June 17, 2021

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Core-Shell Nanostructures for Drug Delivery and Theranostics

Core-Shell Nanostructures for Drug Delivery and Theranostics
Author : Maria Focarete,Anna Tampieri
Publisher : Woodhead Publishing
Release Date : 2018-06-29
Category : Technology & Engineering
Total pages :466
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Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies and Prospects for Novel Carrier Systems contains valuable chapters that deal with the fundamentals of nanotechnology for drug delivery, recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications, and the potential and applications of core-shell nanofiber. This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry. Focuses on core-shell nanoparticles and nanofiber for innovative applications, including cancer therapy, controlled release and multi-drug release Considers future prospects and potential new applications of core-shell nanostructures for drug delivery and theranostics Explains the principles and essential concepts of nanotechnology for drug delivery systems

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering
Author : Ashutosh Tiwari,Atul Tiwari
Publisher : John Wiley & Sons
Release Date : 2013-02-19
Category : Science
Total pages :576
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This groundbreaking, multidisciplinary work is one of the first books to cover Nanotheragnostics, the new developmental edge of nanomedicine. Through a collection of authoritative chapters, the book reports on nanoscopic therapeutic systems that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities. An invaluable reference for researchers in materials science, bioengineering, pharmacy, biotechnology, and nanotechnology, this volume features four main parts on biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and nanoscaffolds technology.

Design of Nanostructures for Theranostics Applications

Design of Nanostructures for Theranostics Applications
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release Date : 2018-01-15
Category : Science
Total pages :692
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Design of Nanostructures for Theranostics Applications focuses on the theranostics applications of nanostructures. In particular, multifunctional nanoparticles for diagnostics and treatment of different diseases, including those relating to the blood-brain barrier, are discussed in detail. Chapters explore different type of nanostructures, covering design, fabrication, functionalization and optimization, helping readers obtain the desired properties. Written by a diverse range of international academics, this book is a valuable reference resource for those working in both nanoscience and the pharmaceutical industry. Explores how the design of a range of nanomaterials make them effective theranostic agents, including multifunctional core-shell nanostructures, mesoporous silica nanoparticles, and quantum dots Shows how nanomaterials are used effectively for a range of diseases, including breast cancer, prostate cancer and neurological disorders Assesses the pros and cons of using different nanomaterials for different types of treatment

ZnO Nanostructures for Tissue Regeneration, Drug-Delivery and Theranostics Applications

ZnO Nanostructures for Tissue Regeneration, Drug-Delivery and Theranostics Applications
Author : Valentina Cauda,Marco Laurenti
Publisher : MDPI
Release Date : 2021-03-25
Category : Science
Total pages :106
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Nanostructured zinc oxide materials are capturing a great deal of interest thanks to their outstanding and multifunctional properties, enabling broad series of intervention in the field of nanomedicine. ZnO can be easily prepared in a broad variety of shapes and shows anticancer and antimicrobial properties that are of interest for tissue engineering, controlled delivery of therapeutics, and even theranostics. This book is thus dedicated to the most recent advances in the field, presented as a collection of research papers and reviews. It spans from the synthesis and characterization of ZnO nanomaterials to their applications in the nanomedicine field, ranging from anticancer nanotherapeutics to dental implants and antibacterial agents.

Design and Evaluation of Plasmonic/Magnetic Au-MFe2O4 (M-Fe/Co/Mn) Core-Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics

Design and Evaluation of Plasmonic/Magnetic Au-MFe2O4 (M-Fe/Co/Mn) Core-Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics
Author : Ravichandran Manisekaran
Publisher : Springer
Release Date : 2017-10-30
Category : Technology & Engineering
Total pages :168
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This thesis documents the development of a multifunctional nanoparticle system to enhance the chemotherapeutic efficiency of anti-cancer drugs, and contributes to research that helps decrease the side-effects in cancer patients while simultaneously increasing their survival rates. The work begins with an introduction to nanomedicine and cancer therapy, and contains a literature review on magnetic, gold, and core-shell nanoparticles. It also covers synthesis techniques, properties, various surface modifications, and the importance of magnetic and gold nanoparticles. The author dedicates a chapter to characterization techniques, experimental setup, and cell cultivation techniques for in-vitro studies. Further chapters describe the background, characterizations, and applications of multifunctional magnetite coated gold core-shell nanoparticles, and the doping of cobalt to magnetite and manganese to magnetite nanoparticles. The important highlight of this research was the control of the size, shape, composition, and surface chemistry of nanoparticles.

Tissue Engineering And Nanotheranostics

Tissue Engineering And Nanotheranostics
Author : Shi Donglu,Liu Qing
Publisher : World Scientific
Release Date : 2017-10-27
Category : Science
Total pages :304
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"This book provides a comprehensive overview of current achievements in biomedical applications of nanotechnology, including stem cell based regenerative medicine, medical imaging, cell targeting, drug delivery, and photothermal/photodynamic cancer therapy. New approaches in early cancer diagnosis and treatment are introduced with extensive experimental results. In particular, some novel materials have been synthesized with new properties that are most effective in cancer therapy. Some of the key issues are also addressed with these recent discoveries such as bio safety and bio degradability, that are essential in the success of nano medicine. An important aspect of this book is the introduction of nanotechnology to the medical communities that are searching for new treatments of cancer, therefore breaking barriers between the physical and medical sciences so that more MDs will be able to appreciate the new discoveries and establishments in medical diagnoses and therapies capable of tackling major clinical issues."--Publisher's website.

Hybrid Nanomaterials

Hybrid Nanomaterials
Author : Weibo Cai,Feng Chen
Publisher : CRC Press
Release Date : 2017-05-25
Category : Medical
Total pages :450
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Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

Studies Towards DNA-polymer-silica-iron Oxide Hybrid Nanoparticles as Stimulus-responsive MR Theranostics

Studies Towards DNA-polymer-silica-iron Oxide Hybrid Nanoparticles as Stimulus-responsive MR Theranostics
Author : Claudia Meneses Shuldberg
Publisher : Unknown
Release Date : 2012
Category :
Total pages :46
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Early detection and treatment of a disease is a desired goal for medical advancements. The concept of theranostics have been introduced to combine diagnosis and therapy. Developing nanoparticles for drug delivery has been considered because they increase therapeutic benefit while minimizing side effects. Synthesizing particles that can promote imaging of areas before, during, and after administration into the organism is beneficial for the treatment of diseases. In this work superparamagnetic iron oxide nanoparticles were synthesized as enhancers for MR imaging by using magnetic imaging resonance. Biocompatible, stimuli-responsive polymers were physisorbed to the particles in a layer-by-layer fashion to induce aggregation of iron oxide nanoparticles site specifically and deliver increased MR signals. The surfaces of the superparamagnetic particles were first modified with silica to increase biocompatability, reduce aggregation of the iron oxide particles and allow potential encapsulation of drugs. The surface of the iron oxide silica core shell particles were next treated with APTES, a coupling agent, to help adhere polymers to the particles. In this study poly(methacrylic acid) (PMA) and poly(N-vinylpyrrolidone) (PVP) were the polymers used for forming crosslinkable polymer shells on the particles through a layer-by-layer approach. The PMA chains were modified with thiol groups to crosslink the multiple layers deposited onto the particle surfaces. The polymer shells could easily be destabilized in the presence of reducing agents. Additionally, PMA was modified with DNA strands which would allow the silica coated iron oxide nanoparticles to aggregate and therefore increase the signal for MR imaging.

Novel Theranostics Based on Hybrid Nanoparticles for Early Cancer Detection and Treatment

Novel Theranostics Based on Hybrid Nanoparticles for Early Cancer Detection and Treatment
Author : Siyue Li
Publisher : Unknown
Release Date : 2017-01-27
Category :
Total pages :129
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This dissertation, "Novel Theranostics Based on Hybrid Nanoparticles for Early Cancer Detection and Treatment" by Siyue, Li, 李思越, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Nanoscience and nanotechnology have advanced rapidly in recent years and have made a profound impact in the medical field. Nanoparticles have attracted great attention for their potential as diagnostic and/or therapeutic tools in oncology owing to their unique properties. Theranostics are nanodevices with diagnostic, therapeutic and possibly treatment-monitoring functions for treating cancers. Different noble metal nanoparticles can provide the basic unit for theranostics. Suitably designed and developed noble metal nanoparticle-based theranostics will have multiple functions. In this project, the design, fabrication and performance of novel multifunctional nanodevices for cancer detection and treatment were investigated. The foundation of this project was laid by investigating different types of hybrid nanoparticles for novel theranostics. Different approaches were developed for fabricating core-shell structured hybrid nanoparticles. Highly branched gold and gold-silver bimetallic nanoparticles were firstly made. pH-sensitive folic acid-chitosan (CS-FA) conjugate was then introduced on these nanoparticles to form hybrid nanoparticles with a metal core (Au@CS-FA and Au-Ag@CS-FA). Poly(lactide-co-glycolide) (PLGA) and chitosan (CS) micro- or nanoparticles were also produced to serve as the polymer core for forming hybrid particles with a gold or gold-silver nanoshell (PLGA@Au, CS@Au and PLGA@Ag-Au). Furthermore, Fe3O4@Au nanoparticles having both magnetic and plasmonic properties were investigated. Thermo-sensitive poly(N-isopropylacrylamide) (pNIPAm) polymer or pH-sensitive CS-FA was then coated on Fe3O4@Au nanoparticles, forming new hybrid nanoparticles. The formation mechanisms of nanoparticles and hybrid nanoparticles were studied. Raman reporters (Rhodamine B or 4-mercaptobenzoic acid) and anti-cancer drugs (paclitaxel or 5-fluorouracil) were loaded into the polymer core or shell of hybrid nanoparticles to form multifunctional nanodevices. While the noble metal unit in the nanodevices provided high light-scattering enhancement for achieving photothermal effect, the polymer component encapsulated Raman reporter molecules and put them close to the metal nanoparticles for generating high surface enhanced Raman scattering (SERS) signals. These nanodevices could also serve as excellent drug carriers, and the stimulus-triggered release of incorporated drug was studied. It was shown in this project that the conjugation of targeting ligand (e.g. folic acid) or antibody (e.g. anti-HER2 monoclonal antibody) on hybrid nanoparticles had formed novel theranostics which allowed selective detection, continuous imaging of intracellular behavior and killing of targeted cancer cells. These theranostics could be taken up by specific cancer cells through receptor-mediated endocytosis and internalized into cytoplasma of the cell. These theranostics as stable SERS-active tags and imaging agents for HeLa cells, SK-BR-3 cancer cells or MCF-7 cancer cells were demonstrated. The targeting ability and intracellular uptake of these theranostics were studied. The photothermal effect of the theranostics was investigated using different laser irradiation powers. The anti-cancer treatment could be significantly improved by the synergistic effects of chemo- and photothermal therapy when these theranostics were also tasked as the carrier of anti-cancer drugs. Therefore, combining plasmonic metal

Near-infrared Nanomaterials

Near-infrared Nanomaterials
Author : Professor Fan Zhang
Publisher : Royal Society of Chemistry
Release Date : 2016-07-28
Category : Science
Total pages :409
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In the last decade, bioimaging and therapy based on near-infrared (NIR) nanomaterials have played an important role in biotechnology due to their intrinsic advantages when compared with the traditional imaging probe and medicine. NIR nanomaterials allow deeper penetration depth, low detection threshold concentration and better targeted performance. This book systematically summarises the recent progress in the fabrication and application of NIR nanomaterials for biomedical imaging and therapy, and discusses the advantages, challenges and opportunities available. Near-infrared Nanomaterials contains a chapter highlighting the outlook of these materials, detailing novel ideas for the further application of NIR nanomaterials in bioimaging and medicine. Written by leading experts working in the field, this title will have broad appeal to those working in chemistry, materials science, nanotechnology, biology and bioengineering, biomedical science and biophysics.

Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery
Author : Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin
Publisher : Morgan & Claypool Publishers
Release Date : 2015-12-01
Category : Science
Total pages :155
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The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.

Synthesis and Characterization of Janus Particle Nanocarriers and DNA Devices Toward Multifunctional Drug Delivery Systems

Synthesis and Characterization of Janus Particle Nanocarriers and DNA Devices Toward Multifunctional Drug Delivery Systems
Author : Alexander H. Mo
Publisher : Unknown
Release Date : 2015
Category :
Total pages :146
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Integrating a diagnostic moiety with a therapeutic payload promises improved prognoses in diseases such as cancer by simultaneously illuminating and treating cancerous tumors. However potential theranostic materials and chemicals must be biocompatible and evade rapid clearance from the body. Such strict constraints require an interdisciplinary approach to research. Working toward to address those constraints requires drawing on such disparate fields as DNA nanotechnology, Janus nanoparticle synthesis, and chemical conjugation in order to one day create a viable theranostic carrier. Using an inosine-based partial strand displacement scheme is reported a nanoscale positioning capabilities are used to provide on-demand activation and deactivation of a pair of split E6 DNAzymes on the device. The device also demonstrates a combined catalytic rate significantly higher than the original E6 DNAzyme under similar operational conditions. This approach can provide structural organization and spatially control the opening and closing of a theranostic particle. Janus nanoparticles (JNP) synthesis methods were pursued to create potential theranostic carriers. Two particular morphologies are explored: (i) a gold-ball like core-shell carrier and (ii) a eccentrically encapsulated JNP. For the golf-ball structure, a hierarchical template synthesis scheme was used to create a carrier consisting of (i) solid silica core with a pitted gold surface and (ii) a hollow/porous gold shell without silica. Along with the golf-ball carrier, a carrier derived eccentric encapsulation of a one material around another. Using a sol-gel synthesis method, eccentric Janus nanoparticles composed of a silica shell partially encapsulating a carboxylate-modified polystyrene core (cPS). Nano-bowl-like structures were derived after the removal of the polystyrene core by organic solvent. The role of the polystyrene core in determining the eccentric JNP morphology and size was also elucidated. These eccentric JPs and nanobowls can be further developed to create a magnetic gold nanobowl (mGNB). Such mGNBs consisted of a silica bowl whose outer surface is coated with iron oxide/gold/PEG in that order and a exposed silica bowl interior. The nanobowls demonstrated a surface enhanced Raman spectroscopy capability, showed cellular uptake in vitro and dose-dependent toxicity. Finally, we demonstrate preliminary work toward loading a payload (fluorophore, anti-cancer prodrug) in the silica bowl.

Advances in Nanotheranostics II

Advances in Nanotheranostics II
Author : Zhifei Dai
Publisher : Springer
Release Date : 2016-01-11
Category : Technology & Engineering
Total pages :381
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This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

Smart and Functional Polymers

Smart and Functional Polymers
Author : Jianxun Ding,Yang Li,Mingqiang Li
Publisher : MDPI
Release Date : 2019-11-20
Category : Science
Total pages :306
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This book is based on the Special Issue of the journal Molecules on “Smart and Functional Polymers”. The collected research and review articles focus on the synthesis and characterization of advanced functional polymers, polymers with specific structures and performances, current improvements in advanced polymer-based materials for various applications, and the opportunities and challenges in the future. The topics cover the emerging synthesis and characterization technology of smart polymers, core−shell structure polymers, stimuli-responsive polymers, anhydrous electrorheological materials fabricated from conducting polymers, reversible polymerization systems, and biomedical polymers for drug delivery and disease theranostics. In summary, this book provides a comprehensive overview of the latest synthesis approaches, representative structures and performances, and various applications of smart and functional polymers. It will serve as a useful reference for all researchers and readers interested in polymer sciences and technologies.

Nanomedicine

Nanomedicine
Author : Marc J. Williams,Serena A. Corr
Publisher : Elsevier Inc. Chapters
Release Date : 2013-09-19
Category : Technology & Engineering
Total pages :196
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The past two decades have seen a surge in the development and application of nanoparticles for biomedical uses, with a focused effort on engineering particles for ‘theranostic’ applications where diagnosis and disease treatment are possible using a single platform. Magnetic nanoparticles, in particular, are ideal candidates for this kind of multimodal action, given their potential use spans magnetic resonance (MR) imaging, magnetic hyperthermia and targeted drug delivery. This is due to unique properties their size bestows on them. Here, we examine these properties of magnetic nanoparticles and how they govern the particle efficacy for a desired application. Given the intimate link between synthetic approach chosen and subsequent properties, we will also discuss typical and emerging routes to magnetic nanoparticle preparation. We will, in detail, describe the uses of magnetic nanoparticles as diagnostic and therapeutic tools, with particular emphasis on their use as MR contrast agents and the most recent developments in targeted drug delivery. Finally, we will present an outlook for the future of these important materials.