June 16, 2021

Download Ebook Free Nanostructured Biomaterials For Regenerative Medicine

Nanostructured Biomaterials for Regenerative Medicine

Nanostructured Biomaterials for Regenerative Medicine
Author : Vincenzo Guarino,Michele Iafisco,Silvia Spriano
Publisher : Woodhead Publishing
Release Date : 2019-10-05
Category : Medical
Total pages :466
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Nanostructured Biomaterials for Regenerative Medicine focuses on the definition of new trends for the design of biomaterials for biomedical applications. It includes the ex novo synthesis as well as technological strategies to manipulate them into appropriate two-dimensional (2D) and three-dimensional (3D) forms, in order to impart all the main physical, chemical, structural and biological properties requested to achieve desired clinical efficacy. This book aims at offering a concise overview of innovative platforms based on nanostructured biomaterials as a function of their chemical nature - established by a consolidated material classification i.e., polymer, ceramics and metals. For each class, emerging bioinspired systems with rapid expansion in the biomedical research area and fabricated via new enabling technologies will be proposed for the use in tissue repair/regeneration and nanomedicine. This book is an essential resource for researchers, academics and professionals interested in the potential of nanostructured biomaterials for regenerative medicine. Classifies materials into three classes for comprehensive discussion Discusses design techniques to create innovative nanostructured biomaterials Looks at enabling technologies and strategies for emerging applications

Nanostructured Biomaterial Surfaces in Regenerative Medicine

Nanostructured Biomaterial Surfaces in Regenerative Medicine
Author : Edwin Lamers
Publisher : Unknown
Release Date : 2012
Category :
Total pages :172
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Engineering Micro- and Nanostructured Biomaterials for Cell and Tissue Engineering

Engineering Micro- and Nanostructured Biomaterials for Cell and Tissue Engineering
Author : Benjamin Li-Ping Lee
Publisher : Unknown
Release Date : 2014
Category :
Total pages :105
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Tissue engineering has emerged as a well-investigated research area that aims to ultimately create biological substitutes, ranging from skin replacement to artificial blood vessels, for regenerative medicine applications. It is a multidisciplinary field that integrates knowledge and advancements from biology, materials, chemistry, and many others. Although the goal of tissue engineering is to engineer tissues with structure and function that closely mimic those of native tissues for not only diagnostic and drug testing applications but also repair and replacement of diseased and injured tissues, it provides in-depth understanding of tissue development and morphogenesis, including the intricate biological systems in the body that together operate to direct growth, repair, and death. The general approach of tissue engineering is to use cells, biomaterials, bioactive molecules, or a combination thereof to best recapitulate the properties of native tissues and reconstitute function. Specifically, biomaterial scaffolds play a key role in that their main function is to serving as a basis to interact with and support cells, promoting their attachment and migration while providing a porous and biomimetic microenvironment for mass transport and integration of bioactive factors. Therefore, in order to fabricate implantable scaffolds with properties that emulate the natural extracellular matrix (ECM) in terms of structure and organization, we utilize and implement electrospinning technology. Electrospinning is a versatile technique with immense potential to create cell-instructive scaffolds possessing ECM-like fibrous structures. Because of the ability to tune scaffold structure with respect to physical (i.e. geometry and mechanical properties) and chemical (i.e. retention and presentation of bioactive molecules) features, electrospun scaffolds, which are made from synthetic, natural, or a combination of the two polymers, have demonstrated functional success in an array of tissue engineering applications. In fact, the fibrous network, especially in the nanoscale, possesses high surface-area-to-volume ratio that is favorable for surface modifications to facilitate cell attachment as well as immobilization and covalent conjugation of bioactive molecules. However, one major shortcoming of electrospun scaffolds as a result of such densely packed network of fibers is their small pore size, limiting cell infiltration and tissue ingrowth essential for desired angiogenesis and tissue integration. Thus, electrospun scaffolds with dense fibrous structure and small pore size have not had enormous success in the regeneration of large, more complex tissues that require abundant vascularization and mass transport of oxygen and nutrients. In this dissertation, we attempt to address both the physical and chemical elements of electrospun scaffolds as we engineer novel ways to modulate their structural features and surface chemistry for their utilization in different cell and tissue engineering applications. We focus primarily on micro- and nanostructures, topographical cues, and chemical modifications and their role in enhancing cell infiltration and promoting better tissue integration in terms of angiogenesis in and overall functional performance of implanted scaffolds as well as vascular graft. Specifically, we detail the employment of an ultrafast, femtosecond (FS) laser system as a promising post-fabrication technology to pattern structural features (i.e. through-holes) that influence cell behavior and improve the integration electrospun scaffolds in vivo. We also demonstrate that changes in biophysical factors, such as increasing pore size and porosity via incorporation and removal of sacrificial fibers from composite scaffolds, can not only improve cell infiltration but more importantly regulate stem cell differentiation. Lastly, we show that we can fabricate small-diameter, nanofibrous vascular graft made of Carbosil®, a commercially available polycarbonate-urethane (PCU), via electrospinning and subsequently manipulate its surface properties through plasma treatment and reductive amination to effectively end-point immobilize heparin to reduce surface thrombogenicity while enhancing bioactivity and short-term in vivo performance. In summary, we offer novel design and fabrication of electrospun scaffolds with large pore size and highly porous structure, and vascular grafts with tailored surface chemistry and bioactivity optimal for their biological performance. We demonstrate through our studies that physical and chemical features of not only electrospun scaffolds but implantable biomaterials in general can be engineered and manipulated using post-fabrication processing (i.e. FS laser and tunable surface chemistry) and unique fabrication approaches (i.e. multiple polymers with sacrificial components). Only with ample vascularization and tissue integration will such biomaterial scaffolds regenerate native tissue function and demonstrate success in both simple, such as skin substitutes, as well as complicated, such as artificial heart, tissues and organs for applications in regenerative medicine.

Nanotechnology and Regenerative Engineering

Nanotechnology and Regenerative Engineering
Author : Cato T. Laurencin,Lakshmi S. Nair
Publisher : CRC Press
Release Date : 2014-10-28
Category : Medical
Total pages :476
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Nanotechnology and regenerative engineering have emerged to the forefront as the most versatile and innovative technologies to foster novel therapeutic techniques and strategies of the twenty-first century. The first edition of Nanotechnology and Tissue Engineering: The Scaffold was the first comprehensive source to explain the developments in nanostructured biomaterials for tissue engineering, the relevance of nanostructured materials in tissue regeneration, and the current applications of nanostructured scaffolds for engineering various tissues. This fully revised second edition, renamed Nanotechnology and Regenerative Engineering: The Scaffold, provides a thorough update to the existing material, bringing together these two unique areas to give a perspective of the emerging therapeutic strategies for a wide audience. New coverage includes: Updated discussion of the importance of scaffolds in tissue engineering Exploration of cellular interactions at the nanoscale Complete range of fabrication processes capable of developing nanostructured scaffolds for regenerative engineering Applications of nanostructured scaffolds for neural, skin, cardiovascular, and musculoskeletal regenerative engineering FDA approval process of nanostructure scaffolds Products based on nanostructured scaffolds Due to the unique and tissue-mimic properties of the nanostructured scaffolds, the past five years have seen a tremendous growth in nanostructured materials for biological applications. The revised work presents the current state-of-the-art developments in nanostructured scaffolds for regenerative engineering.

Nanobiomaterials Science, Development and Evaluation

Nanobiomaterials Science, Development and Evaluation
Author : Mehdi Razavi,Avnesh Thakor
Publisher : Woodhead Publishing
Release Date : 2017-05-22
Category : Technology & Engineering
Total pages :340
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Nanobiomaterials Science, Development and Evaluation examines the practical aspects of producing nanostructured biomaterials for a range of applications. With a strong focus on materials, such as metals, ceramics, polymers, and composites, the book also examines nanostructured coatings and toxicology aspects. Chapters in Part One look at materials classes and their synthesis with information on all major material groups. Part Two focuses on nanostructured coatings and practical aspects associated with the use of nanobiomaterials in vivo. This book brings together the work of international contributors who are actively engaged on the forefront of research in their respective disciplines, and is a valuable resource for materials scientists in academia, industry, and all those who wish to broaden their knowledge in the allied field. Focuses on the synthesis and evaluation techniques for a range of nanobiomaterials Examines nanostructured inorganic coatings for biomaterials Discusses issues related to the toxicology of nanobiomaterials Presents the practical aspects of nanobiomaterials

Biomaterials and Stem Cells in Regenerative Medicine

Biomaterials and Stem Cells in Regenerative Medicine
Author : Murugan Ramalingam,Seeram Ramakrishna,Serena Best
Publisher : CRC Press
Release Date : 2012-07-03
Category : Medical
Total pages :564
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Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction. Featuring contributions by experts in the field, the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications of biomaterials and stem cells. Topics include: Polymeric systems for stem cell delivery The potential of membranes and porous scaffolds in tissue repair, including myocardial, periodontal, ophthalmic, and bone tissues The optimization of the interaction between stem cells and biomaterial substrates The source and nature of stem cells for tissue engineering applications The clinical translation of stem cell–based tissue engineering for regenerative medicine From fundamental principles to recent advances at the macro, micro, nano, and molecular scales, the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions. This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for graduate students, researchers, and practitioners working in the multidisciplinary field of biomedical research.

Nanostructures for the Engineering of Cells, Tissues and Organs

Nanostructures for the Engineering of Cells, Tissues and Organs
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release Date : 2018-02-14
Category : Science
Total pages :630
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Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Nanobiomaterials Science, Development and Evaluation

Nanobiomaterials Science, Development and Evaluation
Author : Mehdi Razavi,Avnesh Thakor
Publisher : Woodhead Publishing Limited
Release Date : 2017-06-01
Category : Technology & Engineering
Total pages :390
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Research is shifting towards the nanoscale modification of fundamental biomaterials and their characteristics to stimulate new tissue creation and improve prospects in tissue engineering. Tissue engineering using nanobiomaterials is still in its infancy but steps are being made to advance and enhance protocols for clinical applications. Nanobiomaterials science, development and evaluation examines the practical aspects of producing nanostructured biomaterials for a range of applications. With a strong focus on materials such as metals, ceramics, polymers and composites, the book also examines nanostructured coatings and toxicology aspects. Chapters in Part 1 look at materials classes and their synthesis with information on all major material groups. Part 2 focusses on nanostructured coatings and practical aspects associated with the use of nanobiomaterials in vivo. This book brings together the work of international contributors, who are actively engaged at the forefront of research in their respective disciplines, and is a valuable resource for materials scientists in academia and industry and all those who wish to broaden their knowledge in the allied field. Focuses on the synthesis and evaluation techniques for a range of nanobiomaterials Examines nanostructured inorganic coatings for biomaterials Discusses issues related to the toxicology of nanobiomaterials Presents the practical aspects of nanobiomaterials

Biomaterials and Nanotechnology for Tissue Engineering

Biomaterials and Nanotechnology for Tissue Engineering
Author : Emeka Arendse
Publisher : Unknown
Release Date : 2017-02
Category :
Total pages :300
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Biomaterials for Artificial Organs

Biomaterials for Artificial Organs
Author : Michael Lysaght,Thomas J Webster
Publisher : Elsevier
Release Date : 2010-12-20
Category : Technology & Engineering
Total pages :320
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The worldwide demand for organ transplants far exceeds available donor organs. Consequently some patients die whilst waiting for a transplant. Synthetic alternatives are therefore imperative to improve the quality of, and in some cases, save people’s lives. Advances in biomaterials have generated a range of materials and devices for use either outside the body or through implantation to replace or assist functions which may have been lost through disease or injury. Biomaterials for artificial organs reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs. Part one discusses commodity biomaterials including membranes for oxygenators and plasmafilters, titanium and cobalt chromium alloys for hips and knees, polymeric joint-bearing surfaces for total joint replacements, biomaterials for pacemakers, defibrillators and neurostimulators and mechanical and bioprosthetic heart valves. Part two goes on to investigate advanced and next generation biomaterials including small intestinal submucosa and other decullarized matrix biomaterials for tissue repair, new ceramics and composites for joint replacement surgery, biomaterials for improving the blood and tissue compatibility of total artificial hearts (TAH) and ventricular assist devices (VAD), nanostructured biomaterials for artificial tissues and organs and matrices for tissue engineering and regenerative medicine. With its distinguished editors and international team of contributors Biomaterials for artificial organs is an invaluable resource to researchers, scientists and academics concerned with the advancement of artificial organs. Reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs Discusses commodity biomaterials including membranes for oxygenators and cobalt chromium alloys for hips and knees and polymeric joint-bearing surfaces for total joint replacements Further biomaterials utilised in pacemakers, defibrillators, neurostimulators and mechanical and bioprosthetic heart valve are also explored

Nanotechnology in Tissue Engineering and Regenerative Medicine

Nanotechnology in Tissue Engineering and Regenerative Medicine
Author : Ketul Popat
Publisher : CRC Press
Release Date : 2010-11-22
Category : Mathematics
Total pages :302
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Although nanotechnology applied to medicine has a potentially huge impact on drug delivery and tissue engineering, significant challenges need to be resolved before clinically viable nanomedicine or nanobiomedicine therapies will be available. Skillfully edited, with contributions from an expert panel of researchers, Nanotechnology in Tissue Engineering and Regenerative Medicine discusses the use of nanotechnology for medical applications with a focus on its use for drug delivery and tissue engineering. It sheds light on the challenges facing the field and examines cutting-edge research that may provide solutions. Topics covered include: Patterning of biomimetic substrates with AFM lithography, primarily focusing on DPN Nanotemplating polymer melts Nanotechnology-based approaches in the treatment of injuries to tendons and ligaments Progress in the use of electrospinning processing techniques for fabricating nanofiber scaffolds for neural applications Nanotopography techniques for tissue-engineered scaffolds and the effects of nanotopography on cells and tissues Vertically aligned TiO2 nanotube surface structuring for optimization of Ti implants utilizing nanotechnology Applications originating from the harmony of nanotechnology to biological systems, especially for the regeneration in the nervous system Current understanding of the mechanisms by which cells sense nano-scale structure at the molecular level and how this understanding can be useful in developing novel antifouling materials While there are books available on tissue engineering and nanotechnology and others about regenerative medicine, most do not comprehensively cover applications of nanotechnology to both these areas. Focusing chiefly on drug delivery, tissue engineering, and regenerative medicine, the book uses an application-based approach to relate laboratory-based research to the development of technologies that can be readily adaptable to an industrial environment.

Nanotechnologies in Preventive and Regenerative Medicine

Nanotechnologies in Preventive and Regenerative Medicine
Author : Vuk Uskokovic
Publisher : Elsevier
Release Date : 2017-11-22
Category : Medical
Total pages :616
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Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage Explains how nanomaterials can be manipulated to create more effective drug treatments Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

NanoScience in Biomedicine

NanoScience in Biomedicine
Author : Donglu Shi
Publisher : Springer
Release Date : 2009-06-15
Category : Medical
Total pages :729
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NanoScience in Biomedicine provides up-to-date information in the frontier fields of nano biomedicine focusing on basic concepts and recent developments in many topical areas including particular nanomaterials synthesis, field emission of carbon nanotubes, flexible dye-sensitized nano-porous films, magnetic nanofluids, and intrinsically electroconducting nanoparticles. Novel methods of synthesizing nanoscale biomaterials and their applications in biomedicine are also included such as nano-sized materials for drug delivery, bioactive molecules for regenerative medicine, nanoscale mechanisms for assembly of biomaterials, and nanostructured materials constructed from polypeptides. This book is organized in three parts: Part I introduces most recent developments in all aspects of design, synthesis, properties, and applications of nanoscale biomaterials. Part II focuses on novel nanotechnologies in biomedicine. Part III includes some of the new developments of nanomaterials’ synthesis and recent studies on nanostructure-properties relationships. The book comprehensively addresses the most critical issues in a tutorial manner so that technical non-specialists and students in both biomedical sciences and engineering will be able to benefit. All chapters are contributed by internationally recognized scholars. Dr. Donglu Shi is a professor at the Chemical and Materials Engineering Department, University of Cincinnati, USA.

Tissue Engineering and Regenerative Medicine

Tissue Engineering and Regenerative Medicine
Author : Murugan Ramalingam,Pekka Vallittu,Ugo Ripamonti,Wan-Ju Li
Publisher : CRC Press
Release Date : 2012-09-18
Category : Medical
Total pages :592
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Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering and Regenerative Medicine: A Nano Approach provides a compilation of the important aspects of tissue engineering and regenerative medicine, including dentistry, from fundamental principles to current advances and future trends. Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas: Nanobiomaterials and scaffolds—including nanocomposites and electrospun nanofibers Tissue mechanics Stem cells and nanobiomaterials Oral and cranial implants and regeneration of bone Cartilage tissue engineering Controlled release—DNA, RNA, and protein delivery Animal science and clinical medicine The editors designed this textbook with a distinctive theme focusing on the utilization of nanotechnology, biomaterials science in tissue engineering, and regenerative medicine with the inclusion of important clinical aspects. In addition to injured veterans and other individuals, increased life expectancy in the industrialized world is creating a growing population that will require regenerative medicine, producing greater pressure to develop procedures and treatments to improve quality of life. This book bridges the gap between nanotechnology and tissue engineering and regenerative medicine, facilitating the merger of these two fields and the important transition from laboratory discoveries to clinical applications.

Nanostructured Polymers and Carbon Nanomaterial/polymer Composites for Bladder Tissue Engineering

Nanostructured Polymers and Carbon Nanomaterial/polymer Composites for Bladder Tissue Engineering
Author : Young Wook Chun,Brown University. Division of Engineering
Publisher : Unknown
Release Date : 2011
Category : Bladder
Total pages :314
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The interaction between bladder cells or tissues and synthetic materials which mimic the natural bladder environment has been a matter of great interest in bladder tissue engineering. In particular, surface properties of biomaterials have been optimized using nanotechnology to improve interactions with bladder cells for regenerative medicine applications. Specifically, in vivo and in vitro studies have demonstrated greater bladder tissue growth on polymeric surfaces with nanoscale to submicron surface features. Improved bladder cell responses on nanostructured polymers has been correlated to unique nanomaterial surface features leading to greater surface energy which influences initial protein interactions. Moreover, coupled with the observed greater in vitro and in vivo bladder cell adhesion as well as proliferation on nano-structured compared to conventional synthetic polymers, decreased calcium stone formation has also been measured. Here ... the importance of nanostructured biomaterial surface features for bladder tissue replacement is suggested with thoughts on future directions for bladder tissue engineering field.