November 30, 2020

Download Ebook Free Haschek And Rousseaux’s Handbook Of Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology
Author : Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig
Publisher : Academic Press
Release Date : 2013-05-01
Category : Medical
Total pages :3054
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Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Handbook of Toxicologic Pathology

Handbook of Toxicologic Pathology
Author : Haschek, Wanda M,Colin George Rousseaux,Matthew A. Wallig
Publisher : San Diego : Academic Press
Release Date : 2002
Category : Pathology, Experimental Handbooks, manuals, etc.
Total pages :129
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A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic Pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicology Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology. This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury. Key Features * Easy to find, up-to-date reference information * Graphic and photographic plates * Current hot topics and anticipated changes in toxicologic pathology * Standardized chapter format * Topics that are addressed in both a broad and deep manner, resulting in a stand alone text * Added coverage of important environmental toxicants * Chapters authored by internationally recognized experts and peer-reviewed.

Fundamentals of Toxicologic Pathology

Fundamentals of Toxicologic Pathology
Author : Wanda M. Haschek,Colin G. Rousseaux
Publisher : Gulf Professional Publishing
Release Date : 1998
Category : Medical
Total pages :563
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Fundamentals of Toxicologic Pathology is an enhanced and edited version of the Handbook of Toxicologic Pathology. The editors have created a more concise and affordable text for students in toxicologic pathology and scientists working in academia or industry. This volume focuses on providing basic information integrated from both toxicology and pathology dealing with the mechanisms of toxic injury and morphologic expression of that injury at subcellular, cellular, and tissue levels. The text addresses basic principles of toxicologic pathology and deals systematically with organ-specific injuries.

Toxicologic Pathology

Toxicologic Pathology
Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard
Publisher : CRC Press
Release Date : 2018-08-31
Category : Medical
Total pages :1224
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Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Toxicology Handbook

Toxicology Handbook
Author : Lindsay Murray,Mark Little,Ovidiu Pascu,Kerry Hoggett
Publisher : Elsevier Health Sciences
Release Date : 2015-02-16
Category : Medical
Total pages :560
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Toxicology Handbook is a practical evidence-based guide on the care of the poisoned patient. This concise text is informed by the latest clinical research and takes a rigorous and structured risk assessment-based approach to decision making in the context of clinical toxicology. It assists the clinician to quickly find information on poisons, toxins, antidotes, envenomings and antivenoms and determine the appropriate treatment for the acutely poisoned patient. Guides clinicians through drug administration and treatmentIncludes 'handy tips' and 'pitfalls'Incorporates drug dosages and administration are based on current pharmacological regulations Content on drug dosage and administration based on the most up-to-date pharmacological regulations on toxicologyGeographical locations of envenomings from snakes, spiders and jellyfish are portrayed on illustrated mapsNew subchapters include Newer oral anticoagulants (NOACs) and Paracetamol: Modified release formulations

A Complete Guide to Quality in Small-Scale Wine Making

A Complete Guide to Quality in Small-Scale Wine Making
Author : John Anthony Considine,Elizabeth Frankish
Publisher : Academic Press
Release Date : 2013-11-21
Category : Technology & Engineering
Total pages :224
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As the wine industry has experienced a period of rapid global expansion, there is a renewed emphasis on quality and consistency even within the small winery industry. Written for the small production program, A Complete Guide to Quality in Small-Scale Wine Making is for the novice to intermediate level winemaker seeking foundational information in chemistry and sensory science as they relate to wine quality at a technical level. Drawing from personal experience as well as scientific literature, this book introduces the core concepts of winemaking before delving into methods and analysis to provide practical insights into creating and maintaining quality in the wine product. Understand the chemistry and sensory science at the foundation of quality wines Explore real-world examples of key analysis and application of concepts Practice methods and exercises for hands-on experience

The Role of the Study Director in Nonclinical Studies

The Role of the Study Director in Nonclinical Studies
Author : William J. Brock,Barbara Mounho,Lijie Fu
Publisher : John Wiley & Sons
Release Date : 2014-05-02
Category : Science
Total pages :560
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A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry

Ruminant Toxicology, An Issue of Veterinary Clinics: Food Animal Practice - E-Book

Ruminant Toxicology, An Issue of Veterinary Clinics: Food Animal Practice - E-Book
Author : Gary Osweiler
Publisher : Elsevier Health Sciences
Release Date : 2011-07-01
Category : Medical
Total pages :296
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Guest Editor Gary Osweiler presents a comprehensive look at ruminant toxicology. Topics will include biofuels co-products tolerance and toxicology for ruminants, diagnostic toxicology for ruminants, metal/mineral poisoning and interactions, reproductive toxicants in forage and grain crops, ruminant mycotoxicoses, antidotes and therapy for ruminant toxicants, western plant hazardous to ruminants, southeastern toxic plants affecting ruminants, northeastern plants toxic to ruminants, industrial and commercial products affecting ruminants, water quality and ruminant health and productivity, ,and much more!

Principles of Toxicology

Principles of Toxicology
Author : Phillip L. Williams,Robert C. James,Stephen M. Roberts
Publisher : John Wiley & Sons
Release Date : 2003-10-10
Category : Science
Total pages :624
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Ethical Justice

Ethical Justice
Author : Brent E. Turvey,Stan Crowder
Publisher : Academic Press
Release Date : 2013-06-07
Category : Law
Total pages :496
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This textbook was developed from an idiom shared by the authors and contributors alike: ethics and ethical challenges are generally black and white - not gray. They are akin to the pregnant woman or the gunshot victim; one cannot be a little pregnant or a little shot. Consequently, professional conduct is either ethical or it is not. Unafraid to be the harbingers, Turvey and Crowder set forth the parameters of key ethical issues across the five pillars of the criminal justice system: law enforcement, corrections, courts, forensic science, and academia. It demonstrates how each pillar is dependent upon its professional membership, and also upon the supporting efforts of the other pillars - with respect to both character and culture. With contributions from case-working experts across the CJ spectrum, this text reveals hard-earned insights into issues that are often absent from textbooks born out of just theory and research. Part 1 examines ethic issues in academia, with chapters on ethics for CJ students, CJ educators, and ethics in CJ research. Part 2 examines ethical issues in law enforcement, with separate chapters on law enforcement administration and criminal investigations. Part 3 examines ethical issues in the forensic services, considering the separate roles of crime lab administration and evidence examination. Part 4 examines ethical issues in the courts, with chapters discussing the prosecution, the defense, and the judiciary. Part 5 examines ethical issues in corrections, separately considering corrections staff and treatment staff in a forensic setting. The text concludes with Part 6, which examines ethical issues in a broad professional sense with respect to professional organizations and whistleblowers. Ethical Justice: Applied Issues for Criminal Justice Students and Professionals is intended for use as a textbook at the college and university, by undergraduate students enrolled in a program related to any of the CJ professions. It is intended to guide them through the real-world issues that they will encounter in both the classroom and in the professional community. However, it can also serve as an important reference manual for the CJ professional that may work in a community that lacks ethical mentoring or leadership. First of its kind overview of the five pillars of criminal justice: academia, law enforcement, forensic services, courts and corrections Written by practicing criminal justice professionals, from across every pillar Offers a realistic overview of ethical issues confronted by criminals justice students and professionals Examines sensitive subjects often ignored in other criminal justice ethics texts Numerous cases examples in each chapter to facilitate instruction and learning

MATLAB for Neuroscientists

MATLAB for Neuroscientists
Author : Pascal Wallisch,Michael E. Lusignan,Marc D. Benayoun,Tanya I. Baker,Adam Seth Dickey,Nicholas G. Hatsopoulos
Publisher : Academic Press
Release Date : 2014-01-09
Category : Computers
Total pages :570
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MATLAB for Neuroscientists serves as the only complete study manual and teaching resource for MATLAB, the globally accepted standard for scientific computing, in the neurosciences and psychology. This unique introduction can be used to learn the entire empirical and experimental process (including stimulus generation, experimental control, data collection, data analysis, modeling, and more), and the 2nd Edition continues to ensure that a wide variety of computational problems can be addressed in a single programming environment. This updated edition features additional material on the creation of visual stimuli, advanced psychophysics, analysis of LFP data, choice probabilities, synchrony, and advanced spectral analysis. Users at a variety of levels—advanced undergraduates, beginning graduate students, and researchers looking to modernize their skills—will learn to design and implement their own analytical tools, and gain the fluency required to meet the computational needs of neuroscience practitioners. The first complete volume on MATLAB focusing on neuroscience and psychology applications Problem-based approach with many examples from neuroscience and cognitive psychology using real data Illustrated in full color throughout Careful tutorial approach, by authors who are award-winning educators with strong teaching experience

Handbook of Arsenic Toxicology

Handbook of Arsenic Toxicology
Author : Swaran Jeet Singh Flora
Publisher : Academic Press
Release Date : 2014-12-26
Category : Medical
Total pages :752
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Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasure

Introduction to Environmental Toxicology

Introduction to Environmental Toxicology
Author : Wayne Landis,Ruth Sofield,Ming-Ho Yu
Publisher : CRC Press
Release Date : 2017-09-29
Category : Science
Total pages :470
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The fifth edition includes new sections on the use of adverse outcome pathways, how climate change changes how we think about toxicology, and a new chapter on contaminants of emerging concern. Additional information is provided on the derivation of exposure-response curves to describe toxicity and they are compared to the use of hypothesis testing. The text is unified around the theme of describing the entire cause-effect pathway from the importance of chemical structure in determining exposure and interaction with receptors to the use of complex systems and hierarchical patch dynamic theory to describe effects to landscapes.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
Publisher : Academic Press
Release Date : 2015-03-13
Category : Medical
Total pages :716
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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Histopathology of Preclinical Toxicity Studies

Histopathology of Preclinical Toxicity Studies
Author : Peter Greaves
Publisher : Elsevier Science Limited
Release Date : 1990
Category : Science
Total pages :824
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Histopathological assessment of tissue sections is an important componant of many preclinical studies which are conducted to support the safety and clinical development of novel therapeutic agents for use in the treatment of human diseases. The drug discovery process, aided by modern biotechnology, is now capable of generating highly potent, pharmacologically active agents which can give rise to quite unusual constellations of tissue pathology. The complexity and the number of histopathological findings in individual studies indicate the need for lucididy in descriptions and conclusions. In the light of these and other difficulties, this text is aimed towards bringing together into one volume a description of histopathological changes which relate to toxicity testing of therapeutic agents in the usual test species: rat, mouse, dog and non-human primate. This book is an excellent starting point for the analysis of drug-induced findings in toxicity studies.