November 27, 2020

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Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles
Author : Goutam Brahmachari
Publisher : Elsevier
Release Date : 2014-11-17
Category : Science
Total pages :632
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Green Synthetic Approaches for Biologically Relevant Heterocycles reviews this significant group of organic compounds within the context of sustainable methods and processes. Each clearly structured chapter features in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles classified on the basis of ring-size and/or presence of heteratoms(s). Techniques covered include microwave heating, ultrasound, ionic liquids, solid phase, solvent-free, heterogeneous catalysis, and aqueous media, along with multi-component reaction strategies. This book also integrates advances in green chemistry research into industrial applications and process developments. Green Synthetic Approaches for Biologically Relevant Heterocycles is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in medicinal, organic, natural product, and agricultural chemistry. Includes global coverage of a wide variety of green synthetic techniques Features cutting-edge research in the field of bioactive heterocyclic compounds Focuses extensively on applications, with numerous examples of biologically relevant heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles
Author : Goutam Brahmachari
Publisher : Elsevier
Release Date : 2021-02-01
Category : Science
Total pages :600
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Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of additional new chapters on hot topics in the field. Volume 1 explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles, classified on the basis of ring-size and/or the presence of heteratoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. Fully revised and updated, Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product, and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles
Author : Goutam Brahmachari
Publisher : Elsevier
Release Date : 2021-02-01
Category : Science
Total pages :600
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Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of additional new chapters on hot topics in the field. Volume 2 explores Green Catalytic Systems and Solvents. Each clearly structured chapter features in-depth coverage of various green protocols for the sustainable use of catalytic processes and solvents. Techniques covered range from metal and magnetic catalysis to organocatalysis and solid acid catalysis, cycloaddition reactions, and varied approaches using ionic liquids. Fully revised and updated, Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product, and green chemistry. Provides fully updated coverage of the field with an emphasis on sustainability Highlights a range of different eco-friendly solvents and environmentally friendly catalysts Collates the experience of a global team of expert contributors

Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, 2 Volume Set

Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, 2 Volume Set
Author : Ana Maria Faisca Phillips
Publisher : John Wiley & Sons
Release Date : 2020-11-18
Category : Science
Total pages :864
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A comprehensive overview of synthetic strategies for nonaromatic nitrogen heterocycles Nitrogen heterocycles are extremely widely distributed in nature, as well as in synthetic substances found in pharmaceuticals, agrochemicals, and materials chemistry. With new structures and medicines that include these structures emerging yearly, and a vast new journal literature to describe them, anyone who wants to be effective in R&D needs to easily access a synthesis of the latest research. This state-of-the-art survey explores recent developments in the most widely used reactions, as well as completely new ones. Highlights the major modern synthetic methods known to obtain nonaromatic nitrogen heterocycles, and their practical applications Topics include enantioselective synthesis and catalysis, photocatalysis, biocatalysis, microwave-assisted synthesis, reactions of oximes and nitrones, and ionic liquids Discusses how to synthesize rings of specific sizes Covers sustainable synthetic approaches for obtaining salts Whether you are using nonaromatic nitrogen compounds as an academic researcher, a synthetic chemist in industry, or an advanced student, this book is an essential, up-to-date resource to support your work.

Organophosphorus Chemistry

Organophosphorus Chemistry
Author : David W Allen,David Loakes,Lee J Higham,John C Tebby
Publisher : Royal Society of Chemistry
Release Date : 2020-04-15
Category : Science
Total pages :390
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This annual review of the literature presents a comprehensive and critical survey of the vast field of study involving organophosphorus compounds, from phosphines and related P-C bonded compounds to phosphorus acids, phosphine chalcogenides and nucleotides. The Editors have added to the content with a timely chapter on the recent developments in green synthetic approaches in organophosphorus chemistry to reflect current interests in the area. With an emphasis on interdisciplinary content, this book is aimed at the worldwide organic chemistry and engineering research communities.

Bioactive Natural Products

Bioactive Natural Products
Author : Goutam Brahmachari
Publisher : John Wiley & Sons
Release Date : 2015-01-20
Category : Science
Total pages :544
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Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Green Synthetic Processes and Procedures

Green Synthetic Processes and Procedures
Author : Roberto Ballini
Publisher : Royal Society of Chemistry
Release Date : 2019-06-28
Category : Science
Total pages :404
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The principles of Green Chemistry aim to improve the sustainability of chemical processes and reduce the generation of hazardous substances. There has been great growth in the field over the past few years and the number of research groups working in this area is still increasing. Now one of the biggest challenges is to embed the Green Chemistry ideals of safety and sustainability as standard, both in industry and academia. In order to do this, it is important to create resources that detail different applications and approaches. Green Synthetic Processes and Procedures brings together expert contributors from across a number of areas of green synthesis to cover a diverse array of subjects. Providing a thorough overview of the current green synthetic toolbox, from biocatalysis to sonochemistry, this book is a useful resource for any chemist wishing to design cleaner and safer processes.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Author : Bimal K. Banik
Publisher : Elsevier
Release Date : 2020-03-27
Category : Medical
Total pages :1044
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Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Green Chemistry: Synthesis of Bioactive Heterocycles

Green Chemistry: Synthesis of Bioactive Heterocycles
Author : K. L. Ameta,Anshu Dandia
Publisher : Springer
Release Date : 2014-06-17
Category : Science
Total pages :412
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The book presents a succinct summary of methods for the synthesis and biological activities of various different-sized bioactive heterocycles using different green chemistry synthetic methodologies, like microwave, ultrasonic, water mediated, ionic liquids, etc. The book also provides an insight of how green chemistry techniques are specific to the bioactive heterocyclic compounds.

Flow Chemistry for the Synthesis of Heterocycles

Flow Chemistry for the Synthesis of Heterocycles
Author : Upendra K. Sharma,Erik V. Van der Eycken
Publisher : Springer
Release Date : 2018-08-29
Category : Science
Total pages :397
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This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability. In recent times, flow chemistry has heralded a paradigm shift in organic synthesis as it offers several unique advantages over conventional methods like drastic acceleration of sluggish transformations, enhanced yields, cleaner reactions etc and is gradually gaining a lot of attention among organic chemist worldwide. Given the importance of heterocycles in natural products, medicinal chemistry and pharmaceuticals, this is a well warranted volume and complements the previous volume of Topics in Organometallic Chemistry ‘Organometallic Flow Chemistry’. This volume offers a versatile overview of the topic, besides discussing the recent progress in the flourishing area of flow chemistry in relevance to heterocyclic chemistry; it will also help researchers to better understand the chemistry behind these reactions. This in turn provides a platform for future innovations towards the designing of novel transformations under continuous flow. Thus, this volume will appeal to both the novices in this field as well as to experts in academia and industry.

Green Chemistry: Synthesis of Bioactive Heterocycles

Green Chemistry: Synthesis of Bioactive Heterocycles
Author : K. L. Ameta,Anshu Dandia
Publisher : Springer
Release Date : 2014-06-17
Category : Science
Total pages :412
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The book presents a succinct summary of methods for the synthesis and biological activities of various different-sized bioactive heterocycles using different green chemistry synthetic methodologies, like microwave, ultrasonic, water mediated, ionic liquids, etc. The book also provides an insight of how green chemistry techniques are specific to the bioactive heterocyclic compounds.

Green Synthesis of Heterocycles

Green Synthesis of Heterocycles
Author : Fabio Arico,Oliver Reiser
Publisher : Frontiers Media SA
Release Date : 2020-03-09
Category :
Total pages :129
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Small-molecule Transcription Factor Inhibitors in Oncology

Small-molecule Transcription Factor Inhibitors in Oncology
Author : David E Thurston,Khondaker Miraz Rahman
Publisher : Royal Society of Chemistry
Release Date : 2018-09-05
Category : Medical
Total pages :199
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Oncogenic transcription factors are an increasingly important target for anticancer therapies. Inhibiting these transcription factors could allow tumour cells to be "reprogrammed", leading to apoptosis or differentiation from the malignant phenotype. As the use of kinase inhibitors is gradually declining, transcription factor inhibition is the next hot topic for oncology research and merits much attention. This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors. It also presents the evidence that this important protein class can be modulated in a number of ways to develop novel classes of therapeutic agents. The broad range of aspects covered by the book is noteworthy and renders it enormously valuable. This title serves as a unique reference book for postgraduates, academic researchers and practitioners working in the fields of biochemistry, biotechnology, cell and molecular biology and bio-inorganic chemistry.

Catalyst-free Organic Synthesis

Catalyst-free Organic Synthesis
Author : Goutam Brahmachari
Publisher : Royal Society of Chemistry
Release Date : 2017-11-06
Category :
Total pages :392
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Fluorinated Heterocyclic Compounds

Fluorinated Heterocyclic Compounds
Author : Viacheslav A. Petrov
Publisher : John Wiley & Sons
Release Date : 2009-09-22
Category : Science
Total pages :432
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A thorough survey of synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles Merging organic, heterocyclic, and fluoroorganic chemistry, fluorinated heterocyclic compounds have distinctively desirable properties suitable for use in pharmaceuticals and agrichemicals, especially their ability to penetrate the cell membrane barrier for drug absorption. Offering a needed overview of this relatively new addition to the heterocyclic family, this essential reference provides the latest state-of-the-art information on key application areas within fluorine chemistry. With contributions from experts from both industry and academia, the book covers the chemistry, synthesis, and applications of fluorinated heterocycles with chapters on: Three-, four-, five-, six-, and seven-membered fluorine-containing heterocycles Fluorinated nucleosides Fluorointermediates Applications of fluorinated heterocycles in agricultural products Pharmaceuticals containing fluorinated heterocycles Technical applications of fluorinated heterocycles Written by a team of world-recognized experts in the area of organic and industrial chemistry of fluorine, Fluorinated Heterocyclic Compounds: Synthesis, Chemistry, and Applications will prove valuable to both students and researchers from academia and industry seeking further knowledge of the synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles.