June 15, 2021

Download Ebook Free Energy Metabolism In Heart Failure

Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease
Author : Gary D. Lopaschuk,Naranjan S. Dhalla
Publisher : Springer
Release Date : 2014-08-22
Category : Science
Total pages :295
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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Cardiac Energy Metabolism in Heart Failure

Cardiac Energy Metabolism in Heart Failure
Author : Society for Heart and Vascular Metabolism
Publisher : Unknown
Release Date : 2006
Category :
Total pages :129
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Special Issue

Special Issue
Author : William C. Stanley
Publisher : Unknown
Release Date : 2002
Category :
Total pages :129
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Cardiac Energy Metabolism in Heart Failure and Metabolic Disease

Cardiac Energy Metabolism in Heart Failure and Metabolic Disease
Author : William C. Stanley
Publisher : Academic Press
Release Date : 2016-01-12
Category : Medical
Total pages :384
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Cardiac Energy Metabolism in Heart Failure and Metabolic Disease

Energy Metabolism in Heart Failure

Energy Metabolism in Heart Failure
Author : HOWARD J. EISEN
Publisher : Academic Press
Release Date : 2018-06-01
Category : Medical
Total pages :256
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Energy Metabolism in Heart Failure

Metabolic Efficiency in Remodeled Failing Hearts

Metabolic Efficiency in Remodeled Failing Hearts
Author : Waleed Gameel Tawfeek Masoud
Publisher : Unknown
Release Date : 2015
Category : Energy metabolism
Total pages :280
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Heart failure is a serious cardiovascular disease that develops following a variety of insults to the heart including hypertrophy and myocardial infarction. While it is clear that heart failure is associated with changes in cardiac energy metabolism, it remains unclear if, and how, such changes might contribute to left ventricular (LV) contractile dysfunction. Two distinct hypotheses have been advanced to link changes in energy metabolism with heart failure: 1) there is a state of energetic crisis / starvation, where rates of energy metabolism decrease and thereby cause LV failure, or 2) there is inefficiency in energy utilization where more energy is required to produce external work. Inefficiency may be due to mismatched rates of glycolysis and glucose oxidation that leads to intracellular proton accumulation resulting in Na+ and Ca2+ overload. Recently, drug-induced modulation of rates of carbohydrate and fat metabolism has been proposed as a new approach for the treatment of LV dysfunction and heart failure. Such metabolic modulation can also be achieved experimentally by the use of genetically-modified experimental animals. This thesis compared the metabolic profile of remodeled post-infarction mouse hearts with normal hearts, studied the response of these hearts to ex vivo ischemia reperfusion (IR) and the ability of metabolic modulation to limit the deterioration of metabolic efficiency and LV dysfunction following myocardial infarction. Using coronary artery ligation, we created a mouse model of post-infarction remodeled heart failure that we verified using in vivo echocardiographic examination. Using ex vivo heart perfusion in the isolated working mode, we provided evidence that CAL hearts are metabolically inefficient rather than energy starved and that mismatched glucose metabolism is a possible contributor to metabolic inefficiency. Using malonyl CoA decarboxylase deficient (MCD-KO) mice that are known to have better matching of glucose metabolism, we confirmed that this metabolic intervention improved glucose matching, metabolic efficiency and limited functional deterioration in CAL hearts. We also studied the response of CAL hearts to ex vivo IR. We showed that CAL hearts have better functional recovery and limited functional deterioration following IR in comparison to SHAM hearts. This was associated with reduced ischemic glycogenolysis, lack of acceleration in fatty acid oxidation during reperfusion and increased triacylglycerol accumulation in reperfused CAL hearts. We provided evidence that mitochondrial mass, Ca2+ handling proteins and AMPK activity are unchanged and are unlikely to contribute to the observed response of CAL hearts to IR. This thesis also studied the potential for further protection of CAL hearts after IR via pharmacologic improvement of the match of glucose oxidation using dichloroacetate (DCA). We showed that in presence of lactate, DCA did not stimulate glucose oxidation, improve functional recovery or improve the match of glucose metabolism. We also showed that in absence of lactate, DCA was able to stimulate glucose oxidation but this was not enough to improve the matching of glucose metabolism. This thesis also discussed differences between mouse and rat heart metabolism that may explain the lack of response to DCA in mouse hearts. Similarly, we studied the possible improvement of metabolic efficiency in CAL hearts via acute ex vivo MCD inhibition but this acute intervention was not sufficient to produce benefit.

The Sinatra Solution

The Sinatra Solution
Author : Stephen T. Sinatra, M.D.
Publisher : ReadHowYouWant.com
Release Date : 2009-04-24
Category : Health & Fitness
Total pages :512
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Board-certified cardiologist Dr. Stephen T. Sinatra discusses the importance of energy metabolism on cardiovascular health and the positive impact these three energy-supplying nutrients have on the cardiovascular system. He guides you through the basics of energy metabolism and cardiac bioenergetics, and clearly explains the role of coenzyme Q10, L-carnitine, and D-ribose in the body and specifically how they affect your heart health. He also provides concise and informative examples of case histories and scientific studies that are testament to the important contribution the supplemental use of these energy-supplying nutrients make in the lives of people with heart disease every day.

The Sinatra Solution

The Sinatra Solution
Author : Stephen T. Sinatra, M.D.
Publisher : ReadHowYouWant.com
Release Date : 2009-04-24
Category : Health & Fitness
Total pages :520
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Board-certified cardiologist Dr. Stephen T. Sinatra discusses the importance of energy metabolism on cardiovascular health and the positive impact these three energy-supplying nutrients have on the cardiovascular system. He guides you through the basics of energy metabolism and cardiac bioenergetics, and clearly explains the role of coenzyme Q10, L-carnitine, and D-ribose in the body and specifically how they affect your heart health. He also provides concise and informative examples of case histories and scientific studies that are testament to the important contribution the supplemental use of these energy-supplying nutrients make in the lives of people with heart disease every day.

The Sinatra Solution

The Sinatra Solution
Author : Stephen T. Sinatra, M.D.
Publisher : ReadHowYouWant.com
Release Date : 2009-04-24
Category : Health & Fitness
Total pages :320
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Board-certified cardiologist Dr. Stephen T. Sinatra discusses the importance of energy metabolism on cardiovascular health and the positive impact these three energy-supplying nutrients have on the cardiovascular system. He guides you through the basics of energy metabolism and cardiac bioenergetics, and clearly explains the role of coenzyme Q10, L-carnitine, and D-ribose in the body and specifically how they affect your heart health. He also provides concise and informative examples of case histories and scientific studies that are testament to the important contribution the supplemental use of these energy-supplying nutrients make in the lives of people with heart disease every day.

The Scientist's Guide to Cardiac Metabolism

The Scientist's Guide to Cardiac Metabolism
Author : Michael Schwarzer,Torsten Doenst
Publisher : Academic Press
Release Date : 2015-11-04
Category : Medical
Total pages :240
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The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

Metabolisme Energetique Cardiaque Et Maladie Coronaire Du Patient Diabetique

Metabolisme Energetique Cardiaque Et Maladie Coronaire Du Patient Diabetique
Author : Association de langue française pour l'étude du diabète et des maladies métaboliques,Biopharma
Publisher : Unknown
Release Date : 2001
Category :
Total pages :1
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Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Release Date : 2019-08-08
Category :
Total pages :89
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Inotropic Stimulation and Myocardial Energetics

Inotropic Stimulation and Myocardial Energetics
Author : H. Just,C. Holubarsch,H. Scholz
Publisher : Springer Science & Business Media
Release Date : 2013-03-14
Category : Medical
Total pages :273
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Inotropic stimulation of the myocardium, as well as vasodilation and diuresis as essential principles in the treatment of congestive heart failure have recently met with considerable criticism and reevaluation. It is generally agreed that unloading of the heart, either through vasodilation and/or diuresis, improves the working conditions of the dilated, failing heart. It reduces myocar dial oxygen consumption through reduction of chamber radius and, thereby, wall tension as the major determinants of myocardial oxygen consumption. Inotropic stimulation, quite in contrast, does not conserve oxygen. It rather consumes energy and that may be disadvantageous in situations of compromised oxygen supply and energy metabolism of the working myocardium. However, under conditions of suf ficient oxygen supply and metabolic support inotropic stimulation may bring about in creased pumping and subsequent improvement of myocardial failure. In recent years it could convincingly be demonstrated that vasodilation leads to symp tomatic improvement of congestive heart failure, improvement of exercise tolerance, and it prolongs life - especially in the case of ACE-inhibitors and the combination of hydra lazine with long-acting nitrates. Quite in contrast, equally beneficial effects could not be demonstrated for inotropic agents in congestive heart failure. Only for the cardiac glyco sides has it been shown that beneficial effects can be achieved, especially if atrial fibril lation with absolute arrhythmia is present. The influence of the cardiac glycosides on the latter represents an effect which is independent of the inotropic action.

The Sinatra Solution

The Sinatra Solution
Author : Stephen T. Sinatra
Publisher : Basic Health Publications, Inc.
Release Date : 2007-10
Category : Health & Fitness
Total pages :253
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A board-certified cardiologist discusses the importance of energy metabolism on cardiovascular health and the positive impact three energy-supplying nutrients--CoQ10, Carnitine, and Ribose--have on the cardiovascular system.

Modulations of Myocardial Energy Metabolism Via Xanthine Oxidase Inhibition, Sca-1+ Stem Cell Treatment and PPAR-delta Gene Ablation

Modulations of Myocardial Energy Metabolism Via Xanthine Oxidase Inhibition, Sca-1+ Stem Cell Treatment and PPAR-delta Gene Ablation
Author : Joseph Lee (Ph.D.)
Publisher : Unknown
Release Date : 2006
Category : Energy metabolism
Total pages :394
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