December 1, 2020

Download Ebook Free Energy Metabolism In Heart Failure

Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease
Author : Gary D. Lopaschuk,Naranjan S. Dhalla
Publisher : Springer
Release Date : 2014-08-22
Category : Science
Total pages :295
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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Release Date : 2019-08-08
Category :
Total pages :89
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ATP and the Heart

ATP and the Heart
Author : Joanne S. Ingwall
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :244
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ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.

The Scientist's Guide to Cardiac Metabolism

The Scientist's Guide to Cardiac Metabolism
Author : Michael Schwarzer,Torsten Doenst
Publisher : Academic Press
Release Date : 2015-11-04
Category : Medical
Total pages :240
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The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

Mitochondrial Diseases

Mitochondrial Diseases
Author : Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publisher : BoD – Books on Demand
Release Date : 2018-08-29
Category : Medical
Total pages :496
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Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

The Failing Heart

The Failing Heart
Author : Naranjan S. Dhalla
Publisher : Raven Press
Release Date : 1995
Category : Medical
Total pages :524
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(Proc./Intl Conf. 5/94) Topics inc. atrial defibrillation & congestive heart failure trmt of symptomatic heart failure.

The Sinatra Solution

The Sinatra Solution
Author : Stephen T. Sinatra
Publisher : Basic Health Publications, Inc.
Release Date : 2007-10
Category : Health & Fitness
Total pages :253
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A board-certified cardiologist discusses the importance of energy metabolism on cardiovascular health and the positive impact three energy-supplying nutrients--CoQ10, Carnitine, and Ribose--have on the cardiovascular system.

Myocardial Energy Metabolism

Myocardial Energy Metabolism
Author : J.W. de Jong
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :310
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Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Release Date : 2019-08-08
Category :
Total pages :89
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Oxford Textbook of Heart Failure

Oxford Textbook of Heart Failure
Author : Theresa A. McDonagh,Roy S. Gardner,Andrew L. Clark,Henry Dargie
Publisher : Oxford University Press
Release Date : 2011-07-14
Category : Medical
Total pages :641
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The Oxford Textbook of Heart Failure takes the reader from an understanding of the basic mechanisms of heart failure, through to an appreciation of the complexities of heart failure management and the improvements possible with good treatment. Written by internationally renowned leaders in the field, this definitive textbook comprehensively covers all aspects necessary to manage a patient with heart failure, and is essential reading for consultant cardiologists, those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses. The online version of the Oxford Textbook of Heart Failure contains the full text of the print edition (which can be browsed by the contents list or searched), links from references in the text to external sources (via PubMed, ISI, and CrossRef), and over 300 figures and illustrations from the print edition, downloadable into PowerPoint.

Post-Genomic Cardiology

Post-Genomic Cardiology
Author : José Marín-García
Publisher : Academic Press
Release Date : 2011-04-28
Category : Science
Total pages :688
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Recent advances in molecular and cellular biology have markedly changed our understanding of the heart, and this is having tremendous ramifications for the clinician. This unique reference offers a comprehensive and critical evaluation of this contribution in the field of cardiovascular molecular medicine providing the reader with a sense of new directions in which molecular medicine might be applied. It begins with a detailed primer that makes readily accessible recent molecular, genetic and cellular techniques. Rounding out the coverage of this exciting field are critical and comprenhesive discussions on the use of molecular, genetic and cellular techniques used to identify the etiology and pathophysiology of specific cardiac diseases. * Discusses diagnostic and therapeutic options available not only in the adult and aging individuals but also in infants/children * Numerous illustrations and flow-charts * Explans cutting-edge molecular techniques, including analysis of mitochondria, their role in cardiac dysfunction and updated analysis of Cardioprotection and Metabolic Syndrome * Presentation of recent translational studies for the treatment of cardiovascular diseases is included (e.g., gene therapy, pharmacological treatments and stem cell transplantation)

Heart Failure: A Companion to Braunwald's Heart Disease E-Book

Heart Failure: A Companion to Braunwald's Heart Disease E-Book
Author : G. Michael Felker,Douglas L. Mann
Publisher : Elsevier Health Sciences
Release Date : 2019-02-06
Category : Medical
Total pages :784
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Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Heart Failure: A Companion to Braunwald's Heart Disease E-book

Heart Failure: A Companion to Braunwald's Heart Disease E-book
Author : Douglas L. Mann
Publisher : Elsevier Health Sciences
Release Date : 2010-11-11
Category : Medical
Total pages :928
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Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Use this Braunwald’s companion as the definitive source to prepare for the ABIM’s new Heart Failure board exam. Access the fully searchable contents of the book online at Expert Consult. This edition includes 67 new authors, who are experts in the field of heart failure Stay on the cutting edge with new chapters on: The latest practice guidelines for medical and device therapy Hemodynamic assessment of heart failure Contemporary medical therapy for heart failure patients with reduced and preserved ejection fraction Biomarkers in heart failure Pulmonary hypertension Management of co-morbidities in heart failure Mechanical cardiac support devices Get up to speed with the latest clinical trials, as well as how they have influenced current practice guidelines Explore what’s changing in key areas such as basic mechanisms of heart failure, genetic screening, cell and gene therapies, pulmonary hypertension, heart failure prevention, co-morbid conditions, telemedicine/remote monitoring, and palliative care

Handbook of Cardiac Anatomy, Physiology, and Devices

Handbook of Cardiac Anatomy, Physiology, and Devices
Author : Paul A. Iaizzo
Publisher : Springer Science & Business Media
Release Date : 2010-03-11
Category : Medical
Total pages :700
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A revolution began in my professional career and education in 1997. In that year, I visited the University of Minnesota to discuss collaborative opportunities in cardiac anatomy, physiology, and medical device testing. The meeting was with a faculty member of the Department of Anesthesiology, Professor Paul Iaizzo. I didn’t know what to expect but, as always, I remained open minded and optimistic. Little did I know that my life would never be the same. . . . During the mid to late 1990s, Paul Iaizzo and his team were performing anesthesia research on isolated guinea pig hearts. We found the work appealing, but it was unclear how this research might apply to our interest in tools to aid in the design of implantable devices for the cardiovascular system. As discussions progressed, we noted that we would be far more interested in reanimation of large mammalian hearts, in particular, human hearts. Paul was confident this could be accomplished on large hearts, but thought that it would be unlikely that we would ever have access to human hearts for this application. We shook hands and the collaboration was born in 1997. In the same year, Paul and the research team at the University of Minnesota (including Bill Gallagher and Charles Soule) reanimated several swine hearts. Unlike the previous work on guinea pig hearts which were reanimated in Langendorff mode, the intention of this research was to produce a fully functional working heart model for device testing and cardiac research.

Acute Heart Failure

Acute Heart Failure
Author : Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo
Publisher : Springer Science & Business Media
Release Date : 2009-12-24
Category : Medical
Total pages :931
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For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.