined in a glossary. The text contains more than 400 color figures, most of which are from the original researchers. Coverage of both historical perspectives and the latest developments Developed from the author’s long-running course, this classroom-tested text gives readers a vivid picture of how the field has grown by presenting historical perspectives and a timeline of seminal discoveries. It also describes numerous state-of-the-art biomedical applications that benefit from "going small," including devices that record the electrical activity of brain cells, measure the diffusion of molecules in microfluidic channels, and allow for high-throughput studies of gene expression.