November 24, 2020

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Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts
Author : Claudiu T Supuran,Giuseppina De Simone
Publisher : Elsevier
Release Date : 2015-01-14
Category : Technology & Engineering
Total pages :398
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Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases

Carbonic Anhydrases
Author : Claudiu Supuran,Alessio Nocentini
Publisher : Academic Press
Release Date : 2019-07-17
Category : Science
Total pages :560
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Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health. Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs. Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications Describes the current biotechnological applications of CAs, including processes for CO2 capture Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author : Peter Grunwald
Publisher : CRC Press
Release Date : 2019-06-27
Category : Medical
Total pages :774
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This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Biocatalysis

Biocatalysis
Author : Andreas S. Bommarius,Bettina R. Riebel-Bommarius
Publisher : John Wiley & Sons
Release Date : 2007-02-27
Category : Science
Total pages :634
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The whole range of biocatalysis, from a firm grounding in theoretical concepts to in-depth coverage of practical applications and future perspectives. The book not only covers reactions, products and processes with and from biological catalysts, but also the process of designing and improving such biocatalysts. One unique feature is that the fields of chemistry, biology and bioengineering receive equal attention, thus addressing practitioners and students from all three areas.

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author : Peter Grunwald
Publisher : CRC Press
Release Date : 2019-06-27
Category : Medical
Total pages :774
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This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Biocatalysis

Biocatalysis
Author : D.A. Abramowicz
Publisher : Springer Science & Business Media
Release Date : 2013-03-09
Category : Technology & Engineering
Total pages :400
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The action of enzymes fascinated mankind long before they were rec ognized for the complex chemicals that they are. The first application of these remarkable compounds to produce ethanol by fermentation is lost to antiquity. Payer and Persoz (Ann. Chim. Phys. , 53, 73 (1833ii)) appear to have provided the first step toward understanding this com plex area when they reported the isolation of diastase in 1833. These workers showed that diastase could catalyze the hydrolysis of starches to sugars. Somewhat earlier Kirchhoff (Schwigger's Journal, 4, 108 (1812)) had shown that a small amount of dilute acid could hydrolyze a seemingly endless amount of starch to sugars. The genius of Berzelius recognized the commonality of these two observations in connection with a few other isolated observations and in 1834 coined the term catalysis to describe such actions. Professor Leibig was one of the giants of the chemical world in 1840. In addition to his own work, Liebig was training the world's next generation of chemists in his laboratory in Giessen. This cadre of chemists were very impressed by the master teacher so that is it only natural that Liebig's views should dominate with this next generation of chemists. Leibig was, in the 1830s and 1840s, developing his mastery of agricultural chemistry. The mechanism of putrefication was of great concern to Leibig, and he turned to the newly defined area of catalysis for an explanation.

Biocatalysis

Biocatalysis
Author : Gonzalo de Gonzalo,Pablo Domínguez de María
Publisher : Royal Society of Chemistry
Release Date : 2017-11-02
Category : Biocatalysis
Total pages :511
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Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Multi-scale Quantum Models for Biocatalysis

Multi-scale Quantum Models for Biocatalysis
Author : Darrin M. York,Tai-Sung Lee
Publisher : Springer Science & Business Media
Release Date : 2009-05-30
Category : Science
Total pages :420
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“Multi-scale Quantum Models for Biocatalysis” explores various molecular modelling techniques and their applications in providing an understanding of the detailed mechanisms at play during biocatalysis in enzyme and ribozyme systems. These areas are reviewed by an international team of experts in theoretical, computational chemistry, and biophysics. This book presents detailed reviews concerning the development of various techniques, including ab initio molecular dynamics, density functional theory, combined QM/MM methods, solvation models, force field methods, and free-energy estimation techniques, as well as successful applications of multi-scale methods in the biocatalysis systems including several protein enzymes and ribozymes. This book is an excellent source of information for research professionals involved in computational chemistry and physics, material science, nanotechnology, rational drug design and molecular biology and for students exposed to these research areas.

Biochemistry of Foods and the Biocatalysts

Biochemistry of Foods and the Biocatalysts
Author : Ishak I. Shahied
Publisher : Unknown
Release Date : 1977
Category : Biochemistry
Total pages :470
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The chemistry of foods; Water in foods; Lipids; Carbohydrates; Proteins; Flavonoids; Flavors in foods; Vegetables and fruits; Milk; Cereal chemistry; The chemistry of vitamins; Vitamin A; Vitamin D; Vitamin E; Vitamin K; Vitamin C; Thiamin (B1); Riboflavin (B2); Niacin; Pantothenic acid; Biotin; Pyridozine (B6); Vitamin B12; Folic acid; The chemistry of minerals; Minerals; Calcium; Phosphorus; Sodium; Potassium; Magnesium; The trace elements; Iron; Copper; Zinc; Manganese; Molybdenum; Cobalt; Selenium; Fluorine; Chromium; Physiology and biochemical reactioons of the hormones; Catecholamines; Hormones of the posterior pituitary; Hormones of the anterior pituitary; Adrenocorticotropic hormone (ACTH); Growth hormone (GH); Prolactin; Thyroid hormones; Parathyroid hormone; Insulin; Glucagon; Gonadotropic and sex hormones; Adrenal cortex hormones; Gastrointestinal hormones.

The Carbonic Anhydrases

The Carbonic Anhydrases
Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
Publisher : Birkhäuser
Release Date : 2013-11-11
Category : Science
Total pages :619
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Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
Author : Susan C. Frost,Robert McKenna
Publisher : Springer Science & Business Media
Release Date : 2013-10-22
Category : Medical
Total pages :430
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The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

Applied Biocatalysis in Specialty Chemicals and Pharmaceuticals

Applied Biocatalysis in Specialty Chemicals and Pharmaceuticals
Author : American Chemical Society Division Of Biochemical,Badal C. Saha,David Charles Demirjian,American Chemical Society. Division of Biochemical Technology,American Chemical Society. Meeting
Publisher : Amer Chemical Society
Release Date : 2001
Category : Science
Total pages :292
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Written for a wide variety of biotechnologists, this book provides a major review of the state-of-the-art in bioethanol production technologies, enzymatic biomass conversion, and biodiesel. It also provides a detailed explanation of a breakthrough in photosynthetic water splitting which could result in a doubling of the efficiency of solar energy conversion by green plants. The book covers production of lactic acid, succinic acid, 1,3-propanediol, 2,3-butanediol, and polyhydroxybutyrate and xylitol. It also includes a chapter on synthesis-gas fermentation.

Biocatalysis

Biocatalysis
Author : Anonim
Publisher : Unknown
Release Date : 1994
Category : Biochemical engineering
Total pages :129
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Characterization and Application of Biocatalysts in Extreme Environments

Characterization and Application of Biocatalysts in Extreme Environments
Author : Peter Christopher Michels
Publisher : Unknown
Release Date : 1996
Category :
Total pages :490
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Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author : Peter Grunwald
Publisher : CRC Press
Release Date : 2020-11-26
Category : Medical
Total pages :424
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Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.