December 5, 2020

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Molecular Neurology

Molecular Neurology
Author : Stephen Waxman
Publisher : Elsevier
Release Date : 2010-07-26
Category : Medical
Total pages :600
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Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

Molecular Neuroscience

Molecular Neuroscience
Author : Colton Easton
Publisher : Unknown
Release Date : 2019-06-20
Category :
Total pages :260
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Molecular neuroscience is a subfield of neuroscience. It focuses on the examination of the concepts in molecular biology in relation to the nervous system. The communication between neurons usually takes place with the help of chemical transmission across gaps between the cells, known as synapses. The topics that are covered under this discipline include molecular neuroanatomy, the molecular basis for neuroplasticity and the effects of genetics and epigenetics on neuronal development. It also focuses on the molecular mechanisms of neurodegenerative diseases. Some of the common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease and Huntington's disease. The transmitted chemicals, called neurotransmitters, are responsible in the regulation of a significant fraction of vital body functions. The ever-growing need of advanced technology is the reason that has fueled the research in the field of molecular neuroscience in recent times. It strives to provide a fair idea about this discipline and to help develop a better understanding of the latest advances within this field. As this field is emerging at a rapid pace, the contents of this book will help the readers understand the modern concepts and applications of the subject.

Applications of Biotechnology in Neurology

Applications of Biotechnology in Neurology
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release Date : 2013-01-05
Category : Medical
Total pages :638
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Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.

Molecular Neuroscience

Molecular Neuroscience
Author : Patricia Revest,Alan Longstaff
Publisher : Garland Science
Release Date : 1998
Category : Medical
Total pages :237
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Molecular Neuroscience takes an interesting and original approach to explaining the present and future impact of molecular biology on the study of neuroscience. It provides the reader with a level of understanding which will allow them to delve deeper into the ever expanding neuroscience literature. A good balance is achieved between a didactic style and well-selected examples of experimental approaches. This book is written for 2nd and 3rd year life science undergraduates and MSc students on a range of courses. Medical students and researchers requiring a concise introduction to neuroscience, particularly the latest molecular approaches, will also find it an essential read.

Molecular Neurobiology in Neurology and Psychiatry

Molecular Neurobiology in Neurology and Psychiatry
Author : Eric R. Kandel
Publisher : Lippincott Williams & Wilkins
Release Date : 1987
Category : Medical
Total pages :199
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Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases

Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases
Author : Jean-Louis Junien,B. Staels
Publisher : IOS Press
Release Date : 2008
Category : Medical
Total pages :117
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Focuses on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders. This book also focuses on possible explanation of pathways involved in pathogenesis, on susceptibility to and prevention of metabolic and neurological disorders, and on the aspects of drug finding.

Neuroscience: From the Molecular to the Cognitive

Neuroscience: From the Molecular to the Cognitive
Author : Floyd E. Bloom
Publisher : Elsevier
Release Date : 1994-07-19
Category : Science
Total pages :283
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This hundredth volume is a commemorative milestone in the prestigeous Progress in Brain Research series. Accordingly, authors were invited to write on any topic, given that their choice represented the topic most near and dear to their own efforts over a significant period of the recent past, and to which they would likely continue to be devoted in the future. In that sense, this volume does not represent a scientific meeting, but rather an overview sample of problems and methodologies that epitomize brain research broadly at this special moment in the maturation of the field. The chapters comprising this volume assort themselves readily into five or six established categories of topics: developmental brain research, molecular brain research, integrative brain research, neuroplasticity, and neuro-psychiatric conditions. This volume reports through a sample of recognized leaders in the neuroscientific community at a significant instant in the history and evolution of the field.

Genetics, Neurology, Behavior, and Diet in Dementia

Genetics, Neurology, Behavior, and Diet in Dementia
Author : Colin R. Martin,Victor R. Preedy
Publisher : Academic Press
Release Date : 2020-09-07
Category : Medical
Total pages :952
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Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Library of Congress Subject Headings

Library of Congress Subject Headings
Author : Library of Congress
Publisher : Unknown
Release Date : 2004
Category : Subject headings, Library of Congress
Total pages :129
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Molecular Neuroscience

Molecular Neuroscience
Author : Fulton Wong
Publisher : Alan R. Liss
Release Date : 1987
Category : Gene expression
Total pages :164
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Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
Author : Roger N. Rosenberg,Juan M. Pascual
Publisher : Elsevier
Release Date : 2014-10-28
Category : Medical
Total pages :1464
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Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

Molecular Imaging

Molecular Imaging
Author : Shankar Vallabhajosula
Publisher : Springer Science & Business Media
Release Date : 2009-07-13
Category : Medical
Total pages :372
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Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

From Neuroscience to Neurology

From Neuroscience to Neurology
Author : Stephen Waxman
Publisher : Elsevier
Release Date : 2004-11-05
Category : Medical
Total pages :552
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The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field

The Brain and Host Defense

The Brain and Host Defense
Author : Anonim
Publisher : Elsevier
Release Date : 2009-12-24
Category : Science
Total pages :358
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It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Molecular and Cellular Approaches to the Treatment of Neurological Disease

Molecular and Cellular Approaches to the Treatment of Neurological Disease
Author : Stephen G. Waxman
Publisher : Lippincott Williams & Wilkins
Release Date : 1993
Category : Medical
Total pages :393
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This volume demonstrates how recent discoveries in molecular and cellular neurobiology can be used to develop new therapies for stroke, brain and spinal cord injury, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and other neurological disorders. More than fifty outstanding basic and clinical neuroscientists detail the molecular and cellular mechanisms of neuronal death and injury, examine these mechanisms in specific diseases, and explore new strategies for treatment by pharmacological intervention or by cellular and molecular replacement. The book highlights important interrelationships between clinical investigation and research using the incisive methods of molecular biology, membrane biophysics and ion channel physiology, optical imaging, positron emission tomography scanning, magnetic resonance imaging and spectroscopy, and computational neuroscience. The contributors analyze the roles of ion channels and exchangers, intracellular calcium, excitatory transmitters, and excitotoxicity in neuronal death and injury and describe how these mechanisms operate in stroke, spinal cord injury, and hereditodegenerative diseases such as Alzheimer's and Huntington's disease. Close attention is given to the therapeutic implications of the ischemic penumbra in stroke and to the prospects for analyzing the ischemic penumbra by nuclear magnetic resonance spectroscopy. A noted expert in neurosurgical research explains how recent clinical trials of high-dose methylprednisolone in spinal cord injury have shed new light on the cellular mechanisms of neuronal injury. The wide variety of new therapeutic strategies explored includes pharmacological modulation of ion channel properties in demyelinating disorders; treatment of ischemic brain injury by calcium channel and postsynaptic receptor blockade and hypothermia; manipulation of neuronal and glial cells using antisense nucleotides; grafting of genetically engineered cells into the central nervous system; and intracerebral transplantation of neurons in neurodegenerative diseases such as Parkinson's disease. This volume is an essential resource for neurologists, neurosurgeons, psychiatrists, and pharmacologists, as well as for scientists investigating the nervous system at the molecular and cellular levels. It offers direction for utilizing the latest findings from basic neuroscience in the search for new neurological therapies.