June 13, 2021

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In Situ Molecular Pathology and Co-Expression Analyses

In Situ Molecular Pathology and Co-Expression Analyses
Author : Gerard J. Nuovo
Publisher : Academic Press
Release Date : 2013-02-07
Category : Science
Total pages :298
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In Situ Molecular Pathology and Co-Expression Analyses explains, in easy-to-understand language, simplified ways of understanding and performing in situ hybridization and immunohistochemistry tests. The book also focuses on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses. The fields of in situ hybridization and immunohistochemistry have expanded rapidly due to the use of computer-based analysis. To get the most out of these automated platforms, researchers and diagnostic biomedical investigators must have a solid understanding of the basics of in situ-based tests, protocols, and regimens for troubleshooting. Practicing molecular pathologists, clinical chemists, and toxicologists, as well as clinicians and researchers in training, will benefit from this book's clear presentation of protocols and theoretical framework. Includes over 200 easy-to-follow experimental protocols Features chapter-ending summaries of "Key Points to Remember" to bring beginners up to speed with any seasoned veteran in the field Offers two chapters written by industry leaders in the fields of in situ hybridization, immunohistochemistry, and computer software for co-expression analyses

In Situ Molecular Pathology and Co-expression Analyses

In Situ Molecular Pathology and Co-expression Analyses
Author : Gerard J. Nuovo
Publisher : Academic Press
Release Date : 2020-09-14
Category : Science
Total pages :418
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Major advancements in the field of in situ molecular pathology have occurred since publication of the first edition. In Situ Molecular Pathology and Co-expression Analyses, Second Edition, continues to teach both the molecular basis for the improvements and the actual protocols. This is the unique feature that separates it from the pack of other "cook-book" type approaches. The fields of in situ hybridization and immunohistochemistry have expanded rapidly where computer-based analyses systems have greatly expanded the power of these methods. Further, knowledge of the marked improvements in the reagents themselves since the first edition can make the difference of excellent versus misleading data. The automated platforms require that researchers and diagnostic biomedical investigators have a good understanding of the basics of in situ based tests, protocols, and biochemistry for troubleshooting in order to maximize the use of these platforms. This second edition focuses attention on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses. Practicing molecular pathologists, diagnostic pathologists, laboratory directors, and toxicologists, as well as clinicians and researchers in training, will benefit from this clear presentation of protocols and theoretical framework. Data derived from in situ hybridization and immunohistochemistry. Explains the theory and foundation of immunohistochemistry and in situ hybridization and presents easy-to-follow experimental protocols with tricks of the trade Includes two new chapters: Recent improvements in immunohistochemistry and in situ hybridization, Quality control for immunohistochemistry and in situ hybridization: How to know if the color change is signal or background The second edition also includes a detailed test to help one learn the basics of histologic interpretation of tissues and a separate detailed test in how to differentiate signal from background Includes chapter-ending summaries of Key Points to Remember, bringing beginners up to speed with any seasoned veteran in the field Thoughtfully tackles the molecular basis if IHC and ISH, along with application of that knowledge to improving the techniques is significant

Pituitary Adenomas

Pituitary Adenomas
Author : Alex M. Landolt,Mary Lee Vance,P. L. Reilly
Publisher : W.B. Saunders Company
Release Date : 1996
Category : Medical
Total pages :540
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This text on pituitary adenomas is divided into three sections, covering their biology and pathology, clinical findings and diagnosis, and their treatment.

Archives of Pathology & Laboratory Medicine

Archives of Pathology & Laboratory Medicine
Author : Anonim
Publisher : Unknown
Release Date : 2008
Category : Diagnosis, Laboratory
Total pages :129
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Annual report

Annual report
Author : National Cancer Institute (U.S.). Division of Cancer Biology, Diagnosis, and Centers
Publisher : Unknown
Release Date : 1994
Category : Health & Fitness
Total pages :129
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New Scientist

New Scientist
Author : Anonim
Publisher : Unknown
Release Date : 2000-08
Category : Science
Total pages :129
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Pathology of the Gastrointestinal Tract

Pathology of the Gastrointestinal Tract
Author : Si-Chun Ming,Harvey Goldman
Publisher : Lippincott Williams & Wilkins
Release Date : 1998
Category : Medical
Total pages :988
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ICN

ICN
Author : ICN Biomedicals, Inc
Publisher : Unknown
Release Date : 1995
Category : Biotechnology
Total pages :129
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Molecular Diagnostics in Pathology

Molecular Diagnostics in Pathology
Author : Cecilia M. Fenoglio-Preiser,Cheryl L. Willman
Publisher : Unknown
Release Date : 1991
Category : Medical
Total pages :379
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Polymerase chain reaction cytogenetics & molecular cytoge- netics/disease assoc. polymorphisms & genetic linkage anlys

Tissue Microarrays

Tissue Microarrays
Author : Ronald Simon
Publisher : Humana
Release Date : 2010-08-19
Category : Science
Total pages :193
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Today’s tissue microarray (TMA) method presents as a modern high-tech technology, one which allows for the linking of clinical data to the tissues that are combined on one slide. In Tissue Microarrays: Methods and Protocols, expert researchers explore the current world of TMA making and TMA applications, providing insight into the inherent and complex aspects of the most popular assays used for in-situ tissue analysis. Chapters examine the range of TMA techniques that allow for a large number of tissues to be included in one TMA, preserve the integrity of donor tissue blocks, and present a highly organized array pattern that allows for the reliable allocation of clinical data to individual tissue spots. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Contemporary and ground-breaking, Tissue Microarrays: Methods and Protocols serves as an essential handbook for pathologists, molecular biologists, researchers in the life sciences, as well as physicians, a reflection of the various applications of current TMA technology.

Science & Culture

Science & Culture
Author : Anonim
Publisher : Unknown
Release Date : 2004
Category : Electronic journals
Total pages :129
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Cancer Research

Cancer Research
Author : Anonim
Publisher : Unknown
Release Date : 2003
Category : Cancer
Total pages :129
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Molecular Biology in Cellular Pathology

Molecular Biology in Cellular Pathology
Author : John Crocker,Paul G. Murray
Publisher : John Wiley & Sons
Release Date : 2003-09-12
Category : Science
Total pages :400
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The latest edition of this highly successful text, covers the major advances in the methods used in cellular and molecular pathology. In recent years, knowledge of the molecular organization of the cell has led to the development of powerful new techniques that bring greater accuracy and objectives to the diagnosis, prognosis and management of many diseases and to the study of pathological states. This book describes the latest molecular techniques available for the analysis of diseases. In particular it includes new techniques using fluorescent dyes, DNA microarrays, protein chemistry, and mass spectrometry. It also incorporates information from the Human Genome Project, and the new disciplines of genomics and proteomics, where relevant to pathology. Color plates are a new feature of this edition, illustrating the advances in fluorescence labeling of cells.

Surgical Pathology of the Pituitary Gland

Surgical Pathology of the Pituitary Gland
Author : Ricardo V. Lloyd
Publisher : W B Saunders Company
Release Date : 1993
Category : Medical
Total pages :257
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Intended for pathologists and endocrinologists, this book covers the diagnosis, surgical and medical treatment of pituitary adenomas. It includes special techniques used to study pituitary adenomas, including electron microscopy, cell culture and molecular biology. The text combines traditional morphologic approaches with more recent information derived from studies with the tools of the new biology. It combines extensive coverage of diagnosis with various aspects of the pituitary adenomas. The integrated approach provides a foundation for making specific diagnoses of pituitary disorders and also indicates the future directions of pituitary pathology. The emphasis is on diagnostic criteria for pituitary tumours. Chapters on medical and surgical management of pituitary adenomas provide a balanced perspective on the approach to the patient with pituitary tumours.

Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas

Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas
Author : M. A. Hayat
Publisher : Elsevier
Release Date : 2005-01-31
Category : Science
Total pages :492
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Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today. This book is the second volume of three planned, individually-sold volumes on this topic. Like Volume 1, this book fully explains the principles and applications of modern techniques used in the field of molecular genetics. It will be of particular interest to pathologists and molecular pathologists conducting both academic and/or clinical research. The only book available that translates molecular genetics into cancer diagnosis The results of each Immunohistochemical and in situ hybridization method are presented in the form of color illustrations Methods discussed were either developed or refined by expert contributors in their own laboratories