November 30, 2020

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Computer-Aided Applications in Pharmaceutical Technology

Computer-Aided Applications in Pharmaceutical Technology
Author : Jelena Djuris
Publisher : Elsevier
Release Date : 2013-04-10
Category : Medical
Total pages :300
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Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
Author : Sandra Grbic,Jelena Parojcic,Zorica Djuric
Publisher : Elsevier Inc. Chapters
Release Date : 2013-04-10
Category : Technology & Engineering
Total pages :300
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This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
Author : Ljiljana Djekic,Dragana Vasiljevic,Marija Primorac
Publisher : Elsevier Inc. Chapters
Release Date : 2013-04-10
Category : Technology & Engineering
Total pages :300
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This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
Author : Jelena Djuris,Svetlana Ibric,Zorica Djuric
Publisher : Elsevier Inc. Chapters
Release Date : 2013-04-10
Category : Technology & Engineering
Total pages :300
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This chapter provides a basic theoretical background on experimental design application and interpretation. Techniques described include screening designs, full and fractional factorial designs, Plackett–Burman design, D-optimal designs, response surface methodology, central composite designs, Box–Behnken design, and mixture designs, etc. The reader will be introduced to the experimental domains covered by specific design, making it easier to select the one appropriate for the problem. After theoretical introduction, a number of illustrative examples of design of experiments application in the field of pharmaceutical technology are presented.

Computer Applications in Pharmaceutical Research and Development

Computer Applications in Pharmaceutical Research and Development
Author : Sean Ekins
Publisher : John Wiley & Sons
Release Date : 2006-07-11
Category : Medical
Total pages :805
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A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
Author : Ivana Masic,Jelena Parojcic,Zorica Djuric
Publisher : Elsevier Inc. Chapters
Release Date : 2013-04-10
Category : Technology & Engineering
Total pages :300
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This chapter introduces the concept of computational fluid dynamics (CFD) and its applications in pharmaceutical technology. Basic theoretical explanations on the mathematics of fluid flow and numerical grids are provided. CFD is a versatile tool that is mainly used in complex dynamical process characterization. Examples of CFD applications in development of inhalers, analysis of dissolution apparatus hydrodynamics, and fluidized bed process simulations are presented.

Computer-aided Technologies

Computer-aided Technologies
Author : Razvan Udroiu
Publisher : BoD – Books on Demand
Release Date : 2016-12-07
Category : Computers
Total pages :170
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The aim of this book is to present the latest applications, trends, and developments of computer-aided technologies (CAx). Computer-aided technologies are the core of product lifecycle management (PLM) and human lifecycle management (HUM). This book has seven chapters, organized in two sections: "Computer-Aided Technologies in Engineering" and "Computer-Aided Technologies in Medicine." The first section treats the different aspects of PLM, including design, simulations and analysis, manufacturing, production planning, and quality assurance. In the second part of the book are presented CAx applications in medicine focused on clinical decision, diagnosis, and biosensor design. CAx plays a key role in a variety of engineering and medical applications, bringing a lot of benefits in product life cycle, extending and improving human life.

Process Systems Engineering for Pharmaceutical Manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing
Author : Ravendra Singh,Zhihong Yuan
Publisher : Elsevier
Release Date : 2018-03-16
Category : Technology & Engineering
Total pages :698
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Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing

18th European Symposium on Computer Aided Process Engineering

18th European Symposium on Computer Aided Process Engineering
Author : Bertrand Braunschweig,Xavier Joulia
Publisher : Elsevier
Release Date : 2008
Category : Computers
Total pages :1205
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The 18th European Symposium on Computer Aided Process Engineering contains papers presented at the 18th European Symposium of Computer Aided Process Engineering (ESCAPE 18) held in Lyon, France, from 1-4 June 2008. The ESCAPE series brings the latest innovations and achievements by leading professionals from the industrial and academic communities. The series serves as a forum for engineers, scientists, researchers, managers and students from academia and industry to: - present new computer aided methods, algorithms, techniques related to process and product engineering, - discuss innovative concepts, new challenges, needs and trends in the area of CAPE. This research area bridges fundamental sciences (physics, chemistry, thermodynamics, applied mathematics and computer sciences) with the various aspects of process and product engineering. The special theme for ESCAPE-18 is CAPE for the Users! CAPE systems are to be put in the hands of end users who need functionality and assistance beyond the scientific and technological capacities which are at the core of the systems. The four main topics are: - off-line systems for synthesis and design, - on-line systems for control and operation, - computational and numerical solutions strategies, - integrated and multi-scale modelling and simulation, Two general topics address the impact of CAPE tools and methods on Society and Education. * CD-ROM that accompanies the book contains all research papers and contributions * International in scope with guest speeches and keynote talks from leaders in science and industry * Presents papers covering the latest research, key top areas and developments in Computer Aided Process Engineering

Pharmaceutical Quality by Design

Pharmaceutical Quality by Design
Author : Sarwar Beg,Md Saquib Hasnain
Publisher : Academic Press
Release Date : 2019-03-27
Category : Business & Economics
Total pages :448
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Pharmaceutical Quality by Design: Principles and Applications discusses the Quality by Design (QbD) concept implemented by regulatory agencies to ensure the development of a consistent and high-quality pharmaceutical product that safely provides the maximum therapeutic benefit to patients. The book walks readers through the QbD framework by covering the fundamental principles of QbD, the current regulatory requirements, and the applications of QbD at various stages of pharmaceutical product development, including drug substance and excipient development, analytical development, formulation development, dissolution testing, manufacturing, stability studies, bioequivalence testing, risk and assessment, and clinical trials. Contributions from global leaders in QbD provide specific insight in its application in a diversity of pharmaceutical products, including nanopharmaceuticals, biopharmaceuticals, and vaccines. The inclusion of illustrations, practical examples, and case studies makes this book a useful reference guide to pharmaceutical scientists and researchers who are engaged in the formulation of various delivery systems and the analysis of pharmaceutical product development and drug manufacturing process. Discusses vital QbD precepts and fundamental aspects of QbD implementation in the pharma, biopharma and biotechnology industries Provides helpful illustrations, practical examples and research case studies to explain QbD concepts to readers Includes contributions from global leaders and experts from academia, industry and regulatory agencies

Computer-Aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates

Computer-Aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates
Author : Jujjvarapu Satya Eswari,Swasti Dhagat,Manisha Yadav
Publisher : CRC Press
Release Date : 2019-09-24
Category : Medical
Total pages :130
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Increase in antibiotic resistance has forced researchers to develop new drugs against microorganisms. Lipopeptides are produced as secondary metabolites by some microorganisms. Computer-aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates provides the identification of novel ligands for different antimicrobial lipopeptides. Along with identification, it also provides some of the in silico drug design processes, namely homology modelling, molecular docking, QSAR studies, drug ADMET studies and pharmacophore studies to check the ligand-lipopeptide interaction. Some lipopeptides have shown anti-cancerous properties too, and this book discusses the required templates to design new drugs using computational techniques. Key Features: Focuses on the use lipopeptides as new antimicrobial compounds Presents the basics of in silico modelling for design and development of new drug molecules, and is therefore of interest to beginners in the field Provides a step-by-step process for identification of drug molecules and testing its efficacy in silico Couples with courses on patents and intellectual property rights

Nanobiomaterials

Nanobiomaterials
Author : Anil K. Sharma,Raj K. Keservani,Rajesh K. Kesharwani
Publisher : CRC Press
Release Date : 2018-01-03
Category : Medical
Total pages :528
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This new volume focuses on the ever-growing and ever-sophisticated use of nanobiomaterials in drug delivery. There have been significant developments in the delivery of the active pharmaceutical ingredients to target sites, thereby sparing the normal functioning biological systems from damage, and this volume highlights some of the most important developments in the field. The book first provides an overview of nanobiomaterials and then goes on to report on new developments in drug delivery and nanotechnology, nanobiomaterials as carriers in cancer therapy, and the diverse uses of nanobiomaterials. Broken into sections, the chapters cover: an overview of nanobiomaterials drug delivery and nanotechnology nanobiomaterials as carriers in cancer therapeutics diverse uses of nanobiomaterials This volume will be a valuable resource on drug delivery for pharmaceutical manufacturers, healthcare personnel, and researchers.

21st European Symposium on Computer Aided Process Engineering

21st European Symposium on Computer Aided Process Engineering
Author : E. N. Pistikopoulos,M. C. Georgiadis,A. C. Kokossis
Publisher : Elsevier
Release Date : 2011-05-26
Category : Science
Total pages :2029
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The European Symposium on Computer Aided Process Engineering (ESCAPE) series presents the latest innovations and achievements of leading professionals from the industrial and academic communities. The ESCAPE series serves as a forum for engineers, scientists, researchers, managers and students to present and discuss progress being made in the area of Computer Aided Process Engineering (CAPE). European industries large and small are bringing innovations into our lives, whether in the form of new technologies to address environmental problems, new products to make our homes more comfortable and energy efficient or new therapies to improve the health and well-being of European citizens. Moreover, the European Industry needs to undertake research and technological initiatives in response to humanity's "Grand Challenges", described in the declaration of Lund, namely, Global Warming, Tightening Supplies of Energy, Water and Food, Ageing Societies, Public Health, Pandemics and Security. Thus, the Technical Theme of ESCAPE 21 will be "Process Systems Approaches for Addressing Grand Challenges in Energy, Environment, Health, Bioprocessing & Nanotechnologies".

Theory and Design of Broadband Matching Networks

Theory and Design of Broadband Matching Networks
Author : Wai-Kai Chen
Publisher : Elsevier
Release Date : 2013-10-22
Category : Technology & Engineering
Total pages :448
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Theory and Design of Broadband Matching Networks centers on the network theory and its applications to the design of broadband matching networks and amplifiers. Organized into five chapters, this book begins with a description of the foundation of network theory. Chapter 2 gives a fairly complete exposition of the scattering matrix associated with an n-port network. Chapter 3 considers the approximation problem along with a discussion of the approximating functions. Chapter 4 explains the Youla's theory of broadband matching by illustrating every phase of the theory with fully worked out examples. The extension of Youla's theory to active load impedance is taken up in Chapter 5. This book will be useful as a reference for practicing engineers who wish to learn how the modern network theory can be applied to the design of many practical circuits.

22nd European Symposium on Computer Aided Process Engineering

22nd European Symposium on Computer Aided Process Engineering
Author : Anonim
Publisher : Elsevier
Release Date : 2012-12-10
Category : Science
Total pages :1400
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Computer aided process engineering (CAPE) plays a key design and operations role in the process industries. This conference features presentations by CAPE specialists and addresses strategic planning, supply chain issues and the increasingly important area of sustainability audits. Experts collectively highlight the need for CAPE practitioners to embrace the three components of sustainable development: environmental, social and economic progress and the role of systematic and sophisticated CAPE tools in delivering these goals. Contributions from the international community of researchers and engineers using computing-based methods in process engineering Review of the latest developments in process systems engineering Emphasis on a systems approach in tackling industrial and societal grand challenges