November 27, 2020

Download Ebook Free Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders
Author : Michael Aschner,Lucio G. Costa
Publisher : Academic Press
Release Date : 2015-06-18
Category : Technology & Engineering
Total pages :450
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Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders Written by an international selection of the world’s foremost experts in the field of neurotoxicology Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience

Environmental Factors in Neurodegenerative Diseases

Environmental Factors in Neurodegenerative Diseases
Author : Anonim
Publisher : Academic Press
Release Date : 2017-09-19
Category : Science
Total pages :290
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Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Neurodegenerative Diseases

Neurodegenerative Diseases
Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
Release Date : 2012-03-12
Category : Medical
Total pages :390
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The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author : Daniela Galimberti,Elio Scarpini
Publisher : Springer Science & Business
Release Date : 2014-04-23
Category : Medical
Total pages :253
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This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Early Intervention in Psychotic Disorders

Early Intervention in Psychotic Disorders
Author : Tandy Miller,Sarnoff A. Mednick,Thomas H. McGlashan,Jan Libiger,Johan Olav Johannessen
Publisher : Springer Science & Business Media
Release Date : 2001-05-31
Category : Medical
Total pages :289
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The papers presented here, written by experts from all parts of the globe, describe efforts that represent a revolutionary moment in the treatment of schizophrenia disorders as, with caution, we begin to shift the standard of treatment toward early intervention and prevention. Contributions are organised according to the early course of psychosis. The book is of critical importance to anyone interested in psychotic disorders and the revolutionary impact that the field of early detection and intervention is having on traditional conceptualisations of psychotic illness.

Predictive Imagable Biomarkers for Brain Disorders

Predictive Imagable Biomarkers for Brain Disorders
Author : Pravat K. Mandal,Lars Ersland
Publisher : Frontiers Media SA
Release Date : 2019-09-19
Category :
Total pages :104
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Recent research on Neurodegenerative disorders such as Alzheimer's Disease, Parkinson's Disease, etc. and Neuropsychiatric disorders such as Schizophrenia, has shown strong evidence that altered brain tissue structure, physiology, and connectivity reflect the extent of severity of behavioral and physical abnormalities. With the advancement of high field strength MR technologies like MRS (Magnetic Resonance Spectroscopy), fMRI (functional Magnetic Resonance Imaging) and DTI (Diffusion Tensor Imaging), it has become possible to non-invasively measure these changes brain microenvironment in terms of levels of antioxidants; neurotransmitters; regional activity, susceptibility and connectivity during transition from healthy to pathological conditions, and during progression of disease stages. Advanced Machine Learning (ML) and Statistical modeling algorithms are utilizing features extracted from multimodal MR based, neuropsychological and neurophysiological data to build classifiers that identify highly sensitive and specific biomarkers to aid in understanding the causal processes of these brain disorders and can be translated from bench to bedside clinical practices for non-invasive diagnostic testing. It is also important to have global clinical research data sharing platforms that utilize data mining and ML to identify early biomarkers and test the sensitivity of old ones from time to time with advancement in research. This Research Topic updates the reader about the latest research in imagable biomarkers using MR methodologies and use of AI for testing the sensitivity of these biomarkers.

New mechanisms and therapeutics in neurodevelopmental disorders

New mechanisms and therapeutics in neurodevelopmental disorders
Author : Daniela Tropea
Publisher : Frontiers E-books
Release Date : 2020
Category :
Total pages :129
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Neurodevelopmental disorders (NDDs) are severe, heritable conditions characterized by impaired brain development and disability in cognition, social interaction and behavior. Genetic predisposition appears to interact with environmental factors to produce the onset of the disease. In the last decade genomic analysis on NDDs advanced the knowledge of the genetic causes of these disorders: most of the genes identified were not predicted from known biology, and almost all of them engage in neurodevelopmental processes. However, the same studies revealed an unexpected outcome regarding the molecular etiology: many of the same susceptibility genes as well as molecular pathways are emerging across hitherto unrelated disorders- such as autism and schizophrenia- challenging how we conceptualize these conditions. These new discoveries call for the establishment of additional criteria for the classification of the genes and related phenotypes. Beyond the classical distinction according to diagnostic criteria, new parameters should be taken into account: the genetics, the neurobiology of the gene products and the molecular mechanisms that they control. Our broad understanding of NDDs, requires a combination of approaches, including human studies, animal models and theoretical computation. Indeed, progress in technology and the generation of accurate models are advancing the field, and the research is rapidly growing. This Research Topic presents recent advances in neurodevelopmental disorders from genes to systems, in single conditions and across different phenotypes, and report the newest treatments in use. Recognized experts in the field discuss recent findings in molecular studies, in vivo imaging, neuropsychology, neuropharmacology and computational neuroscience. This multidisciplinary approach enriches our understanding of the mechanisms involved in the onset and progression of NDDs with the perspective of revealing the biological signs of the disorders and identifying new therapeutics.

Treatment of Neurodevelopmental Disorders

Treatment of Neurodevelopmental Disorders
Author : Randi Hagerman,Robert Hendren
Publisher : Oxford University Press
Release Date : 2014-04-25
Category : Medical
Total pages :352
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This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have led to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.

Diet and Exercise in Cognitive Function and Neurological Diseases

Diet and Exercise in Cognitive Function and Neurological Diseases
Author : Akhlaq A. Farooqui,Tahira Farooqui
Publisher : John Wiley & Sons
Release Date : 2015-02-06
Category : Medical
Total pages :384
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Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Environmental Hazards and Neurodevelopment

Environmental Hazards and Neurodevelopment
Author : Cindy Croft
Publisher : CRC Press
Release Date : 2015-01-28
Category : Medical
Total pages :378
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This title includes a number of Open Access chapters. The rate of identification of children with neurobiological disabilities has been on the increase in recent years. Millions of dollars in research are being spent to understand the factors influencing these increases. The articles within this compendium shed vital light on this issue, confirming that various "ordinary" chemical hazards—of the sort encountered by countless children in their everyday lives—are having serious impacts on development. This volume investigates the impact of exposure to tobacco smoke, household chemicals, lead, agricultural toxins, and flame retardants.

Prenatal and Childhood Nutrition

Prenatal and Childhood Nutrition
Author : Cindy Croft
Publisher : CRC Press
Release Date : 2015-01-28
Category : Medical
Total pages :448
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This title includes a number of Open Access chapters. Nutrition is not only a basic need that all humans have to sustain life, but it is also critical to successful early development. This research compendium lends deeper insights into the links between nutrition and healthy brain function—and from the reverse perspective, between nutrition and neurocognitive disorders. This well-organized and accessible compendium offers a vital research context for policymakers, educators, medical providers, and families. It underlines our urgent responsibility to give children a strong start by improving prenatal and early childhood nutrition.

Neurological Disorders

Neurological Disorders
Author : World Health Organization
Publisher : World Health Organization
Release Date : 2006
Category : Medical
Total pages :218
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Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Glycerophospholipids in the Brain

Glycerophospholipids in the Brain
Author : Akhlaq A. Farooqui,Lloyd A. Horrocks
Publisher : Springer Science & Business Media
Release Date : 2006-10-28
Category : Medical
Total pages :394
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This volume provides a comprehensive description of phospholipid metabolism in brain, activities of phospholipases A2, and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge information in a lively manner that is useful not only to student and teachers but also to researchers and physicians.

Neurodevelopmental Disorders

Neurodevelopmental Disorders
Author : Bin Chen,Kenneth Y. Kwan
Publisher : Academic Press
Release Date : 2020-05-24
Category : Medical
Total pages :426
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Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Covers disorders of the nervous system that arise through defects in neural development

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry
Author : Thomas Lehner,Bruce L. Miller,Matthew W. State
Publisher : Academic Press
Release Date : 2016-06-07
Category : Science
Total pages :796
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This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment