June 16, 2021

Download Ebook Free Hematopoietic Cell Transplantation For Malignant Conditions

Hematopoietic Cell Transplantation for Malignant Conditions

Hematopoietic Cell Transplantation for Malignant Conditions
Author : Qaiser Bashir,Mehdi Hamadani
Publisher : Elsevier Health Sciences
Release Date : 2019-02-14
Category : Medical
Total pages :438
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Get a quick, expert overview of hematologic and non-hematologic malignancies for which hematopoietic cell transplantation is a treatment option. Drs. Qaiser Bashir and Mehdi Hamadani provide easy-to-find information on basic science of hematopoietic cell transplantation, pharmacology, workflows and procedures, possible complications and side effects, in addition to the role of HCT in conjunction with clinical cellular therapy. Discusses high-dose chemotherapeutic regimens and radiation therapy, patient and donor selection and workup, as well as other key aspects of hematopoietic cell transplantation. Includes practical information on complications, infectious disease, and special populations such as patients with HIV infection. Consolidates today’s available information in this fast-changing area into one convenient resource.

Thomas' Hematopoietic Cell Transplantation

Thomas' Hematopoietic Cell Transplantation
Author : Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Publisher : John Wiley & Sons
Release Date : 2015-12-14
Category : Medical
Total pages :1416
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Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Thomas' Hematopoietic Cell Transplantation

Thomas' Hematopoietic Cell Transplantation
Author : Karl G. Blume,Stephen J. Forman,Frederick R. Appelbaum
Publisher : John Wiley & Sons
Release Date : 2008-04-15
Category : Medical
Total pages :1600
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NEW - the leading book in its field now fully updated and revised! Click here to access two FREE sample chapters! An Essential resource for all hematologists, oncologists, pathologists, pediatricians, immunologists and all others interested in this dynamic area of medicine! Why you should buy this book.... Extensive coverage of subject area - from the scientific basis to the view of the future Includes all experimental research and clinical application Combined the knowledge and expertise of over 170 international specialists Clear structure and layout Over 500 illustrations, including a colour plate section Why buy the NEW edition...... New and fully revised to reflect the latest developments in this fast moving field 10 new chapters, covering some of the latest developments - see below for the complete tables of content

Hematopoietic Cell Transplantation in Children with Cancer

Hematopoietic Cell Transplantation in Children with Cancer
Author : Franklin O. Smith,Gregory H. Reaman,Judy M. Racadio
Publisher : Springer Science & Business Media
Release Date : 2013-11-26
Category : Medical
Total pages :358
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This book is a comprehensive and up-to-date compendium on all aspects of blood and marrow transplantation in children. After an introductory chapter describing the history of pediatric blood and marrow transplantation, subsequent chapters discuss pediatric-specific aspects of transplantation, including stem cell sources suitable for transplantation, preparative regimens, graft-versus-host disease, complications related to transplantation, and late effects. The role of blood and marrow transplantation in various specific pediatric diseases is then examined, and the closing chapter considers future directions. The authors are all internationally recognized experts and offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric diseases that are treatable with blood and marrow transplantation and will prove invaluable to specialists, generalists, and trainees alike.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
Author : Jennifer Treleaven,Austin John Barrett
Publisher : Churchill Livingstone
Release Date : 2009
Category : Medical
Total pages :555
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A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.

Stem Cell Transplantation for Hematologic Malignancies

Stem Cell Transplantation for Hematologic Malignancies
Author : Robert J. Soiffer
Publisher : Springer Science & Business Media
Release Date : 2004-01-29
Category : Medical
Total pages :486
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A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.

Mycophenolate Mofetil Pharmacology and Bioavailability in Hematopoietic Cell Transplantation for Malignant Diseases

Mycophenolate Mofetil Pharmacology and Bioavailability in Hematopoietic Cell Transplantation for Malignant Diseases
Author : Kathleen Germaine Evans Green
Publisher : Unknown
Release Date : 2005
Category : Antibiotics
Total pages :104
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Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
Author : Robert J. Soiffer
Publisher : Springer Science & Business Media
Release Date : 2008-11-14
Category : Medical
Total pages :736
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Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

Allogeneic Immunotherapy for Malignant Diseases

Allogeneic Immunotherapy for Malignant Diseases
Author : John Barrett,Yin-Zhen Jiang
Publisher : CRC Press
Release Date : 2000-01-27
Category : Medical
Total pages :408
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This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.

Blood Stem Cell Transplantation

Blood Stem Cell Transplantation
Author : Jane N. Winter
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :416
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Blood Stem Cell Transplantation conveys the excitement that accompanies the newest developments in hematopoietic stem cell transplantation. Some of the applications that stand to impact this field most significantly are based on recent advances in the biological sciences, as demonstrated by the chapters on gene therapy, on the detection of minimal residual disease using molecular techniques, and on the use of radioimmunoconjugates targeting lymphoma and leukemia-associated antigens. Others are the results of clinical observations - e.g., the association between graft-versus-host- disease (GVHD) and durable remissions that have led to creative clinical experiments such as donor leukocyte infusions (DLI). Attempts to unravel the biological events that underlie the responses seen in patients with relapsed chronic myelogenous leukemia treated with DLI are likely to provide the basis for future refinements in this clinical approach. Hopefully, improved response rates and reduced toxicity will result. The power of the immunologic response in controlling malignant disease is underscored in the chapter on post-transplant immunotherapy. The complex immunologic process that results in clinical GVHD may be dissected and engineered to provide clinical benefits that include, in addition to its antineoplastic effects, the amelioration of its clinical manifestations. Better control of GVHD with less global immunosuppression will facilitate the use of mismatched and unrelated donors. This area of investigation perfectly illustrates the continued interplay between the laboratory and the clinic. The continued cross-fertilization of ideas between immunologists, molecular biologists and clinical investigators is likely to yield important advances in this field for years to come. Possible applications of stem cell transplantation continue to grow with the identification of alternative sources of stem cells and the potential to engineer and/or expand the graft. Although the use of unrelated and mismatched donors continues to increase, the possibilities associated with umbilical cord blood transplantation are legion, especially if stem cells can be expanded ex vivo to provide grafts for full-sized adults. Using techniques in which contaminating malignant cells may be eliminated from autografts through positive selection, autologous transplantation may prove highly effective, especially when coupled with post-transplant immunotherapy. Some of these same methodologies have helped facilitate the use of autologous grafts for transplantation in patients with chronic myelogenous leukemia without allogeneic donors. Advances in the supportive care of transplant patients, including the pretransplant identification of those at risk from pulmonary complications and the use of cytokines to speed engraftment, have reduced morbidity and mortality to such a degree that it is appropriate to consider high-dose therapy and stem cell reconstitution in patients with nonmalignant diseases. The impressive advances that have occurred in transplantation for thalassemia are described by pioneers in their area of investigation. The burgeoning field of transplantation for autoimmune disorders, including its immunobiologic basis and soon-to- be-realized clinical potential, is also summarized. Continued progress in the use of high-dose therapy with stem cell rescue for the treatment of pediatric tumors, which derives in part from improved supportive care, is detailed. The sobering voice of the health care economists underscores the necessary limitations to our seemingly unbridled imagination. Cost- consciousness and financial know-how will need to be reflected in future study designs. Given the seemingly endless applications of our technology, strategies to insure its cost-effectiveness will be necessary. Continued financial support for laboratory investigation and for the clinical experiments they generate will be required if we are to go forward. Blood Stem Cell Transplantation lays the foundation for many of these future advances; it is incumbent upon us all to insure its realization.

Thomas' Hematopoietic Cell Transplantation

Thomas' Hematopoietic Cell Transplantation
Author : Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Publisher : John Wiley & Sons
Release Date : 2015-12-23
Category : Medical
Total pages :1416
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Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
Author : Michael R. Bishop
Publisher : Springer Science & Business Media
Release Date : 2009-09-25
Category : Medical
Total pages :589
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The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

Blood and Marrow Transplant Handbook

Blood and Marrow Transplant Handbook
Author : Richard T. Maziarz
Publisher : Springer Nature
Release Date : 2021
Category :
Total pages :129
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Establishing a Hematopoietic Stem Cell Transplantation Unit

Establishing a Hematopoietic Stem Cell Transplantation Unit
Author : Éliane Gluckman,Dietger Niederwieser,Mahmoud Aljurf
Publisher : Springer
Release Date : 2017-11-17
Category : Medical
Total pages :306
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This text aims to provide simplified practical guidelines to start a hematopoietic stem cell transplantation unit which could be implemented in most centers and countries worldwide. The book also provides guidelines for existing transplantation units to upgrade their practice and implement new policies and procedures, in addition to developing therapies according to latest international standards and regulations. The book covers a wide range of practical implementation tools including HSCT program team structure, building inpatient and outpatient HSCT units, requisite laboratory support for transplantation program, practical aspects of stem cell collection and processing, HSCT program quality management, education and training, and data management. The book also addresses cost effectiveness and recommendations for establishing transplantation program in countries with limited resources. Written by group of internationally established experts in their corresponding hematopoietic stem cell transplantation fields, with contributions from many leaders of hematopoietic stem cell transplantation organizations, Establishing a Hematopoietic Stem Cell Transplantation Unit: A Practical Guide is an essential, practical resource for all members of the multidisciplinary hematopoietic stem cell transplantation team.

Blood and Marrow Transplantation Long Term Management

Blood and Marrow Transplantation Long Term Management
Author : Bipin N. Savani
Publisher : John Wiley & Sons
Release Date : 2021-06-28
Category : Medical
Total pages :416
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Hematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances have been made in the field of HCT, to the point where HCT has become an integral part of treatment modality for a variety of hematologic malignancies and some nonmalignant diseases. HCT remains an important treatment option for a wide variety of hematologic and nonhematologic disorders, despite recent advances in the field of immunologic therapies. Factors driving this growth include expanded disease indications, greater donor options (expanding unrelated donor registries and haploidentical HCT), and accommodation of older and less fit recipients. The development of less toxic pretransplant conditioning regimens, more effective prophylaxis of graft-versus-host disease (GVHD), improved infection control, and other advances in transplant technology have resulted in a rapidly growing number of transplant recipients surviving long-term free of the disease for which they were transplanted. The changes over decades in the transplant recipient population and in the practice of HCT will have almost inevitably altered the composition of the long-term survivor population over time. Apart from an increasingly older transplant recipient cohort, the pattern of transplant indications has shifted from the 1990s when chronic myeloid leukemia made up a significant proportion of allo-HCT indications. Changes in cell source, donor types, conditioning regimens, GVHD prophylaxis, and supportive care have all occurred, with ongoing reductions in both relapse and non-relapse mortality (NRM) have been demonstrated. These patients have increased risks for a variety of late complications, which can cause morbidity and mortality. Most long-term survivors return to the care of their local hematologists/oncologists or primary care physicians, who may not be familiar with specialized monitoring and management of long complications after HCT for this patient population. As HCT survivorship increases, the focus of care has shifted to the identification and treatment of long-term complications that may affect quality of life and long-term morbidity and mortality. Preventive care as well as early detection and treatments are important aspects to reducing morbidity and mortality in long-term survivors after allo-HCT. This second edition, Blood and Marrow Transplantation Long-Term Management: Survivorship after Transplant, provides up-to-date information about diagnosis, screening, treatment, and long-term surveillance of long-term survivors after HCT.