November 30, 2020

Download Ebook Free Developmental Human Behavioral Epigenetics

Developmental Human Behavioral Epigenetics

Developmental Human Behavioral Epigenetics
Author : Livio Provenzi,Rosario Montirosso
Publisher : Academic Press
Release Date : 2020-11-20
Category : Science
Total pages :188
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Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

The Developing Genome

The Developing Genome
Author : David S. Moore
Publisher : Oxford University Press, USA
Release Date : 2015
Category : Medical
Total pages :308
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Includes bibliographical references (pages 275-300) and index

Brain, Behavior and Epigenetics

Brain, Behavior and Epigenetics
Author : Arturas Petronis,Jonathan Mill
Publisher : Springer Science & Business Media
Release Date : 2011-05-19
Category : Medical
Total pages :320
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Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Risk and Protective Factors Associated with Early Adversity and Development: Evidence from Human and Animal Research

Risk and Protective Factors Associated with Early Adversity and Development: Evidence from Human and Animal Research
Author : Rosario Montirosso,Livio Provenzi,Ed Tronick
Publisher : Frontiers Media SA
Release Date : 2020-02-13
Category :
Total pages :129
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The Oxford Handbook of Developmental Psychology, Vol. 1

The Oxford Handbook of Developmental Psychology, Vol. 1
Author : Philip David Zelazo
Publisher : Oxford University Press
Release Date : 2013-03-21
Category : Medical
Total pages :1024
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This handbook provides a comprehensive survey of what is now known about psychological development, from birth to biological maturity, and it highlights how cultural, social, cognitive, neural, and molecular processes work together to yield human behavior and changes in human behavior.

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease
Author : Cheryl S Rosenfeld
Publisher : Academic Press
Release Date : 2015-10-10
Category : Science
Total pages :560
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The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Epigenetics in Human Disease

Epigenetics in Human Disease
Author : Trygve O. Tollefsbol
Publisher : Academic Press
Release Date : 2012
Category : Medical
Total pages :577
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

The SAGE Encyclopedia of Lifespan Human Development

The SAGE Encyclopedia of Lifespan Human Development
Author : Marc H. Bornstein
Publisher : SAGE Publications
Release Date : 2018-01-15
Category : Psychology
Total pages :2616
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Lifespan human development is the study of all aspects of biological, physical, cognitive, socioemotional, and contextual development from conception to the end of life. In more than 800 signed articles by experts from a wide diversity of fields, this volume explores all individual and situational factors related to human development across the lifespan. The Encyclopedia promises to be an authoritative, discipline-defining work for students and researchers seeking to become familiar with various theories and empirical findings about human development broadly construed. Some of the broad thematic areas will include: Adolescence and Emerging Adulthood Aging Behavioral and Developmental Disorders Cognitive Development Community and Culture Early and Middle Childhood Education through the Lifespan Genetics and Biology Gender and Sexuality Life Events Mental Health through the Lifespan Research Methods in Lifespan Development Speech and Language Across the Lifespan Theories and Models of Development. Featuring signed articles by experts from the fields of child development, psychology, neuroscience, behavior analysis, education, sociology, and more, this five-volume encyclopedia promises to be an authoritative, discipline-defining work for students and researchers seeking to become familiar with the various approaches to and theories of human development as well as past and current research.

The Neurobiology of Brain and Behavioral Development

The Neurobiology of Brain and Behavioral Development
Author : Robbin Gibb,Bryan Kolb
Publisher : Academic Press
Release Date : 2017-11-02
Category : Science
Total pages :496
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The Neurobiology of Brain and Behavioral Development provides an overview of the process of brain development, including recent discoveries on how the brain develops. This book collates and integrates these findings, weaving the latest information with core information on the neurobiology of brain development. It focuses on cortical development, but also features discussions on how the other parts of the brain wire into the developing cerebral cortex. A systems approach is used to describe the anatomical underpinnings of behavioral development, connecting anatomical and molecular features of brain development with behavioral development. The disruptors of typical brain development are discussed in appropriate sections, as is the science of epigenetics that presents a novel and instructive approach on how experiences, both individual and intergenerational, can alter features of brain development. What distinguishes this book from others in the field is its focus on both molecular mechanisms and behavioral outcomes. This body of knowledge contributes to our understanding of the fundamentals of brain plasticity and metaplasticity, both of which are also showcased in this book. Provides an up-to-date overview of the process of brain development that is suitable for use as a university textbook at an early graduate or senior undergraduate level Breadth from molecular level (Chapters 5-7) to the behavioral/cognitive level (Chapters 8-12), beginning with Chapters 1-4 providing a historical context of the ideas Integrates the neurobiology of brain development and behavior, promoting the idea that animal models inform human development Presents an emphasis on the role of epigenetics and brain plasticity in brain development and behavior

The Oxford Handbook of Evolution, Biology, and Society

The Oxford Handbook of Evolution, Biology, and Society
Author : Rosemary Hopcroft,Rosemary L. Hopcroft
Publisher : Oxford University Press
Release Date : 2018
Category : Science
Total pages :688
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Evolution, biology, and society is a catch-all phrase encompassing any scholarly work that utilizes evolutionary theory and/or biological or behavioral genetic methods in the study of the human social group, and The Oxford Handbook of Evolution, Biology, and Society contains an much needed overview of research in the area by sociologists and other social scientists. The examined topics cover a wide variety of issues, including the origins of social solidarity; religious beliefs; sex differences; gender inequality; determinants of human happiness; the nature of social stratification and inequality and its effects; identity, status, and other group processes; race, ethnicity, and race discrimination; fertility and family processes; crime and deviance; and cultural and social change. The scholars whose work is presented in this volume come from a variety of disciplines in addition to sociology, including psychology, political science, and criminology. Yet, as the essays in this volume demonstrate, the potential of theory and methods from biology for illuminating social phenomena is clear, and sociologists stand to gain from learning more about them and using them in their own work. The theory focuses on evolution by natural selection, the primary paradigm of the biological sciences, while the methods include the statistical analyses sociologists are familiar with, as well as other methods that they may not be familiar with, such as behavioral genetic methods, methods for including genetic factors in statistical analyses, gene-wide association studies, candidate gene studies, and methods for testing levels of hormones and other biochemicals in blood and saliva and including these factors in analyses. This work will be of interest to any sociologist with an interest in exploring the interaction of biological and sociological processes. As an introduction to the field it is useful for teaching upper-level or graduate students in sociology or a related social science.

Neuropsychiatric Disorders and Epigenetics

Neuropsychiatric Disorders and Epigenetics
Author : Dag Yasui,Jacob Peedicayil,Dennis R. Grayson
Publisher : Academic Press
Release Date : 2016-11-15
Category : Science
Total pages :444
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Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Transgenerational Epigenetics

Transgenerational Epigenetics
Author : Trygve Tollefsbol
Publisher : Elsevier
Release Date : 2014-05-02
Category : Science
Total pages :412
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Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies

Medical Epigenetics

Medical Epigenetics
Author : Trygve Tollefsbol
Publisher : Academic Press
Release Date : 2016-06-21
Category : Medical
Total pages :924
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Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Epigenetics In Human Reproduction And Development

Epigenetics In Human Reproduction And Development
Author : Naumova Anna K,Taketo-hosotani Teruko
Publisher : World Scientific
Release Date : 2016-12-20
Category : Medical
Total pages :304
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Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood. Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
Author : Michel Neidhart
Publisher : Academic Press
Release Date : 2015-08-11
Category : Science
Total pages :552
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DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases