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Micro-Drops and Digital Microfluidics

Micro-Drops and Digital Microfluidics
Author : Jean Berthier
Publisher : William Andrew
Release Date : 2012-12-31
Category : Science
Total pages :560
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In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops." A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow) A fresh perspective on the future of microfluidics

Micro-Drops and Digital Microfluidics

Micro-Drops and Digital Microfluidics
Author : Jean Berthier
Publisher : Elsevier
Release Date : 2008-03-20
Category : Technology & Engineering
Total pages :350
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After spending over 12 years developing new microsystems for biotechnology – especially concerned with the microfluidic aspects of these devices – Jean Berthier is considered a leading authority in the field. Now, following the success of his book, Microfluidics for Biotechnology, Dr. Berthier returns to explain how new miniaturization techniques have dramatically expanded the area of microfluidic applications and microsystems into microdrops and digital microfluidics. Engineers interested in designing more versatile microsystems and students who seek to learn the fundamentals of microfluidics will all appreciate the wide-range of information found within Microdrops and Digital Microfluidics. The most recent developments in digital microfluidics are described in clear detail, with a specific focus on the computational, theoretical and experimental study of microdrops. • Over 500 equations and more than 400 illustrations. • Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops."" • A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates. • A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces. • Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow). • A fresh perspective on the future of microfluidics.

Electrowetting-based Microactuation of Droplets for Digital Microfluidics

Electrowetting-based Microactuation of Droplets for Digital Microfluidics
Author : Michael George Pollack
Publisher : Unknown
Release Date : 2001
Category : Microelectromechanical systems
Total pages :306
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Microfluidics for Biotechnology

Microfluidics for Biotechnology
Author : Jean Berthier,Pascal Silberzan
Publisher : Artech House
Release Date : 2010
Category : Science
Total pages :483
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The application of microfluidics to biotechnology is an exciting new area that has already begun to revolutionize how researchers study and manipulate macromolecules like DNA, proteins and cells in vitro and within living organisms. Now in a newly revised and expanded second edition, the Artech House bestseller, Microfluidics for Biotechnology brings you to the cutting edge of this burgeoning field. Among the numerous updates, the second edition features three entirely new chapters on: non-dimensional numbers in microfluidics; interface, capillarity and microdrops; and digital, two-phase and droplet microfluidics.Presenting an enlightening balance of numerical approaches, theory, and experimental examples, this book provides a detailed look at the mechanical behavior of the different types of micro/nano particles and macromolecules that are used in biotechnology. You gain a solid understanding of microfluidics theory and the mechanics of microflows and microdrops. The book examines the diffusion of species and nanoparticles, including continuous flow and discrete Monte-Carlo methods.This unique volume describes the transport and dispersion of biochemical species and particles. You learn how to model biochemical reactions, including DNA hybridization and enzymatic reactions. Moreover, the book helps you master the theory, applications, and modeling of magnetic beads behavior and provides an overview of self-assembly and magnetic composite. Other key topics include the electric manipulation of micro/nanoparticles and macromolecules and the experimental aspects of biological macromolecule manipulation.

The Physics of Microdroplets

The Physics of Microdroplets
Author : Jean Berthier,Kenneth A. Brakke
Publisher : John Wiley & Sons
Release Date : 2012-04-30
Category : Technology & Engineering
Total pages :392
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The Physics of Microdroplets gives the reader the theoretical and numerical tools to understand, explain, calculate, and predict the often nonintuitive observed behavior of droplets in microsystems. Microdrops and interfaces are now a common feature in most fluidic microsystems, from biology, to biotechnology, materials science, 3D-microelectronics, optofluidics, and mechatronics. On the other hand, the behavior of droplets and interfaces in today's microsystems is complicated and involves complex 3D geometrical considerations. From a numerical standpoint, the treatment of interfaces separating different immiscible phases is difficult. After a chapter dedicated to the general theory of wetting, this practical book successively details: The theory of 3D liquid interfaces The formulas for volume and surface of sessile and pancake droplets The behavior of sessile droplets The behavior of droplets between tapered plates and in wedges The behavior of droplets in microchannels The effect of capillarity with the analysis of capillary rise The onset of spontaneous capillary flow in open microfluidic systems The interaction between droplets, like engulfment The theory and application of electrowetting The state of the art for the approach of 3D-microelectronics using capillary alignment

Mechatronics and Computational Mechanics

Mechatronics and Computational Mechanics
Author : Sally Gao
Publisher : Trans Tech Publications Ltd
Release Date : 2013-02-13
Category : Technology & Engineering
Total pages :536
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The collection includes selected, peer reviewed papers from the 2012 International Conference on Mechatronics and Computational Mechanics (ICMCM 2012), 20-21st December,2012, Dubai, UAE. Volume is indexed by Thomson Reuters CPCI-S (WoS). The papers are grouped as follows: Chapter 1: Mechatronics and Control; Chapter 2: Applied Mechanics and Mechanical Engineering; Chapter 3: Applied Materials Engineering; Chapter 4: Organization of Manufacture, Engineering Management and Information Technologies.

VLSI Design and Test

VLSI Design and Test
Author : Brajesh Kumar Kaushik,Sudeb Dasgupta,Virendra Singh
Publisher : Springer
Release Date : 2017-12-21
Category : Computers
Total pages :815
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This book constitutes the refereed proceedings of the 21st International Symposium on VLSI Design and Test, VDAT 2017, held in Roorkee, India, in June/July 2017. The 48 full papers presented together with 27 short papers were carefully reviewed and selected from 246 submissions. The papers were organized in topical sections named: digital design; analog/mixed signal; VLSI testing; devices and technology; VLSI architectures; emerging technologies and memory; system design; low power design and test; RF circuits; architecture and CAD; and design verification.

Formal Modeling and Verification of Cyber-Physical Systems

Formal Modeling and Verification of Cyber-Physical Systems
Author : Rolf Drechsler,Ulrich Kühne
Publisher : Springer
Release Date : 2015-06-05
Category : Computers
Total pages :313
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This book presents the lecture notes of the 1st Summer School on Methods and Tools for the Design of Digital Systems, 2015, held in Bremen, Germany. The topic of the summer school was devoted to modeling and verification of cyber-physical systems. This covers several aspects of the field, including hybrid systems and model checking, as well as applications in robotics and aerospace systems. The main chapters have been written by leading scientists, who present their field of research, each providing references to introductory material as well as latest scientific advances and future research directions. This is complemented by short papers submitted by the participating PhD students.

Advances in Optofluidics

Advances in Optofluidics
Author : Xuming Zhang
Publisher : MDPI
Release Date : 2018-08-15
Category : Technology & Engineering
Total pages :148
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This book is a printed edition of the Special Issue "Advances in Optofluidics" that was published in Micromachines

Finger-powered Digital Microfluidics for Micro Droplet Manipulation

Finger-powered Digital Microfluidics for Micro Droplet Manipulation
Author : Cheng Peng
Publisher : Unknown
Release Date : 2017
Category :
Total pages :201
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Microfluidic devices that do not require bulky peripheral hardware, such as pumps and external battery/power supplies, are a suitable technology for portable applications in resource-constrained settings, such as point-of-care (POC) diagnosis in developed countries, environmental monitoring, and on-site forensic analysis, etc. The existing portable microfluidic devices are mostly based on microchannel structures, in which the pre-defined channels limit their functional flexibility, rendering them difficult to scale up. Digital microfluidics, on the other hand, can tackle this problem since they deal with discrete droplets individually and can therefore provide more on-demand flexibility and versatility. Most digital microfluidic devices, however, require external electric power sources. We first propose finger-powered digital microfluidic (F-DMF) based on electrowetting on dielectric (EWOD). Instead of requiring an external power supply, our F-DMF uses piezoelectric elements to convert the mechanical energy produced by human fingers into electric voltage pulses for droplet manipulation. The voltage outputs of piezoelectric element mounted in cantilever beam configuration are studied theoretically and experimentally. Using this energy conversion scheme, the basic modes of droplet operations, such as droplet transport, splitting, and merging on EWOD devices are confirmed. The key assay steps involved in glucose detection and immunoassay are also successfully performed using F-DMF-EWOD. Exploiting the same energy conversion scheme, F-DMF based on the electrophoretic transport of discrete droplets (EPD), which has the potential to overcome pinning and surface contamination often encountered in EWOD, is then presented. Successful EPD actuation, however, requires the piezoelectric elements to provide both sufficient charge and voltage pulse duration. These requirements are quantified using numerical models to predict the electrical charges induced on the droplets and the subsequent electrophoretic forces. The transport and merging of aqueous droplets as well as direct manipulation of body fluids is experimentally demonstrated using F-EPD-DMF. Further, a mechanical system and an efficient pin-assignment scheme are explored to facilitate the practical implementation of pre-programmed and functional actuation of droplets in the EPD-based system. For the second part of this thesis, one practical issue in digital microfluidics biochip (DMFB) design is discussed: the droplet routing problem, which largely decides the performance and correctness of the system. The problem is formulated to a multi-agent path finding problem (MAPF) and an approximate algorithm based on Independent Detection (ID) is applied to solve the problem. The modified ID algorithm shows promising performance on selected benchmark problems with medium number of droplets ( 12). Overall, it achieves better timing result (~15% reduction) and total routing length (~50% reduction) with no compromise in fault tolerance (indicated by the total number of used cells), when compared with the previous best known results.

Open-Channel Microfluidics

Open-Channel Microfluidics
Author : Jean Berthier,Ashleigh B Theberge,Erwin Berthier
Publisher : Morgan & Claypool Publishers
Release Date : 2019-09-04
Category : Technology & Engineering
Total pages :170
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Open microfluidics, the study of microflows having a boundary with surrounding air, encompasses different aspects such as paper or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which (contrary to paper or thread or droplet microfluidics) is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle (the apparent contact angle which accounts for the presence of air) is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features such as valves and capillary pumps are examined. An introduction to two-phase open-channel microflows is also presented showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is presented, showing the potentialities of open-channel microfluidics.

Nanotechnology Environmental Health and Safety

Nanotechnology Environmental Health and Safety
Author : Matthew Hull,Diana Bowman
Publisher : Elsevier
Release Date : 2009-11-17
Category : Technology & Engineering
Total pages :352
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This book tackles the debate over nanotechnology's environmental health and safety (EHS) by thoroughly explaining EHS issues, financial implications, foreseeable risks (i.e. exposure, dose, hazards of nanomaterials), and the implications of occupational hygiene precautions and consumer protections. Real-world case studies are included, e.g. the discussion of a leading chemical company's unusual pairing with the USA's largest environmental NGO, and an innovative program designed for small- to mid-sized businesses, which became a model approach for proactive nanotechnology EHS risk management. Considers the potential of nanotechnology from multiple perspectives (NGO, insurance industry, small business, etc) Provides guidance and advice for appropriate, proactive risk management strategies Reviews toxicological studies and industrial initiatives, documented with actual case studies Of significant interest to CEOs/CTOs of technology companies (SMEs), Health and Safety officers of technology companies (SMEs), Government officials (HSE), Toxicology experts, and venture capitalists

Microfluidics in Detection Science

Microfluidics in Detection Science
Author : Fatima H Labeed,Henry O Fatoyinbo
Publisher : Royal Society of Chemistry
Release Date : 2014-10-24
Category : Science
Total pages :281
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The concept of a miniaturised laboratory on a disposable chip is now a reality, and in everyday use in industry, medicine and defence. New devices are launched all the time, prompting the need for a straightforward guide to the design and manufacture of lab-on-a-chip (LOC) devices. This book presents a modular approach to the construction and integration of LOC components in detection science. The editors have brought together some of the leading experts from academia and industry to present an accessible guide to the technology available and its potential. Several chapters are devoted to applications, presenting both the sampling regime and detection methods needed. Further chapters describe the integration of LOC devices, not only with each other but also into existing technologies. With insights into LOC applications, from biosensing to molecular and chemical analysis, and presenting scaled-down versions of existing technology alongside unique approaches that exploit the physics of the micro and nano-scale, this book will appeal to newcomers to the field and practitioners requiring a convenient reference.

Interfacial Fluid Mechanics

Interfacial Fluid Mechanics
Author : Vladimir S. Ajaev
Publisher : Springer Science & Business Media
Release Date : 2012-02-07
Category : Technology & Engineering
Total pages :214
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Interfacial Fluid Mechanics: A Mathematical Modeling Approach provides an introduction to mathematical models of viscous flow used in rapidly developing fields of microfluidics and microscale heat transfer. The basic physical effects are first introduced in the context of simple configurations and their relative importance in typical microscale applications is discussed. Then, several configurations of importance to microfluidics, most notably thin films/droplets on substrates and confined bubbles, are discussed in detail. Topics from current research on electrokinetic phenomena, liquid flow near structured solid surfaces,evaporation/condensation, and surfactant phenomena are discussed in the later chapters.

Nanotechnology Applications for Clean Water

Nanotechnology Applications for Clean Water
Author : Mamadou Diallo,Jeremiah Duncan
Publisher : William Andrew
Release Date : 2009
Category : Science
Total pages :592
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"In this truly unique reference, over 80 leading experts from the global scientific community share their research and knowledge to address the global challenges of water quality and remediation in the hopes that nanotechnology can ensure that clean water is available to everyone."--BOOK JACKET.