December 1, 2020

Download Ebook Free Neuromuscular Junction Disorders

Neuromuscular Junction Disorders

Neuromuscular Junction Disorders
Author : A. G. Engel
Publisher : Elsevier
Release Date : 2008-10-22
Category : Medical
Total pages :451
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This volume provides concise and comprehensive information on neuromuscular disorders, including rapid advancements in the understanding of the neurobiology of neuromuscular transmission. In addition, clinicians will find timely discussions on the various forms of these disorders that have been discovered due to increased study within the field. New observations into the immunopathogenesis of myasthenia gravis, and the molecular mechanisms underlying the links between activity and patterns of gene expression, particularly in muscle, are also explored, along with novel information on the understanding of the pathophysiology of the heterogeneous group of peripheral nerve hyperexcitability syndromes. Each of these valuable insights, and their accompanying explanations, provides a framework on which new therapeutic strategies can be built to aid in the enhancement and restoration of normal function in neuromuscular junction disorders. * New insights into the study of neuromuscular junction disorders, including rapid advancements in the field * Comprehensive information on the neuromuscular junction, and a detailed examination of myasthenia gravis and other disorders * A new framework upon which to build therapeutic strategies that will enhance the restoration of normal function in neuromuscular disorders

Neuromuscular Junction Disorders

Neuromuscular Junction Disorders
Author : Matthew N. Meriggioli,James F. Howard, Jr.,C. Michel Harper, Jr.
Publisher : CRC Press
Release Date : 2003-10-21
Category : Medical
Total pages :291
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This resource covers all aspects of the diagnosis and clinical management of patients with diseases of the neuromuscular junction. It breaks down each disease by pathophysiology, clinical presentation and natural history and course for improved diagnosis and treatment.

Myasthenia Gravis and Related Diseases

Myasthenia Gravis and Related Diseases
Author : Myasthenia Gravis Foundation (U.S.). California Chapter,New York Academy of Sciences
Publisher : Unknown
Release Date : 1998
Category : Medical
Total pages :838
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This volume of proceedings includes the latest research on the pathogenesis, diagnosis and treatment of myasthenia gravis and related diseases. It includes reports of progress in the study of the acetylcholine receptor molecule and its function as a ligand-gated ion channel. Further topics include the molecular events involved in presynaptic neurotransmitter release, postsynaptic antigens in autoimmune myasthenia gravis, the immune mechanisms involved in Lambert-Eaton myasthenic syndrome, and genetically determined abnormalities of neuromuscular transmission.

Neuromuscular Disorders in Clinical Practice

Neuromuscular Disorders in Clinical Practice
Author : Bashar Katirji,Henry J. Kaminski,Robert L. Ruff
Publisher : Springer Science & Business Media
Release Date : 2013-10-11
Category : Medical
Total pages :1565
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Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment. Mirroring the first book, this two-volume edition is divided into two parts. Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders. Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes. Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners. General neurologists as well as specialists in neuromuscular medicine and trainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused. Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice.

Neuromuscular Junction Disorders, An Issue of Neurologic Clinics, E-Book

Neuromuscular Junction Disorders, An Issue of Neurologic Clinics, E-Book
Author : Mazen M. Dimachkie,Richard J Barohn
Publisher : Elsevier Health Sciences
Release Date : 2018-04-30
Category : Medical
Total pages :217
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This issue of Neurologic Clinics, edited by Dr. Mazen M. Dimachkie and Dr. Richard J. Barohn, focuses on Neuromuscular Junction Disorders. Topics include--but are not limited to--History of myasthenia gravis and neuromuscular junction disorders; Practical immunology of the neuromuscular junction; Practical anatomy of the neuromuscular junction in health and disease; Generalized myasthenia gravis; Ocular myasthenia gravis; Diagnosis of myasthenia gravis; MuSK and myasthenia gravis due to other autoantibodies; Treatment of myasthenia gravis; Evidenced-based approach of thymectomy for myasthenia gravis; Myasthenia gravis and pregnancy; Congenital myasthenic syndromes; Botulism; Lambert-Eaton myasthenic syndrome; and Measuring clinical treatment response in myasthenia gravis.

Neuromuscular Function and Disorders

Neuromuscular Function and Disorders
Author : Alan J. McComas
Publisher : Butterworth-Heinemann
Release Date : 2013-10-22
Category : Health & Fitness
Total pages :374
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Neuromuscular Function and Disorders focuses on the various processes underlying disordered neuromuscular function. Topics covered include the nature of membrane defects in myotonia and familial periodic paralysis; the disorder of neuromuscular transmission responsible for myasthenia gravis and the various pseudo-myasthenic syndromes; and the disorders of Schwann cell function which cause demyelination. This book is comprised of 28 chapters divided into two sections and begins with a discussion on the normal anatomy and physiology of peripheral nerve and muscle. Included in the first section are descriptions of the ionic mechanisms responsible for the resting and action potentials of nerve and muscle; the sequential stages in neuromuscular transmission; excitation-contraction coupling; the sliding filament mechanism of myofibrillar shortening; and the morphological and functional properties of motor units. The neurophysiology of exercise and muscle fatigue is also considered, along with the nature of the trophic influences exerted by the motoneuron and muscle fiber upon each other. The second half of the book deals entirely with various diseases of peripheral nerve and muscle, together with diagnostic procedures and therapeutic management. A consistent theme in this section is the recognition of neural abnormalities in diseases hitherto considered as primary disorders of the muscle fiber. This monograph should be of value to neurologists, medical students, research workers, and students and research scientists in physiology, zoology, pharmacology, kinesiology, and physical education.

Neuromuscular Disorders

Neuromuscular Disorders
Author : James Russell,Anthony Amato
Publisher : McGraw-Hill Education / Medical
Release Date : 2008-05-06
Category : Medical
Total pages :788
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Everything you need to know about neuromuscular disease--in one concise, full-color volume "...this book will become an indispensable resource for clinicians involved in the diagnosis and management of patients with neuromuscular diseases, as well as for scientists working on the nature and pathogenesis of these disorders. It is a much-needed and welcome addition to the neurological literature and will rapidly gain acceptance as a standard work of reference."--Michael J. Aminoff, MD, DSc, FRCP, (from the foreword) Neuromuscular Disorders is comprehensive in scope, yet concise enough to serve as a valuable point-of-care guide for your day-to-day clinical practice. Grounded by numerous reference sources and enhanced by the experience of two seasoned clinicians, this text provides a pragmatic approach to the evaluation and management of neuromuscular disease. Here, in a single source, you'll get an insightful look at both nerve and muscle conditions, ranging from motor neuron diseases to neuropathies, neuromuscular junction disorders, and myopathies. The book opens with the clinical and laboratory approach to patients with neuromuscular disease, covering electrodiagnostic testing, nerve conduction studies, and muscle and nerve histopathology. With an emphasis on effective diagnosis and treatment, the substance of the text examines the full spectrum of specific neuromuscular diseases, giving you the “big picture” of the discipline in a way that no other text can match. FEATURES: Convenient coverage of both nerve, muscle and neuromuscular transmission disorders--both primary and secondary neuromuscular diseases Specific disease sections encompass the range of conditions likely to be encountered in clinical practice, including amyotrophic lateral sclerosis, myasthenia gravis, radiculopathies and plexopathies, mononeuropathies, various polyneuropathies, toxic myopathies, and dozens more The very latest diagnosis and treatment recommendations and protocols based on the most recent clinical literature and research Well-illustrated with EMGs, histopathology, and clinical photos

Neuromuscular Junction Disorders, An Issue of Neurologic Clinics, E-Book

Neuromuscular Junction Disorders, An Issue of Neurologic Clinics, E-Book
Author : Mazen M. Dimachkie,Richard J Barohn
Publisher : Elsevier Health Sciences
Release Date : 2018-04-30
Category : Medical
Total pages :217
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This issue of Neurologic Clinics, edited by Dr. Mazen M. Dimachkie and Dr. Richard J. Barohn, focuses on Neuromuscular Junction Disorders. Topics include--but are not limited to--History of myasthenia gravis and neuromuscular junction disorders; Practical immunology of the neuromuscular junction; Practical anatomy of the neuromuscular junction in health and disease; Generalized myasthenia gravis; Ocular myasthenia gravis; Diagnosis of myasthenia gravis; MuSK and myasthenia gravis due to other autoantibodies; Treatment of myasthenia gravis; Evidenced-based approach of thymectomy for myasthenia gravis; Myasthenia gravis and pregnancy; Congenital myasthenic syndromes; Botulism; Lambert-Eaton myasthenic syndrome; and Measuring clinical treatment response in myasthenia gravis.

The Fly Neuromuscular Junction: Structure and Function

The Fly Neuromuscular Junction: Structure and Function
Author : Vivian Budnik,Catalina Ruiz-Canada
Publisher : Elsevier
Release Date : 2006-11-02
Category : Medical
Total pages :424
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The Drosophila larval neuromuscular junction (NMJ) has become one of the most powerful model systems to ask key neurobiological questions. This synapse is unparalleled by its accessibility, its simplicity, and the ability to manipulate genes important for synapse development and function. Its synapses have properties shared by many organisms including humans. The vast majority of genes that when mutated cause congenital disorders of the nervous system in humans, are present in the fruit fly genome, and fly models of human disorders are available. Thus, this preparation is a powerful tool to understand the normal function of these genes. This book reviews outstanding work by recognized leaders in the fields of Drosophila cellular neurogenetics including developmental neurobiology, mechanisms of synaptic function, and experience dependent changes at synapses. The book also includes step-by-step protocols to study the cellular biology of the NMJ, making it a vital resource for researchers beginning their investigations with this system, for those who are training students and postdoctoral fellows in this area, or simply as a general reference material for neuroscientists and neuroscience professors in general. * Provides a synthesis of the main topics in modern neurogenetics * Includes step-by-step protocols for the use of the Drosophila NMJ system in neurobiology lab research * Offers genetic approaches to study synapse development and function *

Myasthenia Gravis and Related Disorders

Myasthenia Gravis and Related Disorders
Author : Henry J. Kaminski
Publisher : Springer Science & Business Media
Release Date : 2009-03-02
Category : Medical
Total pages :312
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Advances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common resource for understanding this complex disorder. This new edition begins with discussions of neuromuscular junction structure and function and follows with updated chapters covering a wide range of topics, such as the acetylcholine receptor, clinical presentation, diagnostic evaluation, and treatment. Importantly, new supplemental chapters have been added; these discuss rigorous clinical assessments of patients for research trials and the epidemiology and genetics of myasthenia gravis. The discussion of the most challenging aspects of myasthenia gravis, its impact on patients’ psychological make-up, has been expanded as well. Myasthenia Gravis and Related Disorders, Second Edition retains the “personal approach” of the authors regarding treatment and is a valuable resource for meeting the many and varied needs of patients with myasthenia gravis.

Myasthenia Gravis and Myasthenic Disorders

Myasthenia Gravis and Myasthenic Disorders
Author : Andrew G. Engel
Publisher : Oxford University Press
Release Date : 2012-04-03
Category : Medical
Total pages :304
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Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and the electrophysiologic diagnosis of its disorders. The introductory chapters are followed by a detailed exposition of the pathogenesis, natural history, diagnosis and therapy of the autoimmune myasthenias, the Lambert-Eaton myasthenic syndrome, and the increasingly complex and fascinating diseases collectively referred to as congenital myasthenic syndromes. The acetylcholine receptor is a major target of both autoimmune and inherited myasthenias and a separate chapter reviews its structural and functional properties. The book also describes disorders that often target terminal nerve segment near the neuromuscular junction-- the syndrome of peripheral nerve hyperexcitability and the Guillain-Barré syndrome. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.

Myasthenia Gravis and Related Disorders

Myasthenia Gravis and Related Disorders
Author : Henry J. Kaminski,Linda L. Kusner
Publisher : Humana Press
Release Date : 2018-03-13
Category : Medical
Total pages :353
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The third edition of this important, gold-standard title outlines a range of significant advances in the study and understanding of myasthenia gravis. The overarching goal of this new edition is identical to the first and second -- to provide the clinician and the scientist with a common resource for understanding the profound achievements in the clinical, translational, and basic sciences of neuromuscular transmission disorders. In addition to several new authors and an extensive update of all chapters, this third edition includes summaries of pre-clinical research standards for autoimmune MG, along with a broad summary of MG clinical trial performance. The now greater understanding of the clinical presentation of MuSK-related MG and identification of potential new autoantigens, including LRP-4, is discussed. The development of treatment guidelines by groups in Japan, the United Kingdom, Germany, and an international consortium is also outlined. Myasthenia Gravis and Related Disorders, Third Edition, is an invaluable resource for meeting the many and varied needs of clinicians who treat patients with myasthenia gravis.

Neuromuscular Case Studies E-Book

Neuromuscular Case Studies E-Book
Author : Tulio E. Bertorini
Publisher : Elsevier Health Sciences
Release Date : 2008-05-14
Category : Medical
Total pages :632
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In this unique book, Dr. Bertorini guides you through more than 100 cases that demonstrate the diagnosis and management of a wide range of common and rare neuromuscular disorders. No other reference boasts such a large array of clinical studies devoted to all areas of this broad topic! Each case study reviews the etiologies, pathogenesis, differential diagnosis, and management of a particular disorder, helping you not only recognize its presentation, but also determine a diagnosis and the best treatment plans for your patients. You’ll also find expert guidance on the basic mechanisms of neuromuscular disorders, clinical examination, and diagnostic tests—including EMG, muscle biopsy, genetic testing, and more. More than 100 detailed case studies explore both common and rare neuromuscular disorders and the treatment protocols for each, equipping you with the knowledge you need to confidently manage any challenge. Each case includes a summary of important points or highlights of the study. Case studies are arranged either by complaint or by diagnosis so that you can successfully manage your patients with or without an initial diagnosis. Comprehensive coverage of EMGs and nerve conduction studies and other diagnostic tests, including muscle and nerve biopsies and genetic testing, helps you accurately diagnose nerve, muscle, and neuromuscular transmission disorders. Detailed discussions of treatment plans and commonly used drugs enhance your management of autoimmune disorders, painful neuropathy, dysautonomia, and other neuromuscular disorders. A reader-friendly format takes you step by step through the diagnosis and treatment of neuromuscular disorders, from the basic anatomy and physiology of the nerve and muscle through to clinical evaluation, diagnostic testing, and therapy. More than 350 high-quality illustrations, including full-color patient photographs, biopsies, and EMG tracings, make complex concepts easier to understand and apply.

Clinical Neurology

Clinical Neurology
Author : Michael J. Aminoff,Robert R. Simon,David Greenberg
Publisher : McGraw Hill Professional
Release Date : 2005-03-10
Category : Medical
Total pages :400
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Recognized for a practice-oriented approach to neurology based on the patient’s presenting symptoms or signs. This uniquely readable and concise book provides a strong foundation in basic neuroscience linking it to current approaches in the diagnosis and treatment of neurologic disorders. Features new relevant web sites and a glossary as well as extensive use of charts and tables.

The Hospital Neurology Book

The Hospital Neurology Book
Author : Arash Salardini,Jose Biller
Publisher : McGraw Hill Professional
Release Date : 2016-04-22
Category : Medical
Total pages :129
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A practical, protocol-oriented guide to the practice of neurology in the hospital setting A Doody's Core Title for 2017! Hospital neurology is one of the fastest growing subspecialties within neurology. Running an efficient and effective neurohospitalist line is important to the financial success of hospitals and the physicians employed there. Many neurology patients also have internal medicine problems, and often it is a general hospitalist without neurology training who treat these patients. These physicians sorely need more information on neurology. Conversely, neurologists caring for these patients have only had one year of internal medicine training and require more guidance on medical problems. Given these realities, there is a need for a resource on hospital neurology. With The Hospital Neurology Book, Drs. Salardini and Biller have created a practical, concise, and useful work that guides both neurologists and internists in the areas in which their training is currently not sufficient for hospital practice. The Hospital Neurology Book features a highly readable format, providing information physicians can act upon, including recipes and protocols for patient care and question-based chapter headings that lead physicians to the exact issue they are dealing with in the moment. Each chapter (or chapter section as appropriate) opens with a case study, setting the stage in a highly practical manner, and ends with high yield summary points useful for consolidating learning.