April 13, 2021

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Microcirculation

Microcirculation
Author : Ronald F. Tuma,Walter N. Duran,Klaus Ley
Publisher : Academic Press
Release Date : 2011-04-28
Category : Science
Total pages :1000
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This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume

Ion Channels and Calcium Signaling in the Microcirculation

Ion Channels and Calcium Signaling in the Microcirculation
Author : William F. Jackson
Publisher : Academic Press
Release Date : 2020-06
Category :
Total pages :310
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Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more. Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.

Influence of Magnesium on Local Cerebral Microcirculation in Patients with Subarachnoid Hemorrhage: Preliminary Data Using an Intraoperative Laser-Doppler Spectrophotometry System

Influence of Magnesium on Local Cerebral Microcirculation in Patients with Subarachnoid Hemorrhage: Preliminary Data Using an Intraoperative Laser-Doppler Spectrophotometry System
Author : Bju00f6rn Sommer
Publisher : Unknown
Release Date : 2017
Category :
Total pages :129
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Background and Goal of Study: The intravenous application of magnesium sulfate during neurosurgical procedures can foster vasodilatation, which is a desirable mechanism in vasospasm therapy especially in patients with subarachnoid hemorrhage (SAH). However, there are only few reports dealing with the impact of magnesium on local cerebral microcirculation in those patients. We present our preliminary results using a novel non-invasive, real-time measurement device during neurosurgical procedures.Materials and Methods: In this prospective, single-institution, non-randomized trial we studied local cerebral microcirculation using the non-invasive laser-Doppler spectrophotometry system u201eOxygen-to-see(O2C)u201c in 10 consecutive patients with aneurysmatic SAH Hunt and Hess grade 2 to 5 with aneurysms of the anterior and middle cerebral arteries. After dura opening, a probe was placed onto the cortex next to the site of preparation. In 7 mm tissue depth, capillary venous oxygenation (SO2), post-capillary venous filling pressures (rHb), blood cell velocity (velo) and blood flow (flow) were measured. Data was recorded as baseline immediately before application of 5 g magnesium sulfate 10% and 10 minutes thereafter over a time period of 30 seconds. Magnesium sulfate was administred continously with a infusion rate depending on blood pressure (>100 mmHg systolic) over a time period of max. 60 minutes.Results and Discussion: We observed a higher median flow of 22% (4-70%) and velo of 9% (6-32%), no changes in SO2, and a decrease of rHb of 7% (5-30%) compared to the baseline measurements. This indicates an increased cerebral blood flow on the microcirculatory level. Anesthesiological parameters remained stable with temperature corrected partial carbon dioxide pressure 37.8u00b13.6 mmHg, hemoglobin 11.6u00b11.6 g/dl, hydrogencarbonate 24u00b11.1 mmol/l, positive endexpiratory pressure of 1 to 3 mBar, systolic/diastolic blood pressure of 102u00b113.3 mmHg and 55u00b18.9 mmHg, mean arterial blood pressure of 72.5u00b110.1 mmHg, heart rate 56u00b110.3 bpm, endexpiratory CO2 of 31u00b12.4%, inspiratory O2 of 45u00b17.8%, bladder temperature 35.8u00b10.6u00b0C. Conclusion: Data indicate that local cerebral microcirculation is increased after intravenous application of magnesium sulfate in patients with aneurysmatic subarachnoid hemorrhage. Continous real-time monitoring of brain perfusion parameters could possibly guide the rate, duration and concentration of magnesium sulfate to prevent vasospasm.This study is supported by the Johannes und Frieda Marohn-Stiftung (Erlangen, Germany), grant No. So/2012.

Microcirculation

Microcirculation
Author : Gabor Kaley,Burton M. Altura
Publisher : Unknown
Release Date : 1980
Category : Microcirculation
Total pages :3
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Inflammation and the Microcirculation

Inflammation and the Microcirculation
Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Release Date : 2010
Category : Science
Total pages :86
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The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation.

Microcirculation

Microcirculation
Author : Mary P. Wiedeman
Publisher : Van Nostrand Reinhold
Release Date : 1974
Category : Science
Total pages :429
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Research Awards Index

Research Awards Index
Author : Anonim
Publisher : Unknown
Release Date : 1981
Category : Medicine
Total pages :129
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Serotonin and Microcirculation

Serotonin and Microcirculation
Author : Robert S. Reneman,Alfred Bollinger
Publisher : S Karger Ag
Release Date : 1985
Category : Medical
Total pages :90
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Microcirculation and Inflammation

Microcirculation and Inflammation
Author : K. Messmer,F. Hammersen
Publisher : S Karger Ag
Release Date : 1987
Category : Medical
Total pages :329
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Basic Aspects of Microcirculation

Basic Aspects of Microcirculation
Author : Masaharu Tsuchiya,Makishige Asano,Masaya Oda
Publisher : Unknown
Release Date : 1982
Category : Capillaries
Total pages :376
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Skeletal Muscle Microcirculation

Skeletal Muscle Microcirculation
Author : Frithjof Hammersen,K. Messmer
Publisher : S Karger Ag
Release Date : 1984
Category : Medical
Total pages :148
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Intravital Observation of Organ Microcirculation

Intravital Observation of Organ Microcirculation
Author : Masaharu Tsuchiya
Publisher : Unknown
Release Date : 1983
Category : Capillaires - Examen - Congrès
Total pages :248
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Cerebral Microcirculation

Cerebral Microcirculation
Author : Frithjof Hammersen,K. Messmer
Publisher : S Karger Ag
Release Date : 1990
Category : Medical
Total pages :102
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Biomedical Index to PHS-supported Research

Biomedical Index to PHS-supported Research
Author : Anonim
Publisher : Unknown
Release Date : 1991
Category : Medicine
Total pages :129
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Perspectives in Methodology for Studies of the Microcirculation

Perspectives in Methodology for Studies of the Microcirculation
Author : International Institute for Microcirculation. Meeting,K. Messmer,Frithjof Hammersen
Publisher : S Karger Ag
Release Date : 1984
Category : Medical
Total pages :159
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