January 27, 2021

Download Ebook Free Mechanotransduction: Cell Signaling To Cell Response

Mechanotransduction

Mechanotransduction
Author : Paul A. Sundaram
Publisher : Academic Press
Release Date : 2020-11-18
Category : Technology & Engineering
Total pages :158
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Mechanotransduction: Cell Signaling to Cell Response covers the cell machinery responsible for the process of mechanotransduction and the manner in which cells respond to an external mechanical stimulus. The effect of mechanical stimulus on individual cells and entire tissues is discussed, with an emphasis on the practical results of this physiological process. Mechanotransduction of stem cells and cancerous cells are also covered, along with future directions in this yet nascent field. This book gives insights on basic processes that occur (or may occur) in the human body as a result of the application of mechanical stimulus. It is ideal for both biomedical engineers and biologists, and is an ideal resource for teaching. It provides a current state of conceptual and practical aspects of the field and will enable students and professionals to venture further into this incipient area which is of fundamental importance to biomedical engineering and biology fields. Covers fundamental concepts of signaling in cells as a result of mechanical stimulus Includes the physiological results of mechanical stimulus on the human body Explores the advantages of mechanical loads on the human body

Mechanosensitive Ion Channels

Mechanosensitive Ion Channels
Author : Andre Kamkin,Irina Kiseleva
Publisher : Springer Science & Business Media
Release Date : 2007-10-06
Category : Science
Total pages :382
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This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

Mechanosensitive Ion Channels

Mechanosensitive Ion Channels
Author : Anonim
Publisher : Elsevier
Release Date : 2011-09-21
Category : Science
Total pages :616
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Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells; MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

Handbook of Cell Signaling

Handbook of Cell Signaling
Author : Ralph A. Bradshaw,Edward A. Dennis
Publisher : Academic Press
Release Date : 2009-11-03
Category : Science
Total pages :3048
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Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Molecular and Cell Biology of Pain

Molecular and Cell Biology of Pain
Author : Anonim
Publisher : Academic Press
Release Date : 2015-03-02
Category : Science
Total pages :648
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Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. Written by future leaders in the pain field Covers a wide range of targets Contains provocative ideas about the future direction of the pain field.

Mechanobiology of Cell-Cell and Cell-Matrix Interactions

Mechanobiology of Cell-Cell and Cell-Matrix Interactions
Author : A. Wagoner Johnson,Brendan Harley
Publisher : Springer Science & Business Media
Release Date : 2011-02-21
Category : Technology & Engineering
Total pages :319
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Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Mechanotransduction

Mechanotransduction
Author : Anonim
Publisher : Academic Press
Release Date : 2014-07-29
Category : Science
Total pages :384
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Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Cell Signaling in Vascular Inflammation

Cell Signaling in Vascular Inflammation
Author : Jahar Bhattacharya
Publisher : Springer Science & Business Media
Release Date : 2007-11-15
Category : Medical
Total pages :222
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A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.

Orthodontics - E-Book

Orthodontics - E-Book
Author : Lee W. Graber,Robert L. Vanarsdall,Katherine W. L. Vig,Greg J. Huang
Publisher : Elsevier Health Sciences
Release Date : 2016-07-15
Category : Medical
Total pages :928
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Comprehensive, cutting-edge content prepares you for today’s orthodontics! Orthodontics: Current Principles and Techniques, 6th Edition provides evidence-based coverage of orthodontic diagnosis, planning strategies, and treatment protocols, including esthetics, genetics, temporary anchorage devices, aligners, technology-assisted biomechanics, and much more. New to this edition is an Expert Consult website using videos and additional visuals to show concepts difficult to explain with words alone. Expert Consult also adds three online-only chapters, research updates, and a fully searchable version of the text. From respected editors Lee Graber, Robert Vanarsdall, Katherine Vig, and Greg Huang, along with a veritable Who’s Who of expert contributors, this classic reference has a concise, no-nonsense approach to treatment that makes it the go-to book for orthodontic residents and practitioners! Comprehensive coverage provides a one-stop resource for the field of orthodontics, including foundational theory and the latest on the materials and techniques used in today’s practice. Experienced, renowned editors lead a team of expert, international contributors, bringing the most authoritative clinical practice and supporting science from the best and brightest in the industry. More than 3,400 images include a mixture of radiographs, full-color clinical photos, and anatomic or schematic line drawings, showing examples of treatment, techniques, and outcomes. Extensive references make it easy to look up the latest in orthodontic research and evidence-based information, and all references also appear online. Detailed, illustrated case studies show the decision-making process, showing the consequences of various treatment techniques over time. NEW! Seven all-new chapters include Orthodontic Diagnosis and Treatment Planning with Cone-Beam Computed Tomography Imaging; Upper Airway, Cranial Morphology, and Sleep Apnea; Management of Impactions; Iatrogenic Effects of Orthodontic Appliances; Minimally and Non-Invasive Approaches to Accelerate Tooth Movement; Management of Dental Luxation and Avulsion Injuries in the Permanent Dentition; and Patient Management and Motivation for the Child and Adolescent Patient. NEW! Expert Consult website includes online-only chapters, instructional videos, many references linked to PubMed, and research updates including additional case studies. UPDATED CHAPTERS include Biomechanical Considerations with Temporary Anchorage Devices, Bonding in Orthodontics, Clear Aligner Treatment, Lingual Appliance Treatment, Psychological Aspects of Diagnosis and Treatment, Clinically Relevant Aspects of Dental Materials Science in Orthodontics, The Biologic Basis of Orthodontics, and more. New co-editor Greg J. Huang is joined by new contributors who are highly regarded experts within their respective subspecialties in orthodontics.

Cellular Mechanotransduction

Cellular Mechanotransduction
Author : Mohammad R. K. Mofrad,Roger D. Kamm
Publisher : Cambridge University Press
Release Date : 2009-11-23
Category : Technology & Engineering
Total pages :129
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'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

Orthodontics: Diagnosis of & Management of Malocclusion & Dentofacial Deformities - E Book

Orthodontics: Diagnosis of & Management of Malocclusion & Dentofacial Deformities - E Book
Author : Om Prakash Kharbanda
Publisher : Elsevier Health Sciences
Release Date : 2019-12-04
Category : Medical
Total pages :1022
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The second edition is expanded and rejuvenated with a greater focus on PG students, orthodontic educators, UG students and practitioners. The book covers entire panorama of science and clinical practice of orthodontics, from basics to clinical, presented in 58 chapters organised in 15 sections. The information is provided in-depth, literature supported, complimented with real life scenarios and case reports. A special effort has been made to include structured information on subjects of relevance which are much talked about but found only in journals. Contains a balanced blend of texts, graphics, boxes and clinical case reports encountered in clinical practice A comprehensive coverage of cephalometric radiology, ethnic norms and advances in three-dimensional imaging A detailed step by step approach to orthodontic treatment with contemporary fixed appliances, from diagnosis to finishing Provides an up-to-date information on topics of day-to-day relevance such as epidemiology of malocclusion and orthodontic indices, psychological aspects of orthodontics, debonding, care and maintenance of occlusion after orthodontic treatment Presents updated information on temporary anchorage devices (TAD), impacted and transposed teeth, inter-disciplinary treatment, management of cleft lip and palate and orthognathic surgery Emerging fields such as surgically facilitated rapid tooth movement, distraction osteogenesis and obstructive sleep apnoea (OSA) are included with up-to-date clinically relevant information Includes Companion Website containing procedural videos

Physico-Chemical Control of Cell Function

Physico-Chemical Control of Cell Function
Author : Cesare Gargioli,Giancarlo Forte,Alberto Rainer
Publisher : Frontiers Media SA
Release Date : 2019-10-17
Category :
Total pages :129
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Extracellular Matrix (ECM) has been considered for a long time merely a scaffold sustaining cell and tissue function. Despite this simplistic view shared by many, nowadays ECM and their mechanic-physical and chemical characteristic acquired a progressive larger role actively regulating cell life: survival, proliferation, gene expression and differentiation. The interplay between cells and the ECM is continuously controlled at the cell level in a dynamic way. While cells synthesize the raw components of the ECM, this in turn impacts on cell function by providing chemical, topographical and mechanical hints. Such stimuli have been proven to control several aspects of cell function, including survival, proliferation, differentiation and migration. The molecular pathways activated by cells in response to the physical cues arising from the ECM are being disclosed and thus the possibility to control cell function through materials design is becoming more realistic. Current in vitro protocols, relying in 2D cell culture system, entail reductionist approaches to the complexity of cell-ECM interaction and result in cells rapidly losing their distinctive functions in culture. Understanding and replicating the 3D microenvironmental cues affecting cell function appears as a mandatory requirement for the development of next-generation biomaterials, as well as for the establishment of more physiologically relevant and predictive in vitro models of diseases. Such an effort will require a multidisciplinary approach at the convergence of biophysics, biology, nanotechnology, and bioengineering.

Mechanosensitivity and Mechanotransduction

Mechanosensitivity and Mechanotransduction
Author : Irina Kiseleva,Andre Kamkin
Publisher : Springer Science & Business Media
Release Date : 2010-11-18
Category : Science
Total pages :371
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This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Signalling Pathways in Embryonic Development

Signalling Pathways in Embryonic Development
Author : Juan J. Sanz-Ezquerro,Andrea E. Münsterberg,Sigmar Stricker
Publisher : Frontiers Media SA
Release Date : 2017-11-30
Category :
Total pages :129
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The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.

Mechanosensitive Ion Channels

Mechanosensitive Ion Channels
Author : Andre Kamkin,Irina Kiseleva
Publisher : Springer Science & Business Media
Release Date : 2007-10-06
Category : Science
Total pages :382
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This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.