November 23, 2020

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Modelling Methodology for Physiology and Medicine

Modelling Methodology for Physiology and Medicine
Author : Ewart Carson,Claudio Cobelli
Publisher : Newnes
Release Date : 2013-12-05
Category : Science
Total pages :588
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Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine
Author : Claudio Cobelli,Ewart Carson
Publisher : Academic Press
Release Date : 2019-08-01
Category : Computers
Total pages :384
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Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning

Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine
Author : Claudio Cobelli,Ewart Carson
Publisher : Elsevier
Release Date : 2008-02-06
Category : Technology & Engineering
Total pages :328
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This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Nonlinear Dynamic Modeling of Physiological Systems

Nonlinear Dynamic Modeling of Physiological Systems
Author : Professor Vasilis Z. Marmarelis
Publisher : John Wiley & Sons
Release Date : 2004-09-03
Category : Medical
Total pages :541
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The study of nonlinearities in physiology has been hindered by the lack of effective ways to obtain nonlinear dynamic models from stimulus-response data in a practical context. A considerable body of knowledge has accumulated over the last thirty years in this area of research. This book summarizes that progress, and details the most recent methodologies that offer practical solutions to this daunting problem. Implementation and application are discussed, and examples are provided using both synthetic and actual experimental data. This essential study of nonlinearities in physiology apprises researchers and students of the latest findings and techniques in the field.

Methods In Animal Physiology

Methods In Animal Physiology
Author : Zdenek Deyl
Publisher : CRC Press
Release Date : 2020
Category : Medical
Total pages :448
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The aim of the present volume was to give an overview over different available methodological approaches. The specialists may, perhaps, object that in their particular field the level of information is superficial. However, let them look at other chapters in which different approaches are discussed and which, surely, will appear less superficial from the more general point of view. We hope, at least, that crucial references can be traced throughout the book that would enable the readers to go in more detail when desired. It can be traced throughout the book that would enable the readers to go in more detail when desired. It was really one of our ideas to draw the survey of possibilities available. If this can stimulate the readers to use ideas to draw the survey of possibilities available. If this can stimulate the readers to use other methods that those they are routinely using the goals will be met.

Modeling of Physiological Flows

Modeling of Physiological Flows
Author : Davide Ambrosi,Alfio Quarteroni,Gianluigi Rozza
Publisher : Springer Science & Business Media
Release Date : 2012-10-31
Category : Mathematics
Total pages :418
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This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling the cardiovascular system or, more broadly, physiological flows.

Engineering Approaches to Study Cardiovascular Physiology: Modeling, Estimation, and Signal Processing

Engineering Approaches to Study Cardiovascular Physiology: Modeling, Estimation, and Signal Processing
Author : Riccardo Barbieri,Zhe Chen
Publisher : Frontiers E-books
Release Date : 2020
Category :
Total pages :129
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With cardiovascular diseases being one of the main causes of death in the world, quantitative modeling, assessment and monitoring of the cardiovascular control system plays a critical role in bringing important breakthroughs to cardiovascular care. Quantification of cardiovascular physiology and its control dynamics from physiological recordings and by use of mathematical models and algorithms has been proved to be of important value in understanding the causes of cardiovascular diseases and assisting the prognostic or diagnostic process. Nowadays, development of new recording technologies (e.g., electrophysiology, imaging, ultrasound, etc) has enabled us to improve and expand acquisition of a wide spectrum of physiological measures related to cardiovascular control. An emerging challenge is to process and interpret such increasing amount of information by using state-of-the-art approaches in systems modeling, estimation and control, and signal processing, which would lead to further insightful scientific findings. In particular, multi-disciplinary engineering-empowered approaches of studying cardiovascular systems would greatly deepen our understanding of cardiovascular functions (e.g., heart rate variability, baroreflex sensitivity) and autonomic control, as it would also improve the knowledge about heart pathology, cardiovascular rehabilitation and therapy. Meanwhile, developing cardiovascular biomedical devices or heart-machine interface for either clinical monitoring or rehabilitation purpose is of greater and greater interest for both scientific advancement and potential medical benefits. This Research Topic will bring together established experts whose areas of research cover a wide range of studies and applications. Contributions include but are not limited to state-of-the-art modeling methodologies, algorithmic development in signal processing and estimation, as well as applications in cardiovascular rehabilitation, and clinical monitoring. The Research Topic will consider both invited reviews and original research.

Control Theory in Biomedical Engineering

Control Theory in Biomedical Engineering
Author : Olfa Boubaker
Publisher : Academic Press
Release Date : 2020-06-30
Category : Science
Total pages :396
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Control Theory in Biomedical Engineering: Applications in Physiology and Medical Robotics highlights the importance of control theory and feedback control in our lives and explains how this theory is central to future medical developments. Control theory is fundamental for understanding feedback paths in physiological systems (endocrine system, immune system, neurological system) and a concept for building artificial organs. The book is suitable for graduate students and researchers in the control engineering and biomedical engineering fields, and medical students and practitioners seeking to enhance their understanding of physiological processes, medical robotics (legs, hands, knees), and controlling artificial devices (pacemakers, insulin injection devices). Control theory profoundly impacts the everyday lives of a large part of the human population including the disabled and the elderly who use assistive and rehabilitation robots for improving the quality of their lives and increasing their independence. Gives an overview of state-of-the-art control theory in physiology, emphasizing the importance of this theory in the medical field through concrete examples, e.g., endocrine, immune, and neurological systems Takes a comprehensive look at advances in medical robotics and rehabilitation devices and presents case studies focusing on their feedback control Presents the significance of control theory in the pervasiveness of medical robots in surgery, exploration, diagnosis, therapy, and rehabilitation

Similarity and Modeling in Science and Engineering

Similarity and Modeling in Science and Engineering
Author : Josef Kuneš
Publisher : Springer Science & Business Media
Release Date : 2012-04-05
Category : Mathematics
Total pages :442
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The present text sets itself in relief to other titles on the subject in that it addresses the means and methodologies versus a narrow specific-task oriented approach. Concepts and their developments which evolved to meet the changing needs of applications are addressed. This approach provides the reader with a general tool-box to apply to their specific needs. Two important tools are presented: dimensional analysis and the similarity analysis methods. The fundamental point of view, enabling one to sort all models, is that of information flux between a model and an original expressed by the similarity and abstraction Each chapter includes original examples and applications. In this respect, the models can be divided into several groups. The following models are dealt with separately by chapter; mathematical and physical models, physical analogues, deterministic, stochastic, and cybernetic computer models. The mathematical models are divided into asymptotic and phenomenological models. The phenomenological models, which can also be called experimental, are usually the result of an experiment on an complex object or process. The variable dimensionless quantities contain information about the real state of boundary conditions, parameter (non-linearity) changes, and other factors. With satisfactory measurement accuracy and experimental strategy, such models are highly credible and can be used, for example in control systems.

Animal and Translational Models for CNS Drug Discovery: Neurological disorders

Animal and Translational Models for CNS Drug Discovery: Neurological disorders
Author : Robert A. McArthur,Franco Borsini
Publisher : Unknown
Release Date : 2008
Category : Animal models in research
Total pages :129
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Reforming Transport Pricing in the European Union

Reforming Transport Pricing in the European Union
Author : Bruno de Borger,S. Proost
Publisher : Edward Elgar Publishing
Release Date : 2001-01-01
Category : Business & Economics
Total pages :424
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This work deals with the problem of pricing passenger and freight transportation within Europe. It argues that legislation affecting pricing and regulation is increasingly less successful in dealing with market failures and externalities such as congestion, air pollution, noise and accidents.

Escherichia coli

Escherichia coli
Author : Amidou Samie
Publisher : BoD – Books on Demand
Release Date : 2017-07-12
Category : Medical
Total pages :434
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Escherichia coli is a versatile organism and very diverse. Members of this species vary from very pathogenic agents causing different types of diseases including meningitis, gastroenteritis, and septicemia, just to cite a few, to harmless organisms living in the intestines of both humans and animals. E. coli has also been used as a model organism for most bacteria except a few. For this reason, its study provides a huge advantage and can help understand the mechanisms involved in different processes such as pathogenesis, environmental disinfection, nutrient utilization, antibiotic resistance, and diagnostic/detection methods, and these are indeed the topics discussed in this book. The book has been divided into four main sections representing the different facets of E. coli applications, which include disease, biotechnology, environmental engineering and innovative approaches to detection, and lastly its physiology and cell biology. Such processes can be applied to the study of other organisms as well considering the development of diversity; for example, many organisms are capable of horizontal gene transfer, which is capable of increasing the fitness of the bacterial organisms involved and has a great impact on the control of such bacterial organism.

Drug Delivery to the Brain

Drug Delivery to the Brain
Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
Publisher : Springer Science & Business Media
Release Date : 2013-12-03
Category : Medical
Total pages :731
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The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Interference Analysis

Interference Analysis
Author : John Pahl
Publisher : John Wiley & Sons
Release Date : 2016-04-13
Category : Technology & Engineering
Total pages :560
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The book describes how interference can be managed so that radio systems co-exist, without harmful mutual effects, within a finite amount of spectrum. This is timely in view of the increasing proliferation of wireless systems. It covers both the processes, such as regional or international coordination, as well as the engineering principles. Written by an author with extensive experience in the industry, it describes in detail the main methodologies for calculating or computing the interference between radio systems of the same type, and also between radio systems of different types

Testing Structural Equation Models

Testing Structural Equation Models
Author : Kenneth A. Bollen,J. Scott Long
Publisher : SAGE
Release Date : 1993-02
Category : Social Science
Total pages :320
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What is the role of fit measures when respecifying a model? Should the means of the sampling distributions of a fit index be unrelated to the size of the sample? Is it better to estimate the statistical power of the chi-square test than to turn to fit indices? Exploring these and related questions, well-known scholars examine the methods of testing structural equation models (SEMS) with and without measurement error, as estimated by such programs as EQS, LISREL and CALIS.