January 18, 2021

Download Ebook Free Dynemicin A, Uncialamycin And Analogues

Dynemicin A, Uncialamycin and Analogues

Dynemicin A, Uncialamycin and Analogues
Author : Daniel Best,Mickael Jean,Pierre Van De Weghe
Publisher : Elsevier
Release Date : 2016-06-14
Category : Medical
Total pages :144
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Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds

Anticancer Agents from Natural Products, Second Edition

Anticancer Agents from Natural Products, Second Edition
Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Release Date : 2011-10-10
Category : Science
Total pages :767
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The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author : Atta-ur-Rahman
Publisher : Elsevier
Release Date : 2018-08-08
Category : Science
Total pages :468
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Studies in Natural Products Chemistry, Volume 58, covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Chemical Biology of Natural Products

Chemical Biology of Natural Products
Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
Publisher : CRC Press
Release Date : 2017-09-22
Category : Medical
Total pages :622
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Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

A Theoretical Study of Pd-Catalyzed C-C Cross-Coupling Reactions

A Theoretical Study of Pd-Catalyzed C-C Cross-Coupling Reactions
Author : Max García Melchor
Publisher : Springer Science & Business Media
Release Date : 2013-10-04
Category : Science
Total pages :136
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Find out how theoretical calculations are used to determine, elucidate and propose mechanisms for Pd-catalyzed C-C cross-coupling reactions in Max Garcia Melchor's outstanding thesis. Garcia Melchor investigates one of the most significant and useful types of reactions in modern organic synthesis; the Pd-cross coupling reaction. Due to its versatility, broad scope and selectivity under mild conditions, this type of reaction can now be applied in fields as diverse as the agrochemical and pharmaceutical industry. Garcia Melchor studies the reaction intermediates and transition states involved in the Negishi, the copper-free Sonogashira and the asymmetric version of Suzuki-Miyaura coupling. He also characterizes and provides a detailed picture of the associated reaction mechanisms. The author has won numerous prizes for this work which has led to over eight publications in internationally renowned journals.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author : Carmen Avendano,J. Carlos Menendez
Publisher : Elsevier
Release Date : 2015-06-11
Category : Science
Total pages :768
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Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Introduction to Bioorganic Chemistry and Chemical Biology

Introduction to Bioorganic Chemistry and Chemical Biology
Author : David Van Vranken,Gregory A. Weiss
Publisher : Garland Science
Release Date : 2018-10-08
Category : Medical
Total pages :504
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Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Catalytic Cascade Reactions

Catalytic Cascade Reactions
Author : Peng-Fei Xu,Wei Wang
Publisher : John Wiley & Sons
Release Date : 2013-11-11
Category : Science
Total pages :440
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Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.

Building a Practical Information Security Program

Building a Practical Information Security Program
Author : Jason Andress,Mark Leary
Publisher : Syngress
Release Date : 2016-11-01
Category : Computers
Total pages :202
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Building a Practical Information Security Program provides users with a strategic view on how to build an information security program that aligns with business objectives. The information provided enables both executive management and IT managers not only to validate existing security programs, but also to build new business-driven security programs. In addition, the subject matter supports aspiring security engineers to forge a career path to successfully manage a security program, thereby adding value and reducing risk to the business. Readers learn how to translate technical challenges into business requirements, understand when to "go big or go home," explore in-depth defense strategies, and review tactics on when to absorb risks. This book explains how to properly plan and implement an infosec program based on business strategy and results. Provides a roadmap on how to build a security program that will protect companies from intrusion Shows how to focus the security program on its essential mission and move past FUD (fear, uncertainty, and doubt) to provide business value Teaches how to build consensus with an effective business-focused program

Polyynes

Polyynes
Author : Franco Cataldo
Publisher : CRC Press
Release Date : 2005-08-29
Category : Science
Total pages :528
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Polyynes: Synthesis, Properties, and Applications compiles information found scattered throughout the literature in inorganic, organic, and polymer chemistry into one cohesive volume. In addition to being a precursor of fullerenes, polyynes are one of the key precursors in the formation of soot and carbon dust, or elemental carbon in the galaxy, and their properties can be linked to interstellar band phenomena and other astrophysical behavior. More than 1,000 organic molecules produced by plants, fungi, and other microorganisms are also classified as polyynes, playing a biological role in nature that may be used in the treatment of diseases as antibiotics, anticancer, or anti-infective agents. Polyynes: Synthesis, Properties, and Applications covers breakthrough discoveries, particularly the simplified synthesis of polyynes in solution stabilized by using appropriate end groups and carbon films achieved using chemical, electrochemical, and other sophisticated techniques. The book explains in great detail the conditions, apparatus, and experimental procedures to synthesize polyynes with consistent and reproducible results. By presenting new and unpublished results along with recent discoveries and theories, Polyynes: Synthesis, Properties, and Applications reflects the thriving research status of polyynes in various disciplines as well as new ideas and guidelines for future research, discoveries, and applications of these molecules.

Biosynthesis of Heterocycles

Biosynthesis of Heterocycles
Author : Patrizia Diana,Girolamo Cirrincione
Publisher : John Wiley & Sons
Release Date : 2015-01-30
Category : Science
Total pages :784
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This book describes biosynthetic methods to synthesize heterocycliccompounds, offering a guide for the development of new drugs basedon natural products. The authors explain the role of naturalproducts in chemistry and their formation along with importantanalytical methods and techniques for working withheterocycles. • Covers methods and techniques: isotopic labelling,enzymes and mutants, and pathway identification • Provides a thorough resource of informationspecifically on heterocyclic natural products and their practicalbiosynthetic relevance • Explains the role of natural products in chemistry andtheir formation • Discusses gene cluster identification and the use ofbiogenetic engineering in pharmaceutical application

Pincer and Pincer-Type Complexes

Pincer and Pincer-Type Complexes
Author : Kálmán J. Szabó,Ola F. Wendt
Publisher : John Wiley & Sons
Release Date : 2014-06-10
Category : Science
Total pages :320
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This new book on this hot topic summarizes the key achievements for the synthesis and catalytic applications of pincer and pincer-type complexes, providing readers with the latest research highlights. The editors have assembled an international team of leaders in the field, and their contributions focus on the application of various pincer complexes in modern organic synthesis and catalysis, such as C-C and C-X bond forming reactions, C-H bond functionalization, and the activation of small molecules, as well as asymmetric catalysis. A must-have for every synthetic chemist in both academia and industry intending to develop new catalysts and improved synthetic protocols.

Systems Biology and Its Application in TCM Formulas Research

Systems Biology and Its Application in TCM Formulas Research
Author : Wei-Dong Zhang
Publisher : Academic Press
Release Date : 2018-02-16
Category : Medical
Total pages :380
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Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment of cardiovascular diseases. The content combines theory and practice, and includes guidance for both theoretical concepts and operable technical routes. This is a valuable source not only for biomedical researchers involved in Systems Biology studies, but also for students and scientists interested in learning more about Traditional Chinese Medicine and its applications in contemporary medicine. Explains, in detail, the Shexiang Baoxin Pill (SBP), a TCM formula efficiently applied in the treatment of cardiovascular diseases Presents TCM formulas from perspectives of systems biology, basic chemical material groups, modern pharmacology and network biology Offers an overview on biology, modern chemistry and information technology as applied in Systems Biology research

Mechanochemical Organic Synthesis

Mechanochemical Organic Synthesis
Author : Davor Margetic,Vjekoslav Štrukil
Publisher : Elsevier
Release Date : 2016-04-23
Category : Science
Total pages :386
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Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area. Features cutting-edge research in the field of mechanochemical organic synthesis for more sustainable reactions Integrates advances in green chemistry research into industrial applications and process development Focuses on designing techniques in organic synthesis directed toward mild reaction conditions Includes global coverage of mechanochemical synthetic protocols for the generation of organic compounds

Computational Organic Chemistry

Computational Organic Chemistry
Author : Steven M. Bachrach
Publisher : John Wiley & Sons
Release Date : 2014-03-03
Category : Science
Total pages :632
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The Second Edition demonstrates how computational chemistry continues to shed new light on organic chemistry The Second Edition of author Steven Bachrach’s highly acclaimed Computational Organic Chemistry reflects the tremendous advances in computational methods since the publication of the First Edition, explaining how these advances have shaped our current understanding of organic chemistry. Readers familiar with the First Edition will discover new and revised material in all chapters, including new case studies and examples. There’s also a new chapter dedicated to computational enzymology that demonstrates how principles of quantum mechanics applied to organic reactions can be extended to biological systems. Computational Organic Chemistry covers a broad range of problems and challenges in organic chemistry where computational chemistry has played a significant role in developing new theories or where it has provided additional evidence to support experimentally derived insights. Readers do not have to be experts in quantum mechanics. The first chapter of the book introduces all of the major theoretical concepts and definitions of quantum mechanics followed by a chapter dedicated to computed spectral properties and structure identification. Next, the book covers: Fundamentals of organic chemistry Pericyclic reactions Diradicals and carbenes Organic reactions of anions Solution-phase organic chemistry Organic reaction dynamics The final chapter offers new computational approaches to understand enzymes. The book features interviews with preeminent computational chemists, underscoring the role of collaboration in developing new science. Three of these interviews are new to this edition. Readers interested in exploring individual topics in greater depth should turn to the book’s ancillary website www.comporgchem.com, which offers updates and supporting information. Plus, every cited article that is available in electronic form is listed with a link to the article.