December 5, 2020

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Industrial Process Scale-up

Industrial Process Scale-up
Author : Jan Harmsen
Publisher : Elsevier
Release Date : 2013-04-25
Category : Technology & Engineering
Total pages :112
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This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Industrial Process Scale-Up

Industrial Process Scale-Up
Author : Jan Harmsen
Publisher : Elsevier Science Limited
Release Date : 2013
Category : Science
Total pages :116
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This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Scale-up Methodology for Chemical Processes

Scale-up Methodology for Chemical Processes
Author : Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier
Publisher : Editions TECHNIP
Release Date : 1993
Category : Technology & Engineering
Total pages :240
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Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Scaleup and Design of Industrial Mixing Processes

Scaleup and Design of Industrial Mixing Processes
Author : Gary B. Tatterson
Publisher : Unknown
Release Date : 2003
Category : Technology & Engineering
Total pages :392
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Mistakes in process scaleup can be costly. This text is a comprehensive and highly practical source to all types of mixing and scaleup issues.

Pharmaceutical Process Scale-Up, Third Edition

Pharmaceutical Process Scale-Up, Third Edition
Author : Michael Levin
Publisher : CRC Press
Release Date : 2011-02-02
Category : Medical
Total pages :530
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The third edition of Pharmaceutical Process Scale-Up deals with the theory and practice of scale-up in the pharmaceutical industry. This thoroughly revised edition reflects the rapid changes in the field and includes: New material on tableting scale-up and compaction. Regulatory appendices that cover FDA and EU Guidelines. New chapters on risk evaluation and validation as related to scale-up. Practical advice on scale-up solutions from world renowned experts in the field. Pharmaceutical Process Scale-Up, Third Edition will provide an excellent insight in to the practical aspects of the process scale-up and will be an invaluable source of information on batch enlargement techniques for formulators, process engineers, validation specialists and quality assurance personnel, as well as production managers. It will also provide interesting reading material for anyone involved in Process Analytical Technology (PAT), technology transfer and product globalization.

Process Understanding

Process Understanding
Author : Ian Houson
Publisher : John Wiley & Sons
Release Date : 2011-06-09
Category : Science
Total pages :370
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Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Chemical Projects Scale Up

Chemical Projects Scale Up
Author : Joe M. Bonem
Publisher : Elsevier
Release Date : 2018-05-31
Category : Technology & Engineering
Total pages :232
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Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Scale-up in Chemical Engineering

Scale-up in Chemical Engineering
Author : Marko Zlokarnik
Publisher : John Wiley & Sons
Release Date : 2006-08-21
Category : Science
Total pages :296
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Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Scaleup of Chemical Processes

Scaleup of Chemical Processes
Author : Attilio Bisio,Bisio,Robert Lynn Kabel,Robert L. Kabel
Publisher : Wiley-Interscience
Release Date : 1985-07-25
Category : Science
Total pages :699
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The focus of this book is on the technical factors that are critical to th e design and startup of a commercial manufacturing facility.

Scaling Chemical Processes

Scaling Chemical Processes
Author : Jonathan Worstell
Publisher : Butterworth-Heinemann
Release Date : 2016-10-27
Category : Technology & Engineering
Total pages :186
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Scaling Chemical Processes: Practical Guides in Chemical Engineering is one of a series of short texts that each provides a focused introductory view on a single subject. The full library spans the main topics in the chemical process industries for engineering professionals who require a basic grounding in various related topics. They are ‘pocket publications’ that the professional engineer can easily carry with them or access electronically while working. Each text is highly practical and applied, and presents first principles for engineers who need to get up to speed in a new area fast. The focused facts provided in each guide will help you converse with experts in the field, attempt your own initial troubleshooting, check calculations, and solve rudimentary problems. This book discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant. It bases scaling on similarity principles and uses dimensional analysis to derive the dimensionless parameters necessary to ensure a successful chemical process development program. This series is fully endorsed and co-branded by the IChemE, and they help to promote the series. Offers practical, short, concise information on the basics to help you get an answer or teach yourself a new topic quickly Includes industry examples to help you solve real world problems Provides key facts for professionals in convenient single subject volumes Discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant

Pharmaceutical Process Scale-Up, Second Edition

Pharmaceutical Process Scale-Up, Second Edition
Author : Michael Levin
Publisher : Informa Health Care
Release Date : 2005-10-18
Category : Medical
Total pages :576
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Keeping pace with the increased influence of PAT in the pharmaceutical industry, this completely updated reference spans the latest research and regulations, technologies, and expert solutions for every significant aspect of pharmaceutical process scale-up-clearly introducing readers to the theoretical concept of dimensional analysis to quantify similar processes on varying scales.

The Pilot Plant Real Book

The Pilot Plant Real Book
Author : Francis X. McConville
Publisher : Fxm Engineering & Design
Release Date : 2006-12-01
Category : Science
Total pages :320
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Pharmaceutical Process Scale-Up

Pharmaceutical Process Scale-Up
Author : Michael Levin
Publisher : CRC Press
Release Date : 2001-12-12
Category : Medical
Total pages :584
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Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling, granulation and drying, fluid bed applications, compaction and tableting, and film coating and regulatory requirements for scale-up and postapproval changes. Drawing on the experience of twenty contributing researchers, the book employs dimensional analysis as a unified scientific approach to quantify similar processes on different scales.

Treatise on Process Metallurgy, Volume 3: Industrial Processes

Treatise on Process Metallurgy, Volume 3: Industrial Processes
Author : Anonim
Publisher : Newnes
Release Date : 2013-12-09
Category : Technology & Engineering
Total pages :1810
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Process metallurgy provides academics with the fundamentals of the manufacturing of metallic materials, from raw materials into finished parts or products. Coverage is divided into three volumes, entitled Process Fundamentals, encompassing process fundamentals, extractive and refining processes, and metallurgical process phenomena; Processing Phenomena, encompassing ferrous processing; non-ferrous processing; and refractory, reactive and aqueous processing of metals; and Industrial Processes, encompassing process modeling and computational tools, energy optimization, environmental aspects and industrial design. The work distils 400+ years combined academic experience from the principal editor and multidisciplinary 14-member editorial advisory board, providing the 2,608-page work with a seal of quality. The volumes will function as the process counterpart to Robert Cahn and Peter Haasen’s famous reference family, Physical Metallurgy (1996)--which excluded process metallurgy from consideration and which is currently undergoing a major revision under the editorship of David Laughlin and Kazuhiro Hono (publishing 2014). Nevertheless, process and extractive metallurgy are fields within their own right, and this work will be of interest to libraries supporting courses in the process area. Synthesizes the most pertinent contemporary developments within process metallurgy so scientists have authoritative information at their fingertips Replaces existing articles and monographs with a single complete solution, saving time for busy scientists Helps metallurgists to predict changes and consequences and create or modify whatever process is deployed

Protein Chromatography

Protein Chromatography
Author : Giorgio Carta,Alois Jungbauer
Publisher : John Wiley & Sons
Release Date : 2020-06-02
Category : Science
Total pages :432
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An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.