January 17, 2021

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Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
Author : Benjamin Blass
Publisher : Elsevier
Release Date : 2015-04-24
Category : Medical
Total pages :580
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Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

Drug Discovery from Nature

Drug Discovery from Nature
Author : S. Grabley,R. Thiericke
Publisher : Springer Science & Business Media
Release Date : 1998-11-26
Category : Medical
Total pages :347
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This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Biomarker Methods in Drug Discovery and Development

Biomarker Methods in Drug Discovery and Development
Author : Feng Wang
Publisher : Springer Science & Business Media
Release Date : 2008-03-11
Category : Medical
Total pages :396
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In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols. This book is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.

Pharmaceutical Profiling in Drug Discovery for Lead Selection

Pharmaceutical Profiling in Drug Discovery for Lead Selection
Author : Ronald Borchardt,Edward Kerns,Christopher Lipinski,Dhrien Thakker,Binghe Wang
Publisher : Springer Science & Business Media
Release Date : 2005-12-05
Category : Medical
Total pages :482
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This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Structure-based Drug Discovery

Structure-based Drug Discovery
Author : R. E. Hubbard
Publisher : Royal Society of Chemistry
Release Date : 2006-01-01
Category : Medical
Total pages :261
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A collection of methods to determine and analyse the 3-D structure of biomolecules. These methods have been enhanced to improve the speed and quality of drug discovery.

Evaluation of Enzyme Inhibitors in Drug Discovery

Evaluation of Enzyme Inhibitors in Drug Discovery
Author : Robert A. Copeland
Publisher : John Wiley & Sons
Release Date : 2005-04-01
Category : Science
Total pages :384
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Drug Discovery and Evaluation: Pharmacological Assays

Drug Discovery and Evaluation: Pharmacological Assays
Author : Hans Vogel
Publisher : Springer Science & Business Media
Release Date : 2007-10-30
Category : Medical
Total pages :2068
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The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Drug Discovery and Development, Volume 1

Drug Discovery and Development, Volume 1
Author : Mukund S. Chorghade
Publisher : John Wiley & Sons
Release Date : 2006-07-18
Category : Science
Total pages :476
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This two volume set provides a comprehensive account of the entiresequence of operations involved in discovering a drug through theactual delivery of the drug to clinicians and medicalpractitioners. Includes case studies of the discovery of erythromycin analogs(antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents for the treatment andmanagement of bacterial infections, Parkinson's disease, psoriasis,ulcers and stomach pain, atopic dermatitis, asthma, and cancer Contains chapters on combinatorial chemistry, molecularbiology-based drug discovery, genomics, and chemogenomics The first volume of this set thoroughly describesconceptualizing a drug, creating a library of candidates fortesting, screening those candidates for in vitro and in vivoactivity, conducting and analyzing the results of clinical trials,and revising the drug as necessary.

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
Author : Robert M. Stroud,Janet Finer-Moore
Publisher : Royal Society of Chemistry
Release Date : 2008
Category : Medical
Total pages :382
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This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery
Author : Alexander Hillisch,Rolf Hilgenfeld
Publisher : Springer Science & Business Media
Release Date : 2002-12-11
Category : Medical
Total pages :292
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Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Target Validation in Drug Discovery

Target Validation in Drug Discovery
Author : Brian W. Metcalf,Susan Dillon
Publisher : Elsevier
Release Date : 2011-04-28
Category : Medical
Total pages :296
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This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Drug Discovery and Evaluation

Drug Discovery and Evaluation
Author : H. Gerhard Vogel
Publisher : Springer Science & Business Media
Release Date : 2006-01-01
Category : Medical
Total pages :889
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This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.

Antiparasitic and Antibacterial Drug Discovery

Antiparasitic and Antibacterial Drug Discovery
Author : Paul M. Selzer
Publisher : John Wiley & Sons
Release Date : 2009-06-08
Category : Medical
Total pages :489
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Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Natural Product Chemistry for Drug Discovery

Natural Product Chemistry for Drug Discovery
Author : Antony D. Buss,Mark S. Butler,Royal Society of Chemistry (Great Britain)
Publisher : Royal Society of Chemistry
Release Date : 2010
Category : Medical
Total pages :440
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This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

Drug Discovery

Drug Discovery
Author : Walter Sneader
Publisher : John Wiley & Sons
Release Date : 2005-06-23
Category : Science
Total pages :468
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This edition provides expanded coverage of pre-20th century drugs, including emphasis on setting chapters in a wide historical and social context.