November 27, 2020

Download Ebook Free Growth Factors And Their Receptors In Cell Differentiation, Cancer And Cancer Therapy

Growth Factors and their Receptors in Cancer Metastasis

Growth Factors and their Receptors in Cancer Metastasis
Author : Wen G. Jiang,K. Matsumoto,T. Nakamura
Publisher : Springer Science & Business Media
Release Date : 2006-04-11
Category : Medical
Total pages :303
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about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release Date : 2011
Category : HEALTH & FITNESS
Total pages :347
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Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.

Principles of Tumors

Principles of Tumors
Author : Leon P. Bignold
Publisher : Academic Press
Release Date : 2019-11-01
Category : Medical
Total pages :686
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Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine. Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compounds Presents translational approaches for every topic to improve conceptual insights for new research projects Covers a broad range of subjects, making it easier for the reader to understand related fields Includes diagrams for complex topics to aid in understanding for non-specialists

Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release Date : 2013-07-26
Category : Medical
Total pages :310
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Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

Molecular Approach to Cancer Management

Molecular Approach to Cancer Management
Author : Gajanan V. Sherbet
Publisher : Academic Press
Release Date : 2017-06-15
Category : Medical
Total pages :352
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Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

Growth Factors and Receptors

Growth Factors and Receptors
Author : Ian A. McKay,Kenneth D. Brown
Publisher : OUP Oxford
Release Date : 1998-07-02
Category : Medical
Total pages :288
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Growth Factors and Receptors: A Practical Approach provides comprehensive protocols for studies of growth factors and their interactions with receptors. It covers a wide range from simple analytical techniques to sophisticated in vivo applications including: RT-PCR and immunocytochemistry for detection of growth factors and receptors; production and purification of recombinant growth factors and receptors; labelling of growth factors for binding studies; in vivo mutagenesis; the yeast two-hybrid assay of proteinprotein interactions; phage display of factors; application of factors to wound-healing processes using the gene gun; treatment of cancers with factor/toxin chimeras; and analysis of important factor domains using chimeric proteins. This book updates and extends the current literature and describes important novel approaches to the study of growth factors and their receptors, including the use of RNA aptamers as receptor antagonists, and the development of receptor superantagonists. It will be of tremendous value to both researchers and teachers, and, through an appendix that lists a large number of growth factors and receptors, will serve as a handy reference text.

Molecular Basis of Thyroid Cancer

Molecular Basis of Thyroid Cancer
Author : NADIR R. FARID
Publisher : Springer Science & Business Media
Release Date : 2006-02-03
Category : Medical
Total pages :444
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- This series is indexed in index Medicus - The turn around time for this series is fast, making the research as accurate as a journal

Cytokines and Cancer

Cytokines and Cancer
Author : Leonidas C. Platanias
Publisher : Springer Science & Business Media
Release Date : 2005-03-04
Category : Medical
Total pages :378
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The first book to cover both basic science and clinical research, providing a comprehensive review of the current knowledge on cytokines and cancer. Written by leading figures in the field of cytokine biology and cytokine therapeutics.

Prostate Cancer

Prostate Cancer
Author : John N. Lucas
Publisher : Nova Publishers
Release Date : 2004
Category : Medical
Total pages :243
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Prostate cancer is one of the most common type of cancer in men (other than skin cancer). Of all the men who are diagnosed with cancer each year, more than one-fourth have prostate cancer. This book includes within its scope the prevention, risk factors, symptoms, diagnosis, treatment and rehabilitation of prostate cancer. Leading-edge scientific research from throughout the world is presented.

Cancer Therapy

Cancer Therapy
Author : Hans G. Beger,Markus Büchler,Ralph A. Reisfeld,Gregor Schulz
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :308
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A variety of new cancer therapy modalities are discussed and evaluated in this book. It aims to demonstrate that the combination of classical chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-CSF and monoclonal antibodies against gastrointestinal tumors and melanoma are included. The progress in regional chemotherapy strategies, for example of the liver, is shown. In addition, the development of new chemotherapeutic agents with a different mode of action as well as better tolerability is presented. The use of hormones, such as LH-RH agonists, allows hormone-dependent tumors such as prostatic and breast cancer to be treated without strong adverse reactions. These recent findings give the reader insight into exciting therapeutic directions made possible by such combined, rather than single, modalities.

Abeloff's Clinical Oncology E-Book

Abeloff's Clinical Oncology E-Book
Author : John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
Publisher : Elsevier Health Sciences
Release Date : 2013-09-12
Category : Medical
Total pages :2224
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Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Transforming Growth Factor-Beta in Cancer Therapy, Volume I
Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
Release Date : 2010-01-01
Category : Medical
Total pages :735
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Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Viral Therapy of Cancer

Viral Therapy of Cancer
Author : Kevin J. Harrington
Publisher : John Wiley & Sons
Release Date : 2008-05-23
Category : Science
Total pages :432
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In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient. Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer Describes the use of viruses as oncolytic agents, killing cells directly Editors are experts in the field, with experience of both laboratory and clinical research Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.

Transforming Growth Factor-Beta in Cancer Therapy, Volume II

Transforming Growth Factor-Beta in Cancer Therapy, Volume II
Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
Release Date : 2010-01-01
Category : Medical
Total pages :786
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Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

The Molecular Basis of Cancer

The Molecular Basis of Cancer
Author : Peter B. Farmer,John M. Walker
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Juvenile Nonfiction
Total pages :349
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This book aims to describe the current state of knowledge and possible future developments in a number of major areas of research into the nature, causes and treatment of cancer. The contributing authors have been encouraged to discuss their subjects at the molecular level. It will become apparent to the reader that considerable developments in the understanding of the fundamental nature of cancer, in molecular terms, are constantly being made. This is particularly the case in the area of oncogene research where differences between tumour and normal cells can now be defined in terms of altered expression of DNA sequences. An understanding of the methods available for detecting cancer, of the process of carcinogenesis and of the means available for treating cancer can only be achieved with a precise knowledge of the basic biochemical and molecular processes involved. Since it is all to easy for the research scientist to become totally absorbed within the specialised area of research in which he is involved, the first chapter is an attempt to encourage a broader field of vision by introducing the clinician's view of the cancer problem, which illustrates the broad spectrum of basic problems that need to be solved by the cancer researcher.