November 26, 2020

Download Ebook Free Gene Therapy

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
Author : Roland W. Herzog,Sergei Zolotukhin
Publisher : World Scientific
Release Date : 2010
Category : Medical
Total pages :388
GET BOOK

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Gene Therapy

Gene Therapy
Author : Mauro Giacca
Publisher : Springer Science & Business Media
Release Date : 2010-11-01
Category : Medical
Total pages :303
GET BOOK

I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection of gene transfer laboratory protocols or deal with the subject in a rather superficial manner. Hence the idea to write a gene therapy textbook that is broad and comprehensive, but at the same time provides sufficient molecular and clinical detail to be of interest to students, professors, and specialists in the various disciplines that contribute to gene therapy. I have tried to keep the language plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical areas, whenever technical descriptions are required, they are provided.

Gene Therapy

Gene Therapy
Author : Joseph Panno
Publisher : Infobase Publishing
Release Date : 2005
Category : Biology
Total pages :193
GET BOOK

Many diseases are caused by a simple point mutation.

Gene Therapy

Gene Therapy
Author : Evelyn B. Kelly
Publisher : Greenwood Publishing Group
Release Date : 2007
Category : Health & Fitness
Total pages :198
GET BOOK

Presents an introduction to gene therapy, discussing its scientific background, the types of disorders which it can potentially treat, the ethical, social, and religious issues surrounding its use, and the role of government regulation.

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
Author : David T. Curiel
Publisher : Academic Press
Release Date : 2016-03-10
Category : Science
Total pages :868
GET BOOK

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Gene Therapy of Cancer

Gene Therapy of Cancer
Author : Stanton L. Gerson,Edmund C. Lattime
Publisher : Elsevier
Release Date : 2002-04-04
Category : Science
Total pages :534
GET BOOK

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
Author : Curtis A. Machida
Publisher : Springer Science & Business Media
Release Date : 2003
Category : Medical
Total pages :608
GET BOOK

Comprehensive and highly practical, Viral Vectors for Gene Therapy provides researchers with the basic tools needed to design targeted gene delivery vectors, and clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system.

The Ethics of Human Gene Therapy

The Ethics of Human Gene Therapy
Author : LeRoy Walters,Joseph P Kennedy Professor of Christian Ethics at the Kennedy Institute of Ethics LeRoy Walters,Julie Gage Palmer,Julie G. Palmer
Publisher : Oxford University Press, USA
Release Date : 1997
Category : Medical
Total pages :209
GET BOOK

They start with the current techniques of gene addition, using non-reproductive (somatic) cells in an effort to cure or treat disease. Next they address the technical problems and moral issues facing attempts to prevent disease through genetically modifying early human embryos or sperm and egg cells. These changes would be passed on to future generations. Chapter 4, in many ways the most original part of this volume, confronts the issue of employing genetic means to improve human abilities and appearance.

Gene Therapy

Gene Therapy
Author : Lisa Yount
Publisher : Unknown
Release Date : 2002
Category : Juvenile Nonfiction
Total pages :128
GET BOOK

Discusses the history of genetics, how knowledge of genes has been developed to treat illnesses, and ethical issues related to gene therapy.

Gene Therapy: Prospective Technology assessment in its societal context

Gene Therapy: Prospective Technology assessment in its societal context
Author : Jörg Niewöhner,Christof Tannert
Publisher : Elsevier
Release Date : 2011-08-19
Category : Technology & Engineering
Total pages :274
GET BOOK

This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law. * Discusses biological and cellular barriers limiting the clinical application of nonviral gene delivery systems * Addresses such questions as: Does patent granting hinder the development of Gene Therapy products? * Offers insight in the future of public perception of gene therapy in Europe * Provides details on how to communicate risks in gene therapy

Gene Therapy

Gene Therapy
Author : Nancy Smyth Templeton,D. D. Lasic
Publisher : CRC Press
Release Date : 2000-06-15
Category : Medical
Total pages :584
GET BOOK

This text covers all aspects of gene therapy, including basic principles, viral and nonviral delivery systems, targeted diseases, regulatory issues, and FDA requirements. It investigates genetic bullets to block HIV-1 replication and genetic guns to deliver antiviral agents.

A Special Report on Gene Therapy

A Special Report on Gene Therapy
Author : K. K. Jain
Publisher : John Wiley & Sons
Release Date : 2000-04-14
Category : Business & Economics
Total pages :291
GET BOOK

This special report on Gene Therapy Companies by K.K. Jain provides an up-to-date overview of the gene therapy industry. It contains a wealth of very practical information on 105 companies. For each company, information is available on the people to contact, their contact details, a corporate history, the company's technologies and products, financial data, patents held, products in clinical trials, collaborations with other companies and selected publications from the company's scientists. Almost 200 companies were initially considered for inclusion but just over 100 companies were finally selected as they fulfilled the necessary criteria to be classified as a 'Gene Therapy Company, ', defined broadly to include cell therapy companies. Not all of the companies devote their activity exclusively to gene therapy but they have sufficient relevance to be included. As part of this project, new companies were discovered that have not been reported in other publications or on the internet. Dr. Jain has spared no effort to ensure that the information is up-to-date and accurate at the time of publishing. In most instances, the information was reviewed by the companies to correct any outdated information or to add any complementary or recent information. In addition to the detailed descriptions of each company, the data is also presented in summary tabular form so that at a glance the reader can identify collaborations within the gene therapy industry, or determine which companies are pursuing strategies involving viral, non-viral or other approaches to gene therapy, and which diseases are being targetted. Given that much of the gene therapy research and development is currently being carried out within the industrial sector, it is important for scientists, managers and investors to have the relevant information at their fingertips. This special report provides that information in one accurate, easy to consult and up-to-date source

Gene Therapy: Prospective Technology assessment in its societal context

Gene Therapy: Prospective Technology assessment in its societal context
Author : Jörg Niewöhner,Christof Tannert
Publisher : Elsevier
Release Date : 2011-08-19
Category : Technology & Engineering
Total pages :274
GET BOOK

This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law. * Discusses biological and cellular barriers limiting the clinical application of nonviral gene delivery systems * Addresses such questions as: Does patent granting hinder the development of Gene Therapy products? * Offers insight in the future of public perception of gene therapy in Europe * Provides details on how to communicate risks in gene therapy

Suicide Gene Therapy

Suicide Gene Therapy
Author : Caroline J. Springer
Publisher : Springer Science & Business Media
Release Date : 2004
Category : Medical
Total pages :555
GET BOOK

The first comprehensive review of both the theory and practice of suicide gene therapy. The authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, immunological implications, and its clinical impact. They also describe all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Understand the latest developments in suicide gene therapy Use readily reproducible methods to explore, study, and advance suicide gene therapy Refer to the first book to integrate the theory and practice of suicide gene therapy.

Human gene therapy.

Human gene therapy.
Author : Anonim
Publisher : DIANE Publishing
Release Date : 2020
Category :
Total pages :129
GET BOOK