November 26, 2020

Download Ebook Free Modern Computational Approaches To Traditional Chinese Medicine

Modern Computational Approaches to Traditional Chinese Medicine

Modern Computational Approaches to Traditional Chinese Medicine
Author : Zhaohui Wu,Huajun Chen,Xiaohong Jiang
Publisher : Elsevier
Release Date : 2012-10-22
Category : Computers
Total pages :250
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Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM’s independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Serum Pharmacochemistry of Traditional Chinese Medicine

Serum Pharmacochemistry of Traditional Chinese Medicine
Author : Xijun Wang,Aihua Zhang,Hui Sun
Publisher : Academic Press
Release Date : 2016-12-27
Category : Medical
Total pages :378
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Serum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications provides a valuable and indispensable guide on the latest methods, research advances, and applications in this area. Chapters offer cutting-edge information on pharmacokinetics and pharmacodynamics, analytical chemistry, traditional medicine, natural products, bioinformatics, new technologies, therapeutic applications, and more. For researchers and students in academia and industry, this book provides a hands-on description of experimental techniques, along with beneficial guidelines to help advance research in the fields of Traditional Chinese Medicine and drug development. Provides a valuable guide for practitioners of serum pharmacochemistry of Traditional Chinese Medicine, along with insights to its current use and future applications Edited and written by leading scientists at the forefront of this research Presents well written chapters that include an introduction, description of the method, and identification of chemical constituents, with applications and references to the latest research and literature

Traditional Chinese Medicine

Traditional Chinese Medicine
Author : James David Adams (Jr.),Eric J. Lien
Publisher : Royal Society of Chemistry
Release Date : 2013
Category : Science
Total pages :349
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Traditional Chinese medicine has a strong scientific basis, but the science of these important preparations is often rarely discussed. Western approaches often simplify traditional Chinese medicine to drug discovery in Chinese plants, however, the majority of traditional Chinese medications use complex mixtures of plant extracts, rather than single purified drugs. The combination of different extracts is based on yin, yang and chi theories, which are often poorly understood in the West. Yin and yang are known to be the balance of agonists and antagonists, whereas chi derives from signalling processes in the body and regulates bodily functions. Traditional Chinese medical practitioners understand that yin, yang and chi constantly interact in the body to maintain health. Western medical practitioners understand how to use agonists and antagonists and how to modify signalling processes, but generally do not accept the use of complex plant extracts to perform these functions. Aimed at medical scientists, and including detailed explanations of the theories behind the science, this text may help researchers to understand Chinese medical practitioners and to communicate more effectively with them. It will also lead to greater acceptance of traditional medications in the West. Presenting a clear rationale for the use of traditional Chinese medications in Western medical facilities, it enables scientists to find new directions in experimental design and encourage examination of these useful, but often poorly understood, preparations in clinical trials.

Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals

Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals
Author : Apostolos Zarros,Tilli Tansey
Publisher : Frontiers Media SA
Release Date : 2019-11-27
Category :
Total pages :137
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Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology
Author : Rudy J Richardson,Dale E Johnson
Publisher : Royal Society of Chemistry
Release Date : 2017-03-01
Category : Science
Total pages :332
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The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

Computational Science - ICCS 2007

Computational Science - ICCS 2007
Author : Yong Shi,Geert Dick van Albada,Jack Dongarra,Peter M.A. Sloot
Publisher : Springer Science & Business Media
Release Date : 2007-05-18
Category : Computers
Total pages :1214
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Part of a four-volume set, this book constitutes the refereed proceedings of the 7th International Conference on Computational Science, ICCS 2007, held in Beijing, China in May 2007. The papers cover a large volume of topics in computational science and related areas, from multiscale physics to wireless networks, and from graph theory to tools for program development.

Computational Toxicology

Computational Toxicology
Author : Sean Ekins
Publisher : John Wiley & Sons
Release Date : 2018-01-08
Category : Science
Total pages :432
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A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. • Provides a perspective of what is currently achievable with computational toxicology and a view to future developments • Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment • Assembles cutting-edge concepts and leading authors into a unique and powerful single-source reference • Includes in-depth looks at QSAR models, physicochemical drug properties, structure-based drug targeting, chemical mixture assessments, and environmental modeling • Features coverage about consumer product safety assessment and chemical defense along with chapters on open source toxicology and big data

Evidence-Based Validation of Herbal Medicine

Evidence-Based Validation of Herbal Medicine
Author : Pulok K. Mukherjee
Publisher : Elsevier
Release Date : 2015-02-17
Category : Medical
Total pages :556
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Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including –omic technologies, phyto-chemical analysis, hyphenated techniques, and many more. Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques Covers biosynthesis, synthesis, and biological activity related to natural products Consolidates information to save time and money in research Increases confidence levels in quality and validity of natural products

Denslow's Mother Goose

Denslow's Mother Goose
Author : W. W. Denslow
Publisher : B&R Samizdat Express
Release Date : 2018-03-01
Category : Juvenile Fiction
Total pages :32
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Children's picture book, first published in 1901. With 98 color illustrations. "For these books W.W. Denslow has revised and adapted several of the best classical fairy tales. He has improved these stories by elimination of all coarseness, cruelty, and everything that might frighten children. They are new; more beautiful and striking in both text and picture than any children's books heretofore published." According to Wikipedia: "William Wallace Denslow (May 25, 1856 – May 27, 1915) – usually credited as W. W. Denslow – was an American illustrator and caricaturist..."

Willie Mouse

Willie Mouse
Author : Alta Tabor
Publisher : Prabhat Prakashan
Release Date : 101-01-01
Category :
Total pages :129
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Great Stories and poems for children is a collection of most delightful childrens stories.

The Real Mother Goose

The Real Mother Goose
Author : Blanche Fisher Wright
Publisher : Prabhat Prakashan
Release Date : 2018-01-01
Category : Fiction
Total pages :214
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Little Bo-Peep has lost her sheep, And can't tell where to find them; Leave them alone, and they'll come home, And bring their tails behind them.

Food Cures and Manipulative Therapy in Traditional Chinese Medicine

Food Cures and Manipulative Therapy in Traditional Chinese Medicine
Author : Henry C. Lu
Publisher : Createspace Independent Publishing Platform
Release Date : 2016-07-22
Category :
Total pages :472
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In the past century, Western medicine has made such tremendous progress, particularly in diagnostics and surgery that it has become indispensable to human health. Unfortunately, one thing gets in the way of Western medicine as a medical science: individual physical conditions. Individuals do not share the same physical conditions; some people feel unusually cold, which means that they have a cold physical condition; others feel unusually hot, which means that they have a hot physical condition; still others feel unusually fatigued, which means that they have a weak physical condition; still others feel unusually thirsty, which means that they have a dried physical condition; to mention only a few types. If you have a cold physical condition, you need to warm your body; if you have a hot physical condition, you need to cool your body; if you have a weak physical condition, you need to strengthen your body; if you have a dried physical condition, you need to moisten your body. Each physical condition needs different things and should avoid different things. This is a fundamental principle of health and healing, which runs counter to the scientific principle of Western medicine. A drug in Western medicine targets a disease that may attack many thousands of individuals, and the same drug treats them indiscriminately. This is one important reason why drugs used in Western medicine cause so many side effects, because it takes a dim view of different physical conditions. A renowned Chinese doctor in the 17th century put forward the following points of view., The attack of pathogens affects a victim in the same way that intoxication affects a drunk. A drunk will normally display a flooding and rapid pulse, being in high spirits, feeling hot sensations in the body, with a red color of the face and pink eyes, which apply to average persons. However, in some cases, a drunk may act like a wild animal, and he will forget everything after sleeping off a drunk. Another drunk may remain normal in thought and spirit; still another may display a pale color of the face; still another may appear stronger than usual; still another may shiver with chills; still another may get intoxicated easily and sober up quickly; still another may not be easily intoxicated, nor can he sober up quickly; still another may yawn and sneeze; still another may feel dizzy and headache. Thus, people have different reactions to intoxication, due to their differences in physical conditions. By the same token, when people are under the attack of pathogens, normally they will display a fever day and night, which reduces at dawn; they will have headache and body ache, a white layer of coating on the tongue, gradually feeling thirsty; such are normal patterns. However, some people under the same attack may vomit or feel dry in the throat, or discharge phlegm from the mouth, or have only fever, or, have fever with chills, or have fever after chill. Thus, people have different reactions to the attack, due to their differences in physical conditions. To be sure, Western doctors know very well that intoxication affects different people differently, which is why they maintain that the amount of alcohol present in the blood does not provide completely valid information about the degree of intoxication. Why not? It is because of the ability of the central nervous system to adapt to alcohol. Since each individual has a different central nervous system, it logically follows that intoxication affects different individuals differently. This is very true indeed, but the inherent fallacy is that a doctor should take each patient's central nervous system into serious consideration, instead of shrugging off the individual difference and treating all patients with the same drug for the same disease.

Friendly Fairies

Friendly Fairies
Author : Johnny Gruelle
Publisher : BoD – Books on Demand
Release Date : 2020-07-28
Category : Fiction
Total pages :100
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Reproduction of the original: Friendly Fairies by Johnny Gruelle

Drug Discovery and Development

Drug Discovery and Development
Author : Omboon Vallisuta,Suleiman Olimat
Publisher : BoD – Books on Demand
Release Date : 2015-06-03
Category : Medical
Total pages :330
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It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Traditional Chinese Medicines: Molecular Structures, Natural Sources and Applications

Traditional Chinese Medicines: Molecular Structures, Natural Sources and Applications
Author : Xinjian Yan,Guirong Xie,Jiaju Zhou,G. W. A. Milne
Publisher : Routledge
Release Date : 2018-10-03
Category : Social Science
Total pages :1396
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This title was first published in 2003. In laboratories around the world the active principles in traditional herbal medicines are being isolated and characterized. A systematic effort at the Chinese Academy of Sciences is underway to identify the structure-activity relationships that result from the link between chemistry and medicine that is permitted by this data. This book, which provides the only systematic English-language description of the chemical structures and pharmacological effects of compounds active in traditional Chinese medicines (TCMs), is now in its second edition. The new edition provides English-language monographs on over 9000 chemicals isolated from nearly 4000 natural sources used in Chinese medicine and features the addition of in-depth bioactivity data for many of the compounds. Effects and indications of the medicines are included. Extensive indexing permits cross-referencing among English, Chinese and Latin names for natural medicinal sources, effects and indications, and the chemical components of the medicines. The second edition of Traditional Chinese Medicines includes 2300 new compounds, 2400 additional plant sources, more CAS Registry Numbers, and more pharmacological data. The structure of the book has been extensively reorganised to make cross referencing the data much simpler. This new edition is therefore a substantial improvement on the first edition of this important reference on the structural chemistry of traditional Chinese medicines.