January 21, 2021

Download Ebook Free Non Coding Rna And The Reproductive System

Non-coding RNA and the Reproductive System

Non-coding RNA and the Reproductive System
Author : Dagmar Wilhelm,Pascal Bernard
Publisher : Springer
Release Date : 2015-12-11
Category : Medical
Total pages :198
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This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.

Molecular and Cellular Mechanisms in Reproduction and Early Development

Molecular and Cellular Mechanisms in Reproduction and Early Development
Author : Rafael A. Fissore,Adam Burton,Karin Lykke-Hartmann
Publisher : Frontiers Media SA
Release Date : 2019-08-20
Category :
Total pages :129
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The Research Topic aims to support progress towards understanding the different sets of developmental processes that are absolutely required to complete all the steps essential for successful embryonic development, under physiological conditions. We sought contributions that dealt with single cells, interaction between cells as well as intra- and extracellular signal transduction. The Research Topic presents original studies covering experimental and theoretical approaches, descriptions of new methodologies, reviews and opinions.

Molecular Mechanisms of Cell Differentiation in Gonad Development

Molecular Mechanisms of Cell Differentiation in Gonad Development
Author : Rafal P. Piprek
Publisher : Springer
Release Date : 2016-06-14
Category : Science
Total pages :434
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This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.

Computational Non-coding RNA Biology

Computational Non-coding RNA Biology
Author : Yun Zheng
Publisher : Academic Press
Release Date : 2018-09-14
Category : Science
Total pages :320
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Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, quantifying, and visualizing non-coding RNAs from high throughput sequencing datasets at high volume is complex. Therefore, it is usually possible for biologists to complete all of the necessary steps for analysis. Presents a comprehensive resource of computational methods for the identification and quantification of non-coding RNAs Introduces 23 practical computational pipelines for various topics of non-coding RNAs Provides a guide to assist biologists and other researchers dealing with complex datasets Introduces basic computational methods and provides guidelines for their replication by researchers Offers a solution to researchers approaching large and complex sequencing datasets

Long Non Coding RNA Biology

Long Non Coding RNA Biology
Author : M.R.S. Rao
Publisher : Springer
Release Date : 2017-08-16
Category : Medical
Total pages :323
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This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Regulation by non-coding RNAs Volume 1

Regulation by non-coding RNAs Volume 1
Author : Nicholas Delihas
Publisher : MDPI
Release Date : 2018-10-09
Category : Non-coding RNA.
Total pages :850
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Printed Edition of the Special Issue Published in IJMS

Applications of RNA-Seq and Omics Strategies

Applications of RNA-Seq and Omics Strategies
Author : Fabio Marchi,Priscila Cirillo,Elvis Cueva Mateo
Publisher : BoD – Books on Demand
Release Date : 2017-09-13
Category : Medical
Total pages :328
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The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
Author : Jayprokas Chakrabarti,Sanga Mitra
Publisher : Academic Press
Release Date : 2017-10-13
Category : Medical
Total pages :576
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Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Non Coding RNAs in Plants

Non Coding RNAs in Plants
Author : Volker A. Erdmann,Jan Barciszewski
Publisher : Springer Science & Business Media
Release Date : 2011-07-20
Category : Science
Total pages :510
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In the most recent years, each of the RNA silencing pathways of plants have appeared to generate ncRNAs with dedicated functions, specialized biological activities and specific functional scopes. RNA silencing plays a crucial role in coordinating the expression, stability, protection and inheritance of eukaryotic genomes. It compromises several mechanisms, that invariably depend on core small non coding RNAs and that achieve dedicated sequence-specific functions. RNA silencing has been recognized to carry critical developmental, stress-response and bodyguard functions be coordinating the expression, protection, stability and inheritance of virtually all eukaryotic genomes. Thus, the ncRNAs encompass a wide set of mechanisms that achieve specialized functions.

Long Non-Coding RNAs

Long Non-Coding RNAs
Author : Yi Feng,Lin Zhang
Publisher : Humana Press
Release Date : 2016-01-01
Category : Medical
Total pages :298
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This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Long Non-Coding RNAs: Methods and Protocols is a must-have for molecular biologists, cell and developmental biologists, specialists who conduct disease-oriented research, and bioinformatics experts who seek a better understanding on lncRNA expression and function by computational analysis of the massive sequencing data that are rapidly accumulating in recent years.

Small Non-Coding RNAs

Small Non-Coding RNAs
Author : Mathieu Rederstorff
Publisher : Humana Press
Release Date : 2015-03-21
Category : Medical
Total pages :238
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This volume contains state-of-the-art methods tackling all aspects of small non-coding RNAs biology. Small Non-Coding RNAs: Methods and Protocols guides readers through customized dedicated protocols and technologies that will be of valuable help to all those willing to contribute deciphering the numerous functions of small non-coding RNAs. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubles troubleshooting and avoiding known pitfalls. Instructive and practical, Small Non-Coding RNAs: Methods and Protocols reaches out to biochemists, cellular and molecular biologists already working in the field of RNA biology and to those just starting to study small non-coding RNAs.

Regulatory Non-Coding RNAs

Regulatory Non-Coding RNAs
Author : Gordon G. Carmichael
Publisher : Humana Press
Release Date : 2014-09-20
Category : Medical
Total pages :181
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Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls. Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.

Etiology and Morphogenesis of Congenital Heart Disease

Etiology and Morphogenesis of Congenital Heart Disease
Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Publisher : Springer
Release Date : 2016-06-24
Category : Medical
Total pages :383
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This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Long Non-coding RNAs in Plants

Long Non-coding RNAs in Plants
Author : Santosh Kumar Upadhyay
Publisher : Academic Press
Release Date : 2020-11-20
Category : Science
Total pages :390
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Long Non-coding RNAs in Plants: Roles in Development and Stress provides the most recent advances in LncRNAs, including identification, characterization, and potential applications and uses. Introductory chapters include the discovery and development of lncRNAs, a comparative analysis of coding versus non-coding lncRNAs, and the role of lncRNAs in abiotic and biotic stress management. The book then provides methodology and protocols for identification and characterization, followed by chapters covering the various different applications of lncRNAs. Written by leading experts, this book is a must-have resource for students and researchers interested in plant science and biotechnology, horticulture, agriculture, and crop science. Stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests largely affect the productivity of various horticultural plants and agricultural crops. However, the ever-increasing human population regularly demands an increase in yield and quality of produce. Long non-coding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses, and signaling, and can provide an alternative strategy for stress management in plants. Includes the latest advances and research in long non-coding RNAs in plants Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops Focuses on the application and uses of long non-coding RNAs

Reproduction in Domestic Ruminants VII

Reproduction in Domestic Ruminants VII
Author : M. C. Lucy,J. L. Pate,M. F. Smith,T.E. Spencer
Publisher : Nottingham University Press
Release Date : 2011-02-01
Category : Medical
Total pages :636
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The combined work of eminent scientists in the field, this compilation contains the latest information on ruminant nutrition from the eighth annual International Ruminant Reproduction Symposium. With discussions on how to improve reproduction by applying nutrition and physiology, this collection spotlights the recent advances regarding the ruminant genome and includes chapters about specific animals, including the dairy buffalo, camel, and reindeer.