April 13, 2021

Download Ebook Free Medicinal Chemistry Of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author : Carmen Avendano,J. Carlos Menendez
Publisher : Elsevier
Release Date : 2008-06-04
Category : Medical
Total pages :400
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Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Advances in Anticancer Agents in Medicinal Chemistry

Advances in Anticancer Agents in Medicinal Chemistry
Author : Michelle Prudhomme
Publisher : Bentham Science Publishers
Release Date : 2013-06-14
Category : Medical
Total pages :485
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Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.

The Anticancer Drugs

The Anticancer Drugs
Author : William B. Pratt,William D. Ensminger,Raymond W. Ruddon
Publisher : Oxford University Press, USA
Release Date : 1994
Category : Medical
Total pages :352
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This is an up-to-date review of the pharmacology, mechanisms of action, development of resistance, and toxicity of cancer chemotherapeutic agents. A rationale for their clinical use, based on cancer cell biology, is given for each class of drugs.

Chemistry and Pharmacology of Anticancer Drugs

Chemistry and Pharmacology of Anticancer Drugs
Author : David E. Thurston,Ilona Pysz
Publisher : CRC Press
Release Date : 2021-03-18
Category : Medical
Total pages :594
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While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"

Chemistry and Pharmacology of Anticancer Drugs, Second Edition

Chemistry and Pharmacology of Anticancer Drugs, Second Edition
Author : David E. Thurston
Publisher : CRC Press
Release Date : 2016-12-20
Category : Medical
Total pages :416
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Bringing together a broad spectrum of information relating to the chemistry and pharmacology of anticancer drugs and therapies, this book covers the complete range of anticancer drug families and the chemical structures of all anticancer agents in clinical use, many at the research or clinical evaluation stage. The second edition features a new chapter on the quest for selectivity, which has become increasingly important in developing targeted drugs, that includes a table of all therapeutic classes along with their benefits and challenges. The text provides up-to-date information on biomarkers, pharmacogenetics and pharmacogenomics as well as agents used in the palliative care of cancer patients.

Metal-based Anticancer Agents

Metal-based Anticancer Agents
Author : Angela Casini,Anne Vessières,Samuel M Meier-Menches
Publisher : Royal Society of Chemistry
Release Date : 2019-04-23
Category : Science
Total pages :355
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Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.

Anticancer Agents Based on Natural Product Models

Anticancer Agents Based on Natural Product Models
Author : John M. Cassady,John Douros
Publisher : Unknown
Release Date : 1980
Category : Antibiotics
Total pages :500
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Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Author : Bimal K. Banik
Publisher : Advances in Green Chemistry
Release Date : 2020-04
Category : Medical
Total pages :610
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Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6.

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Author : Franco Cataldo,Tatiana da Ros
Publisher : Springer Science & Business Media
Release Date : 2008-09-08
Category : Science
Total pages :408
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Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks. Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances. In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications. The application of fullerenes and nanotubes in medicine is at the frontier of our knowledge, thus the work in this field represents the basis for future novel developments.

Taxane Anticancer Agents

Taxane Anticancer Agents
Author : Gunda I. Georg,American Chemical Society. Meeting,American Chemical Society. Division of Chemical Health and Safety
Publisher : Amer Chemical Society
Release Date : 1995
Category : Literary Collections
Total pages :353
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Presents an overview of the development of paclitaxel as an anticancer drug, including the discovery, initial development, current status, supply issues, and recent clinical developments. Discusses in detail the cellular mechanism of action and the toxicity of paclitaxel. Presents drug delivery and taxotere metabolism. Explains semisynthetic and medicinal chemistry studies. Covers approaches to the total synthesis of paclitaxel.

Methods of Development of New Anticancer Drugs

Methods of Development of New Anticancer Drugs
Author : National Cancer Institute (U.S.).,Akademii︠a︡ medit︠s︡inskikh nauk SSSR, Moscow. Cancer Research Center,National Cancer Institute (U.S.)
Publisher : Unknown
Release Date : 1977
Category : Antineoplastic agents
Total pages :262
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In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development

In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
Author : Dhanya Sunil,Pooja R Kamath,Raghu Chandrashekhar H
Publisher : CRC Press
Release Date : 2017-05-18
Category : Medical
Total pages :105
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This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials. In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates in a wide category of anticancer assays demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules. The major emphasis of the book is to present those bioassays which can be readily set up and practiced in any laboratory with limited funds, facilities or technical know-how.

Anticancer Therapeutics

Anticancer Therapeutics
Author : Adam Todd,Paul W. Groundwater,Jason H. Gill
Publisher : John Wiley & Sons
Release Date : 2018-02-20
Category : Medical
Total pages :448
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An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

Medicinal Chemistry

Medicinal Chemistry
Author : Sriram
Publisher : Pearson Education India
Release Date : 2007
Category :
Total pages :129
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Doxorubicin

Doxorubicin
Author : Federico Arcamone
Publisher : Elsevier
Release Date : 2012-12-02
Category : Health & Fitness
Total pages :369
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Doxorubicin: Anticancer Antibiotics details the development of doxorubicin as a wide-spectrum antitumor antibiotic. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as (a) the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials; (b) the well-established, pioneering expertise in experimental chemotherapy of Professor Aurelio di Marco and his group at Istituto Nazionale Tumori, Milan; and (c) the highly motivated interest of experienced clinicians. The remaining chapters provide an overview of basic studies in the area of medicinal chemistry and related fields that have resulted from doxorubicin development. Such studies have been concerned with both biochemical and biophysical investigations at the molecular level and at different levels of biological organization. A large body of work aimed at developing synthetic procedures for the drug and for new related analogs of potential clinical usefulness has also been carried out.