December 5, 2020

Download Ebook Free Low-Abundance Proteome Discovery

Low-Abundance Proteome Discovery

Low-Abundance Proteome Discovery
Author : Egisto Boschetti,Pier Giorgio Righetti
Publisher : Newnes
Release Date : 2013-03-26
Category : Science
Total pages :364
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Low-Abundance Proteome Discovery addresses the most critical challenge in biomarker discovery and progress: the identification of low-abundance proteins. The book describes an original strategy developed by the authors that permits the detection of protein species typically found in very low abundance and that may yield valuable clues to future discoveries. Known as combinatorial peptide ligand libraries, these new methodologies are one of the hottest topics related to the study of proteomics and have applications in medical diagnostics, food quality, and plant analysis. The book is written for university and industry scientists starting proteomic studies of complex matrices (e.g., biological fluids, biopsies, recalcitrant plant tissues, foodstuff, and beverage analysis), researchers doing wet chemistry, and graduate-level students in the areas of analytical and biochemistry, biology, and genetics. Covers methodologies for enhancing the visibility of low-abundance proteins which, until now, has been the biggest challenge in biomarker progress Includes detailed protocols that address real-life needs in laboratory practice Addresses all applications, including human disease, food and beverage safety, and the discovery of new proteins/peptides of importance in nutraceutics Compiles the research and analytic protocols of the two scientists who are credited with the discovery of these landmark methodologies, also known as combinatorial peptide ligand libraries, for the identification of low-abundance proteins

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
Author : Haleem J. Issaq,Timothy D. Veenstra
Publisher : Academic Press
Release Date : 2019-10-24
Category : Science
Total pages :504
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Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Biomarkers of Kidney Disease

Biomarkers of Kidney Disease
Author : Charles L. Edelstein
Publisher : Academic Press
Release Date : 2016-11-08
Category : Science
Total pages :632
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Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine. Explores both the practical and conceptual steps performed in the discovery of biomarkers in kidney disease Presents a comprehensive account of newer biomarker discover strategies, such as metabolomics and proteomics, all illustrated by clear examples Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including AKI, transplantation, cancer, CKD, PKD, diabetic nephropathy, preeclampsia, and glomerular disease

Renal and Urinary Proteomics

Renal and Urinary Proteomics
Author : Visith Thongboonkerd
Publisher : John Wiley & Sons
Release Date : 2009-12-21
Category : Science
Total pages :384
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Based on research and results from the international Human Kidney and Urine Proteome Project, this handbook and reference presents current methods and protocols for the analysis of human kidney and urine. The world's leading experts cover everything from basic techniques for routine analysis to advanced methods for difficult samples or analytes. Written with the practitioner in mind, all the methods and techniques are described with step-by-step protocols backed by much valuable practical advice taken from real life experiments.

Proteomic Applications in Cancer Detection and Discovery

Proteomic Applications in Cancer Detection and Discovery
Author : Timothy D. Veenstra
Publisher : John Wiley & Sons
Release Date : 2013-05-30
Category : Science
Total pages :320
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Helps researchers in proteomics and oncology work together tounderstand, prevent, and cure cancer Proteomic data is increasingly important to understanding theorigin and progression of cancer; however, most oncologicresearchers who depend on proteomics for their studies do notcollect the data themselves. As a result, there is a knowledge gapbetween scientists, who devise proteomic techniques and collect thedata, and the oncologic researchers, who are expected to interpretand apply proteomic data. Bridging the gap between proteomics andoncology research, this book explains how proteomic technology canbe used to address some of the most important questions in cancerresearch. Proteomic Applications in Cancer Detection and Discoveryenables readers to understand how proteomic data is acquired andanalyzed and how it is interpreted. Author Timothy Veenstra hasfilled the book with examples—many based on his own firsthandresearch experience—that clearly demonstrate the applicationof proteomic technology in oncology research, including thediscovery of novel biomarkers for different types of cancers. The book begins with a brief introduction to systems biology,explaining why cancer is a systems biology disease. Next, it coverssuch topics as: Mass spectrometry in cancer research Application of proteomics to global phosphorylationanalysis Search for biomarkers in biofluids Rise and fall of proteomic patterns for cancer diagnostics Emergence of protein arrays Role of proteomics in personalized medicine The final chapter is dedicated to the future prospects ofproteomics in cancer research. By guiding readers through the latest proteomic technologies andtheir applications in cancer research, Proteomic Applications inCancer Detection and Discovery enhances the ability ofresearchers in proteomics and researchers in oncology tocollaborate in order to better understand cancer and developstrategies to prevent and treat it.

Proteomics Sample Preparation

Proteomics Sample Preparation
Author : Jörg von Hagen
Publisher : John Wiley & Sons
Release Date : 2011-08-24
Category : Science
Total pages :485
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This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.

Mass Spectrometry for Microbial Proteomics

Mass Spectrometry for Microbial Proteomics
Author : Haroun N. Shah,Saheer E. Gharbia
Publisher : John Wiley & Sons
Release Date : 2010-10-28
Category : Science
Total pages :534
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New advances in proteomics, driven largely by developments in mass spectrometry, continue to reveal the complexity and diversity of pathogenic mechanisms among microbes that underpin infectious diseases. Therefore a new era in medical microbiology is demanding a rapid transition from current procedures to high throughput analytical systems for the diagnosis of microbial pathogens. This book covers the broad microbiological applications of proteomics and mass spectrometry. It is divided into six sections that follow the general progression in which most microbiology laboratories are approaching the subject –Transition, Tools, Preparation, Profiling by Patterns, Target Proteins, and Data Analysis.

Comprehensive Biomarker Discovery and Validation for Clinical Application

Comprehensive Biomarker Discovery and Validation for Clinical Application
Author : Peter Horvatovich,Rainer Bischoff,David E. Thurston
Publisher : Royal Society of Chemistry
Release Date : 2013
Category : Medical
Total pages :384
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This book covers proteomics biomarker discovery and validation procedures from the clinical perspective.

Molecular Biology and Biotechnology

Molecular Biology and Biotechnology
Author : John M. Walker,Ralph Rapley
Publisher : Royal Society of Chemistry
Release Date : 2009-01-01
Category : Science
Total pages :604
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This popular textbook has been revised and updated to provide a comprehensive overview and to reflect the latest developments in this rapidly developing area. Continuing with the broad base style of both current molecular and traditional biotechnology, chapters have been updated to reflect current interest and include new areas such as stem cell technology and important areas in drug discovery such as IP and patents. By presenting information in an easily assimilated form, this book makes an ideal undergraduate text for students of biology and chemistry, as well as to postgraduates.

Issues in Proteins and Peptides Research and Application: 2011 Edition

Issues in Proteins and Peptides Research and Application: 2011 Edition
Author : Anonim
Publisher : ScholarlyEditions
Release Date : 2012-01-09
Category : Science
Total pages :1110
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Issues in Proteins and Peptides Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Proteins and Peptides Research and Application. The editors have built Issues in Proteins and Peptides Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Proteins and Peptides Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Proteins and Peptides Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Proteomics in Diagnostics

Proteomics in Diagnostics
Author : T.D. Veenstra
Publisher : IOS Press
Release Date : 2004
Category : Medical
Total pages :83
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For many diseases, such as heart disease and cancer, early detection plays a pivotal role in the survival rate of the patient. When detected early, many such lethal diseases can be effectively treated with existing remedies. The difficulty remains, however, how to effectively detect such conditions at the earliest possible stage with a high enough positive predictive value so that they can be treated effectively without overwhelming the medical system with false positive diagnoses. What is required is the identification of more effective or additional biomarkers, as well as other types of technologies, that can aid in the diagnosis of early stage diseases. The challenge is how to identify more effective biomarkers or technologies that can provide an earlier indication of a disease with a higher positive predictive value than presently utilized methods. Proteomics, along with genomics and transcriptomics, has benefited greatly from the development of high-throughput methods to study thousands of proteins almost simultaneously. Based on the rate of interesting leads already being discovered using proteomics, it is likely that not only will biomarkers with better sensitivity and specificity be identified but individuals will be treated using customized therapies based on their specific protein profile. Since many of the proteomic technologies and data management tools are still in their infancy, the future of proteomics in disease diagnostics looks extremely promising.

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book
Author : Nigel Clarke,Andrew N. Hoofnagle
Publisher : Elsevier Health Sciences
Release Date : 2011-10-03
Category : Medical
Total pages :104
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This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Proteomics in Cancer Research

Proteomics in Cancer Research
Author : Daniel C. Liebler
Publisher : Wiley-Liss
Release Date : 2004
Category : Science
Total pages :216
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Proteomics in Cancer Research covers both the basic principles of proteomics along with detailed presentations of new and emerging technology that represent promising breakthroughs in cancer prevention and treatment. The topics covered include: Basic concepts, including setting up a proteomics laboratory, mass spectrometry, protein separations, protein array technologies, and informatics tools Application of emerging technologies to proteomic analysis of cancer cells and tissues, including discussion of critical issues such as characteristics of cancer cell proteomes and protein-protein interactions Application of proteomics approaches in clinical cancer research and a forecast of future research and applications In most cases, applications of methods in basic and translational cancer research that are discussed in the text represent the first uses of these proteomics approaches to study any disease. Critical issues that readers in cancer research need to understand are covered in detail, including: Advantages and limitations of different technologies New approaches to the molecular classification of tumors Discovery of new biomarkers and imaging targets and development of new proteomic platforms for profiling and screening The unique proteomic features that characterize cancers offer new opportunities for disease prevention and treatment. Despite intense interest, however, proteomics is just beginning to become a part of the cancer research mainstream, as relatively few cancer researchers have training in proteomics methods and approaches. This book, therefore, is both a timely and an essential guide that will help readers understand key concepts of proteomics and use its methods to search for ways to both cure and prevent cancer.

Drug Discovery and Evaluation: Pharmacological Assays

Drug Discovery and Evaluation: Pharmacological Assays
Author : Hans Vogel
Publisher : Springer Science & Business Media
Release Date : 2007-10-30
Category : Medical
Total pages :2068
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The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Advances in Clinical Chemistry

Advances in Clinical Chemistry
Author : Anonim
Publisher : Academic Press
Release Date : 2014-11-20
Category : Science
Total pages :284
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Volume 67 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory. Expertise of international contributors Latest cutting-edge technologies Comprehensive in scope