December 1, 2020

Download Ebook Free Bursting Neurons And Fading Memories

Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories
Author : Michael R. D'Andrea
Publisher : Academic Press
Release Date : 2014-10-10
Category : Medical
Total pages :170
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Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

Intracellular Consequences of Amyloid in Alzheimer's Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease
Author : Michael R. D'Andrea
Publisher : Academic Press
Release Date : 2016-02-21
Category : Science
Total pages :220
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Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer’s Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer’s is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer’s

Alzheimer’s Turning Point

Alzheimer’s Turning Point
Author : Jack C. de la Torre
Publisher : Springer
Release Date : 2016-06-25
Category : Medical
Total pages :251
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This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.

Glia in Health and Disease

Glia in Health and Disease
Author : Tania Spohr
Publisher : BoD – Books on Demand
Release Date : 2020-05-20
Category : Science
Total pages :162
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The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.

From Neuron to Cognition Via Computational Neuroscience

From Neuron to Cognition Via Computational Neuroscience
Author : Michael A. Arbib,James J. Bonaiuto
Publisher : MIT Press
Release Date : 2016-11-11
Category : Computers
Total pages :808
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A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition.

Advances in Natural Computation

Advances in Natural Computation
Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
Publisher : Springer Science & Business Media
Release Date : 2006-09-19
Category : Computers
Total pages :992
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This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural systems and cognitive science, neural network applications, as well as evolutionary computation: theory and algorithms.

Knobil and Neill's Physiology of Reproduction

Knobil and Neill's Physiology of Reproduction
Author : Tony M. Plant,Anthony J. Zeleznik
Publisher : Academic Press
Release Date : 2014-11-15
Category : Science
Total pages :2684
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The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.

Annual Editions

Annual Editions
Author : Karen L. Freiberg
Publisher : McGraw-Hill/Dushkin
Release Date : 2003-11
Category : Psychology
Total pages :240
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This updated thirty-second edition gives you a variety of carefully selected articles from the best of the public press, including magazines, newspapers, and journals. Topics covered include genetic and parental influences on development, development during infancy and early childhood and many others.

Aging

Aging
Author : Harold Cox
Publisher : Dushkin Publishing Group
Release Date : 2005-07
Category : Medical
Total pages :191
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This eighteenth edition of ANNUAL EDITIONS: AGING (2006 UPDATE) provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM is offered as a practical guide for instructors. ANNUAL EDITIONS titles are supported by our student website, www.dushkin.com/online.

Annual Editions: Aging

Annual Editions: Aging
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release Date : 2006-04
Category : Medical
Total pages :207
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Using an interdisciplinary approach, provides current articles selected from the best of the public press, including articles from medicine, nursing, psychology, sociology, social work, and the biological sciences.

Annual Editions

Annual Editions
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release Date : 2004-08
Category : Social Science
Total pages :208
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These public press articles were chosen because they address the most relevant and current problems in the area of aging. A variety of divergent views on the appropriate solutions to these problems is presented. The well-illustrated articles are written by gerontologists, educators, researchers, and writers. The articles provide an effective and useful perspective on today's important topics in the study of aging. This title is supported by the student website, Dushkin Online (www.dushkin.com/online).

Annual Editions: Aging 08/09

Annual Editions: Aging 08/09
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release Date : 2008-03-17
Category : Medical
Total pages :224
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This Twenty-First Edition of ANNUAL EDITIONS: AGING provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM, ISBN 0073301906, is offered as a practical guide for instructors. ANNUAL EDITIONS titles are supported by our student website, www.mhcls.com/online.

Newsweek

Newsweek
Author : Anonim
Publisher : Unknown
Release Date : 2002
Category : Current events
Total pages :129
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Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers
Author : Peter Whittle
Publisher : World Scientific
Release Date : 2010
Category : Computers
Total pages :230
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Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels.Design is based on the criterion that an associative memory must be able to cope with ?fading data?, i.e., to form an inference from the data even as its memory of that data degrades. The resultant net shows striking biological parallels. When these principles are combined with the Freeman specification of a neural oscillator, some remarkable effects emerge. For example, the commonly-observed phenomenon of neuronal bursting appears, with gamma-range oscillation modulated by a low-frequency square-wave oscillation (the ?escapement oscillation?). Bridging studies and new results of artificial and biological neural networks, the book has a strong research character. It is, on the other hand, accessible to non-specialists for its concise exposition on the basics.

The Brain That Changes Itself

The Brain That Changes Itself
Author : Norman Doidge
Publisher : Scribe Publications
Release Date : 2010
Category : Adaptation (Physiology)
Total pages :427
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An astonishing new scientific discovery called neuroplasticity is overthrowing the centuries-old notion that the adult human brain is fixed and unchanging. It is, instead, able to change its own structure and function, even into old age. Psychiatrist and rersearcher Norman Doidge, M.D., travelled around the United States to meet the brilliant scientists championing neuroplasticity, and the people whose lives they've transformed — people whose mental limitations or brain damage were previously seen as unalterable, and whose conditions had long been dismissed as hopeless. We see a woman born with half a brain that rewired itself to work as a whole; a woman labeled retarded who cured her deficits with brain exercises and now cures those of others; blind people who learn to see; learning disorders cured; IQs raised; ageing brains rejuvenated; stroke patients recovering their faculties; children with cerebral palsy learning to move more gracefully; entrenched depression and anxiety disappearing; and lifelong character traits changed. Doidge takes us onto terrain that might seem fantastic. We learn that our thoughts can switch our genes on and off, altering our brain anatomy. We learn how people of average intelligence can, with brain exercises, improve their cognition and perception, develop muscle strength, or learn to play a musical instrument — simply by imagining doing so. Using personal stories from the heart of this neuroplasticity revolution, Dr Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.