June 17, 2021

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Microfluidics for Pharmaceutical Applications

Microfluidics for Pharmaceutical Applications
Author : Helder A. Santos,Dongfei Liu,Hongbo Zhang
Publisher : William Andrew
Release Date : 2018-10-12
Category : Science
Total pages :495
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Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications. Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness Includes a variety of case studies that explain principles Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world

Microfluidics for Biological Applications

Microfluidics for Biological Applications
Author : Wei-Cheng Tian,Erin Finehout
Publisher : Springer
Release Date : 2010-10-12
Category : Technology & Engineering
Total pages :416
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Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.

Characterization of Pharmaceutical Nano- and Microsystems

Characterization of Pharmaceutical Nano- and Microsystems
Author : Leena Peltonen
Publisher : John Wiley & Sons
Release Date : 2021-01-11
Category : Science
Total pages :416
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Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.

Microsystems for Pharmatechnology

Microsystems for Pharmatechnology
Author : Andreas Dietzel
Publisher : Springer
Release Date : 2016-01-22
Category : Technology & Engineering
Total pages :348
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This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.

Development of Microwave/droplet-microfluidics Integrated Heating and Sensing Platforms for Biomedical and Pharmaceutical Lab-on-a-chip Applications

Development of Microwave/droplet-microfluidics Integrated Heating and Sensing Platforms for Biomedical and Pharmaceutical Lab-on-a-chip Applications
Author : Gurkan Yesiloz
Publisher : Unknown
Release Date : 2017
Category : Biomedical engineering
Total pages :251
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Microfluidics for Biological Applications

Microfluidics for Biological Applications
Author : Wei-Cheng Tian,Erin Finehout
Publisher : Springer
Release Date : 2008-10-27
Category : Technology & Engineering
Total pages :416
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Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.

Microfluidics for Cellular Applications

Microfluidics for Cellular Applications
Author : Gerardo Perozziello,Ulrich Kruhne,Paola Luciani
Publisher : Elsevier
Release Date : 2021-07-15
Category : Technology & Engineering
Total pages :352
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Microfluidics for Cellular Applications describes microfluidic devices for cell screening from a physical, technological and applications point of view, giving a comparison with the cell microenvironment and the conventional instruments used in medicine. Microfluidic technologies, protocols, devices for cell screening and treatment have reached an advanced state, but, still, they are mainly used in research and for research purposes. They have not broken into practical applications and conventional medical procedures due to the fact that, most of the time, they are cumbersome to use, unreliable or require complicated or expensive set-ups to be handled. On the other hand, microfluidic devices can offer unique insights and analysis and can reach higher resolutions and fast operations in comparison to conventional medical and biotechnologies. This is an important resource for those from an engineering and technology background to understand more about the microfluidic methods that can be used to gain additional insights into cell screening processes. Outlines the major applications of microfluidic devices in medicine and biotechnology Assesses the major challenges of using microfluidic devices in terms of complexity of the control set-up, ease of use, integration capability, automation level, analysis throughput, content and costs Describes the major fabrication techniques for assembling effective microfluidic devices for bioapplications

National Science Council Review

National Science Council Review
Author : Anonim
Publisher : Unknown
Release Date : 2007
Category : Engineering
Total pages :129
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Biological Applications of Microfluidics

Biological Applications of Microfluidics
Author : Frank A. Gomez
Publisher : John Wiley & Sons
Release Date : 2008-02-15
Category : Science
Total pages :517
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Microfluidics-today's applications and tomorrow's potential Microfluidics has facilitated major biochemical application advancements in point-of-care diagnostics, bioterrorism detection, and drug discovery. There are numerous potential applications in biotechnology, pharmaceuticals, the life sciences, defense, public health, and agriculture. Microfluidic lab-on-a-chip (LOC) technologies represent a revolution in laboratory experimentation, bringing the benefits of miniaturization, integration, and automation to many research-based industries. Biological Applications of Microfluidics details recent advances in the biological applications of microfluidics, including cell sorting, DNA sequencing on a chip, microchip capillary electrophoresis, and synthesis on a microfluidic format. After an overview of microfluidics highlighting recent seminal works, it includes multiple chapters on: * Cell analysis on microfluidic devices * Chemical (enzymatic and non-enzymatic) reactions on microchips * Separations on microchips * Biomedical applications of microfluidics * Microfluidic fabrication * Hybrid microfluidic applications Microfluidics has incredible potential in a variety of areas. This book covers many recent advances, including microfabricated LOC technologies, advanced microfluidic tools, microfluidic culture platforms for stem cell and neuroscience research, a novel application of microfluidic LOC devices that facilitates fundamental research in proteomics that cannot be performed without miniaturization, the nano fountain pen, and more. With contributions from leading experts in chemistry, physics, bioengineering, material science, biomedicine, and other fields plus references at the end of each chapter to facilitate further study, this is an all-in-one, hands-on resource for analytical chemists and researchers. It is also an excellent resource for students studying analytical chemistry or biotechnology.

Introduction to Microfluidics

Introduction to Microfluidics
Author : Patrick Tabeling
Publisher : Oxford University Press
Release Date : 2010-05-06
Category : Medical
Total pages :312
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Microfluidics is a young discipline which enables scientists and engineers to handle fluids in the biochips of the future.The book is an introduction to this discipline. It presents in simple terms the most important notions of the domain: how fluids move on the chip, conveying materials, molecules, electrical charges, and heat.

Microfluidics for Biological Applications

Microfluidics for Biological Applications
Author : Wei-Cheng Tian,Erin Finehout
Publisher : Springer
Release Date : 2008-10-27
Category : Technology & Engineering
Total pages :416
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Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.

Towards Reconfigurable Lab-on-chip Using Virtual Electrowetting Channels

Towards Reconfigurable Lab-on-chip Using Virtual Electrowetting Channels
Author : Ananda Banerjee
Publisher : Unknown
Release Date : 2013
Category :
Total pages :112
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Lab-on-a-chip systems rely on several microfluidic paradigms. The first uses a fixed layout of continuous microfluidic channels. Such lab-on-a-chip systems are almost always application specific and far from a true "laboratory." The second involves electrowetting droplet movement (digital microfluidics), and allows two-dimensional computer control of fluidic transport and mixing. Integrating the two paradigms in the form of programmable electrowetting channels would take advantage of both the "continuous" functionality of rigid channels, which are used in numerous applications, and the "programmable" functionality of digital microfluidics which permits electrical control of on-chip functions. In this dissertation, for the first time, such programmable virtual microfluidic channels were demonstrated using an electrowetting platform. These "wall-less" virtual channels can be formed reliably and rapidly, with propagation rates of 3.5-3.8 mm/s. Pressure driven transport in these virtual channels at flow rates up to 100 *L/min can be achieved without distortion of the channel shape. Further, these channels can be split into segments or droplets of precise volumes, with accuracies exceeding 99%. Critical parameters for such deterministic splitting of liquid samples have been identified with the aid of numerical models and confirmed experimentally. A number of reconfigurable operations were demonstrated, including interactions between continuously-flowing channels and programmed droplet motion. This approach was used to develop a programmable heterogeneous immunoassay protocol, showing a significant improvement in performance by using continuous flow washing as compared to the droplet-based washing in conventional digital microfluidics. The limit of detection obtained with this technique for a streptavidin -- biotin binding assay was 10 nM, illustrating potential for improved performance with other heterogeneous immunoassays. The first demonstration of reconfigurable electrowetting channels in this dissertation and their seamless integration with digital microfluidics makes this approach applicable to a wide range of clinical or pharmaceutical applications.

Microfluidic Technologies for Human Health

Microfluidic Technologies for Human Health
Author : Ali Khademhosseini,Utkan Demirci,Robert Langer
Publisher : World Scientific
Release Date : 2012
Category : Medical
Total pages :478
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Ch. 1. A microscale bioinspired cochlear-like sensor / Robert D. White, Robert Littrell, and Karl Grosh -- ch. 2. Systematic evaluation of the efficiencies of proteins and chemicals in pharmaceutical applications / Morgan Hamon and Jong Wook Hong -- ch. 3. Microfluidic glucose sensors / Jithesh V. Veetil ... [et al.] -- ch. 4. Applications of microfabrication and microfluidic techniques in mesenchymal stem cell research / Abhijit Majumder ... [et al.] -- ch. 5. Patient-specific modeling of low-density lipoprotein transport in coronary arteries / Ufuk Olgac -- ch. 6. Point-of-care microdevices for global health diagnostics of infectious diseases / Sau Yin Chin ... [et al.] -- ch. 7. Integrated microfluidic sample preparation for chip-based molecular diagnostics / Jane Y. Zhang ... [et al.] -- ch. 8. Microfluidic devices for cellular proteomic studies / Yihong Zhan and Chang Lu -- ch. 9. Microfluidics for neuroscience: novel tools and future implications / Vivian M. Hernandez and P. Hande Ozdinler -- ch. 10. Microfluidics: on-chip platforms as in vitro disease models / Shan Gao, Erkin Seker, and Martin L. Yarmush -- ch. 11. Application of microfluidics in stem cell and tissue engineering / Sasha H. Bakhru, Christopher Highley, and Stefan Zappe -- ch. 12. Microfluidic "on-the-fly" fabrication of microstructures for biomedical applications / Edward Kang, Sau Fung Wong, and Sang-Hoon Lee -- ch. 13. Microfluidics as a promising tool toward distributed viral detection / Elodie Sollier and Dino Di Carlo -- ch. 14. Electrophoresis and dielectrophoresis for lab-on-a-chip (LOC) analyses / Yagmur Demircan, Gurkan Yilmaz, and Haluk Kulah -- ch. 15. Ultrasonic embossing of carbon nanotubes for the fabrication of polymer microfluidic chips for DNA sample purification / Puttachat Khuntontong, Min Gong, and Zhiping Wang -- ch. 16. Ferrofluidics / A. Rezzan Kose and Hur Koser -- ch. 17. Antibody-based blood bioparticle capture and separation using microfluidics for global health / ZhengYuan Luo ... [et al.] -- ch. 18. Applications of quantum dots for fluorescence imaging in biomedical research / ShuQi Wang ... [et al.]

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
Author : Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
Publisher : Elsevier
Release Date : 2018-09-12
Category : Science
Total pages :396
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Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.