April 13, 2021

Download Ebook Free Comparative Toxicogenomics

Comparative Toxicogenomics

Comparative Toxicogenomics
Author : Anonim
Publisher : Elsevier
Release Date : 2008-07-11
Category : Science
Total pages :352
GET BOOK

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. * Reviews some of the first really fruitful studies made in this area * Covers different organisms ranging from humans to model species and environmental sentinels * Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher : Unknown
Release Date : 2004
Category : United States
Total pages :129
GET BOOK

Environmental Health Perspectives

Environmental Health Perspectives
Author : Anonim
Publisher : Unknown
Release Date : 2008
Category : Environmental health
Total pages :129
GET BOOK

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations
Author : United States. Congress. Senate. Committee on Appropriations
Publisher : Unknown
Release Date : 2005
Category :
Total pages :129
GET BOOK

Design, Management, and Quality Control of Toxicogenomic Experiments

Design, Management, and Quality Control of Toxicogenomic Experiments
Author : Lyle David Burgoon
Publisher : Unknown
Release Date : 2005
Category : Electronic dissertations
Total pages :338
GET BOOK

Bulletin of the Mount Desert Island Biological Laboratory

Bulletin of the Mount Desert Island Biological Laboratory
Author : Mount Desert Island Biological Laboratory
Publisher : Unknown
Release Date : 2009
Category : Biology
Total pages :129
GET BOOK

Development and Validation of the Daphnia CDNA Microarray as a Method for Predicting Contamination in Aquatic Environments

Development and Validation of the Daphnia CDNA Microarray as a Method for Predicting Contamination in Aquatic Environments
Author : Helen Catherine Poynton
Publisher : Unknown
Release Date : 2007
Category :
Total pages :346
GET BOOK

Encyclopedia of Ecology

Encyclopedia of Ecology
Author : Sven Erik Jørgensen,Brian D. Fath
Publisher : Unknown
Release Date : 2008
Category : Ecology
Total pages :4122
GET BOOK

The Encyclopedia of Ecology contains contributions from international experts on a diverse array of topics related to ecology. It provides current and comprehensive information on many themes, including behavioral ecology, ecological processes, ecological modeling, ecological engineering, ecological indicators, ecological informatics, ecosystems, ecotoxicology, evolutionary ecology, general ecology, global ecology, human ecology, and systems ecology. The online version includes extensive internal cross-referencing and dynamic linking to journal articles and abstract databases.

Comparative Biochemistry and Physiology

Comparative Biochemistry and Physiology
Author : Anonim
Publisher : Unknown
Release Date : 2003
Category : Biochemistry
Total pages :129
GET BOOK

Comparative Genomics

Comparative Genomics
Author : James R. Brown
Publisher : CRC Press
Release Date : 2007-12-03
Category : Science
Total pages :400
GET BOOK

When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both highly premature and wonderfully inaccurate. In the last ten years, we’ve witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. Moreover, genomic sequences, which are becoming available for several species have proven to be highly relevant to drug research with regard to a number of otherwise intractable conditions. Rather than offering a comprehensive volume covering every aspect of comparative genomics, Comparative Genomics: Basic and Applied Research embodies the diverse interests of prominent researchers in the field. Compiling first hand descriptions of their pioneering work, the text focuses on commonalities and synergies across the broad field of comparative genomics. Among its many topics it covers— · Revolutionary advances in DNA-sequencing technology · Bold new approaches to the organization and analysis of large phylogenetic data sets · The impact of comparative genomics on our understanding of evolution · Efforts toward developing novel antimicrobial drugs, through the use of bacterial pathogen genomes Ultimately, future breakthroughs in comparative genomics will depend upon the continued interaction and interdependency of applied and basic research. This seminal volume demonstrates both the means and the fruits of that cooperation, and in doing so defines and lays the groundwork for continued progress.

Application of Toxicogenomic Approaches to Study Chemical-induced Effects on the Hypothalamic-pituitary-gonadal (HPG) Axis of the Japanese Medaka (Oryzias Latipes)

Application of Toxicogenomic Approaches to Study Chemical-induced Effects on the Hypothalamic-pituitary-gonadal (HPG) Axis of the Japanese Medaka (Oryzias Latipes)
Author : Xiaowei Zhang
Publisher : Unknown
Release Date : 2008
Category : Endocrine disrupting chemicals
Total pages :218
GET BOOK

Genomic Approaches for Cross-Species Extrapolation in Toxicology

Genomic Approaches for Cross-Species Extrapolation in Toxicology
Author : William H. Benson,Richard T. Di Giulio
Publisher : CRC Press
Release Date : 2006-12-13
Category : Mathematics
Total pages :216
GET BOOK

The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from

Toxicogenomics of Bisphenol A and Neurodevelopmental Disorders

Toxicogenomics of Bisphenol A and Neurodevelopmental Disorders
Author : Bingling Wang
Publisher : Unknown
Release Date : 2017
Category : Science
Total pages :129
GET BOOK

Bisphenol A (BPA) has been widely used in many industrial and consumer products and is known as an endocrine-disrupting chemical. To find the underlying genetic basis and molecular mechanisms of BPA-associated neurodevelopmental disorders (NDs), this chapter addressed the toxicogenomics of BPA with publicly accessed Comparative Toxicogenomics Database. The present results indicated that the key cellular components (CC) of the nervous system such as neuron, synapse, dendrite and axon are common in CC annotation; the commonly found molecular functions are neurotransmitter receptor or transducer binding or activity; and the main common biological processes include synaptic signalling, cognition, learning or memory, behaviour, the development of nervous system and brain. Neuroactive ligand-receptor interaction, dopaminergic, glutamatergic and serotonergic synapses, monoamine transport and synaptic vesicle pathway were the common pathways. Simultaneously, the BPA-disease may share the common pathways with drug addictions such as cocaine addiction. Unique pathways might also contribute to the BPA action in different NDs such as one carbon metabolism and detoxification of oxidative stress in Down syndrome. Although GO and pathway results indicate some common annotations, the predicted PPI molecular function clusters are quite different for each ND. In addition, some of the NDs share the same transcription factors (TFs) and miRNAs, which indicate these disorders have the similar expression profiles. Finally, chemicals having comparable interacting genes to BPA should be considered.

In Vivo Examination of the Inhibitory Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on Estrogen-mediated Gene Expression Responses

In Vivo Examination of the Inhibitory Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on Estrogen-mediated Gene Expression Responses
Author : Darrell Ralph Boverhof
Publisher : Unknown
Release Date : 2005
Category : Electronic dissertations
Total pages :476
GET BOOK

Science

Science
Author : John Michels (Journalist)
Publisher : Unknown
Release Date : 2006
Category : Science
Total pages :129
GET BOOK