June 12, 2021

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Monoclonal Antibodies

Monoclonal Antibodies
Author : Johann H. Peters,Horst Baumgarten
Publisher : Springer
Release Date : 1992-11-03
Category : Medical
Total pages :488
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The present new version of this popular laboratory manual is at the same time the first one of this text in the English language - and this makes me even a little proud, as it reminds me of probably the first collection of monoclonal recipes in English, written by myself, which circulated for a couple of years in many laboratories. In the meantime many researchers have put enormous effort into improving methods for monoclonal antibody production. The proce dures have become more and more standardized and by this have more and more lost the character of magic secrets. Hinrich Peters and Horst Baumgarten, who had followed this good tradition already in the previous edition, written in German, suc ceeded in making laboratory tricks teachable. They had contributed their own experiences in cell culture and immunology, and were able to engage a number of experienced authors to contribute to the work. They were all willing to follow the general concept of this book, which contains a brief theoretical background for the methods described and presents the procedures in a highly organized structure. So the book has retained its shape as a "cook-book", which I especially like.

Monoclonal Antibodies

Monoclonal Antibodies
Author : James W. Goding
Publisher : Unknown
Release Date : 1996
Category : Medical
Total pages :492
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* Comprehensively updated to cover the rapid advances that have occurred since the publication of the Second Edition.

Trends in Monoclonal Antibody Research

Trends in Monoclonal Antibody Research
Author : Marie A. Simmons
Publisher : Nova Publishers
Release Date : 2005
Category : Medical
Total pages :148
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This new and important international source of information brings together leading-edge research dedicated to monoclonal antibodies. Monoclonal antibodies (MABs) are: antibodies of exceptional purity and specificity; components of the immune system; able to recognise and bind to a specific antigen. Monoclonal antibodies are currently utilised in many diagnostic procedures, including: measuring protein and drug levels in serum; typing tissue and blood; identifying infectious agents; identifying clusters of differentiation for the classification and follow-up therapy of leukaemias and lymphomas; identifying tumour antigens and auto-antibodies; identifying the specific cells involved in the immune response; identifying and quantifying hormones. For example, monoclonal antibodies (MABs or MOABs) work on cancer cells in the same way natural antibodies work, by identifying and binding to the target cells. They then alert other cells in the immune system to the presence of the cancer cells. MABs are specific for a particular antigen-one designed for a B-cell lymphoma will not work on cells for ovarian cancer cells for example.

Monoclonal Antibodies

Monoclonal Antibodies
Author : Roger H. Kennett
Publisher : Springer
Release Date : 2012-03-30
Category : Medical
Total pages :424
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On August 7, 1975, Kohler and Milstein published in Nature (256:495) a report describing "Continuous cultures of fused cells secreting antibody of predefined specificity. " Their report has become a classic and has already had a profound effect on basic and applied research in biology and medicine. By the time the first Workshop on Lymphocyte Hybridomas (Current Topics in Microbiology and Im munology 81, 1978) was held on April 3-5, 1978, in Bethesda, Maryland, investi gators from many laboratories had made hybrids between plasmacytomas and spleen cells from immunized animals and had obtained monoclonal antibodies reacting with a broad variety of antigenic determinants. At the time Kohler and Milstein introduced this new technology, the editors of this volume were involved in the production of antisera against differentiation antigens (K. B. B. ), histocompatibility antigens (T. ]. McK. ), and human tumor associated antigens (R. H. K. ). Because of the potential usefulness of monoclonal antibodies in these areas, we each began production of hybridomas and analysis of the resulting monoclonal reagents. One of the most interesting aspects of participation in the early stages of the development and application of hybrid oma technology has been observing how the implications of the initial observa tions gradually spread first among the practitioners of immunology and immu nogenetics, and then to other areas of the biological sciences, such as developmental biology, biochemistry, human genetics, and cell and tumor biology.

Monoclonal Antibodies

Monoclonal Antibodies
Author : Philip Shepherd,Christopher J. Dean
Publisher : Practical Approach (Paperback)
Release Date : 2000
Category : Medical
Total pages :479
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Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

The Pharmacology of Monoclonal Antibodies

The Pharmacology of Monoclonal Antibodies
Author : Martin Rosenberg,Gordon P. Moore
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :406
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A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.

Monoclonal Antibodies

Monoclonal Antibodies
Author : Maher Albitar
Publisher : Springer Science & Business Media
Release Date : 2007-06-25
Category : Medical
Total pages :228
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This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy.

Monoclonal Antibody and Immunosensor Technology

Monoclonal Antibody and Immunosensor Technology
Author : A.M. Campbell
Publisher : Elsevier
Release Date : 1991-12-12
Category : Medical
Total pages :426
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This highly practical book, and successor to Volume 13 in the Laboratory Techniques series, explores further and provides more comprehensive, autoritative information on the production of Mabs. Much new and illuminating material has been included covering the concepts behind the application of recombinant DNA technology and biosensor technology to monoclonal antibodies, and all the human Mab technology facilitated by PCR of antibody genes. Also included in this latest volume is a section focussing on other methods of obtaining B cell clones such as short-term culture and oncogene transformation and an interesting section on Mab patents.

A Practical Guide to Monoclonal Antibodies

A Practical Guide to Monoclonal Antibodies
Author : J. Eryl Liddell,A. Cryer
Publisher : John Wiley & Sons
Release Date : 1991-08-26
Category : Medical
Total pages :206
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Includes all of the information required to produce monoclonal antibodies in the laboratory and to prepare them for use in a multitude of given applications. Production procedures are treated in chronological order, beginning with basic tissue culture techniques, immunization strategies and screening test design, followed by production of hybridoma cell lines and basic antibody characterization, purification and labeling. Each chapter contains explanatory text on each step with comparative analysis of methods where appropriate. All necessary experimental protocols are presented in a self-contained format that is easy to follow in the laboratory. Alternative protocols are provided where relevant; for others not included in full, source references are presented. Surveys the current status of human hybridoma production and antibody engineering using molecular biology techniques.

Monoclonal Antibodies

Monoclonal Antibodies
Author : James W. Goding
Publisher : Unknown
Release Date : 1983
Category : Immunoglobulines monoclonales
Total pages :276
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Accounts of the theory, production, purification, fragmentation, storage, and radiolabelling of monoclonal antibodies are given, along with descriptions of their use in antigen characterization, affinity chromatography, and immunoflourescence.

Monoclonal Antibodies

Monoclonal Antibodies
Author : Steven Shire
Publisher : Woodhead Publishing
Release Date : 2015-04-24
Category : Medical
Total pages :224
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Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) Presents strategies to meet the challenges in development of MAbs for SC and IV administration Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration

Monoclonal antibodies

Monoclonal antibodies
Author : Anonim
Publisher : Unknown
Release Date : 1982
Category : Monoclonal antibodies
Total pages :129
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Monoclonal Antibodies

Monoclonal Antibodies
Author : Heddy Zola
Publisher : CRC Press
Release Date : 2013-11-20
Category : Medical
Total pages :232
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This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each method, and th

Monoclonal Antibodies in Clinical Medicine

Monoclonal Antibodies in Clinical Medicine
Author : Andrew J. McMichael,John W. Fabre
Publisher : Unknown
Release Date : 1982
Category : Medical
Total pages :663
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Monoclonal Antibodies in Agriculture

Monoclonal Antibodies in Agriculture
Author : A. Schots
Publisher : Center Agricultural Pub & Document
Release Date : 1990
Category : Agricultural innovations
Total pages :92
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