November 28, 2020

Download Ebook Free Introduction To Nuclear Mechanics And Genome Regulation

Introduction to Nuclear Mechanics and Genome Regulation

Introduction to Nuclear Mechanics and Genome Regulation
Author : G.V. Shivashankar
Publisher : Academic Press
Release Date : 2019-06-01
Category : Medical
Total pages :200
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Introduction to Nuclear Mechanics and Genome Regulation provides a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, this book will be an invaluable reference for students, researchers and clinicians looking to understand this area of cutting-edge study. Contains applied case studies and full color images that support concept illustration Features a diverse range of chapters that cover the fundamentals of nuclear mechanics and genome regulation, including physico-chemical constraints in DNA Introduces advanced biophysical methods, bio-imaging methods, and new molecular biology tools for studying nuclear structures

Exam Prep for: Introduction to Nuclear Mechanics and Genome ...

Exam Prep for: Introduction to Nuclear Mechanics and Genome ...
Author : Anonim
Publisher : Unknown
Release Date : 2020
Category :
Total pages :129
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Nuclear Mechanics and Genome Regulation

Nuclear Mechanics and Genome Regulation
Author : Anonim
Publisher : Academic Press
Release Date : 2010-10-12
Category : Science
Total pages :392
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In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields

Nuclear Organization in Development and Disease

Nuclear Organization in Development and Disease
Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Release Date : 2006-02-08
Category : Science
Total pages :300
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This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include: How nuclear structure and location within a nucleus affect gene expression Chromatin organization and cell differentiation The nature of the interactions between the nuclear envelope and the cytoskeleton The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.

Cell Mechanics

Cell Mechanics
Author : Yu-Li Wang,Dennis E. Discher
Publisher : Academic Press
Release Date : 2007-07-05
Category : Science
Total pages :632
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Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells

Lipid Droplets

Lipid Droplets
Author : H. Robert Yang,Peng Li
Publisher : Academic Press
Release Date : 2013-10-04
Category : Science
Total pages :270
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This new volume of Methods in Cell Biology looks at lipid droplets LDs, covering sections on analyses of LDs in model systems, cell/tissue-specific analyses of LDs and imaging and in vitro analyses of LD biogenesis and growth. Chapters are written by experts in the field. With cutting-edge material, this comprehensive collection is intended to guide researchers of LDs for years to come. Covers sections on analyses of lipid droplets (LDs) in model systems, cell/tissue-specific analyses of LDs and imaging, and in vitro analyses of LD biogenesis and growth Chapters are written by experts in the field Cutting-edge material

The Zebrafish: Cellular and Developmental Biology

The Zebrafish: Cellular and Developmental Biology
Author : Anonim
Publisher : Academic Press
Release Date : 2010-12-24
Category : Science
Total pages :366
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This volume of Methods in Cell Biology, the first of 3 parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This first volume provides state-of-the-art descriptions of novel cellular imaging technologies and methods for culture of zebrafish stem cells, summarizes protocols for analyzingthe development of major organ systems including the central nervous system (CNS), and introduces the use of the zebrafish as a model system for human diseases. Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls Summarizes the Zebrafish Genome Project

The Nuclear Envelope

The Nuclear Envelope
Author : David Evans,Chris Hutchison,John Bryant
Publisher : Garland Science
Release Date : 2004-09-01
Category : Science
Total pages :320
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The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.

Nuclear Structure and Function

Nuclear Structure and Function
Author : J.R. Harris,I.B. Zbarsky
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Science
Total pages :504
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This collection of 101 short communications, submitted by some of the participants at the 11th Nuclear Workshop held in Suzdal, USSR, 18-23 September, 1989, provides a representative survey of the material presented at the Workshop. Articles have been submitted by both those who delivered lectures and those who had poster presentations. The order of presentation at the Nuclear Workshop is roughly maintained within this proceedings book, but the session titles within the scientific program have not been utilized as discrete subdivisions within the book, because of the considerable overlap of subject matter. The overall sequence is as follows: Genome structure, Gene Structure and Expression, Nucleolar Genes, Structure and Proteins, Chromatin and Nuclear Granules, Nuclear Matrix and Nuclear Proteins, Replication and Transcription and finally Nuclear Envelope and Nuclear Cytoplasmic Transport. Several articles on Nuclear Lipids are also included, stemming from an evening round-table discussion on lipids. The third Wilhelm Bernhard Lecture was delivered in Suzdal by Professor Harris Busch, who can be seen in the photograph above (on the left) in the presence of Professor Ilya B. Zbarsky, President of the organizing committee for the 11th Nuclear Workshop. (Previous Wilhelm Bernhard lecturers have been Ronald H. Reeder, in Krakow, Poland, 1985 and Oscar L. Miller, Jr. , in Stevensbeek, The Netherlands, in 1987).

Mechanisms of Gene Regulation

Mechanisms of Gene Regulation
Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer Science & Business Media
Release Date : 2013-12-11
Category : Medical
Total pages :210
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This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading from students of all the biomedical sciences in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule which states that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

Cancer Biology and the Nuclear Envelope

Cancer Biology and the Nuclear Envelope
Author : Eric C. Schirmer,Jose I. de las Heras
Publisher : Springer Science & Business Media
Release Date : 2014-02-22
Category : Medical
Total pages :611
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"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

Chromatin

Chromatin
Author : Ralf Blossey
Publisher : CRC Press
Release Date : 2017-08-04
Category : Medical
Total pages :172
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An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author : Bruce Alberts
Publisher : Unknown
Release Date : 2004
Category :
Total pages :129
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Nuclear Structure and Gene Expression

Nuclear Structure and Gene Expression
Author : R. Curtis Bird,Wilfred D. Stein,Jane B. Lian,Janet L. Stein
Publisher : Elsevier
Release Date : 1996-11-28
Category : Science
Total pages :304
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Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology

Materials Science & Engineering

Materials Science & Engineering
Author : Anonim
Publisher : Unknown
Release Date : 2004
Category : Biochemistry
Total pages :129
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