December 3, 2020

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Gene Therapy for Viral Infections

Gene Therapy for Viral Infections
Author : Patrick Arbuthnot
Publisher : Academic Press
Release Date : 2015-06-01
Category : Science
Total pages :392
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Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Gene Therapy for Viral Infections

Gene Therapy for Viral Infections
Author : Patrick Arbuthnot
Publisher : Academic Press
Release Date : 2015-03-02
Category : Science
Total pages :392
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Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
Author : David T. Curiel
Publisher : Academic Press
Release Date : 2016-03-10
Category : Science
Total pages :868
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Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Modern Tools for Genetic Engineering

Modern Tools for Genetic Engineering
Author : Michael Kormann
Publisher : BoD – Books on Demand
Release Date : 2016-05-18
Category : Science
Total pages :226
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Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun.

Gene Therapy for HIV and Chronic Infections

Gene Therapy for HIV and Chronic Infections
Author : Ben Berkhout,Hildegund C.J. Ertl,Marc S. Weinberg
Publisher : Unknown
Release Date : 2015
Category :
Total pages :129
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This volume examines gene therapy and gene transfer approaches to preventing or treating chronic virus infections, focusing on the Big Three viral pathogens- HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). It explores molecular antiviral strategies, including RNA interference, aptamer-siRNA chimeras, U1i interference, editing CCR5, alternative genetic vaccination by intramuscular gene transfers of virus vectors, and HIV latency in the context of non-coding RNA. This title is a volume of the American Society of Gene and Cell Therapy, a sub-series of the highly successful Advances in Experimental Medicine and Biology. In eleven illustrated chapters, leading international researchers contextualize the structure, operation, and impact of pathogens; examine the existing genetic and molecular research; and extract possible methods of preventing and treating chronic viral infections while evaluating the current body of knowledge. Authoritative and multifaceted, Gene Therapy for HIV and Chronic Infections is an ideal guide for researchers in the fields of gene therapy and immunology interested in expanding their knowledge on how to design an effective gene therapy against a viral pathogen.

Cancer Gene Therapy

Cancer Gene Therapy
Author : David T. Curiel,Joanne T. Douglas
Publisher : Springer Science & Business Media
Release Date : 2007-11-03
Category : Medical
Total pages :490
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A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Viruses and Human Disease

Viruses and Human Disease
Author : Ellen G. Strauss,James H. Strauss
Publisher : Elsevier
Release Date : 2007-09-21
Category : Science
Total pages :480
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Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text

Essential Human Virology

Essential Human Virology
Author : Jennifer Louten
Publisher : Academic Press
Release Date : 2016-03-29
Category : Science
Total pages :344
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Essential Human Virology is written for the undergraduate level with case studies integrated into each chapter. The structure and classification of viruses will be covered, as well as virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters will focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses, and emerging and dangerous viruses. Additionally, how viruses cause disease, or pathogenesis, will be highlighted during the discussion of each virus family, and a chapter on the immune response to viruses will be included. Further, research laboratory assays and viral diagnosis assays will be discussed, as will vaccines, anti-viral drugs, gene therapy, and the beneficial uses of viruses. By focusing on general virology principles, current and future technologies, familiar human viruses, and the effects of these viruses on humans, this textbook will provide a solid foundation in virology while keeping the interest of undergraduate students. Focuses on the human diseases and cellular pathology that viruses cause Highlights current and cutting-edge technology and associated issues Presents real case studies and current news highlights in each chapter Features dynamic illustrations, chapter assessment questions, key terms, and summary of concepts, as well as an instructor website with lecture slides, test bank, and recommended activities

Advances in Molecular Retrovirology

Advances in Molecular Retrovirology
Author : Shailendra K. Saxena
Publisher : BoD – Books on Demand
Release Date : 2016-03-16
Category : Science
Total pages :202
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This book gives a comprehensive overview of recent advances in Retrovirology, as well as general concepts of molecular biology of retroviral infections, immunopathology, diagnosis, and prevention, to current clinical recommendations in management of retroviruses, including endogenous retroviruses, highlighting the ongoing issues, recent advances, with future directions in diagnostic approaches and therapeutic strategies.

Adeno-Associated Virus (AAV) Vectors in Gene Therapy

Adeno-Associated Virus (AAV) Vectors in Gene Therapy
Author : Kenneth I. Berns,Catherine Giraud
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :173
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Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this may be either the genomic or the cDNA form) in a stable form, ability to introduce the gene into the desired cell type, ability to express the introduced gene in an appropriately regulated manner for an extended period of time, and a lack of toxicity for the recipient. Also of concern is the frequency of cell transformation and, in some cases, the ability to introduce the gene into nondividing stem cells. Sev eral animal viruses have been tested as potential vectors, but none has proven to have all the desired properties described above. For example, retroviruses are difficult to propagate in sufficient titers, do not integrate into nondividing cells, and are of concern because of their oncogenic properties in some hosts and because they integrate at many sites in the genome and, thus, are potentially insertional mutagens. Additionally, genes introduced by retroviral vectors are frequently expressed for relatively short periods of time. A second virus used as a vector in model systems has been adenovirus (Ad).

Tumor Metastasis

Tumor Metastasis
Author : Ke Xu
Publisher : Unknown
Release Date : 2016-09-14
Category :
Total pages :266
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Molecular Virology of Human Pathogenic Viruses

Molecular Virology of Human Pathogenic Viruses
Author : Wang-Shick Ryu
Publisher : Academic Press
Release Date : 2016-03-30
Category : Science
Total pages :440
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Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank

Cystic Fibrosis in the Light of New Research

Cystic Fibrosis in the Light of New Research
Author : Dennis Wat
Publisher : BoD – Books on Demand
Release Date : 2015-08-24
Category : Medical
Total pages :392
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Cystic Fibrosis in the Light of New Research provides the latest research and clinical evidence that will be useful for clinicians, scientists and researchers to further their knowledge around this fascinating condition. The authors have brought along their expertise and wealth of knowledge to produce this book, including the basic science that underlies the disease, the burden of bacterial and viral infections, immunologic aspects of CF, a variety of clinical measurements to predict prognosis and novel therapies including gene therapy. This book will be invaluable and entertaining for anyone who is involved in the care of patients with cystic fibrosis.

Gene Therapy for Acute and Acquired Diseases

Gene Therapy for Acute and Acquired Diseases
Author : Phillip Factor
Publisher : Springer Science & Business Media
Release Date : 2001-01-31
Category : Medical
Total pages :291
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In recent years much enthusiasm and energy has been directed toward the development of human gene therapies, especially for inherited conditions and cancers. However, current gene transfer technology is limited in its transduction efficiency and ability to permanently and safely correct genomic defects. Thus the promise of gene therapy for these conditions is as yet unrealized. The progression of gene transfer technology will eventually surmount these limitations. Gene Therapy for Acute and Acquired Diseases includes selected examples of ongoing studies in molecular genetics that have the potential to evolve into human therapies for acute illnesses. These chapters are intended to highlight lesser known applications of gene therapy for acquired disorders. It is expected that human gene therapy trials for these conditions will be forthcoming in the near future, leading to previously unimaginable therapies. Thus, this first-ever book about gene therapy for acute and acquired diseases is intended to serve as a glimpse into the future.

Current Issues in Molecular Virology

Current Issues in Molecular Virology
Author : Victor Romanowski
Publisher : BoD – Books on Demand
Release Date : 2013-11-20
Category : Science
Total pages :296
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This book is a collection of chapters dealing with examples of RNA and DNA viruses, and issues such as how these gene packages have learnt to take advantage of their hosts, molecular recognition events that hosts may use to counterattack the viruses, and how researchers have developed strategies to use viruses or their parts as tools for different purposes.