December 5, 2020

Download Ebook Free Molecular Biological Markers For Toxicology And Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment
Author : Bruce A. Fowler
Publisher : Academic Press
Release Date : 2016-06-10
Category : Medical
Total pages :164
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Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Biomarkers in Toxicology

Biomarkers in Toxicology
Author : Ramesh C. Gupta
Publisher : Academic Press
Release Date : 2019-02-13
Category : Medical
Total pages :1246
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Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
Author : Wai Nang Choy
Publisher : CRC Press
Release Date : 2001-08-31
Category : Medical
Total pages :406
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Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Computational Toxicology

Computational Toxicology
Author : Bruce A. Fowler
Publisher : Academic Press
Release Date : 2013-06-04
Category : Computers
Total pages :274
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Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared

Biologic Markers in Urinary Toxicology

Biologic Markers in Urinary Toxicology
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Subcommittee on Biologic Markers in Urinary Toxicology
Publisher : National Academies Press
Release Date : 1995-08-28
Category : Science
Total pages :322
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Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).

Environmental Toxicology and Risk Assessment

Environmental Toxicology and Risk Assessment
Author : Diane S. Henshel
Publisher : ASTM International
Release Date : 1996
Category : Medical
Total pages :476
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Papers presented at symposium as in title, held 3-5 April 1995, Denver, Colo.

Molecular, Clinical and Environmental Toxicology

Molecular, Clinical and Environmental Toxicology
Author : Andreas Luch
Publisher : Springer Science & Business Media
Release Date : 2012-06-07
Category : Medical
Total pages :574
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Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Toxicogenomics in Predictive Carcinogenicity

Toxicogenomics in Predictive Carcinogenicity
Author : Michael D. Waters,Russell S. Thomas
Publisher : Royal Society of Chemistry
Release Date : 2016-06-10
Category : Medical
Total pages :524
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Describes toxicogenomics methods in predictive carcinogenicity testing and cancer risk assessment. Addresses the use of stem cells and bioinformatics in toxicogenomics. For postgraduates, academics and industrialists.

Encyclopaedia of Occupational Health and Safety: The body, health care, management and policy, tools and approaches

Encyclopaedia of Occupational Health and Safety: The body, health care, management and policy, tools and approaches
Author : Jeanne Mager Stellman
Publisher : International Labour Organization
Release Date : 1998
Category : Electronic books
Total pages :1174
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Revised and expanded, this edition provides comprehensive coverage of occupational health and safety. A new CD-ROM version is available which provides the benefits of computer-assisted search capabilities.

Molecular Toxicology Protocols

Molecular Toxicology Protocols
Author : Phouthone Keohavong,Stephen G. Grant
Publisher : Springer Science & Business Media
Release Date : 2005
Category : Medical
Total pages :489
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New state-of-the-art molecular techniques promise to transform the field of genetic toxicology by making it possible to directly detect genotoxic exposures and their consequences in humans, to identify the agent(s) involved, and to clinically manage the exposed population. In Molecular Toxicology Protocols, researchers from prominent universities and cancer centers around the world describe in detail their best techniques for analyzing genotoxic exposure and the resulting biological effects, including intermediate biomarkers such as DNA and chromosomal damage, mutations in reporter and oncogenes, and the earliest possible detection of cancer. The authors emphasize analytical methods specifically developed for use in human populations and in cancer patients, or in other in vivo systems such as transgenic mice. Among the applications detailed are the analysis of interactions of chemical and physical agents with cellular macromolecules, especially DNA, the assessment of medically relevant toxicity, and the individualized characterization of genetic damage and repair. There are also methods to assess and characterize the modulation of this damage and repair through individual differences in specific and genome-wide gene expression, including metabolic profiling and apoptotic capacity. These methods mark a shift in emphasis from studies of the agents themselves to the exposed population, and from studies of small populations with significant known exposures to a single agent, to studies of common diseases, such as breast cancer, caused by normal levels of generalized genotoxic exposure. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Molecular Toxicology Protocols offers a gold-standard collection of cutting-edge techniques designed to investigate a broad range of exposures-endogenous, accidental, medical, environmental, and occupational-and their role in human carcinogenesis and other diseases of aging.

Toxicology and Risk Assessment

Toxicology and Risk Assessment
Author : Helmut Greim,Robert Snyder
Publisher : John Wiley & Sons
Release Date : 2008-04-15
Category : Science
Total pages :698
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This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps. In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections: Principles in Toxicology Organ Toxicology Methods in Toxicology Risk Assessment Risk Management Toxicity of Chemicals Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Release Date : 2000-11-21
Category : Nature
Total pages :354
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Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Molecular Biology of the Toxic Response

Molecular Biology of the Toxic Response
Author : Alvaro Puga,Kendall Wallace
Publisher : CRC Press
Release Date : 1998-10-14
Category : Medical
Total pages :581
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Encouraging the incorporation of molecular biology techniques into the experimental approach to various toxicological problems, the format of the book is two-staged. Each chapter first introduces how various molecular techniques can be successfully applied to solving a specific toxicology question and proceeds to describe the techniques themselves. Also included is a discussion of the benefits and limitations of these techniques . This book will prove of value to practising researchers, but also to graduate students dealing with conceptual issues relating to molecular toxicology.

Environmental Toxicology and Risk Assessment

Environmental Toxicology and Risk Assessment
Author : Diane Susan Henshel
Publisher : ASTM International
Release Date : 1999
Category : Biochemical markers
Total pages :495
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Environmental Toxicology and Risk Assessment

Environmental Toxicology and Risk Assessment
Author : Wayne G. Landis,Jane S. Hughes
Publisher : ASTM International
Release Date : 1993
Category : Electronic book
Total pages :431
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