November 28, 2020

Download Ebook Free Early Vascular Aging

Early Vascular Aging (EVA)

Early Vascular Aging (EVA)
Author : Peter M Nilsson,Michael Hecht Olsen,Stephane Laurent
Publisher : Academic Press
Release Date : 2015-08-06
Category : Medical
Total pages :376
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Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures. Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures

Early Vascular Aging (Eva)

Early Vascular Aging (Eva)
Author : Peter M. Nilsson,Michael Hect Olsen,Stephane Laurent
Publisher : Academic Press
Release Date : 2015-08-06
Category : Medical
Total pages :376
GET BOOK

Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures. Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures

ASSOCIATION OF CARDIOVASCULAR RISK FACTORS AND EARLY VASCULAR AGEING IN TYROLEAN ADOLESCENTS - EVA TYROL STUDY.

ASSOCIATION OF CARDIOVASCULAR RISK FACTORS AND EARLY VASCULAR AGEING IN TYROLEAN ADOLESCENTS - EVA TYROL STUDY.
Author : Anonim
Publisher : Unknown
Release Date : 2017
Category :
Total pages :129
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BACKGROUND AND AIM Atherosclerosis is the most common cause of cardiovascular disease (CVD) and has its origin early in life. The prevalence of classic CVD risk factors like smoking, overweight, hypertension and unfavorable blood lipids in childhood and adolescence is associated with an increased risk for CVD in adulthood. Therefore this study aims to assess vascular changes and predictors for early vascular ageing (EVA) in a large cohort of healthy Tyrolean adolescents.METHODS Volunteering Tyrolean schools and companies were invited to take part in this regional cohort study. Common risk factors for CVD like smoking, activity, and diet were assessed as well as anthropometric data (BMI, blood pressure) and blood lipids. Vascular changes were evaluated by measuring intima-media-thickness of the common carotid artery (cIMT) by high resolution ultrasound as a marker for subclinical atherosclerosis.RESULTS 1573 (691 male, 882 female) adolescents with a mean age of 16 years were included in this analysis. 1556 participants had ultrasound measurement of cIMT. In a multivariable linear regression analysis male sex, BMI, daily physical activity and systolic blood pressure showed a positive relation to mean cIMT. Maximum cIMT was predicted by sex, BMI and systolic blood pressure. CONCLUSION Risk factors for atherosclerosis are present in Tyrolean adolescents and are associated with early vascular aging. The positive association between physical activity and mean cIMT may be explained by a non-atherosclerotic adaptation process. Maximum cIMT as a marker for first atherosclerotic lesions is not affected by physical activity.

Textbook of Vascular Medicine

Textbook of Vascular Medicine
Author : Rhian M. Touyz,Christian Delles
Publisher : Springer
Release Date : 2019-08-02
Category : Medical
Total pages :503
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This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Arterial Aging and Age-Associated Arterial Diseases

Arterial Aging and Age-Associated Arterial Diseases
Author : Mingyi Wang,Jiguang Wang,Gianfranco Pintus,Cuntai Zhang
Publisher : Frontiers Media SA
Release Date : 2019-01-24
Category :
Total pages :129
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The underlying mechanisms behind aging has long been a great scientific mystery that the biomedical research community has long studied. In developed nations, as the population grows older, increases in life expectancy is increasingly limited by our relatively poor control of chronic aging-associated diseases such as arterial aging. Among age-related conditions that negatively influence longevity. Growing evidence demonstrates that arterial aging is fundamentally caused by a proinflammatory process that begins at birth and results in detrimental effects that affects every organ system. Vascular aging is the leading risk factor for quintessential cardiovascular diseases such as hypertension and atherosclerosis. With aging, vascular walls develop a pro-inflammatory and stressed microenvironment characterized by both an upregulation of pro-inflammatory chemokines and cytokines as well as a down-regulation anti-inflammatory counterparts. This chronic imbalance in inflammatory regulatory networks is the key driver of changes at the cellular and molecular level that result in hypertensive and atherosclerotic arterial. Thus, an intervention of proinflammation may be a viable therapeutic intervention to reduce morbidity and mortality from cardiovascular diseases. In this eBook, we aim to supply an updated overview of the physiological and biochemical mechanisms that affect inflammation and vascular aging. We believe that this eBook will contribute to the understanding of the pathogenesis of many chronic or age-related diseases, as well as to their treatment with both current and new therapeutic approaches.

Endothelial Dysfunction

Endothelial Dysfunction
Author : Helena Lenasi
Publisher : BoD – Books on Demand
Release Date : 2018-10-24
Category : Medical
Total pages :430
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The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Aging and Aging-Related Diseases

Aging and Aging-Related Diseases
Author : Zhao Wang
Publisher : Springer
Release Date : 2018-09-19
Category : Science
Total pages :282
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This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

Vascular Aging: Facts and Factors

Vascular Aging: Facts and Factors
Author : Elisabet Vila,Francesc Jiménez-Altayó,Paula Dantas
Publisher : Frontiers E-books
Release Date : 2020
Category :
Total pages :129
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The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.

Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases
Author : Michel E. Safar,Michael F. O'Rourke,Edward D. Frohlich
Publisher : Springer
Release Date : 2014-07-30
Category : Medical
Total pages :567
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In cardiovascular prevention, there is classically a small number of cardiovascular risk factors to treat, such as hypertension, diabetes, hyperlipidemia and smoking excess, which are widely detected and treated. Recently, it has been widely recognized that new mechanical factors should be detected and treated and involves specifically pulsatile arterial hemodynamic (PAH) parameters such as: arterial stiffness, pulse pressure, and, to a lesser extent, augmentation index and pulse pressure amplification. The pedagogic aspect of this new CV specialty involves 3 principal parts: a. –Basic concepts and pathophysiological mechanisms of PAHb. –Clinical aspects and end-organ damage in PAHc. – Clinical pharmacology and therapeutics of PAH This book represents the first that spans basic science and clinical management of this new CV subspecialty. Much has been learned regarding the management of these patients in recent years and this book presents extensive data on the techniques needed to maximize outcomes.​

Stem Cell and Gene Therapy for Cardiovascular Disease

Stem Cell and Gene Therapy for Cardiovascular Disease
Author : Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson
Publisher : Academic Press
Release Date : 2015-08-21
Category : Science
Total pages :538
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Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Geriatrics Health

Geriatrics Health
Author : Hülya Çakmur
Publisher : BoD – Books on Demand
Release Date : 2018-10-10
Category : Psychology
Total pages :76
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Aging is characterized by functional decline in every organ due to several cellular, biological, and physiological changes over time. Molecular and cellular damages are gradually decreasing in the physical and mental capacities of the human body. Health results have shown that lifespan has dramatically increased during the twenty-first century. Increasing elderly population naturally deals with many health problems leading to a rise in health expenditure and labor loss. The good news is that the clinical trials in gene therapy have almost stopped and/or reversed human aging. Regenerative medicine can repair and reverse aging in all body cells. Thus, the body's own repair mechanisms may struggle with aging and age-related diseases. Research is promising and suggests that human aging will be eradicated on earth.

Gerontology

Gerontology
Author : Grazia D’Onofrio,Daniele Sancarlo,Antonio Greco
Publisher : BoD – Books on Demand
Release Date : 2018-07-04
Category : Psychology
Total pages :276
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Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. The book includes topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality.

Handbook of Research on Geriatric Health, Treatment, and Care

Handbook of Research on Geriatric Health, Treatment, and Care
Author : Prasad, Barre Vijaya,Akbar, Shamsi
Publisher : IGI Global
Release Date : 2018-03-30
Category : Medical
Total pages :604
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Mental and physical disorders are common in old age but frequently remain undetected and untreated. Managing treatment and controlling symptoms of these disorders is imperative to the longevity and quality of life of patients. The Handbook of Research on Geriatric Health, Treatment, and Care provides emerging research on promoting health in older adults by preventing and treating diseases and disabilities. By highlighting topics such as alternative treatment, clinical diagnosis, and positive psychology, this publication explores the methods and approaches of identifying and diagnosing epidemiological factors that contribute to geriatric health issues. This book is an important resource for healthcare professionals, academicians, medical practitioners, researchers, and students seeking current research on the methods and strategies for maintaining healthy and successful care for the elderly.

Up

Up
Author : Hilary Tindle
Publisher : Penguin
Release Date : 2013-05-30
Category : Health & Fitness
Total pages :288
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Why looking up matters A positive attitude is important, but until now we didn’t know how important. In Up, a practicing physician and NIH-funded researcher draws on her research and experience to show that our outlook on life— our unique patterns of thinking and feeling about ourselves, others, and the world—may be the key to how well and how fast we age. From wrinkles to cognitive decline, our outlook affects our health at every level. Using the framework of outlook GPS, Up illustrates how we can gauge our current attitude latitude and move to healthier ground. Tindle brings a fresh eye to attitudinal traits such as optimism, noting that it has many faces, including the face of her own struggling optimism. Using the 7 Steps of Attitudinal Change that she applies to her own patients, Tindle offers us a path toward healthy aging. Prescriptive and accessible, Up puts forward a paradigm shift in how we age and treat disease, giving even the most struggling optimists a chance for hope. It will appeal to readers of The Longevity Project by Howard S. Friedman and Leslie R. Martin as well as The Blue Zones by Dan Buettner.

Biophysical Regulation of Vascular Differentiation and Assembly

Biophysical Regulation of Vascular Differentiation and Assembly
Author : Sharon Gerecht
Publisher : Springer Science & Business Media
Release Date : 2011-01-06
Category : Science
Total pages :254
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Because of their ability to differentiate and develop into functional vasculature, stem cells hold tremendous promise for therapeutic applications. However, the scientific understanding and the ability to engineer these cellular systems is still in its early stages, and must advance significantly for the therapeutic potential of stem cells to be realized. Stem cell differentiation and function are exquisitely tuned by their microenvironment. This book will provide a unique perspective of how different aspect of the vasculature microenvironment regulates differentiation and assembly. Recent efforts to exploits modern engineering techniques to study and manipulate various biophysical cues will be described including: oxygen tension during adult and embryonic vasculogenesis (Semenza and Zandstra), extracellular matrix during tube morphogenesis and angiogenesis (Wirtz, Davis, Ingber), surface topography and modification (Chen and Gerecht), shear stress and cyclic strain effect on vascular assembly and maturation (Vunjak-Novakovic and Niklason), and three dimensional space for angio-andvasculogensis (Ferreria and Fischbach).