April 13, 2021

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Estrogen Effects on Traumatic Brain Injury

Estrogen Effects on Traumatic Brain Injury
Author : Kelli A Duncan
Publisher : Academic Press
Release Date : 2014-12-29
Category : Science
Total pages :172
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This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury. Written to provide a foundational view of estrogens as neuroprotectors in TBI, appropriate for both researchers and advanced students Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to understand results. A multidisciplinary approach to the methods, issues, empirical findings in the field of estrogen mediated neuroprotection. Detailed focus on how studies relate and build upon each other and the ways different methods of analysis inform each other. Written to provide clinicians with new and developing treatment options for patients in their field.

Estrogens and Memory

Estrogens and Memory
Author : Karyn M. Frick
Publisher : Oxford University Press, USA
Release Date : 2020
Category : Psychology
Total pages :516
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"A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory did not truly capture more widespread attention until the pioneering work of Barbara Sherwin and colleagues in 1988 and beyond. In her initial paper, Sherwin showed that bilateral removal of the ovaries (aka surgical menopause) led to impaired short-term and long-term memory, whereas treatment of surgically menopausal women with estradiol alone, testosterone alone, or estradiol plus testosterone prevented this decline (Sherwin, 1988). As a search for the terms "estrogen" and "memory" in PubMed illustrates, well over 2000 papers have been published on the subject of estrogens and memory in the ensuing decades. The vast majority of these studies have focused on the hippocampus, a bilateral medial temporal lobe structure essential for the formation of episodic memories, particularly those with spatial, contextual, relational, temporal, and recognition components (Olton et al., 1979; Morris et al., 1982; Kim and Fanselow, 1992; Squire, 1992; Cohen and Stackman, 2015; Tonegawa et al., 2015; Eichenbaum, 2017). Although various forms of learning and memory are mediated by numerous brain regions, including the prefrontal cortex, medial temporal lobe cortices, amygdala, striatum, and cerebellum, the hippocampus has received the lion's share of attention due to its central importance for episodic memory formation. Hippocampal damage produces profound retrograde amnesia for facts and events, as well as anterograde amnesia for new information and impairments in spatial navigation (Winocur, 1990; Anagnostaras et al., 2001; Clark et al., 2002; Gilboa et al., 2006). Hippocampal dysfunction in middle-aged and aged subjects is a primary contributor to age-related memory decline (Golumb et al., 1996; Grady et al., 2003; Apostolova et al., 2010; Burke and Barnes, 2010; Small et al., 2011; Yassa et al., 2011), and has also been implicated in the cognitive impairments observed in diseases such as schizophrenia and depression (Small et al., 2011; Nakahara et al., 2018; Santos et al., 2018; Ott et al., 2019). Moreover, the hippocampi of patients with Alzheimer's disease are substantially atrophied and burdened with copious amounts of amyloid plaques and neurofibrillary tangles, the hallmark pathologies of this insidious disease (Hyman et al., 1984; Walsh and Selkoe, 2004; Selkoe and Hardy, 2016). As such, understanding how estrogens influence hippocampal functioning may provide important insights not only about the fundamental neurobiology of memory processes, but also into the etiology of neuropsychiatric and neurodegenerative diseases"--

Cumulated Index Medicus

Cumulated Index Medicus
Author : Anonim
Publisher : Unknown
Release Date : 1991
Category : Medicine
Total pages :129
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Biomedical Index to PHS-supported Research: pt. A. Subject access A-H

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H
Author : Anonim
Publisher : Unknown
Release Date : 1993
Category : Medicine
Total pages :129
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Traumatic Brain Injury

Traumatic Brain Injury
Author : Mark J. Ashley,David A. Hovda
Publisher : CRC Press
Release Date : 2017-07-28
Category : Medical
Total pages :768
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The fourth edition of this text constitutes a continuation of 20 years of coverage of traumatic brain injury, and broadens the discussion of acquired brain injury. Within TBI, the paradigm shift from an injury occurring at a point in time to a disease entity of a chronic nature is changing the discussion of diagnosis, management, treatment and outcome assessment. Disease specification that differentiates TBIs by the mechanism of injury, the exact nature of the injury, the extent of injury, presence of co-morbidities and their exact nature, gender, age, race, and genome are emerging as crucial. Disease differentiation has impacted diagnosis, treatment and outcome.

Pfizer Global Research and Development Scientific Publications, 2000

Pfizer Global Research and Development Scientific Publications, 2000
Author : Anonim
Publisher : Unknown
Release Date : 2000
Category : Pharmaceutical chemistry
Total pages :408
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Estrogen Synthesis in the Central Nervous System

Estrogen Synthesis in the Central Nervous System
Author : Richard Scott Peterson
Publisher : Unknown
Release Date : 2004
Category :
Total pages :306
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Estradiol Reduction of Ischemia-induced Cerebral Edema

Estradiol Reduction of Ischemia-induced Cerebral Edema
Author : Jennifer Marie Rutkowsky
Publisher : Unknown
Release Date : 2009
Category :
Total pages :334
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Neurodegenerative Dementias

Neurodegenerative Dementias
Author : Christopher Clark,John Q. Trojanowski
Publisher : Appleton & Lange
Release Date : 2000
Category : Medical
Total pages :491
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Presents a logical and elegant review of basic science, diagnosis, and treatment of the most heavily researched and most commonly encountered group of devastating neurologic illnesses: the neurodegenerative dementias.

CSA Neurosciences Abstracts

CSA Neurosciences Abstracts
Author : Anonim
Publisher : Unknown
Release Date : 2000
Category : Neurology
Total pages :129
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Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry
Author : Anonim
Publisher : Unknown
Release Date : 1998
Category : Pharmaceutical chemistry
Total pages :129
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Women's Health in Primary Care

Women's Health in Primary Care
Author : Anonim
Publisher : Unknown
Release Date : 2005
Category : Generative organs, Female
Total pages :129
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Community Integration Following Traumatic Brain Injury

Community Integration Following Traumatic Brain Injury
Author : John Nicholas Walton
Publisher : Paul H Brookes Publishing Company
Release Date : 1990
Category : Medical
Total pages :338
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Dissertation Abstracts International

Dissertation Abstracts International
Author : Anonim
Publisher : Unknown
Release Date : 2008
Category : Dissertations, Academic
Total pages :129
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