May 11, 2021

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Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics
Author : Anita Göndör
Publisher : Academic Press
Release Date : 2016-10-25
Category : Science
Total pages :496
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Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Chromatin

Chromatin
Author : Ralf Blossey
Publisher : CRC Press
Release Date : 2017-08-04
Category : Medical
Total pages :172
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An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.

Stem Cell Proliferation and Differentiation

Stem Cell Proliferation and Differentiation
Author : Thomas Fazzio
Publisher : Academic Press
Release Date : 2020-04
Category :
Total pages :362
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Stem Cell Proliferation and Differentiation, Volume 138, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Plant Chromatin Dynamics

Plant Chromatin Dynamics
Author : Marian Bemer,Célia Baroux
Publisher : Humana Press
Release Date : 2017-10-20
Category : Science
Total pages :659
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This volume provides a comprehensive collection of protocols that can be used to study plant chromatin structure and composition. Chapters divided into three sections detail the profiling of chromatin features in relation to epigenetic regulation, investigate the interaction between chromatin modifications and gene regulation, and explore the 3D spatial organization of the chromatin inside the nucleus. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant Chromatin Dynamics: Methods and Protocols aims to ensure successful results in the further study of this vital field.

The Nuclear Pore Complex and Chromatin Domain Dynamics

The Nuclear Pore Complex and Chromatin Domain Dynamics
Author : Guilia Jale Gurun Ruben
Publisher : Unknown
Release Date : 2011
Category :
Total pages :264
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On Possible Role of DNA Electrodynamics in Chromatin Regulation

On Possible Role of DNA Electrodynamics in Chromatin Regulation
Author : Anonim
Publisher : Unknown
Release Date : 2018
Category :
Total pages :129
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Nuclear Dynamics

Nuclear Dynamics
Author : K. Nagata,K. Takeyasu
Publisher : Springer Science & Business Media
Release Date : 2007-12-03
Category : Science
Total pages :279
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The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

Transgenerational Epigenetics

Transgenerational Epigenetics
Author : Anonim
Publisher : Academic Press
Release Date : 2019-05-18
Category : Science
Total pages :518
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Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research. Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer Examines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery Features chapter contributions from international experts

Chromatin Accessibility Dynamics Underlie a Decline in Neural Stem Cell Migratory Ability with Age

Chromatin Accessibility Dynamics Underlie a Decline in Neural Stem Cell Migratory Ability with Age
Author : Robin William Alexander Koerner Yeo
Publisher : Unknown
Release Date : 2020
Category :
Total pages :129
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Chromatin accessibility is emerging as a critical component of genetic regulation through its role in physically permitting or restricting access to genomic loci. Here I present two studies from my thesis work on chromatin regulation: one that leverages chromatin accessibility dynamics to identify novel age-related changes to adhesion and migratory pathways in murine neural stem cells, and another that uses dynamic chromatin accessibility changes throughout C. elegans development to identify and spatiotemporally characterize novel functional enhancers. In the murine brain, the adult sub-ventricular zone (SVZ) is a neurogenic niche comprised of a number of rare cell types including quiescent and activated neural stem cells (qNSCs and aNSCs). Epigenomic regulation is tightly linked to cell fate decisions and has been demonstrated to become dysregulated with age in a variety of systems. Yet, how the epigenomic landscape of NSCs changes upon activation and with age remains unknown. Here I profile the chromatin landscape of rare populations of SVZ niche cells, including qNSCs and aNSCs, isolated from young and old adult murine brains. Aging causes a differential response in the global chromatin landscape of qNSCs and aNSCs involving accessibility changes in adhesion and migration pathways. Functionally, old aNSCs migrate slower than young aNSCs while the opposite is true for the quiescent population. This age-related decline in aNSC migratory speed is accompanied by increased staining of the focal adhesion protein vinculin. Inhibiting the cytoskeletal regulator ROCK in old aNSCs improves migration speeds, promotes neurite outgrowth, and reduces actin stress fibers associated with biophysical adhesion. In another model system, the nematode C. elegans, I use chromatin accessibility dynamics throughout development from embryogenesis to adulthood to generate a list of putative enhancers that play a role in development. I then generate multiple transgenic fluorescent reporter strains in order to validate the cis-regulatory activity of these genomic regions and spatiotemporally characterize the activity of multiple novel functional enhancers during C. elegans development. Validated functional enhancers display unique spatiotemporal regulatory activity that corresponds to accessibility dynamics at those chromatin peaks in vivo during C. elegans development. Together, these results demonstrate that chromatin accessibility dynamics can be a powerful tool to uncover previously unknown biology and identify novel cis-regulatory elements during aging and development in multiple systems.

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Release Date : 2015-10-19
Category : Science
Total pages :482
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Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Microtubule Dynamics and Their Effectors

Microtubule Dynamics and Their Effectors
Author : Amanda J. Johnson
Publisher : Unknown
Release Date : 1998
Category :
Total pages :68
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Biochemical and Structural Dynamics of the Cell Nucleus

Biochemical and Structural Dynamics of the Cell Nucleus
Author : John L. Wang,Shu Chien,Wei-Yiu Cheung,Cheng-Wen Wu
Publisher : Unknown
Release Date : 1990
Category : Science
Total pages :269
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Biochemical and Structural Dynamics of the Cell Nucleus ...

The Cell Cycle Dependent Regulation of Microtubule Dynamics

The Cell Cycle Dependent Regulation of Microtubule Dynamics
Author : Lisa D. Belmont
Publisher : Unknown
Release Date : 1995
Category : Cell cycle
Total pages :180
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Regulation of Higher-order Chromatin Structure in Drosophila Melanogaster

Regulation of Higher-order Chromatin Structure in Drosophila Melanogaster
Author : Stephanie A. McClymont
Publisher : Unknown
Release Date : 2011
Category :
Total pages :124
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Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation
Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Release Date : 1996
Category : Science
Total pages :692
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Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.