December 1, 2020

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Neural Crest Cells

Neural Crest Cells
Author : Paul Trainor
Publisher : Academic Press
Release Date : 2013-11-23
Category : Science
Total pages :488
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Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects. BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association Provides timely, comprehensive synthesis of the current knowledge of neural crest cells Covers the evolution and development of neural crest cells Includes content on applications for tissue engineering, repair and regeneration

Evolving Neural Crest Cells

Evolving Neural Crest Cells
Author : Brian Frank Eames,Daniel Meulemans Medeiros,Igor Adameyko
Publisher : CRC Press
Release Date : 2020-07-29
Category : Nature
Total pages :284
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Vertebrates possess lineage-specific characteristics. These include paired anterior sense organs and a robust, modular head skeleton built of cellular cartilage and bone. All of these structures are derived, at least partly, from an embryonic tissue unique vertebrates - the neural crest. The evolutionary history of the neural crest, and neural crest cells, has been difficult to reconstruct. This volume will use a comparative approach to survey the development of the neural crest in vertebrates, and neural crest-like cells, across the metazoa. This information will be used to reveal neural crest evolution and identify the genomic, genetic, and gene-regulatory changes that drove them. Key selling features: Summarizes the data regarding neural crest cells and nerural crest derivatives Uses a broad-based comparative approach Suggests hypothesis that the origin of neural crest cells involved the novel co-activation of ancient metazoan gene programs in neural border cells Illustrates how the emergences of neural crest made possible the diversification of vertebrate heads

The Neural Crest

The Neural Crest
Author : Nicole Le Douarin,Nicole M. LeDouarin,Chaya Kalcheim
Publisher : Cambridge University Press
Release Date : 1999-11-28
Category : Science
Total pages :445
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This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.

Neural Crest Cells

Neural Crest Cells
Author : Quenten Schwarz,Sophie Wiszniak
Publisher : Humana
Release Date : 2020-08-14
Category : Science
Total pages :230
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This detailed book provides a wide range of techniques, from those that have been used extensively since the very first investigations into neural crest cells to those that are currently cutting-edge, in order to explore the development of neural crest cells in human, mice, rat, chick, quail, medaka, and shark. With a bit of imagination and adjustment, many of these methodologies can be adaptable to any species desirable for study. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neural Crest Cells: Methods and Protocols serves as an ideal reference guide for aspiring and experienced developmental biologists alike.

The neural crest

The neural crest
Author : Anonim
Publisher : Unknown
Release Date : 1988
Category :
Total pages :129
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The Neural Crest in Development and Evolution

The Neural Crest in Development and Evolution
Author : Brian K. Hall
Publisher : Springer Science & Business Media
Release Date : 1999-07-30
Category : Science
Total pages :313
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A discussion of the neural crest and neural crest cells, dealing with their discovery, their embryological and evolutionary origins, their cellular derivatives - in both agnathan and jawed vertebrates or gnathostomes - and the broad topics of migration and differentiation in normal development. The book also considers what goes wrong when development is misdirected by mutations, or by exposure of embryos to exogenous agents such as drugs, alcohol, or excess vitamin A, and includes discussions of tumours and syndromes and birth defects involving neural crest cells.

Neural Crest Induction and Differentiation

Neural Crest Induction and Differentiation
Author : Jean-Pierre Saint-Jeannet
Publisher : Springer Science & Business Media
Release Date : 2007-08-10
Category : Medical
Total pages :248
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Written by an international panel of recognized leaders in the field, Neural Crest Induction and Differentiation discusses all aspects of modern neural crest biology from its evolutionary significance to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Abundant color figures enhance the text providing clear and attractive illustrations of central issues and concepts.

The Stemness of Neural Crest Cells and Their Derivatives

The Stemness of Neural Crest Cells and Their Derivatives
Author : Anonim
Publisher : Unknown
Release Date : 2014
Category :
Total pages :129
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Abstract Neural crest cells (NCCs) are unique to vertebrates and emerge from the border of the neural plate and subsequently migrate extensively throughout the embryo after which they differentiate into many types of cells. This multipotency is the main reason why NCCs are regarded as a versatile tool for stem cell biology and have been gathering attention for their potential use in stem cell based therapy. Multiple sets of networks comprised of signaling molecules and transcription factors regulate every developmental phase of NCCs, including maintenance of their multipotency. Pluripotent stem cell lines, such as embryonic stem cells and induced pluripotent stem (iPS) cells, facilitate the induction of NCCs in combination with sophisticated culture systems used for neural stem cells, although at present, clinical experiments for NCC‐based cell therapy need to be improved. Unexpectedly, the multipotency of NCCs is maintained after they reach the target tissues as tissue neural crest stem cells (NCSCs) that may contribute to the establishment of NCC‐derived multipotential stem cells. In addition, under specific culture conditions, fate‐restricted unipotent descendants of NCCs, such as melanoblasts, show multipotency to differentiate into melanocytes, neurons, and glia cells. These properties contribute to the additional versatility of NCCs for therapeutic application and to better understand NCC development. Birth Defects Research (Part C) 102:251–262, 2014. © 2014 Wiley Periodicals, Inc.

Neurotrophins and the Neural Crest

Neurotrophins and the Neural Crest
Author : Maya Sieber-Blum
Publisher : CRC Press
Release Date : 1998-06-29
Category : Science
Total pages :288
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The target of much current research, the neural crest is a transitory tissue of the vertebrate embryo that gives rise to many diverse structures in the adult organism, including the autonomic nervous system, the enteric nervous system, and most primary sensory ganglia, among other cell types and tissues. Reflecting recent investigations, Neurotrophins and the Neural Crest is dedicated to the roles neurotrophins play in neural crest cell differentiation and in the survival of neural crest derivatives. This timely book correlates in vitro data with results obtained from knock-out mice with targeted neurotrophin or receptor deletions, with the goal of determining the fidelity and usefulness of various experimental culture systems. It also covers embryonic expression patterns and functions of neurotrophins and their receptors. Chapters are organized to begin with neural crest-derived tissues as sources for experimental material, including sensory neurons, sympathetic neurons, enteric neurons, melanocytes, and calcitonin-producing cells from the thyroid, and concludes with discussions of the neural crest cells. A broad range of researchers and scientists involved in growth factors, neuroscience, developmental and cell biology, embryology, and many other fields, will find that Neurotrophins and the Neural Crest targets this fast-moving area of research completely and concisely.

Neural Crest and Placodes

Neural Crest and Placodes
Author : Anonim
Publisher : Academic Press
Release Date : 2015-02-03
Category : Science
Total pages :542
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Neural Crest and Placodes provides in-depth coverage of the topic, including information on their critical role in vertebrate development, evolution, and the way defects in their development underlie a wide range of congenital disorders. It delves deep into advances made in our understanding of the mechanisms governing the formation, migration, and differentiation of these two cell populations, also discussing their integration during embryonic development. The text highlights the application of fundamental knowledge in investigating the etiology and pathogenesis of congenital disorders and the ways the data applies to the field of regenerative medicine. Written by leading experts in the field Includes descriptions of the most recent advances in the field Highlights the applications of this knowledge in investigating the etiology and pathogenesis of congenital disorders Explores their usage in the field of regenerative medicine

Neural Crest Cell Epithelial to Mesenchymal Transition and Proliferation in the Zebrafish Hindbrain

Neural Crest Cell Epithelial to Mesenchymal Transition and Proliferation in the Zebrafish Hindbrain
Author : Jason D. Berndt
Publisher : Unknown
Release Date : 2006
Category :
Total pages :165
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A Study of the Metabolism of Amphibian Neural Crest Cells During Their Migration and Pigmentation in Vitro

A Study of the Metabolism of Amphibian Neural Crest Cells During Their Migration and Pigmentation in Vitro
Author : Reed A. Flickinger
Publisher : Unknown
Release Date : 1949
Category : Metabolism
Total pages :34
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Pattern Formation in Zebrafish

Pattern Formation in Zebrafish
Author : Lilianna Solnica-Krezel
Publisher : Springer Science & Business Media
Release Date : 2002-08-21
Category : Science
Total pages :438
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Authored by leading experts in the field, this book provides the first comprehensive overview of the mechanisms of early patterning and morphogenesis in zebrafish. It summarizes the current knowledge and the key questions for the next decade of research.

Assessment of Cranial Neural Crest Cell Differentiation Towards an Osteoblastic Fate

Assessment of Cranial Neural Crest Cell Differentiation Towards an Osteoblastic Fate
Author : Sean Congdon
Publisher : Unknown
Release Date : 2018
Category : Electronic dissertations
Total pages :129
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The world health organization estimates that craniofacial defects affect between 2-3% of all live births, with complications ranging from aesthetic issues to severe mental retardation (Marcucio 2015). It is estimated that for a pathology resulting in craniofacial aberrations, each affected individual costs society ~1 million dollars in corrective and palliative care (Singh 2014). Current investigations into genetics underlying these defects have revealed 564 human (HPO 2017) and 3297 murine (MGI 2017) genes thought to be involved in craniofacial pathologies. Facial development requires a population of cells known as Cranial Neural Crest Cells (CNCCs) to properly migrate from the neural plate border and to populate the tissue of the future face (Douarin 2007). CNCCs are multipotent progenitors that respond to extrinsic signaling to make fate choices. Dysregulation of this process can result in craniofacial pathologies, such as clefting. Not only will understanding the genetic factors behind craniofacial development allow for better treatment of craniofacial disease, but can aid in genetic counseling to ultimately save millions of dollars in healthcare costs. Currently, discovery of genes involved with craniofacial development rely on high throughput genetic manipulations in animal models and/or epidemiological information obtained from human populations. These discoveries mainly employ top-down approaches to understand the genetics involved in craniofacial disorders. We propose that we can employ a bottom-upapproach to elucidate novel genetic components involved in normal craniofacial development to interrogate craniofacial diseases, chiefly, ones affecting craniofacial skeletal development. Our lab's focus is to resolve the transcriptic profile of populations of cells, using single-cell RNA sequencing during murine development. Of note is the ability of our lab to identify genes that co-vary with one another in populations of cells and are thought to coordinate genetic programs, a concept known as a metagene (Wilson 2012). Recently, our efforts have been to characterize populations of cells from theiler stage 19 (TS19) murine embryos, a developmental stage critical in craniofacial development (Kawauchi 2005). We propose three specific aims in order to evaluate craniofacial development in a bottom-up manner; (1) identify metagenes in putative CNCCs and osteoblastic progeny in our TS19 data set, (2) create a model system to interrogate CNCC metagene expression patterns and (3) perturb metagenes to broaden our understanding of CNCC fate decisions, particularly towards an osteoblastic fate. Our proposed research will broadly impact the field by expanding methods to evaluate genetic programs guiding fate decisions. These findings will help to identify novel genes participating in craniofacial development and can be used to understand genetic dysregulation occurring in craniofacial pathologies.

Patterning of Neural Crest-derived Pigment Cells in the Avian Embryo

Patterning of Neural Crest-derived Pigment Cells in the Avian Embryo
Author : Melissa Locke Harris
Publisher : Unknown
Release Date : 2008
Category :
Total pages :300
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