June 20, 2021

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Dengue Virus Disease

Dengue Virus Disease
Author : Adnan Qureshi,Omar Saeed
Publisher : Academic Press
Release Date : 2019-10-15
Category :
Total pages :210
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Dengue Virus Disease: From Origin to Outbreak provides a detailed accounting of one of the world's fastest growing infections. According to the World Health Organization, Dengue virus incidence has increased 30-fold over the past 50 years, with up to 50 to 100 million infections occurring annually in over 100 endemic countries. This estimate puts nearly half the world's population at risk. This book reviews the history, clinical and diagnostic aspects of dengue virus, also presenting our current knowledge on the pathophysiology of severe dengue and addressing the importance of dengue virus infections in those traveling to parts of the world where it is endemic. Covers every important aspect of Dengue virus disease, from biological, to its social and economic impacts Highlights the unique aspects of Dengue virus infection and the evolving nature of our understanding of the virus Provides a complete description of Dengue virus disease, with details on more recent outbreaks, clinical features, first hand experiences, treatment modalities, and recent novel treatment regimens Gives insights into the detailed psychological impact the disease has caused in outbreak regions

Dengue Virus Disease

Dengue Virus Disease
Author : Adnan I. Qureshi,Omar Saeed
Publisher : Academic Press
Release Date : 2019-11-23
Category : Science
Total pages :202
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Dengue Virus Disease: From Origin to Outbreak provides a detailed accounting of one of the world's fastest growing infections. According to the World Health Organization, Dengue virus incidence has increased 30-fold over the past 50 years, with up to 50 to 100 million infections occurring annually in over 100 endemic countries. This estimate puts nearly half the world’s population at risk. This book reviews the history, clinical and diagnostic aspects of dengue virus, also presenting our current knowledge on the pathophysiology of severe dengue and addressing the importance of dengue virus infections in those traveling to parts of the world where it is endemic. Covers every important aspect of Dengue virus disease, from biological, to its social and economic impacts Highlights the unique aspects of Dengue virus infection and the evolving nature of our understanding of the virus Provides a complete description of Dengue virus disease, with details on more recent outbreaks, clinical features, first hand experiences, treatment modalities, and recent novel treatment regimens Gives insights into the detailed psychological impact the disease has caused in outbreak regions

Development of Safe, Effective Vaccines for Dengue Virus Disease by Recombinant Baculovirus. Subtitle: Development of Safe, Effective Vaccines for Dengue Disease Utilizing Viral Envelope and NSI Glycoproteins Expressed by Recombinant Baculovirus

Development of Safe, Effective Vaccines for Dengue Virus Disease by Recombinant Baculovirus. Subtitle: Development of Safe, Effective Vaccines for Dengue Disease Utilizing Viral Envelope and NSI Glycoproteins Expressed by Recombinant Baculovirus
Author : Anonim
Publisher : Unknown
Release Date : 1991
Category :
Total pages :21
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During the initial phase of this study we have completed construction of recombinant baculoviruses that separately express full-length E or NS1 glycoprotein of dengue type 2 and type 4 viruses. Radio-immunoprecipitation was performed to analyze the dengue product in the lysate of recombinant virus infected cells. The results showed that insect cells infected with recombinant b (DEN 4, 100%E) produced a protein with molecular weight of 55-60 kilodalton (Kd) as predicted for the glycosylated form of dengue E glycoprotein. Similarly, recombinant b (DEN 4, NS1) or b (DEN 2, NS1) produced a protein in infected insect cells that was approximately 40-44 Kd, the size predicted for the dengue NS1 glycoprotein. In the next phase of this study we plan to prepare lysates of insect cells infected with various recombinant baculoviruses. These lysates will be analyzed quantitatively and used for evaluation of immunogenicity of the expressed dengue protein products in mice. These studies will allow us to determine separately the protective efficacy afforded by each of these dengue virus proteins, and therefore, select the most immunogenic as well as the most protective recombinant products for further evaluation in primates.

Dengue and Dengue Hemorrhagic Fever

Dengue and Dengue Hemorrhagic Fever
Author : D. J. Gubler,Goro Kuno
Publisher : Cabi
Release Date : 1997
Category : Medical
Total pages :478
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Dengue and dengue hemorrhagic fever is the most important arboviral disease of humans today. Over 2.5 billion people are at risk from infection; each year there are 50 to 100 million cases of dengue fever and several hundred thousand cases of dengue hemorrhagic fever. The public health importance of dengue and dengue hemorrhagic fever, and the dramatic increase in published literature on this disease make this book particularly timely. It provides for the first time a comprehensive review of the subject, including history, epidemiology, virus-vector relationships, transmission, clinical diagnosis and management. It also brings together the latest research on dengue fever, with chapters contributed by the leading experts in the field. This book is essential reading for all clinicians, public health practitioners and policy makers concerned with dengue and dengue hemorrhagic fever. It is also invaluable for anyone working in urban tropical medicine.

New Treatment Strategies for Dengue and Other Flaviviral Diseases

New Treatment Strategies for Dengue and Other Flaviviral Diseases
Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Release Date : 2006-10-02
Category : Science
Total pages :276
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Dengue virus is a member of the Flaviviridae family, which includes viruses associated with human diseases such as yellow fever, Japanese encephalitis and hepatitis C. Dengue fever is transmitted by mosquitoes, principally Aedes aegypti. There are four serotypes of dengue virus, of which DENV-2 has been the most prevalent in many recent epidemics. Following primary infection, lifelong immunity develops, preventing repeated assault by the same serotype. However, the non-neutralizing antibodies from a previous infection or maternally acquired antibodies are thought to form complexes with a different serotype during a subsequent infection and cause dengue haemorrhagic fever/dengue shock syndrome, which can be fatal. There is no treatment or vaccine available today that can combat this emerging and uncontrolled disease. This book features contributions from the world’s leading researchers working on dengue and related flaviviruses who examine the current state of the art in the molecular biology of the dengue virus. Particular emphasis is placed on the structure and function of the virus and the targeting of virus proteins by potential antiviral agents. The pathogenesis of dengue and dengue haemorrhagic fever are discussed in detail, especially the target cells and the specific receptors on these cells, thereby developing a clear overview of host and viral factors that contribute to dengue haemorrhagic fever. Finally, the book reviews the therapeutic options, paying particular attention to ways in which vector, host and environment can play a critical role in the spread of this disease. With dengue fever and other emerging viral diseases becoming increasingly prevalent around the world, this book provides valuable insight into the virus that causes this disease and potential ways to manage it. It is essential reading for all those working in tropical diseases, public health and virology. Praise from the reviews: "The book provides an excellent summary of dengue/flavivirus research and is important for individuals and institutions interested in emerging infectious diseases." MICROBIOLOGY TODAY

Dengue Viruses

Dengue Viruses
Author : R.W. Schlesinger
Publisher : Springer
Release Date : 2012-01-19
Category : Medical
Total pages :136
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2. Virological Findings. 90 3. Immunity. . . . . 90 C. Secondary Dengue: Dengue Hemorrhagic Fever and the Shock Syndrome 92 1. General Remarks. . . . . . . . . . . . . . 92 2. Clinical Course and Clinical Laboratory Findings 93 3. Virological and Serological Findings. . . 95 4. Immunopathology of Secondary Dengue. 98 XI. Immunization. . . . . . . . . . . . . . . 104 A. Anamnestic Immune Responses in Sequential Infections With Dengue and Other Group B Togaviruses . . . . . . . . 104 1. Results With Members of the Dengue Subgroup 104 2. Results With Dengue and Other Flaviviruses. 107 B. Dengue Vaccines for Use in Man 108 XII. Opportunities for the Future 113 Acknowledgments. 114 References. . . . . . . . . . . 114 I. Introduction Dengue fever is a mosquito-transmitted disease of man which has afflicted untold millions of people over the past two centuries. It is caused by viruses classified as a subgroup of the group B togaviruses. Along with other members of that group as well as group A, the dengue viruses have been investigated intensively during recent years. Certain unique aspects of their structure, composition, antigenicity, replication, and antigenic relationships have established the togavirus family as quite distinct from other families of enveloped RNA viruses (see recent review of PFEFFERKORN and SHAPIRO, 1974). The basic studies leading to this conclusion have coincided with epidemiological field investigations which have resulted in a continuing increase in the number of viruses now designated as group A or B togaviruses. This, in turn, has led to a growing appreciation of their immense importance as actual or potential pathogens of man and beast.

Development of Safe, Effective Vaccines for Dengue Virus Disease by Recombinant Baculovirus

Development of Safe, Effective Vaccines for Dengue Virus Disease by Recombinant Baculovirus
Author : Anonim
Publisher : Unknown
Release Date : 1992
Category :
Total pages :29
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Outbreaks and major epidemics of dengue continue to afflict human populations, especially in the tropical and subtropical regions of the world. Dengue viruses, transmitted predominantly by mosquito species of the Aedes genus, include four serotypes that are distinguishable by plaque reduction-- neutralization with type specific monoclonal antibodies. Dengue is characterized by fever, rash, severe headache, and joint pain. Its mortality rate is low. However, over the past few decades, a more severe form of dengue, characterized by hemorrhage and shock has been observed with increasing frequency in children and young adults. This severe form of dengue has a high mortality rate. Despite years of intensive research, an effective vaccine is still not available for prevention of dengue infection. For these reasons, research on dengue viruses and development of safe and effective vaccines have been given a high priority by the World Health Organization ... Dengue virus, Genetic engineering, Recombinant DNA, Vaccines, Biotechnology, Diseases, ID, RA I.

ZIKA VIRUS DISEASE

ZIKA VIRUS DISEASE
Author : Adnan Quereshi
Publisher : Academic Press
Release Date : 2017-11-17
Category : Science
Total pages :180
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Zika Virus provides an authoritative account of one of most fascinating viruses of the 21st century, covering all the main points. It includes coverage of clinical manifestations, such as fever and fatigue, but also delves into neurological manifestations like acute demyelinating neuropathy. In addition, the book discusses new evidence that suggests that Zika fever in pregnant women can cause abnormal brain development in fetuses by mother-to-child transmission. The Zika virus infection has become one of the first where women are actively discouraged from getting pregnant. Readers will find this book to be a comprehensive resource on the topic. Covers every important aspect of the Zika virus disease, from biological, to social and economic impacts Focuses on women’s health issues that have surfaced, including birth defects in newborns Written in an easy to comprehend manner, with technical terms clearly defined in chapters that highlight genetics

Dealing with Dengue: Diagnosing, Treating, and Recovering from Dengue Fever

Dealing with Dengue: Diagnosing, Treating, and Recovering from Dengue Fever
Author : Godfree Roberts Ed.D.
Publisher : Thailand Retirement Press
Release Date : 2014-09-25
Category : Health & Fitness
Total pages :114
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In 114 pages 'Dealing with Dengue' covers every aspect of Dengue Fever. Here are the chapter titles: 1. What not to Do... 2. What is Dengue? 3. Diagnosing Dengue 5.Folk Remedies 6. Children & Dengue 7. Pregnancy & Dengue 8. Severe Dengue 9. Painkillers & Your Liver 10. Recovery & TCM 11. Doctors & Drugs 12. Immunity 13. Lab Tests 14. Somebody Stop Me! 15. Call Me Aedes 16. 99% Prevention 17. Insecticides & Repellents 18. Traps, Nets, Coils & More 19. Case Studies 20. Transmission 21. Vaccines, Bacteria & GMOs 22. Regular Mosquito Bites 23. Your Community 24. Blogs, Links, Downloads 25. Myths & Rumors 26. Videos 27. Dengue for MDs See what I mean? It's everything you need to know about Dengue.

Dengue Fever

Dengue Fever
Author : Katherine White
Publisher : The Rosen Publishing Group
Release Date : 2004
Category : Dengue
Total pages :64
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Describes the symptoms and spread of dengue fever, an Asian disease that is now advancing rapidly through tropical areas throughout the world, and discusses treatments, preventive measures, and the search for a cure.

Characterization of Quasispecies in Dengue Virus Disease Severity

Characterization of Quasispecies in Dengue Virus Disease Severity
Author : 鄭洁晶
Publisher : Unknown
Release Date : 2018
Category :
Total pages :78
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Dengue Disease

Dengue Disease
Author : Huan-Yao Lei
Publisher : Unknown
Release Date : 2008-01-01
Category : Dengue
Total pages :309
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PART 1 -- Dengue virus infection is an emerging infectious disease with an increasing prevalence of global scale, especially in the tropical countries. Several socioeconomic and environmental factors are responsible for the surging of dengue outbreaks in the 21st century. The easy access to transportation and global urbanization contribute most significantly to the prevalence of dengue infection in the late 20th century. The poor environmental conditions in many countries make the control of mosquito vector a difficult or even impossible task and the dengue outbreaks therefore become an uncontrollable issue in these countries. In central/southern America and southeastern Asia, dengue outbreaks up to a scale of beyond hundred thousands cases occurred annually. The control measures depend largely on improving the proper management of patients with dengue hemorrhagic fever/ dengue shock syndrome (DHF/DSS). The past decades have witnessed the improvement of mortality of DHF/DSS from around 10% to the current 0.1% in these DHF/DSS cases. However, the development of dengue vaccine turned out to be unsuccessful using the live attenuated viruses due to the incomplete immune response to the tetravalent vaccine and the high morbidity associated with vaccination. The story behind the failure of vaccine development reflects our lack of understanding regarding the complex immunopathogenesis of virus-host interaction in dengue virus infection. In the past years, the scientific field started to understand the importance of basic researches in the development of anti-virus compounds and vaccine development in dengue virus infection. Under the combined efforts of Pediatric Dengue Vaccine Initiative (PDVI) led by Professor Scott Halstead, and the establishment of Novartis Institute for Tropical Diseases in Singapore, a significant improvement in our understanding of the virology, virus-host interaction, and immune response in dengue infection have been achieved. In Taiwan, the dengue research is actively sponsored by National Health Research Institutes starting from 2000. Since then, several progresses such as the epitpoe mapping for the antibody dependent enhancement and the development of autoantibodies against endothelial cells and platelets have been achieved. Significant progresses have also been made in diagnostic technology and molecular epidemiology of dengue infections. The urgent demand in dengue research is to develop a good animal model to study the pathogenesis and also for the development of anti-viral compounds and dengue vaccine. Based on the results obtained from the researches in the past decade, scientific knowledge on basic and clinical fields of dengue infection accumulated and a special book to summarize these knowledge becomes necessary. Under the coordination of Professor Lei HY in the National Cheng Kung University Medical School, scientists in Taiwan and in Asian regions contribute their expertise in each chapter to publish a book to address the specific issues in each field of dengue virus infection. These knowledge will not only provide scientific data in each specific topic but also offer the direction for future studies. Hopefully, we can reach some breakthrough in the coming years to develop strategy for anti-viral compounds and vaccine development. PART 2 -- Dengue fever and Dengue hemorrhagic fever is an important tropical infectious disease, afflicting millions of people every year. It is also alarmingly spreading northward to North America. The virus has been studied for many years and its molecular structure is thoroughly known. It is a flavivirus and consists of 4 serotypes (and genotypes). It is spread through mosquito as a vector. Repeated infections with viruses of different genotypes result in severe hemorrhagic fever. Despite such wealth of knowledge, Dengue fever and Dengue virus remain a scientific and medial challenge. First of all, the mechanism of Dengue hemorrhagic fever remains elusive. Is it a viral load problem? Or, is it due to genetic makeup of certain hemorrhagic virus strains? Or, as suggested by several articles in this book, is it an autoimmune disease? Convincing scientific evidence presented in this book showed a pathogenic role for the auto-antibodies against some viral proteins. Also, cytokine storms may trigger the pathology. This hypothesis was a major contribution from Dengue researchers in Taiwan previously and is elaborated by several chapters in this book. The understanding of Dengue pathogenesis has been hampered by lack of animal models for hemorrhagic fever. An animal model is described in this book. Second, the diagnosis of Dengue fever remains slow and time-consuming. It used to rely mainly on serological tests. This book outlined molecular detection and biochip detection methods, which may facilitate Dengue diagnosis. Third, treatment for Dengue hemorrhagic fever remains mainly symptomatic. There are still no effective antivirals available for Dengue. This book did not address this issue but outlined the strategies for managing Dengue hemorrhagic fever. Finally, the most important issue concerns vaccines. Several clinical trials for Dengue vaccines are currently ongoing. The most challenging issue in Dengue vaccine development is whether the vaccine can produce broad enough immunity to ensure that all the potential virus strains of different genotypes are covered by the antibodies induced. Only the complete coverage can prevent viral superinfection, which may cause hemorrhagic fever. A summary chapter by the editor Dr. Huan-Yao Lei elegantly discusses the challenges and opportunities for Dengue vaccine development. Taiwan has been a stronghold for Dengue research. All the authors in this book are from various institutions in Taiwan. This collection of articles provides excellent glimpses into the quality of research in this regard in this country and also represents the state of arts in Dengue virus research. Besides the topics discussed above, this book also addresses virology of Dengue virus, including virus entry, apoptosis, autophagy, production of interferon and immune responses. It is rare that there is such a concentration of Dengue researchers in a small country like Taiwan. It is even rarer that these scientists together will contribute to a book like this. As a fellow virologist, I am proud to write a preface for this book. PART 3 -- The global prevalence of dengue has grown dramatically and is now endemic in more than 100 countries. There are at least 50 million cases of dengue infection and several hundred thousand cases of dengue hemorrhagic fever (DHF) per year. Dengue disease is an important health problem in tropical or sub-tropical areas and the DHF is the leading cause of hospitalization for children in Southeastern Asia. So far, there is no effective dengue vaccine, although several candidate vaccines are currently being evaluated. Serious dengue disease involves life-threatening complications such as vascular leakage and hemorrhagic diathesis. In endemic areas such as southeastern Asia or Latin America, most of the DHF/DSS are children while some are infants. However, in non-endemic areas like Taiwan, the majority of the DHF/DSS cases are adults and the infected elders tend to have high mortality. Taiwan s dengue outbreaks also have a unique type of transmission: starting from imported cases from abroad, spreading out locally, and ending in the winter. This pattern repeats every year. The dengue disease pattern in Taiwan represents a new type of epidemiology which is different from that in the endemic area of Southeast Asia. In this book, a comprehensive review from dengue epidemiology, diagnosis, clinical, dengue genome, cellular response post dengue virus infection, animal model, dengue-induced autoimmunity, antibody-dependent enhancement, immunopathogenesis, patient management, to dengue vaccine development is covered. All chapters are contributed by Taiwanese dengue researchers. Based on the Dengue Research Team in Department of Microbiology and Immunology, National Cheng Kung University Medical College, we have established a vigorous research network linking various laboratories in National Taiwan University Medical College, Academia Sinica, Center for Disease Control, and National Defense Medical Center with the financial support for dengue program project by National Health Research Institute. We also collaborate with dengue investigators from Canada, Thailand, and Vietnam. Through intensive communication, research ideas are generated, fine-tuned and executed by members from different laboratories within an interactive and cooperative atmosphere. Using approaches aimed at the patient, virus, animal, cellular, and molecular levels, an intensive study of dengue pathogenesis by this highly-integrated research network is helping to develop new understanding and strategies to cope with dengue disease. In particularly, acute dengue virus infection can induce autoimmunity due to molecular mimicry between dengue NS-1, prM and platelet, endothelial cells. A new autoantibody-associated immunopathogenesis is proposed and offers new insights into the molecular mechanisms underlying DHF/DSS, and will have impact on the future design of safe and protective dengue vaccines.

Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench

Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench
Author : Simona Zompi,Scott Halstead
Publisher : Frontiers Media SA
Release Date : 2015-04-14
Category :
Total pages :129
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Dengue is the most important mosquito-transmitted viral disease in humans. Half of the world population is at risk of infection, mostly in tropical and sub-tropical areas. The World Health Organization (WHO) estimates that 50 to 100 million infections occur yearly, with 50,000 to 100,000 deaths related to dengue, mainly in children. Recent estimates show higher numbers, up to three times more, with 390 million estimated dengue infections per year, among which 96 million apparent infections (Bhatt et al. 2013). Initially localized to South-East Asia, dengue virus (DENV) started its spread in Latin America in the 80’s. Little is known about DENV spread in Africa, but multiple seroprevalence surveys over several years are now clearly showing endemic areas in East and West Africa (Brady et al. 2013). Finally, due to global warming and intense traveling there is a risk of global spread towards more temperate regions, and both US Key islands (FL) and southern Europe recently faced DENV outbreaks. There are currently no specific treatments or vaccines available. Even though several dengue vaccines are in the pipeline, clear correlates of protection are still lacking. The recent failure of the live-attenuated Sanofi vaccine Phase 2b trial (Sabchareon et al. 2013) and the lack of correlation between clinical protection and in vitro neutralization assays, clearly underlines the necessity to better understand the role of the different components of the immune system in protection against dengue virus infection and the requirement for the development of additional and/or improved predictive assays. The aim of this research topic is to provide novel data, opinions and literature reviews on the best immune correlates of protection and recent advances in the immune response to DENV infection that can allow rapid progress of dengue vaccines. Authors can choose to submit original research papers, reviews or opinions on pre-clinical or clinical observations that will help unify the field, with perspectives from epidemiology, virology, immunology and vaccine developers. This research topic will discuss different aspects of the protective immune response to DENV that can influence vaccine development. It will include a review of epidemiological data generated in the field, which will address spatio-temporal diversity of DENV epidemics, the importance of cross-reactive protection and of the time-interval between infections as a predictor of disease. It will further include a review of the role of both the innate and adaptive immunity in DENV infection control, and discuss the usefulness of new improved animal models in dissecting the role of each immunological compartment, which will help define new correlate of immune protection. New data concerning the DENV structure and anti-dengue antibody structure will address the necessity of improved neutralization assays. The ultimate test to prove vaccine efficacy and study immune correlates of protection in humans before large trials will open up the discussion on human DENV challenges using controlled attenuated viral strains. Finally, the role of vaccines, administered in flavi-immune populations, in the modification of future epidemics will also be approached and will include novel studies on mosquitoes infection thresholds.

Dengue Fever and Other Hemorrhagic Viruses

Dengue Fever and Other Hemorrhagic Viruses
Author : Tirtha Chakraborty,I. Edward Alcamo,David L. Heymann
Publisher : Infobase Publishing
Release Date : 2008
Category : Dengue
Total pages :102
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Dengue fever is an infectious disease found around the world that is caused by four closely related, but distinct, types of viruses commonly transmitted by Aedes aegypti mosquitoes. Triggering excessive bleeding, dengue fever, dengue hemorrhagic fever, and dengue hemorrhagic shock can be fatal. Dengue Fever and Other Hemorrhagic Viruses explores the biology of the dengue virus and similar viruses such as Ebola, Marburg virus, and Lassa fever, as well as their symptoms, where they are commonly found, how they are transmitted, and the efforts to treat and eradicate them.Chapters include: Ins and Outs of Dengue; Hemorrhagic Fevers; Vectors - Bugs That Carry Disease; The Immune System: Our Line of Defense; and, Vaccination - Waking Up the Army in Us.

Dengue

Dengue
Author : Márcia Aparecida Sperança
Publisher : BoD – Books on Demand
Release Date : 2017-07-26
Category : Medical
Total pages :152
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This edited book Dengue - Immunopathology and Control Strategies contains eight chapters divided in three sections that underline important aspects of dengue virus, the most prevalent and life-threatening arbovirus in the world, including virus replication cycle and pathology, diagnostic methods, and control. The first section brings knowledge on basic aspects of dengue virus replication which can be associated to its immunopathology. The second section includes two chapters on dengue diagnosis and emphasizes that in spite of the many scientific efforts, this subject continues to be a drawback in the disease control. Vector-based control strategies are discussed in the third section which also contains a chapter on regulation of dengue vaccines and the experience of Mexico in the implementation of the unique registered dengue vaccine.