January 16, 2021

Download Ebook Free Developmental And Fetal Origins Of Differences In Monozygotic Twins

Developmental and Fetal Origins of Differences in Monozygotic Twins

Developmental and Fetal Origins of Differences in Monozygotic Twins
Author : Alexandra Matias,Isaac Blickstein
Publisher : Academic Press
Release Date : 2020-05-15
Category : Medical
Total pages :386
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Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout. Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis Features contributions from international experts in twin genetics and developmental biology

Gamete and Embryo-fetal Origins of Adult Diseases

Gamete and Embryo-fetal Origins of Adult Diseases
Author : He-Feng Huang,Jian-Zhong Sheng
Publisher : Springer Science & Business Media
Release Date : 2013-11-19
Category : Health & Fitness
Total pages :222
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The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians. Editor He-Feng Huang, M.D., is Professor and President of Women’s Hospital, School of Medicine, Zhejiang University, China. Editor Jian-Zhong Sheng, Ph.D., is Professor at the Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, China.

RUNX Proteins in Development and Cancer

RUNX Proteins in Development and Cancer
Author : Yoram Groner,Yoshiaki Ito,Paul Liu,James C. Neil,Nancy A. Speck,Andre van Wijnen
Publisher : Springer
Release Date : 2017-03-15
Category : Medical
Total pages :515
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This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.

Family Matters

Family Matters
Author : Gita D. Mishra
Publisher : Oxford University Press
Release Date : 2009-04-02
Category : Family & Relationships
Total pages :341
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Life course epidemiology considers how adult health is affected by a variety of factors and influences over the entire life-course. This book provides the reader with the knowledge and skills to design, analyse, and correctly interpret family-based studies, which are increasingly being used to explore life course epidemiology.

Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book

Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book
Author : Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh
Publisher : Elsevier Health Sciences
Release Date : 2019-04-11
Category : Medical
Total pages :1850
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Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.

Epigenetics and Human Health

Epigenetics and Human Health
Author : Alexander Haslberger,Sabine Greßler
Publisher : John Wiley & Sons
Release Date : 2011-08-24
Category : Science
Total pages :316
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After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Oncology of Infancy and Childhood E-Book

Oncology of Infancy and Childhood E-Book
Author : Stuart H. Orkin,David E. Fisher,A. Thomas Look,Samuel Lux,David Ginsburg,David G. Nathan
Publisher : Elsevier Health Sciences
Release Date : 2009-06-09
Category : Medical
Total pages :1392
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To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.

Multiple Pregnancy

Multiple Pregnancy
Author : Julio Elito Jr.
Publisher : BoD – Books on Demand
Release Date : 2019-01-30
Category : Medical
Total pages :232
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Multiple Pregnancy - New Challenges is a comprehensive book, written in an organized and concise format. The book offers an immersion into multiple pregnancy. Each chapter presents the reader with various important issues related to the subject matter. The book covers all spectrums of multiple pregnancy such as epidemiology, etiology, diagnosis, prenatal care, unique complications in monochorionic pregnancies, preterm birth and mode of delivery. Through its 10 chapters the book contemplates the most relevant aspects of multiple pregnancy. Authors from all over the world have contributed to this book, bringing the best from their research experiences. The book give the reader a state-of-the-art update of multiple pregnancy.

Pathology of Multiple Pregnancy

Pathology of Multiple Pregnancy
Author : Virginia J. Baldwin
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :409
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Pathology of Multiple Pregnancy collates case material from over 500 autopsies (including embryos) and 1200 placentas from twins, triplets, and higher multiples with selected literature on human multiple reproduction. It emphasizes important new concepts of pathophysiology and interpretation of less than ideal outcomes of multiple conception based on over 30 years experience in the field. Aspects of perinatal pathology unique to twins and higher multiples are emphasized, with practical suggestions for the service pathologist, including items of potential medico-legal significance. Controversial topics, such as the value of studies of concordance for diseases or malformations, and the significance of inter-twin anastomoses, are addressed and suggestions made for further investigation. A close working relationship between pathologists and clinical colleagues is encouraged by discussion of clinico-pathological correlations. And, the most recent discussions on mechanisms of twinning and genetic versus environmental influences on the development of twins are presented.

The influence of maternal, fetal and child nutrition on the development of chronic disease in later life

The influence of maternal, fetal and child nutrition on the development of chronic disease in later life
Author : Scientific Advisory Committee on Nutrition
Publisher : The Stationery Office
Release Date : 2011-06-23
Category : Business & Economics
Total pages :194
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In this final report on the 'The influence of maternal, fetal and child nutrition on the development of chronic disease in later life', the Subgroup on Maternal and Child Nutrition (SMCN) reviews the evidence that early life nutrition exerts long-term effects and influences the risk of chronic disease in adulthood, bringing together findings from both observational and experimental studies, and considering implications for maternal and child nutrition in the UK. SACN concludes that there is cause for concern about the later health consequences of compromised or excessive nutrient supply during early fetal and infant life. It notes that in the context of reproduction, the impact of current dietary patterns on women and girls is of particular concern, and considers that improving the nutritional status of women of childbearing age, infants and young children has the potential to improve the health of future generations. The Committee also offers recommendations for future research in this area, particularly emphasising the need for data which better characterise dietary patterns and patterns of pre and postnatal growth.

Development of Normal Fetal Movements

Development of Normal Fetal Movements
Author : Alessandra Piontelli
Publisher : Springer Science & Business Media
Release Date : 2010-11-08
Category : Medical
Total pages :133
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This work sees the light for various reasons. There is a general lack of detailed information about the earliest stages of human motor development. The reasons for this are explained more fully in the Introduction; here we may simply state that, apart from their intrinsic interest, earlier phenomena are fundamental to the comprehension of later phenomena rooted in them, whether pathological or normal. This is especially so in the rapidly - veloping young organism. At birth the neonate is catapulted into a profoundly different physical and social envir- ment requiring extremely diverse functioning: suffice it to mention aerial respiration, no longer being fed through the placenta and the cord, and the full impact of gravity on neonatal movements. The neonate generally adapts smoothly to the transition, as it has been equipped to do so during the 9 months of pregnancy. However, the study of the early stages of fetal motor development should not be exclusively directed towards the und- standing of functioning in the neonate.

RAS Pathway Activation in the Development of Myeloproliferative Disorders and Acute Myeloid Leukemia

RAS Pathway Activation in the Development of Myeloproliferative Disorders and Acute Myeloid Leukemia
Author : Stephen Michael Wiesner
Publisher : Unknown
Release Date : 2005
Category :
Total pages :260
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Old and New Perspectives on Mortality Forecasting

Old and New Perspectives on Mortality Forecasting
Author : Tommy Bengtsson,Nico Keilman
Publisher : Springer
Release Date : 2019-03-28
Category : Social Science
Total pages :349
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This open access book describes methods of mortality forecasting and discusses possible improvements. It contains a selection of previously unpublished and published papers, which together provide a state-of-the-art overview of statistical approaches as well as behavioural and biological perspectives. The different parts of the book provide discussions of current practice, probabilistic forecasting, the linearity in the increase of life expectancy, causes of death, and the role of cohort factors. The key question in the book is whether it is possible to project future mortality accurately, and if so, what is the best approach. This makes the book a valuable read to demographers, pension planners, actuaries, and all those interested and/or working in modelling and forecasting mortality.

Pathology of Multiple Pregnancy

Pathology of Multiple Pregnancy
Author : Virginia J. Baldwin
Publisher : Springer Science & Business Media
Release Date : 1994
Category : Health & Fitness
Total pages :409
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Pathology of Multiple Pregnancy collates case material from over 500 autopsies (including embryos) and 1200 placentas from twins, triplets, and higher multiples with selected literature on human multiple reproduction. It emphasizes important new concepts of pathophysiology and interpretation of less than ideal outcomes of multiple conception based on over 30 years experience in the field. Aspects of perinatal pathology unique to twins and higher multiples are emphasized, with practical suggestions for the service pathologist, including items of potential medico-legal significance. Controversial topics, such as the value of studies of concordance for diseases or malformations, and the significance of inter-twin anastomoses, are addressed and suggestions made for further investigation. A close working relationship between pathologists and clinical colleagues is encouraged by discussion of clinico-pathological correlations. And, the most recent discussions on mechanisms of twinning and genetic versus environmental influences on the development of twins are presented.

Ultrasound in Obstetrics and Gynaecology

Ultrasound in Obstetrics and Gynaecology
Author : Juri W. Wladimiroff,Sturla Eik-Nes
Publisher : Elsevier Health Sciences
Release Date : 2009
Category : Medical
Total pages :324
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European Practice in Gynaecology and Obstetrics is a series of books conceived and endorsed by the European Board and College of Obstetrics and Gynaecology (EBCOG). The topics chosen for each volume are those of significant clinical interest where treatment is changing in response to research findings and developments in practice. The volume editor and contributing authors are European specialists invited to contribute because of their expertise in their field. The books concentrate on various types of management used in European practice as well as published results. The authors present treatments for which a consensus exists and - when there is no consensus - they discuss the key elements of the controversy. Each book provides a review of the basic science, recent concepts in pathophysiology, clinical aspects, treatment and unresolved problems or controversies, as well as the major recent references. A final section provides multiple-choice questions for each chapter. Series concentrates on important and changing areas of clinical practice Each volume editor is a leading European expert in the field Contributors are drawn from a wide range of European countries All volumes include a review of basic science and pathophysiology, as well as clinical aspects, treatment, unresolved problems Current references are included for each chapter Multiple choice questions are provided at the end of each chapter This volume comes with a CD containing all the colour images in the book plus 106 extra images