November 30, 2020

Download Ebook Free Estrogen Effects On Traumatic Brain Injury

Estrogen Effects on Traumatic Brain Injury

Estrogen Effects on Traumatic Brain Injury
Author : Kelli A Duncan
Publisher : Academic Press
Release Date : 2014-12-29
Category : Science
Total pages :172
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This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury. Written to provide a foundational view of estrogens as neuroprotectors in TBI, appropriate for both researchers and advanced students Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to understand results. A multidisciplinary approach to the methods, issues, empirical findings in the field of estrogen mediated neuroprotection. Detailed focus on how studies relate and build upon each other and the ways different methods of analysis inform each other. Written to provide clinicians with new and developing treatment options for patients in their field.

New Therapeutics for Traumatic Brain Injury

New Therapeutics for Traumatic Brain Injury
Author : Kim Heidenreich
Publisher : Academic Press
Release Date : 2016-09-27
Category : Medical
Total pages :352
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New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

Brain Injury Medicine

Brain Injury Medicine
Author : Nathan Zasler,Douglas Katz, MD,Ross Zafonte, DO
Publisher : Demos Medical Publishing
Release Date : 2007
Category : Medical
Total pages :1275
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Covers the full continuum from early diagnosis and evaluation through rehabilitation, post-acute care, and community re-entry. Includes assessment and treatment, epidemiology, pathophysiology, neuroanatomy, neuroimaging, the neuroscientific basis for rehabilitation, ethical and medicolegal issues, life-care planning, and more.

Traumatic Brain Injury

Traumatic Brain Injury
Author : Mark J. Ashley
Publisher : CRC Press
Release Date : 2016-04-19
Category : Medical
Total pages :1084
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Since the bestselling second edition was published almost a decade ago, the field of brain injury treatment has undergone tremendous change, largely impacting access to treatment. But, while the healthcare marketplace has evolved, the needs of brain injury victims remain the same. With updated and expanded clinical coverage, Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition delineates a broad spectrum of advanced theoretical clinical constructs and detailed diagnostic and treatment interventions for traumatic brain injury. Details Specific Diagnostic and Treatment Approaches for Nearly All Aspects of Dysfunction Observed Following Brain Injury With contributions from more than 50 authorities in both academia and industry, this highly respected text stands apart as a clinical guide to rehabilitative treatment of persons with traumatic brain injury following the acute phase of treatment. It provides a concise source of information about the scientific and therapeutic realms involved in the rehabilitation of a person with traumatic brain injury, specifically as they relate to persistent deficits. The book also details long-term consequences of brain injury and effective approaches to vocational rehabilitation and case management. Widening coverage from the previous edition, this book includes details on: Metabolic and bioenergetic factors in brain injury Neuroendocrine dysfunction following brain injury Blast injury Ethical issues in treatment of brain injury Neuropharmacological and neuropsychological interventions following brain injury Interventions for the minimally conscious patient Dietary and exercise considerations after brain injury Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition is a complete source of pharmacological, anatomical, and physiological information for basic therapeutic rationales that are often not well understood in the field. It is an ideal reference for both new and experienced clinicians.

Traumatic Brain Injury in Sports

Traumatic Brain Injury in Sports
Author : Mark Lovell,Jeffrey Barth,Michael Collins,Ruben Echemendia
Publisher : CRC Press
Release Date : 2004-01-01
Category : Psychology
Total pages :520
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Traumatic brain injury (TBI) in sports has become an important international public health issue over the past two decades. However, until recently, return to play decisions following a sports-related traumatic brain injury have been based on anecdotal evidence and have not been based on scientifically validated clinical protocols. Over the past decade, the field of Neuropsychology has become an increasingly important component of the return to play decision making process following TBI. Neuropsychological assessment instruments are increasingly being adapted for use with athletes throughout the world and the field of sports neuropsychology appears to be a rapidly evolving subspecialty. This book provides a comprehensive overview of the application of neuropsychological assessment instruments in sports, and it is structured to present a global perspective on contemporary research. In addition to a review of current research, Traumatic Brain Injury in Sports: An International Neuropsychological Perspective, presents a thorough review of current clinical models that are being implemented internationally within American and Australian rules football, soccer, boxing, ice hockey, rugby and equestrian sports.

Sex Hormones in Neurodegenerative Processes and Diseases

Sex Hormones in Neurodegenerative Processes and Diseases
Author : Gorazd Drevensek
Publisher : BoD – Books on Demand
Release Date : 2018-05-02
Category : Medical
Total pages :358
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The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Estrogen — Mystery Drug for the Brain?

Estrogen — Mystery Drug for the Brain?
Author : Christian Behl
Publisher : Springer Science & Business Media
Release Date : 2011-06-28
Category : Medical
Total pages :231
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It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women. Besides up-to-date information on estrogen and the brain, this book explains in a highly understandable manner molecular and cellular techniques by which basic data have been collected. The reader, which may include the professional specialist as well as the interested non-specialist, will also gain insight into the scientific transfer process of knowledge from basic science to the clinical situation and therefore "from bench to bed”.

Neuronal and Cognitive Effects of Oestrogens

Neuronal and Cognitive Effects of Oestrogens
Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Release Date : 2003-10-31
Category : Medical
Total pages :292
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Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain. This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans. Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed. The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions.

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Release Date : 2015-12-01
Category : Medical
Total pages :412
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Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Trauma Intensive Care

Trauma Intensive Care
Author : Samuel A. Tisherman,Raquel M. Forsythe,John A. Kellum
Publisher : Oxford University Press
Release Date : 2013-07-11
Category : Medical
Total pages :336
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An ideal resource for intensivists caring for trauma victims in the ICU, Trauma Intensive Care provides point-of-care guidelines for establishing the priorities of care, minimizing complications, and returning patients to the best possible functional outcome.

Estradiol, Synthesized by Reactive Glia, is a Potent Anti-inflammatory in the Injured Vertebrate Brain

Estradiol, Synthesized by Reactive Glia, is a Potent Anti-inflammatory in the Injured Vertebrate Brain
Author : Alyssa Pedersen
Publisher : Unknown
Release Date : 2015
Category : Brain
Total pages :27
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Neuroinflammation following traumatic brain injury (TBI) may have detrimental and beneficial effects that likely differ between the acute and chronic periods post-trauma. In birds and mammals, traumatic brain injury increases the expression of cytokines in microglia and aromatase ( estrogen synthase) in astroglia. In the songbird, TBI-induced synthesis of estrogens by glial aromatization is neuroprotective as aromatase inhibition and replacement with estradiol (E2) exacerbates and mitigates the extent of damage and apoptosis, respectively. The effect of glial estrogens on inflammation, however, remains unstudied. We hypothesized that induced astrocytic aromatization may affect neuroinflammation following TBI, via the synthesis of neural E2 around the site of damage. In three separate experiments on adult zebra finches (Taeniopygia guttata) of both sexes we tested the influence of (a) mechanical TBI, (b) inhibition of induced aromatase expression, and (c) inhibition of induced aromatase with central E2 replacement, on the expression of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL-6, and aromatase. At 2-hour post-injury, in both sexes, TBI increased, and tended to elevate, TNFalpha and IL-1beta respectively. At 24-hour post-injury, also in both sexes, cytokines appeared to have returned to baseline, but aromatase is robustly elevated in the lobe that sustained TBI. Pharmacological inhibition of induced aromatization resulted in persistent neuroinflammation, as administration of fadrozole increased IL-1beta in females and TNFalpha in males 24 hour following TBI. This prolonged neuroinflammation following aromatase inhibition appears to be due to a failure to synthesize E2 locally, since E2 replacement lowered TNFalpha and IL-1beta relative to fadrozole alone. IL-6 was not affected by TBI, aromatase inhibition or E2 replacement in either sex. These data suggest that astrocytic E2 synthesis following TBI is a potent and inducible anti-inflammatory signal, with specific modulation of discrete cytokine signaling. Induced neural provision of E2 following damage and compromise of central pathways may protect the brain from the deleterious effects of prolonged neuroinflammation.

Brain Aromatase, Estrogens, and Behavior

Brain Aromatase, Estrogens, and Behavior
Author : Jacques Balthazart,Gregory Ball
Publisher : Oxford University Press
Release Date : 2012-11-15
Category : Medical
Total pages :530
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This book concerns how estrogens are synthesized in the brain and their two modes of action on behavior: a slow process involving gene transcription and a faster action at the cell membrane. The significance of the regulation and distribution of the estrogen synthesizing enzyme aromatase in the brain is also highlighted.

Hormones, Cognition and Dementia

Hormones, Cognition and Dementia
Author : Eef Hogervorst,Victor W. Henderson,Robert B. Gibbs,Roberta Diaz Brinton
Publisher : Cambridge University Press
Release Date : 2009-09-24
Category : Medical
Total pages :129
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A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.

Drug Metabolism in Diseases

Drug Metabolism in Diseases
Author : Wen Xie
Publisher : Academic Press
Release Date : 2016-09-12
Category : Medical
Total pages :294
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Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Growth Hormone Deficiency in Adults

Growth Hormone Deficiency in Adults
Author : Jens O. L. Jørgensen,Jens Sandahl Christiansen
Publisher : Karger Medical and Scientific Publishers
Release Date : 2005-01-01
Category : Science
Total pages :227
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It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.