May 6, 2021

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Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis
Author : P. Perlmutter
Publisher : Elsevier
Release Date : 2013-10-22
Category : Science
Total pages :394
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This book provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organised in terms of the major classes of conjugate acceptors. Within each of these classes, the chemistry and applications of conjugate additions with several different categories of nucleophiles have been examined. Where several different nucleophiles achieve the same synthetic transformation, they are cross-referenced within the book and qualitative comparisons offered where appropriate. Examples of the use of conjugate additions in total synthesis of important molecules are included, with a special emphasis throughout the book on stereoselectivity. This will be a useful main text for graduate and postgraduate courses on conjugate addition reactions or the Michael reaction. It could also serve as a supplementary text for courses on topics such as the chemistry of organocopper reagents, enamines and carbanion chemistry.

Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis
Author : Patrick Perlmutter
Publisher : Elsevier
Release Date : 2020-12-29
Category : Science
Total pages :512
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Conjugate Addition Reactions in Organic Synthesis, second edition, provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organized according to class of acceptor rather than the class of nucleophile, which makes for easier synthetic problem solving. All aspects of conjugate addition reactions are covered, including theory, mechanism, catalysis, and total synthesis. Asymmetric processes are featured heavily, and there is emphasis on catalysis, given its importance in all aspects of organic synthesis today. Extensive examples in total synthesis illustrate how particular synthetic challenges are addressed and resolved with conjugate addition chemistry. The second edition features new coverage of acceptors and nucleophiles, as well as organocatalysis, gold catalysis, peptide catalysis, arene additions, and emerging areas such as biocatalytic methods and advances in mechanism theory. This book is an ideal reference for advanced undergraduates, post-graduates, researchers, and academics working in medicinal, pharmaceutical, polymer and industrial chemistry. Features a unique structure for this subject which enables readers to readily access information based on specific classes of conjugate acceptor Provides a thorough account of the latest thinking of the mechanistic basis of conjugate addition reactions and all the latest - and best - methods for achieving the highest selectivity in conjugate addition reactions Includes over 200 examples of total synthesis illustrating how particular synthetic challenges are addressed and resolved with conjugate addition chemistry Covers an up to date treatment of the latest aspects of conjugate addition reactions including inter alia, cascade reactions, organocatalysis and flow chemistry

Organocatalytic Enantioselective Conjugate Addition Reactions

Organocatalytic Enantioselective Conjugate Addition Reactions
Author : Jose L. Vicario
Publisher : Royal Society of Chemistry
Release Date : 2010
Category : Science
Total pages :354
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This book, unique in its field, is a comprehensive description of all the methodologies reported for carrying out conjugate addition reactions in a stereoselective way, using small chiral organic molecules as catalysts (organocatalysts). In the last 3-4 years, this has been a rapidly growing field in organic chemistry, and many papers have appeared reporting excellent protocols for carrying out these highly efficient transformations that compete well with other classical approachse using transition metal catalysts. A particularly attractive feature of this transformation relies upon the fact that the conjugate addition (Michael and Hetero-Michael reactions) is an extraoridinarily effective means to initiate cascade processes which result in the formation of complex molecules from very small and simple starting blocks. The book, written by noted experts, covers all recent advances in this not topic, and provides a good state-of-the-art review for organic chemists working in this field and all those who wish to start projects in this area. The Series is intended to provide an accessible reference for postgraduates and industrialists working in the field of catalysis and its applications. Books will be produced either as monographs or reference handbooks. The Series will cover research developments and applications of catalysis, in both academia and industry.

Modern Methods of Organic Synthesis

Modern Methods of Organic Synthesis
Author : J. E. Carruthers,W. Carruthers,Iain Coldham
Publisher : Cambridge University Press
Release Date : 2004-10-14
Category : Science
Total pages :493
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Textbook on modern methods of organic synthesis.

Cycloaddition Reactions in Organic Synthesis

Cycloaddition Reactions in Organic Synthesis
Author : Sh & umacr
Publisher : John Wiley & Sons
Release Date : 2002
Category : Science
Total pages :332
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During the miners' strike in the 1980s, a worker is killed in the striking coalfields of Wales. Some months later, a government minister thought to be connected with the death is also shot. Lewis Redfern—once a radical but now a political analyst and journalist—pursues the sniper, a lonely hunt that leads him through an imbroglio of civil service leaks to a secret organization: a source of insurrection far more powerful than anyone could have suspected known as the Volunteers. In this fast-paced narrative of espionage and intrigue, Redfern, through his obsessive pursuit of justice, finally encounters the truth about himself as the novel discusses the conflict between moral choice and political loyalty.

The Chemistry of Organocopper Compounds

The Chemistry of Organocopper Compounds
Author : Zvi Rappoport,Ilan Marek
Publisher : John Wiley & Sons
Release Date : 2010-01-07
Category : Science
Total pages :1178
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Copper in organic synthesis has seen a tremendous development over the past ten years. This text represents the most comprehensive survey on the use of Copper and Cuprates in organic synthesis. The first time that the Patai Series touches on Copper compounds, it contains contributions by leading experts, and delivers the quality expected from the Patai Series.

Advanced Organic Chemistry

Advanced Organic Chemistry
Author : Reinhard Bruckner
Publisher : Elsevier
Release Date : 2001-08-03
Category : Science
Total pages :636
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A best-selling mechanistic organic chemistry text in Germany, this text's translation into English fills a long-existing need for a modern, thorough and accessible treatment of reaction mechanisms for students of organic chemistry at the advanced undergraduate and graduate level. Knowledge of reaction mechanisms is essential to all applied areas of organic chemistry; this text fulfills that need by presenting the right material at the right level.

Catalysis in Asymmetric Synthesis

Catalysis in Asymmetric Synthesis
Author : Vittorio Caprio,Jonathan Williams
Publisher : John Wiley & Sons
Release Date : 2009-03-09
Category : Science
Total pages :393
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Written from a synthetic organic chemistry perspective, this is a highly practical and relevant text for undergraduates, postgraduates and industrial organic chemists.

Organic Chemistry

Organic Chemistry
Author : G. Marc Loudon
Publisher : Roberts Publishers
Release Date : 2009
Category : Science
Total pages :1374
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"Introduces organic chemistry through a mechanistic approach within a functional group framework. Contains 1,668 exercises--many of which are taken directly from the scientific literature--that encourage readers to analyze and synthesize chemical concepts. Includes modern topics such as alkene metathesis, Suzuki and Stille cross-coupling reactions, and examples drawn from contemporary medical practice."--Provided by the publisher.

Organic Chemistry

Organic Chemistry
Author : Jonathan Clayden,Nick Greeves,Stuart Warren
Publisher : Oxford University Press
Release Date : 2012-03-15
Category : Science
Total pages :1234
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Rev. ed. of: Organic chemistry / Jonathan Clayden ... [et al.].

Iron Catalysis in Organic Chemistry

Iron Catalysis in Organic Chemistry
Author : Bernd Plietker
Publisher : John Wiley & Sons
Release Date : 2008-09-08
Category : Science
Total pages :295
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This first comprehensive book to cover this exciting field also deals with the biological aspects, such as enzymes with iron. Following an introduction, this handy reference and handbook goes on to deal with reductions, oxidations of C, H- and C=C bonds, oxidative allylic oxygenation and amination, the oxidation of heteroatoms, cross coupling reactions, aromatic and nucleophilic substitutions, addition to carbonyl compounds, and cyclisations as well as ring opening reactions. The chapters are clearly classified according to the reaction type, allowing readers to quickly locate the desired information.

Organic Reactions

Organic Reactions
Author : Scott E. Denmark
Publisher : John Wiley & Sons
Release Date : 2016-06-20
Category : Science
Total pages :952
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The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

Organic Synthesis at High Pressures

Organic Synthesis at High Pressures
Author : Roy Morrin Acheson
Publisher : Wiley-Interscience
Release Date : 1991-04-12
Category : Science
Total pages :456
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Presented here is a state-of-the-art examination of organic syntheses at high pressures designed to help synthetic organic chemists decide whether high pressure technology, with its advantages and limitations, might or might not be useful in solving their current problems. Following the introduction, chapters cover the basic principles, mechanisms, apparatus and operation of using high pressure technology. Further explores specific reactions and how they relate to various chemical compounds under high pressure.

Organometallics in Organic Synthesis

Organometallics in Organic Synthesis
Author : Ei-ichi Negishi
Publisher : Wiley
Release Date : 1980-04-25
Category : Science
Total pages :532
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Bridges the gap between the typical organic and organometallic texts by providing a current overall description of the chemistry of organometallics in organic synthesis in a digested form. Offers a highly systematic and logical account of virtually all the important aspects of the use of organometallics in organic synthesis. Primarily treats the reactant-product relationship, as well as some tentative but reasonable interpretations provided by the authors of individual papers and the author of this book. Over 1,200 references are cited, along with the great majority of relevant reviews and monographs.

Catalytic Asymmetric Conjugate Reactions

Catalytic Asymmetric Conjugate Reactions
Author : Armando Cordova
Publisher : John Wiley & Sons
Release Date : 2010-12-01
Category : Science
Total pages :464
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This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles. Top international authors deal with modern forms of achieving stereoselective conjugate additions based on the use of chiral auxiliaries or asymmetric catalysis, such as P-N ligands, organocatalysis, domino reactions, Lewis acid and base catalysis. There is also a discussion of the employment of enantioselective conjugate addition transformations in total synthesis of important molecules. With its reliable and previously unpublished experimental procedures, this is a true source of high quality information.