June 17, 2021

Download Ebook Free Nanostructures For The Engineering Of Cells, Tissues And Organs

Nanostructures for the Engineering of Cells, Tissues and Organs

Nanostructures for the Engineering of Cells, Tissues and Organs
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release Date : 2018-02-14
Category : Science
Total pages :630
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Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Biomaterials and Nanotechnology for Tissue Engineering

Biomaterials and Nanotechnology for Tissue Engineering
Author : Emeka Arendse
Publisher : Unknown
Release Date : 2017-02
Category :
Total pages :300
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Tissue and Organ Regeneration

Tissue and Organ Regeneration
Author : Lijie Grace Zhang,Ali Khademhosseini,Thomas Webster
Publisher : CRC Press
Release Date : 2016-04-19
Category : Medical
Total pages :822
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Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell–based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo, because stem cells are rather sensitive to even minute changes in their environment. Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. Moreover, it covers and details cutting-edge research in nano- and microfabrication techniques and biomaterials for the regeneration of various tissues and organs, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder, cardiac, and vascular tissues.

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration
Author : Nihal Vrana,Helena Knopf-Marques,Julien Barthes
Publisher : Woodhead Publishing
Release Date : 2020-03-20
Category : Medical
Total pages :846
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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Micro and Nanotechnologies in Engineering Stem Cells and Tissues

Micro and Nanotechnologies in Engineering Stem Cells and Tissues
Author : Murugan Ramalingam,Esmaiel Jabbari,Seeram Ramakrishna,Ali Khademhosseini
Publisher : John Wiley & Sons
Release Date : 2013-05-10
Category : Science
Total pages :328
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A cutting-edge look at the application of micro andnanotechnologies in regenerative medicine The area at the interface of micro/nanotechnology and stemcells/tissue engineering has seen an explosion of activity inrecent years. This book provides a much-needed overview of theseexciting developments, covering all aspects of micro andnanotechnologies, from the fundamental principles to the latestresearch to applications in regenerative medicine. Written and edited by the top researchers in the field, Microand Nanotechnologies in Engineering Stem Cells and Tissuesdescribes advances in material systems along with currenttechniques available for cell, tissue, and organ studies. Readerswill gain tremendous insight into the state of the art of stemcells and tissue engineering, and learn how to use the technologyin their own research or clinical trials. Coverage includes: Technologies for controlling or regulating stem cell and tissuegrowth Various engineering approaches for stem cell, vascular tissue,and bone regeneration The design and processing of biocompatible polymers and otherbiomaterials Characterization of the interactions between cells andbiomaterials Unrivaled among books of this kind, Micro andNanotechnologies in Engineering Stem Cells and Tissues is theultimate forward-looking reference for researchers in numerousdisciplines, from engineering and materials science to biomedicine,and for anyone wishing to understand the trends in thistransformative field.

Engineering Micro- and Nanostructured Biomaterials for Cell and Tissue Engineering

Engineering Micro- and Nanostructured Biomaterials for Cell and Tissue Engineering
Author : Benjamin Li-Ping Lee
Publisher : Unknown
Release Date : 2014
Category :
Total pages :105
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Tissue engineering has emerged as a well-investigated research area that aims to ultimately create biological substitutes, ranging from skin replacement to artificial blood vessels, for regenerative medicine applications. It is a multidisciplinary field that integrates knowledge and advancements from biology, materials, chemistry, and many others. Although the goal of tissue engineering is to engineer tissues with structure and function that closely mimic those of native tissues for not only diagnostic and drug testing applications but also repair and replacement of diseased and injured tissues, it provides in-depth understanding of tissue development and morphogenesis, including the intricate biological systems in the body that together operate to direct growth, repair, and death. The general approach of tissue engineering is to use cells, biomaterials, bioactive molecules, or a combination thereof to best recapitulate the properties of native tissues and reconstitute function. Specifically, biomaterial scaffolds play a key role in that their main function is to serving as a basis to interact with and support cells, promoting their attachment and migration while providing a porous and biomimetic microenvironment for mass transport and integration of bioactive factors. Therefore, in order to fabricate implantable scaffolds with properties that emulate the natural extracellular matrix (ECM) in terms of structure and organization, we utilize and implement electrospinning technology. Electrospinning is a versatile technique with immense potential to create cell-instructive scaffolds possessing ECM-like fibrous structures. Because of the ability to tune scaffold structure with respect to physical (i.e. geometry and mechanical properties) and chemical (i.e. retention and presentation of bioactive molecules) features, electrospun scaffolds, which are made from synthetic, natural, or a combination of the two polymers, have demonstrated functional success in an array of tissue engineering applications. In fact, the fibrous network, especially in the nanoscale, possesses high surface-area-to-volume ratio that is favorable for surface modifications to facilitate cell attachment as well as immobilization and covalent conjugation of bioactive molecules. However, one major shortcoming of electrospun scaffolds as a result of such densely packed network of fibers is their small pore size, limiting cell infiltration and tissue ingrowth essential for desired angiogenesis and tissue integration. Thus, electrospun scaffolds with dense fibrous structure and small pore size have not had enormous success in the regeneration of large, more complex tissues that require abundant vascularization and mass transport of oxygen and nutrients. In this dissertation, we attempt to address both the physical and chemical elements of electrospun scaffolds as we engineer novel ways to modulate their structural features and surface chemistry for their utilization in different cell and tissue engineering applications. We focus primarily on micro- and nanostructures, topographical cues, and chemical modifications and their role in enhancing cell infiltration and promoting better tissue integration in terms of angiogenesis in and overall functional performance of implanted scaffolds as well as vascular graft. Specifically, we detail the employment of an ultrafast, femtosecond (FS) laser system as a promising post-fabrication technology to pattern structural features (i.e. through-holes) that influence cell behavior and improve the integration electrospun scaffolds in vivo. We also demonstrate that changes in biophysical factors, such as increasing pore size and porosity via incorporation and removal of sacrificial fibers from composite scaffolds, can not only improve cell infiltration but more importantly regulate stem cell differentiation. Lastly, we show that we can fabricate small-diameter, nanofibrous vascular graft made of Carbosil®, a commercially available polycarbonate-urethane (PCU), via electrospinning and subsequently manipulate its surface properties through plasma treatment and reductive amination to effectively end-point immobilize heparin to reduce surface thrombogenicity while enhancing bioactivity and short-term in vivo performance. In summary, we offer novel design and fabrication of electrospun scaffolds with large pore size and highly porous structure, and vascular grafts with tailored surface chemistry and bioactivity optimal for their biological performance. We demonstrate through our studies that physical and chemical features of not only electrospun scaffolds but implantable biomaterials in general can be engineered and manipulated using post-fabrication processing (i.e. FS laser and tunable surface chemistry) and unique fabrication approaches (i.e. multiple polymers with sacrificial components). Only with ample vascularization and tissue integration will such biomaterial scaffolds regenerate native tissue function and demonstrate success in both simple, such as skin substitutes, as well as complicated, such as artificial heart, tissues and organs for applications in regenerative medicine.

Biofabrication

Biofabrication
Author : Gulden Camci-Unal,Pinar Zorlutuna,Ali Khademhosseini
Publisher : Elsevier Inc. Chapters
Release Date : 2013-03-18
Category : Medical
Total pages :288
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Microscale hydrogels are potentially useful materials for controlling cellular behavior to mimic native microenvironments for tissue engineering applications. In this chapter, various fabrication techniques to generate microscale hydrogels and their applications in tissue engineering have been outlined. In addition, we provide examples of microscale hydrogels with different physical and chemical properties for generation of tissue constructs. Finally, we discuss potential future directions in fabrication of hydrogels to address challenges in tissue engineering. It is expected that these techniques will enable engineering of three-dimensional (3D) structures with controlled features for the formation of functional tissues and organs.

Smart Materials for Tissue Engineering

Smart Materials for Tissue Engineering
Author : Qun Wang
Publisher : Royal Society of Chemistry
Release Date : 2017
Category : Science
Total pages :692
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In the last couple of decades, research in the area of tissue engineering has witnessed tremendous progress. The focus has been on replacing or facilitating the regeneration of damaged or diseased cell, tissue or organs by applying a biomaterial support system, and a combination of cells and bioactive molecules. In addition new smart materials have been developed which provide opportunities to fabricate, characterize and utilize materials systematically to control cell behaviours and tissue formation by biomimetic topography that closely replicate the natural extracellular matrix. Following on from Smart Materials for Tissue Engineering: Fundamental Principles, this book comprehensively covers the different uses of smart materials in tissues engineering, providing a valuable resource for biochemists, materials scientists and biomedical engineers working in industry and academia.

Chitin and Chitosan for Regenerative Medicine

Chitin and Chitosan for Regenerative Medicine
Author : Pradip Kumar Dutta
Publisher : Springer
Release Date : 2015-09-04
Category : Technology & Engineering
Total pages :389
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The book is an excellent reference for scientists, researchers and students working in the field of areas of biopolymeric biomaterials, biomedical engineering, therapeutics, tissue engineering and regenerative medicine. The book is divided into two parts: Part I will focus on the tissue engineering and Part II focuses on therapeutics, functionalization and computer-aided techniques. The book consists of 13 chapters contributed by 20 international contributors who are leading experts in the field of biopolymers and its applications. It will focus on the advancements of chitin and chitosan in regenerative medicine. Regenerative medicine in tissue engineering is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. It is an incredibly progressive field of medicine that may, in the near future, help with the shortage of life-saving organs available through donation for transplantation vis-a-vis regenerative medicine focuses on therapeutics, functionalization and computer-aided techniques. It also covers physical and chemical aspects of chitin and chitosan, structural modifications for biomedical applications, chitosan based scaffolds and biomodelling in tissue engineering, nanomedicines and therapeutic applications. With the broad range of applications, the world is waiting for biopolymers to serve as the basis for regenerative medicine and biomedical applications.

Stem-Cell Nanoengineering

Stem-Cell Nanoengineering
Author : H. Baharvand
Publisher : John Wiley & Sons
Release Date : 2014-12-30
Category : Science
Total pages :432
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Stem Cell Nanoengineering reviews the applications of nanotechnology in the fields of stem cells, tissue engineering, and regenerative medicine. Topics addressed include various types of stem cells, underlying principles of nanobiotechnology, the making of nano-scaffolds, nano tissue engineering, applications of nanotechnology in stem cell tracking and molecular imaging, nano-devices, as well as stem cell nano-engineering from bench to bedside. Written by renowned experts in their respective fields, chapters describe and explore a wide variety of topics in stem cell nanoengineering, making the book a valuable resource for both researchers and clinicians in biomedical and bioengineering fields.

Regenerative Medicine - from Protocol to Patient

Regenerative Medicine - from Protocol to Patient
Author : Gustav Steinhoff
Publisher : Springer
Release Date : 2016-04-12
Category : Science
Total pages :244
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Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes, Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. The collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 3: Tissue engineering, Biomaterials and Nanotechnology focuses the development of technologies, which enable an efficient transfer of therapeutic genes and drugs exclusively to target cells and potential bioactive materials for clinical use. Principles of tissue engineering, vector technology, multifunctionalized nanoparticles, biodegradable materials, controlled release, and biointerface technology are described with regard to the development of new clinical cell technology. Imaging and targeting technologies as well as biological aspects of tissue and organ engineering are depicted.

Experimental Biology and Medicine

Experimental Biology and Medicine
Author : Anonim
Publisher : Unknown
Release Date : 2009
Category : Biology, Experimental
Total pages :129
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Magnetic Resonance Imaging in Tissue Engineering

Magnetic Resonance Imaging in Tissue Engineering
Author : Mrignayani Kotecha,Richard L. Magin,Jeremy J. Mao
Publisher : John Wiley & Sons
Release Date : 2017-02-21
Category : Technology & Engineering
Total pages :432
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Magnetic Resonance Imaging in Tissue Engineering provides a unique overview of the field of non-invasive MRI assessment of tissue engineering and regenerative medicine Establish a dialogue between the tissue-engineering scientists and imaging experts and serves as a guide for tissue engineers and biomaterial developers alike Provides comprehensive details of magnetic resonance imaging (MRI) techniques used to assess a variety of engineered and regenerating tissues and organs Covers cell-based therapies, engineered cartilage, bone, meniscus, tendon, ligaments, cardiovascular, liver and bladder tissue engineering and regeneration assessed by MRI Includes a chapter on oxygen imaging method that predominantly is used for assessing hypoxia in solid tumors for improving radiation therapy but has the ability to provide information on design strategies and cellular viability in tissue engineering regenerative medicine

Manufacturing Engineering and Materials Handling--2005

Manufacturing Engineering and Materials Handling--2005
Author : Anonim
Publisher : Unknown
Release Date : 2005
Category : Machining
Total pages :1487
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Journal of Nanoscience and Nanotechnology

Journal of Nanoscience and Nanotechnology
Author : Anonim
Publisher : Unknown
Release Date : 2006
Category : Nanoscience
Total pages :129
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