May 11, 2021

Download Ebook Free Computer-Aided Vaccine Design

Computer-Aided Vaccine Design

Computer-Aided Vaccine Design
Author : Joo Chuan Tong,Shoba Ranganathan
Publisher : Elsevier
Release Date : 2013-07-31
Category : Medical
Total pages :164
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Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. Essential reading for any biologist who wants to understand methods of computer-aided vaccine design Description of available data sources and publicly available software, with detailed analysis of strengths and weaknesses Theoretical concepts and practical examples of database design and development for a virtual screening campaign

Scientific Modeling and Simulations

Scientific Modeling and Simulations
Author : Sidney Yip,Tomas Diaz Rubia
Publisher : Springer Science & Business Media
Release Date : 2010-04-07
Category : Science
Total pages :402
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Although computational modeling and simulation of material deformation was initiated with the study of structurally simple materials and inert environments, there is an increasing demand for predictive simulation of more realistic material structure and physical conditions. In particular, it is recognized that applied mechanical force can plausibly alter chemical reactions inside materials or at material interfaces, though the fundamental reasons for this chemomechanical coupling are studied in a material-speci c manner. Atomistic-level s- ulations can provide insight into the unit processes that facilitate kinetic reactions within complex materials, but the typical nanosecond timescales of such simulations are in contrast to the second-scale to hour-scale timescales of experimentally accessible or technologically relevant timescales. Further, in complex materials these key unit processes are “rare events” due to the high energy barriers associated with those processes. Examples of such rare events include unbinding between two proteins that tether biological cells to extracellular materials [1], unfolding of complex polymers, stiffness and bond breaking in amorphous glass bers and gels [2], and diffusive hops of point defects within crystalline alloys [3].

Computer-Aided Drug Design

Computer-Aided Drug Design
Author : Dev Bukhsh Singh
Publisher : Springer Nature
Release Date : 2020-10-09
Category : Medical
Total pages :306
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This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

Annual Report

Annual Report
Author : India. Department of Scientific & Industrial Research
Publisher : Unknown
Release Date : 2005
Category : Research
Total pages :129
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Computer-aided Molecular Design

Computer-aided Molecular Design
Author : William Graham Richards
Publisher : Vch Pub
Release Date : 1989
Category : Science
Total pages :266
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Annual Report - Council of Scientific and Industrial Research

Annual Report - Council of Scientific and Industrial Research
Author : Council of Scientific & Industrial Research (India)
Publisher : Unknown
Release Date : 2004
Category : Research
Total pages :129
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Science & Culture

Science & Culture
Author : Anonim
Publisher : Unknown
Release Date : 2005
Category : India
Total pages :129
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Proceedings

Proceedings
Author : Anonim
Publisher : Unknown
Release Date : 1999
Category : Neural computers
Total pages :1240
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India, a Reference Annual

India, a Reference Annual
Author : India. Ministry of Information and Broadcasting
Publisher : Unknown
Release Date : 2006
Category : India
Total pages :129
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Post-Genomic Approaches in Drug and Vaccine Development

Post-Genomic Approaches in Drug and Vaccine Development
Author : Kishore R. Sakharkar,Meena K. Sakharkar ,Ramesh Chandra
Publisher : River Publishers
Release Date : 2015-04-11
Category : Medical
Total pages :450
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Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: Drug discoveryTarget identification and prioritizationHypothesis driven multi-target drug designGenomics in vaccine developmentGene regulatory networks Vaccine design and developmentPrediction of drug side effects in silico

Computer Aided Design and Optimization of Probes for Hepatic Microwave Ablation

Computer Aided Design and Optimization of Probes for Hepatic Microwave Ablation
Author : Punit Prakash
Publisher : Unknown
Release Date : 2008
Category :
Total pages :145
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Genetic Engineering and Biotechnology Monitor

Genetic Engineering and Biotechnology Monitor
Author : Anonim
Publisher : Unknown
Release Date : 1988
Category : Biotechnology
Total pages :129
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Computer-Aided Software Design

Computer-Aided Software Design
Author : Max Schindler
Publisher : John Wiley & Sons Incorporated
Release Date : 1990
Category : Computers
Total pages :475
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Now with the advent of CASE tools, you can start to build your very own software--for your specific needs. This book presents a detailed guide to the use of these tools that puts the problems, solutions, and tradeoffs of personal software development into perspective--in plain English. Included is expert guidance on software methodologies, computer languages, and the management of software. You will also learn about architectural design, algorithms, descriptive languages, programming, and futuristic subjects such as artificial intelligence. Useful appendices cover computer history, software jargon, and supplier information.

Computer-aided Molecular Design

Computer-aided Molecular Design
Author : Anonim
Publisher : Unknown
Release Date : 1985
Category : Biomolecules
Total pages :200
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Parasites, Molecular Biology, Drug and Vaccine Design

Parasites, Molecular Biology, Drug and Vaccine Design
Author : Nina Agabian,Anthony Cerami
Publisher : Unknown
Release Date : 1990
Category : Antigènes parasitaires - Congrès
Total pages :504
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This wide-ranging collection of edited papers examines the many mechanisms that allow parasites to survive and interact in a host environment. The research explains how a more knowledgeable understanding of host-parasite interactions aids in the development of unique strategies for vaccine design and applied research in clinical diagnostics and therapeutics. Divided into five parts, the text covers gene expression during parasite differentiation and development; the potential for molecular genetics in parasite systems; molecules of the parasite membrane; molecular modeling and parasite drug design; and vaccines.